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This course covers advanced study of cytochrome P450 in relation to drug toxicity and molecular mechanisms of drug - and xenobiotic-induced toxicity and selected areas of immunopharmacology, immunotoxicology, reproductive and developmental toxicology, carcinogenesis and teratogenesis.
Course Co-ordinator: Dr H.M. Wallace (437956)
The students will be conversant with advanced aspects of molecular toxicology, by means of lectures, assignments, computer workshops, interactive tutorials and group presentations. Practical classes will be used to illustrate and reinforce the principles covered in molecular toxicology.
Toxicological significance of drug oxidation : Dr H.M. Wallace
This lecture will outline the importance of drug oxidation in relation to toxicity in man
Drug targeting and gene therapy I and II: Dr H.M. Wallace
Basics of drug delivery and targeting will be covered. This will include monoclonal antibodies and antibody engineering. Gene therapy and the issues surrounding gene delivery will be discussed.
Practical: Dr J. Crockett
In this practical you will explore the mechanisms by which cytotoxic drugs cause cell death. You will learn to distinguish between apoptosis and necrosis by applying a panel of assays to cultures of cells that have been exposed to a range of concentrations of drug. The practical will require you to work in teams and to share data between teams in the tutorial to obtain the overall picture of the likely mechanism of cell death induced by the drug.
The Practical tutorial will provide the opportunity to share and discuss your team data with the rest of the class. Each team will come prepared with up to 4 slides describing the principle behind the assay that they used, the method they used, results obtained and the pro's and con's of the assay. We will provide you with instruction on what is required for your assignment.
Drug Transporters: Dr H.M. Wallace
This lecture will describe the major classes of drug transporters and the role these play in drug development
Immunopharmacology: Dr K. Stewart
These three lectures will:
• Review the use of immunosuppressive drugs in transplantation and autoimmune diseases. Explain the rationale behind the use of immunosuppressive regimes. Discuss the different categories of immunosuppressive drugs and agents.
• Describe the structure and action of CsA, FK506 and rapamycin. Compare and contrast their side effects and pharmacology. Discuss, using examples, therapeutic efficacy and monitoring.
• Explain the mode of action of fungal immunosuppressant’s at the molecular level. Compare and contrast the calcium-dependent and -independent mechanisms
• Explore the increasing significance of monoclonal and polyclonal antibodies and their role in more specifically targeting the rejection process. As well as their role in the pre-transplantation setting in inducing transplantation tolerance ..The ultimate goal in clinical transplantation.
Reproductive and developmental toxicity: Professor N. Brown
These sessions cover developmental toxicity, that is to say, adverse effects that are caused by exposures during pregnancy, either drugs, chemicals or physical agents. General principles will be covered, including the different types of adverse outcomes and the importance of genotype, developmental stage and pharmacokinetics. Mechanisms of action will be covered including the major classes of receptor-mediated mechanisms. Current approaches to the “3R’s” in developmental toxicology will be reviewed, including in vitro approaches to testing. Finally, a number of case studies, including valproic acid, will be used to illustrate key points.
Molecular carcinogenesis: Dr H.M. Wallace
The regulation of cell growth and the cell cycle will be described as will the role of proto-oncogenes and oncogenes and tumour suppressor genes.
Mechanisms of drug induced toxicity I and II and II: Dr H.M. Wallace
The processes of cell death including apoptosis, necrosis and autophagy will be described and the regulation of each process will be discussed.
Part1: Introduction to Drug Discovery R&D: Dr R. Weaver
Part2: Drug Development Process
Part3: Pharmacokinetics in Development
Overview:
The lecture offers students an introduction to drug discovery & development in the pharmaceutical industry. Topics covered include how research programmes are selected, types of medicines, drug discovery, non-clinical and clinical R&D, and the Regulatory framework. Scientific disciplines covered includes applied in vitro and in vivo toxicology, drug metabolism, pharmacokinetics and safety pharmacology.
