SM3003 - Frontiers of Applied Medical Science

Course Summary

This course provides core material regarding the physiological responses to acute exercise and the adaptations that occur in response to repeated bouts of exercise. It deals with the measurement of energy, work and power, the structure and function of skeletal muscle, respiration and control of acid-base status, cardiovascular function, temperature regulation during exercise, the adaptation to training, and mechanisms of fatigue.
Course Co-ordinators: Dr Alison Jenkinson (ext 7539) a.jenkinson@abdn.ac.uk Dr Michael Scholz (ext 8022) m.e.scholz@abdn.ac.uk

Course Timetable

See course timetable

Learning Outcomes

To provide students with core knowledge appropriate to the study of the physiological responses and adaptations to physical exercise. Specifically, to:
1.Provide a basic understanding of the concepts of energy, work and power as applied to the exercising human.
2.Give an overview of the factors that determine muscle strength in man, the adaptations of skeletal muscle to strength training, and the contractile and metabolic properties of different muscle fibre types.
3.Explain the control of ventilation and the ventilatory response to exercise: considering both gas transport and acid-base roles of the lungs.
4.Present the function of the cardiovascular system at rest and during exercise, and discuss possible sites of limitation to the transport of oxygen and the adaptations that occur with training.
5.Explain thermal balance of man during exercise in different environments.
6.Introduce the theory of training and the adaptations that occur in response to different types of training.

Lecture Synopsis

1. Applied Medical Sciences: an overview. - Dr Michael Scholz & Dr Alison Jenkinson
Description of the content of Course SR3001 and introduction to the physiology of exercise. Expectations with regard to continuous assessment (essay & presentation).
2-3. Energy, work and power. - Dr Henning Wackerhage
2. Units of measurement. Energy, work and power defined. Laboratory measurement of work and power. Measurement of energy expenditure.
3. Laboratory measures of aerobic and anaerobic power and capacity. Absolute and relative power output: maximum oxygen uptake. Limitations to predictive methods. Calculation of mechanical efficiency. Laboratory tests of performance.
4-6. Respiration and acid-base balance. - Dr Derek Scott
4. Mechanics & control of breathing. Lung structure and function. Physics of breathing. Transport of oxygen and carbon dioxide. Controls of breathing: central and peripheral chemoreception. Other control mechanisms.
5. Ventilation during exercise. Energy for respiration. Effects of exercise intensity and duration. The lungs as a limiting factor in exercise.
6. Acid-base balance in exercise. Metabolic acidosis. Respiratory compensation. Renal and non-renal mechanisms.
7-11. Skeletal muscle structure and function. - Dr Alison Jenkinson
8. Skeletal Muscle - an overview : muscle structure and mechanisms of contraction. Isometric, isotonic and isokinetic contraction. Neural control of movement.
9. Determinants of muscle strength. Muscle size; anatomical and physiological cross section. Experimental models in man. Voluntary and evoked contractions.
10. Muscle fibre types. Contractile and metabolic characteristics of different fibre types. Recruitment patterns in different activities. Implications for muscle strength.
11. Effects of training on muscle strength. Hypertrophy vs hyperplasia. Limits to adaptation. Effects of disuse on muscle mass and function. Effects of ageing on strength.
12-16. Cardiovascular function. - Dr Stephen Davies & Prof Mike Greaves
12. The heart. Heart rate, stroke volume and cardiac output. Control of heart rate at rest and during exercise of varying intensities. Cardiac drift. Control of blood pressure. Cardiac output as a limitation to oxygen uptake. Adaptations to training. (SND)
13. The peripheral circulation. Muscle capillarity. Fibre types and capillary density. Adaptations to endurance exercise. Implications of altered capillary density. (SND)
14. Oxygen utilisation in the periphery. Muscle metabolic capacity as a limitation to maximum oxygen uptake. Integration of the metabolic and cardio-respiratory response to exercise. Adaptations to training. (SND)
15. Blood. The red blood cell. Haemoglobin and oxygen transport. Haldane and Bohr effects. Gender differences. Oxygen transport at altitude. (MG)
16-20. Training and Adaptation – Dr Henning Wackerhage
16. Principles of training. Classical and contemporary views of mechanisms that control adaptation to training.
17. Strength training; training forms to increase muscle size and neural activations. Muscle protein synthesis response to resistance training. Neural adaptations.
18. Endurance training; ACSM guidelines, programmes for athletes, introduction to mechanisms that regulate fibre phenotype, mitochondrial biogenesis and cardiac hypertrophy.
19. Designing training programmes. Introduction of ‘feedback’ model.
20. Overtraining, microinjury.
21-24. The body in extreme environments –Dr Michael Scholz
21. Principles of heat production and heat loss during exercise. Exercise in the heat: physiological impact and effect on performance.

22. Exercise in the cold: heat conservation mechanisms, risks and tolerance.

23. Exercise at altitude: atmospheric changes at altitude, physiological adjustments, impact on performances, acclimatization.

24. Diving - water as surrounding media: buoyancy, density, viscosity, gasses under high pressure, nitrogen narcosis, oxygen toxicity, tissue saturation, decompression, SCUBA-diving, apnoea diving
25-27. Fatigue and limitations to exercise performance. - Dr Aivaras Ratkevicius
26. Performance measures and assessment of fatigue. Causes of fatigue in high intensity exercise. Depletion and accumulation hypotheses. Anaerobic capacity and oxygen deficit. Oxygen supply. Acid-base and manipulation of performance.
27. Causes of fatigue in prolonged exercise. Substrate depletion. Cardiovascular function: maintenance of muscle perfusion and skin blood flow. Maintenance of central venous pressure.
28. The central fatigue hypothesis. Serotonin and fatigue. Circumstantial evidence. Experimental interventions: pharmacological studies. Animal models. Training and serotonergic function.