Mechanisms of drug induced toxicity IV: Dr K. Thompson
This lecture will discuss the mechanism of direct drug-induced liver injury (DILI) using examples including the painkiller paracetamol and the general anaesthetic halothane. Immune cell-mediated liver damage will also be discussed, with a particular focus on the cell types involved and how they modulate reparative mechanisms following DILI.
Biomarkers in pre-clinical toxicology: Dr E. Collie-Duguid
This lecture will outline the use of biomarkers to improve the clinical management of a wide range of human diseases, with a specific emphasis on their use in cancer diagnosis and treatment. A biomarker is a biological molecule found in blood, other body fluids or tissues that can be objectively measured and is an indicator of a normal or abnormal biological process, pathogenic process or pharmacological responses to a therapeutic intervention. Modern ‘omics technologies have revolutionalised drug scheduling and development and the comprehensive molecular typing of common human diseases such as cancer has stratified different cancers into distinct molecular subtypes that have distinct prognostic outlooks and distinct responses to different types of anti-cancer agents. These data are being used to develop biomarkers to improve patient outcomes and move towards personalised treatments. The lecture will discuss risk/ screening, diagnostic, prognostic, predictive and pharmacodynamic biomarkers, providing examples of how they are being used to improve the clinical management of human diseases.
Risk assessment: Dr C. Elcombe
Toxicological pathology: Professor S. Price
Histopathology plays a central part in toxicological evaluation. Although most major studies employ an experienced pathologist, it is necessary for all toxicologists to appreciate the basic principles of pathology. These lectures aim to introduce the principles of pathology, including the preparation and examination of tissues from toxicity studies.
Learning Outcomes:
You should understand basic pathological findings in a broader context which will assist you in communicating with specialist pathologists. You will:
• know and understand the themes and major causes and processes in pathology;
• have a knowledge of the biochemical bases of pathological change;
• appreciate the major microscopic changes associated with toxicity at the cellular and tissue level;
• be able to integrate the role of histopathology within the context of toxicity studies.
Lecture content:
• Themes, causes and processes in pathology;
• Causes of pathological changes;
• Disorders of tissue growth - hypertrophy, dysplasia and neoplasia;
• Cell necrosis and degeneration;
• Tissue restoration and repair;
• Thrombosis and embolism; their origins and consequences.
Mechanisms of drug induced toxicity oxidative stress:
Professor H. Galley
Definition of a free radical; sources of free radicals; damage caused by free radicals; antioxidant protection mechanisms; and free radical mediated mechanisms of drug toxicity; recent studies of preventative strategies.
Immunotoxicology: Professor I. Kimber
These lectures will provide an overview of the adaptive immune system, the health consequences of impaired immune function and a consideration of allergy caused by chemicals and proteins.
Laboratory Work
The details of the practicals are given in the Practical Manual. Please ensure that you bring clean white laboratory coats to the practical and all students must read and observe the Notes on Behaviour and Safety in Laboratories enclosed with the laboratory manual.
Laboratory reports should be prepared with the aid of a word-processor and the data analysed with the aid of appropriate software packages. The DEADLINE for handing in completed laboratory reports is as given in the timetable.
The practical work required in this course may present difficulties to students with special educational needs. For such students, alternative arrangements will be made. Any student with special needs should make these known to the Course Co-ordinator when registering for the class, and should then also discuss their needs with the School Disabilities Co-ordinator, Dr Derryck Shewan to ensure that they have the best possible outcome.
Work to be handed in:
Essay to be handed in by 9.00am Monday 3rd December. Practical Reports to be handed in by 9.00am on the Monday 10 days after the practical.
There is a regular programme of seminars given throughout the academic year by invited specialists from within the broad field of biomedical research.
These are usually held on Wednesdays from 1.00-2.00pm in the IMS Building at Foresterhill (check the School or IMS websites for specific locations of seminars).
As you are studying within research-driven disciplines, we strongly feel that you should attend these whenever possible, with a view to broadening your appreciation of medical sciences. You will also be directed to attend any other relevant seminars when they arise.
General Reading List
Books recommended for purchase
1 Rang, Dale, Ritter & Moore Pharmacology
The following are available at Foresterhill Library Counter (Heavy Demand)
1. Pratt & Taylor Principles of Drug Action (Third edition). ISBN. 0443086761
2. Casarett & Doull’s Toxicology. (Fifth edition). ISBN. 0071054766.
3. Lu Basic Toxicology. (Sixth edition). ISBN. 978-1-84184-953-9 (earlier editions: 1 copy FH; 3 copies QML).
4. Comprehensive Toxicology (Reference Section, Foresterhill) (13 volumes)
5. Boelsterli, A. Mechanistic toxicology: the molecular basis of how chemicals disrupt biological targets. ISBN. 0415284589. (4 copies FH).
6. Hayes, A.W. Principles and methods of toxicology. ISBN. 1560328142. (4 copies FH).
7. Yin & Dong. Essentials of apoptosis: a guide for basic and clinical research. ISBN.
1588291464. (2 copies FH).
or Foresterhill Library
Trends in Pharmacological Sciences
The University has strict regulations on plagiarism. If you are unsure about what constitutes plagiarism read the University guide on plagiarism at http://www.abdn.ac.uk/writing
Copying or plagiarising another persons work, either from other students or published material in books or papers and submitted as your own for assessment is considered a form of cheating. This is considered by the University to be a serious offence and will be penalised according to the extent involved and whether it is decided there was an attempt at deliberate deception, or whether bad practice was involved. If you do use information or ideas obtained from textbooks or other published material you must give a precise reference to the source both at the appropriate point in your narrative and in a list of references at the end of your work. Direct quotations from published material should be indicated by quotation marks and referenced in the text as above.
Students are expected to attend the lectures, practicals and tutorials. Any period of absence must be covered by a medical certificate in accordance with University regulation (see Notice Boards). Practical reports and assignments must be handed in for marking by the dates indicated. A 100% attendance is required at practicals. If assignments are not handed in on time eg if an assignment is more that 1 week late without good cause, it will not be marked.
The distribution of assessments is as follows:
1.Degree written exam 2h paper, answer 3 questions (one from section A; one from section B and one other from either section) = 70% of CAS mark for this course
2.Continuous assessment Practical report, essay and problem solving = 30% of CAS mark for this course.
Past papers for PA4302 are available on the Web.
Dr Steven Tucker
Dr Heather Wallace
Professor N Brown (NB), St. George’s Hospital Medical School, London Dr J Crockett (JC), Division of Applied Medicine Dr E Collie-Duguid, Division of Applied Medicine Dr C Elcombe (CE), University of Dundee/CXR Biosciences Professor H Galley (HFG), Division of Applied Medicine Professor I Kimber (IK), University of Manchester Professor S Price (SCP), University of Surrey Dr K Stewart (KS), Division of Applied Medicine Dr K Thompson (KT), Division of Applied Medicine Dr R J Weaver (RW), Bioanalysis & New Technologies Division, Safety Assessment, France
If students have difficulties with any part of the course that they cannot cope with alone they should notify someone immediately. If the problem relates to the subject matter you may be best advised to contact the member of staff who is teaching that part of the course. Students with registered disabilities should contact either the IMS based School Office or the Old Aberdeen office associated with the teaching laboratories (Mrs Sheila Jones s.jones@abdn.ac.uk) to ensure that the appropriate facilities have been made available. Otherwise, you are strongly encouraged to contact any of the following as you see appropriate:
Course student representatives.
Course co-ordinator, Dr Heather Wallace
Convenor of the student-staff liaison committee. Dr Gordon McEwan
Adviser of studies.
Disabilities Co-ordinator. Dr Derryck Shewan
Staff are based at Foresterhill and we strongly encourage the use of email or telephone the School Office. You may be wasting your time to travel to Foresterhill only to find staff unavailable.
Support Available to Students
The University is keen to help you successfully complete your studies. If at any time you feel you need assistance, there is a range of support services available to help you. These include support to assist with unexpected and/or exceptional financial difficulty, support for disabled students and academic learning support through the Student Learning Service. Further details about all these services area available at http://www.abdn.ac.uk/studenthelpguide/.
Transition into level 4 and beyond
As students progress through their degree programme, they will notice a change in the style and approach of teaching and the expectations upon them as learners. Expectations again change as students progress into Honours year, where they are expected to become more independent and self-directed in their learning. To help with this transition, a variety of activities will be planned to address any new challenges faced by students at level 4. The level 4 retention co-ordinator - Dr Steve Tucker (s.j.tucker@abdn.ac.uk; 01224 437491) will organise such events and is a point of contact for any level 4 SMS students facing any kind of difficulty. Regular activities and workshops will be designed around key issues faced by Honours students much in the same way as it was at level 3. In addition, Dr Tucker will hold regular, advertised drop-in surgeries for students to raise any issues face to face and all level 4 SMS students will have access to a MyAberdeen site that will offer information, feedback, guidance and discussion forums designed to ease students through to the completion of their degree.
Absence from Classes on Medical Grounds
Candidates who wish to establish that their academic performance has been adversely affected by their health are required to secure medical certificates relating to the relevant periods of ill health (see General Regulation 17.3).
The University’s policy on requiring certification for absence on medical grounds or other good cause can be accessed at:
www.abdn.ac.uk/registry/quality/appendix7x5.pdf
You are strongly advised to make yourself fully aware of your responsibilities if you are absent due to illness or other good cause. In particular, you are asked to note that self-certification of absence for periods of absence up to and including eleven weekdays is permissible. However, where absence has prevented attendance at an examination or where it may have affected your performance in an element of assessment or where you have been unable to attend a specified teaching session, you are strongly advised to provide medical certification (see section 3 of the Policy on Certification of Absence for Medical Reasons or Other Good Cause).
Class Certificates
Students who attend and complete the work required for a course are considered to have been awarded a ‘Class Certificate’. Being in possession of a valid Class Certificate for a course entitles a student to sit degree examinations for that course. From 2010/11 class certificates will be valid for two years and permit a total of three attempts at the required assessment within that two year period i.e. the first attempt plus up to two resits.
We value students’ opinions in regard to enhancing the quality of teaching and its delivery; therefore in conjunction with the Students’ Association we support the operation of a Class Representative system.
The students within each course, year, or programme elect representatives by the end of the fourth week of teaching within each half-session. In this school we operate a system of course representatives. Any student registered within a course that wishes to represent a given group of students can stand for election as a class representative. You will be informed when the elections for class representative will take place.
What will it involve?
It will involve speaking to your fellow students about the course you represent. This can include any comments that they may have. You will attend a Staff-Student Liaison Committee and you should represent the views and concerns of the students within this meeting. As a representative you will also be able to contribute to the agenda. You will then feedback to the students after this meeting with any actions that are being taken.
Training
Training for class representatives will be run by the Students Association. Training will take place in the fourth or fifth week of teaching each half-session. For more information about the Class representative system visit www.ausa.org.uk or email the VP Education & Employability vped@abdn.ac.uk. Class representatives are also eligible to undertake the STAR (Students Taking Active Roles) Award, further information about the co-curricular award is available at: www.abdn.ac.uk/careers.
Monitoring Students' Progress
The University operates a system for monitoring students' progress to identify students who may be experiencing difficulties in a particular course and who may be at risk of losing their class certificate. If the Course Co-ordinator has concerns about your attendance and/or performance, the Registry will be informed. The Registry will then write to you (by e-mail in term-time) to ask you to contact their office in the first instance. Depending on your reason for absence the Registry will either deal directly with your case or will refer you to your Adviser of Studies or a relevant support service. This system is operated to provide support for students who may be experiencing difficulties with their studies. Students are required to attend such meetings with their Adviser of Studies in accordance with General Regulation 8.
Set criteria are used to determine when a student should be reported in the monitoring system. You will be asked to meet your Adviser if any of the following criteria apply for this course:-
either (i) if you are absent for a continuous period of two weeks or 25% of the course (whichever is less) without good cause being reported;
or (ii) if you are absent from two small group teaching sessions e.g. (laboratory/tutorial classes) without good cause;
or (iii) if you fail to submit a piece of summative or a substantial piece of formative in-course assessment by the stated deadline
If you fail to respond within the prescribed timescale (as set out in the e-mail or letter) you will be deemed to have withdrawn from the course concerned and will accordingly be ineligible to take the end of course assessment or to enter for the resit. The Registry will write to you (by e-mail in term-time) to inform you of this decision. If you wish consideration to be given to reinstating you in the course you will be required to meet the Convener of the Students' Progress Committee.
Transition into level 4 and beyond
As students progress through their degree programme, they will notice a change in the style and approach of teaching and the expectations upon them as learners. Expectations again change as students progress into Honours year, where they are expected to become more independent and self-directed in their learning. To help with this transition, a variety of activities will be planned to address any new challenges faced by students at level 4. The level 4 retention co-ordinator - Dr Steve Tucker (s.j.tucker@abdn.ac.uk; 01224 437491) will organise such events and is a point of contact for any level 4 SMS students facing any kind of difficulty. Regular activities and workshops will be designed around key issues faced by Honours students much in the same way as it was at level 3. In addition, Dr Tucker will hold regular, advertised drop-in surgeries for students to raise any issues face to face and all level 4 SMS students will have access to a MyAberdeen site that will offer information, feedback, guidance and discussion forums designed to ease students through to the completion of their degree.
Students who attend and complete the work required for a course are considered to have been awarded a ‘Class Certificate’. Being in possession of a valid Class Certificate for a course entitles a student to sit degree examinations for that course. From 2010/11 class certificates will be valid for two years and permit a total of three attempts at the required assessment within that two year period i.e. the first attempt plus up to two resits.
You will receive a University e-mail account when you register with the University Computing Centre. The University will normally use e-mail to communicate with you during term-time. These e-mails will be sent to your University e-mail account, which you can access using Eudora or SquirrelMail.
It is your responsibility to check your e-mail on a regular (at least weekly) basis and to tidy the contents of your e-mail inbox to ensure that it does not go over quota (see http://www.abdn.ac.uk/diss/email/mailquota.hti for guidance on managing your e-mail quota). It is recommended that you use your University e-mail account to read and respond to University communications. If you already have a non-University e-mail account that you use for personal correspondence, it is possible to set up automatic forwarding of messages from your University e-mail account to your personal e-mail address (see http://www.abdn.ac.uk/local/mail.forward/) but, should you do so, it is your responsibility to ensure that this is done correctly. The University takes no responsibility for delivery of e-mails to non-University accounts.
You should note that failure to check your e-mail or failure to receive e-mail due to being over quota or due to non-delivery of an e-mail forwarded to a non-University e-mail account would not be accepted as a ground for appeal (for further information on appeals procedures, please refer to http://www.abdn.ac.uk/registry/quality/appendix5x17.hti).
TurnitinUK
TurnitinUK is an online service which compares student assignments with online sources including web pages, databases of reference material, and content previously submitted by other users across the UK. The software makes no decision as to whether plagiarism has occurred; it is simply a tool which highlights sections of text that have been found in other sources thereby helping academic staff decide whether plagiarism has occurred.
As of Academic Year 2011/12, TurnitinUK will be accessed directly through MyAberdeen. Advice about avoiding plagiarism, the University’s Definition of Plagiarism, a Checklist for Students, Referencing and Citing guidance, and instructions for TurnitinUK, can be found in the following area of the Student Learning Service website www.abdn.ac.uk/sls/plagiarism/.
Requirements for the Award of an Honours Degree
All students who are admitted to an Honours programme, in or after 2004/05, will be required to achieve 480 credit points, including at least 180 at levels 3 and 4, of which at least 90 must be at level 4. This change to the requirements for the award of an Honours Degree was made by the Senate to ensure that Honours degrees are awarded in compliance with the Scottish Credit and Qualifications Framework (SCQF). This is a common national Framework for all awards in Scotland. Further information is available at www.scqf.org.uk.
Accordingly, students failing to meet this credit requirement at the first attempt will require to make up this credit shortfall before graduating. General Regulation 21, as outlined below, sets out the procedures available to enable students to make up this credit shortfall.
In the case of a candidate who has failed to complete satisfactorily an element of Honours degree assessment at the time prescribed by Regulation 9.3, then the appropriate procedure from (a) to (e) below shall apply:
a) If, but only if, the failure is on account of illness or other good causes, the candidate shall be required to submit themselves for assessment at the next available opportunity, and shall be permitted to count the result of that assessment towards Honours classification.
b) If the failure is the result of absence or non-submission of any other cause, the candidate shall be awarded zero for the assessment concerned and shall be required to submit themselves for assessment at the next available opportunity, but shall not be permitted to count the result of that assessment towards Honours classification.
c) For courses at level 4 and above only, if the candidate has completed the assessment but been awarded a mark on the Common Assessment Scale between 6 and 8 inclusive, they shall be awarded the same amount of unnamed specific credit, not exceeding 30 credit points in total, at level 1.
d) If the candidate has completed the assessment, but the course is at level 3, or the course is at level 4 or above and the mark awarded on the Common Assessment Scale is less than 6, the candidate shall be required to submit themselves for assessment at the next available opportunity, but shall not be permitted to count the result of that assessment towards Honours classification. Alternatively, for courses at level 4 and above only, such candidates may elect to attend and submit themselves for assessment in another course of equivalent credit value, which may be at any level.
e) If any options (a), (b) or (d) above would normally apply, but medical advice indicates that it would be unreasonable to require a candidate to appear for assessment on a subsequent occasion, and if the candidate’s past record provides sufficient evidence that they would have obtained Honours, the examiners may recommend the award of an Aegrotat degree, but only after obtaining the consent of the candidate. The award of an Aegrotat degree will debar candidates from counting towards Honours degree assessment any result achieved thereafter.
Notes (i) For courses at level 4 and above, the timing and format of the assessment required under any of sub-sections (a), (b) or (d) above shall be determined by the Academic Standards Committee (Undergraduate) on the recommendation of the Head of the relevant School.
(ii) The options to achieve or be awarded credit under (b), (c) and (d) above shall be available to candidates who have accumulated less than 90 credit points at level 4 or who have failed to complete satisfactorily the assessment for a course which, on the recommendation of the Head of the relevant School, has been prescribed by the Academic Standards Committee (Undergraduate) as compulsory for the award of a degree with honours. Such candidates will be able to qualify for a non-Honours degree only.
Further guidance is also available in the Guidance Note for Students who either Fail, or who Fail to Attend or Complete, and Element of Prescribed Degree Assessment which can be accessed at:
http://www.abdn.ac.uk/registry/quality/appendix7x6.pdf
Honours Degree Classification (Grade Spectrum)
All Honours Degrees are classified using the University’s Grade Spectrum which is available at http://www.abdn.ac.uk/registry/quality/appendix7x4.pdf. The Grade Spectrum, an extract of which is outlined below, is used to determine degree classification on the basis of the CAS mark awarded for each element of Honours Degree Assessment.
First: Marks at 18 or better in elements constituting half the total elements
and
Marks at 15 or better in elements constituting three quarters of the total elements
and
Normally marks at 12 or better in all elements
2i: Marks at 15 or better in elements constituting half the total elements
and
Marks at 12 or better in elements constituting three quarters of the total elements
and
Normally marks at 9 or better in all elements
2ii: Marks at 12 or better in elements constituting half the total elements
and
Marks at 9 or better in elements constituting three quarters of the total elements
Third:Marks at 9 or better in elements constituting three quarters of the total elements.
The Grade Spectrum defines the threshold standards against which the different classes of honours degree are awarded. The Examiners, however, have discretion (in the circumstances defined in Note 4 of the Grade Spectrum) to depart from this and may choose to award a higher degree than that indicated by the Grade Spectrum.
Feedback Framework
Feedback on assessment:
The University recognises that the provision of timely and appropriate feedback on assessment plays a key part in students learning and teaching. The guiding principles for the provision of feedback within the University are detailed in the Institutional Framework for the Provision of Feedback on Assessment available at:
www.abdn.ac.uk/registry/quality/appendix7x8.pdf
Feedback on assessment:
The University recognises that the provision of timely and appropriate feedback on assessment plays a key part in students learning and teaching. The guiding principles for the provision of feedback within the University are detailed in the Institutional Framework for the Provision of Feedback on Assessment available at: www.abdn.ac.uk/registry/quality/appendix7x8.pdf
Appeals and Complaints
The University’s appeals and complaints procedures provide students with a framework through which to formalise their concerns about aspects of their academic experience or to complain when they feel that standards of non-academic service have fallen short of that which they expected.
The process has been designed to make the appeals and complaints process as accessible and simple as possible and to provide a robust, fair mechanism through which to ensure that all appeals and complaints are considered in the appropriate way at the appropriate level.
A major feature of the process is the emphasis it places on early or informal resolution. All students should note that there is an expectation that they will take responsibility for seeking resolution of their academic or non-academic concerns by raising and discussing them at the earliest possible stage with the relevant individuals in an academic School or administrative Service.
Further details of the processes for making an appeal or complaint, including where to find further help and support in the process, is given at:
www.abdn.ac.uk/registry/appeals
Transcripts at Graduation
It is anticipated that students who commenced their studies in, or after, 2009/10, will receive a more detailed transcript of their studies on graduation. The increased details will include a record of all examination results attained. For students graduating in 2012/13 transcripts will show details of all CAS marks awarded, including marks which are fails. Where a resit has been required as a result of medical circumstances or other good cause (MC/GC) this will not be shown, but all other circumstances (i.e. No Paper ‘NP’) will be included.
My Aberdeen (the University of Aberdeen’s Virtual Learning Environment)
MyAberdeen replaces WebCT as students’ virtual learning environment. This is where you will find learning materials and resources associated with the courses you are studying.
MyAberdeen also provides direct access to TurnitinUK, the online originality checking service, through which you may be asked to submit completed assignments.
You can log in to MyAberdeen by going to www.abdn.ac.uk/myaberdeen and entering your University username and password (which you use to access the University network).
Further information on MyAberdeen including Quick Guides and video tutorials, along with information about TurnitinUK, can be found at: www.abdn.ac.uk/students/myaberdeen.php.
Information about academic writing and how to avoid plagiarism can be found at www.abdn.ac.uk/sls/plagiarism.
Aberdeen Graduate Attributes
Graduate Attributes are a wide-ranging set of qualities which students will develop during their time at Aberdeen in preparation for employment, further study and citizenship.
There are four main areas of the Graduate Attributes:
• Academic excellence
• Critical thinking and communication
• Learning and personal development
• Active citizenship
Students have many opportunities to develop and achieve these attributes. These include learning experiences on credit-bearing courses and co-curricular activities such as work placements, study abroad and volunteering. In accordance with the University’s commitment to Equality and Diversity, students can request support with any aspect of the Graduate Attributes framework.
The ACHIEVE website offers resources that enable students to assess and reflect upon their present skills and development needs. The website also contains resources to help students to improve their skills and links to a range of university services such as the Careers Service and the Student Learning Service. Students can access ACHIEVE from their MyAberdeen site in the ‘My Organisations’ section. More information about Aberdeen Graduate Attributes and ACHIEVE can be found at www.abdn.ac.uk/graduateattributes.
The Co-curriculum
The co-curriculum enhances a student’s employability and provides opportunities to develop and achieve Aberdeen Graduate Attributes. Co-curricular activities complement a student’s degree programme and include: work placements, study abroad, enterprise and entrepreneurship activities, the BP Student Tutoring Scheme, career mentoring and the STAR (Students Taking Active Roles) Award initiative. Below are examples of credit-bearing co-curricular activities. It is anticipated that these types of activity will be included on an enhanced transcript for students graduating in, or after, 2012/13
ERASMUS is an exchange programme funded by the European Commission which enables students to study or work in another European country as part of their degree programme. Eligible students will receive a grant to help with extra costs while abroad and a number of our partner institutions teach through English. For more information, visit www.abdn.ac.uk/erasmus/. The University also has opportunities for students to study in a non-European country as part of their degree through the International Exchange Programme. International partners include universities and colleges in North America, Hong Kong and Japan (www.abdn.ac.uk/undergraduate/international-exchange.php). The University aims to ensure full academic recognition for study periods abroad, therefore the credits gained from study abroad will count towards the Aberdeen degree programme for students participating in both ERASMUS and the International Exchange Programme.
Work placements can also form an integral part of a degree programme and attract academic credit. Placements are available locally, nationally and internationally, lasting from a few weeks to a full year and are generally paid. Visit the Careers Service website for further placement information and to find available work placements.
Further information about the co-curriculum is available at: www.abdn.ac.uk/careers
School of Medical Sciences - Guide to Citing and Referencing
This guide should be used to assist you when completing any work for disciplines in the School of Medical Sciences. All work should include citations at appropriate places in the text, with a complete reference list at the end of the assignment. If diagrams/ graphs/ tables are copied or adapted from other publications/ websites, the sources must also be cited in the legend for that item, and included in your reference list.
Good citing and referencing not only improves the quality of your work, but it gives credit to the authors of original work, and makes it less likely that you can be accused of plagiarism. Further guidance on writing and plagiarism may be found at http://www.abdn.ac.uk/writing/ . When you submit work for marking, you are declaring that YOU are the author, that you have not copied it or plagiarised any material from other sources, AND that all sources of information have been acknowledged in your text. Students may be penalised by the University if found guilty of plagiarism.
Students are warned to be careful if using websites as sources of information. These may be inaccurate and are often not peer-reviewed. You are strongly encouraged to use advanced textbooks, peer-reviewed papers or reviews as the sources of your information in your work. Students are also advised to avoid quoting chunks of text in their work. Just because you put quotation marks around some text does not mean that you have not plagiarised it. Try and explain ideas and concepts in your own words.
The referencing style used here is Harvard, similar to that recommended by the University Library (see their factsheet for further information on referencing). Students must use this style of citing and referencing for all work. Other styles are not acceptable. Marks may be deducted if students do not cite or reference properly (see specific marking schemes for details).
Citing references within the text
You must provide citations in the text at the appropriate places by putting the author’s surname and year of publication in round brackets immediately after the relevant text (author, date method).
Author, date method
Jones et al. (1999) has argued that….
Studies have produced conflicting results…..(Bloggs, 2000; MacDuff et al., 1993)
Smith stated (1990)…..and then later work confirmed this (2003)…..
Bloggs (2001) investigated…..
One author (Bloggs, 2000)
Two authors (Smith & Jones, 1982)
Three or more authors (Chesterfield et al., 1995)
If the same author(s) wrote two or more papers in the same year Thwaites et al. stated (1990a)…..and then provided further evidence (1990b)…..
N.B. “et al.” should be in italics, as should all other Latin words/phrases in your text (e.g. in vitro). There is also a full stop after “et al.”, since it is an abbreviation of “et alia” (“and others”).
Listing your references at the end of your work
Your list of references must place the surnames of the first authors in alphabetical order. List all authors of a piece of work unless there are a large number.
Format of references at the end of your work
Book - whole Rang, H.P., Dale, M.M., Ritter, J.M. & Flower, R.J. (2007) Pharmacology. 6th Ed. Edinburgh: Churchill Livingstone.
Book – article or chapter within Johnson, D. & Smart, J.S. (1983) Advanced techniques in measuring athletic performance. In: S. Roberts, ed., Sports Science in the Laboratory. London: Macmillan, pp. 3-28.
Journal – article within Furchgott, R.F., Zawadzki, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288(5789), 373-6.
Website Department for Education and Employment (2000). Student loans: guidance on terms and conditions from April 2000. [online]. Available from: http://www.dfee.gov.uk/loan2000/index.html [Accessed 23rd March 2006]