Safety

Health and Safety
Before you start your laboratory work you will have to attend a short course on Health and Safety. This is a legal requirement and you will have to complete and submit a short test to show that you have attended. You will not be allowed to continue with the rest of the course unless you have satisfactorily completed this test.

Course Work

All students will complete a 1,500 word essay on a set subject. Your essay should include a list of cited references and these should be cited at appropriate places in the text. The essay must be submitted in word-processed format. The deadline for essay completion is Friday 18th November at 13.00 and should be submitted in the designated box in the basement of the Zoology Building. The essay content and titles will be discussed during the Essay Topics tutorial.
In addition you will have to complete a seminar based on the content of your course essay to the class. Each seminar will consist of a 10 minute PowerPoint presentation followed by a 5 minute discussion and a further 5 minutes to allow peer assessment. The criteria for assessing each presentation is given on a separate sheet.

Research Seminars

There is a regular programme of seminars given throughout the academic year by invited specialists from within the broad field of biomedical research.

These are usually held on Thursdays from 12noon -1pm in the IMS Building at Foresterhill (check the School or IMS websites for specific locations of seminars).
As you are studying within research-driven disciplines, we strongly feel that you should attend these whenever possible, with a view to broadening your appreciation of medical sciences. You will also be directed to attend any other relevant seminars when they arise.

Reading List

Astrand, P.O., Rodahl, K, Dahl, M.A & Stromme, S.B. Textbook of Work Physiology (Physiological Bases of Exercise), 2004, ISBN 0-7360-0140-9, Human Kinetics
McArdle, W. D., Katch, F. I. & Katch, V. L. Exercise Physiology. Energy, Nutrition, and Human Performance . 2007, ISBN 0-7817-4990-5 Lippincott Williams & Wilkins

Plagiarism

The University has strict regulations on plagiarism. If you are unsure about what constitutes plagiarism read the University guide on plagiarism at http://www.abdn.ac.uk/writing

Copying or plagiarising another persons work, either from other students or published material in books or papers and submitted as your own for assessment is considered a form of cheating. This is considered by the University to be a serious offence and will be penalised according to the extent involved and whether it is decided there was an attempt at deliberate deception, or whether bad practice was involved. If you do use information or ideas obtained from textbooks or other published material you must give a precise reference to the source both at the appropriate point in your narrative and in a list of references at the end of your work. Direct quotations from published material should be indicated by quotation marks and referenced in the text as above.

Assessments/Examinations

Students are expected to attend all lectures, laboratory classes, and tutorials, and to complete all class exercises by stated deadlines. The minimum performance acceptable for the granting of a class certificate is attendance at 75% of the practical classes, and 100% attendance at the presentation of all set course work, written and oral.
The continuous assessment (CA) accounts for 30% of the total assessment. The continuous assessment is based on the course essay (12.5%), the oral presentation (7.5%) and the data analysis and blood pressure practicals (5% each).
Written Examination: 70% of the total assessment is based on one three hour written paper. The student has to answer four questions of equal weighting selected from a choice of six questions.
Common assessment scale (CAS) grade: The overall performance of the student is expressed as a grade awarded on the common spine marking scale. See attached sheet.
The degree examination is held in January, with the re-sit examination in August.

Staff List

School Staff

Dr Guy Bewick
Dr Stephen Davies
Dr Alison Jenkinson
Dr Aivaras Ratkevicius
Dr Michael Scholz
Dr Henning Wackerhage

Other Staff

Peter Fantom (PSF), Student & Academic Services, Careers Prof Mike Greaves (MG), Medicine and Therapeutics Susan McCourt (SM), Library & Information Services Dr Derek Scott (DAS), Biomedical Sciences

Problems with Coursework

If students have difficulties with any part of the course that they cannot cope with alone they should notify someone immediately. If the problem relates to the subject matter you may be best advised to contact the member of staff who is teaching that part of the course. Students with registered disabilities should contact either the IMS based School Office (Miss Lyndsay McEwan l.mcewan@abdn.ac.uk) or the Old Aberdeen office associated with the teaching laboratories (Mrs S.Jones s.jones@abdn.ac.uk) to ensure that the appropriate facilities have been made available. Otherwise, you are strongly encouraged to contact any of the following as you see appropriate:
Course student representatives.
Course co-ordinator, (Dr Michael Scholz)
Convenor of the student-staff liaison committee, (Dr Gordon McEwan)
Adviser of studies.
Disabilities Co-ordinator, (Dr Derryck Shewan)
Staff are based at Foresterhill (IMS & Health Sciences Building) and we strongly encourage the use of email or telephone the School office. You may be wasting your time to travel to Foresterhill only to find staff unavailable.
Support Available to Students
The University is keen to help you successfully complete your studies. If at any time you feel you need assistance, there is a range of support services available to help you. These include support to assist with unexpected and/or exceptional financial difficulty, support for disabled students and academic learning support through the Student Learning Service. Further details about all these services area available at http://www.abdn.ac.uk/studenthelpguide/.

Class Representatives

We value students’ opinions in regard to enhancing the quality of teaching and its delivery; therefore in conjunction with the Students’ Association we support the operation of a Class Representative system.

The students within each course, year, or programme elect representatives by the end of the fourth week of teaching within each half-session. In this school we operate a system of course representatives. Any student registered within a course that wishes to represent a given group of students can stand for election as a class representative. You will be informed when the elections for class representative will take place.

What will it involve?

It will involve speaking to your fellow students about the course you represent. This can include any comments that they may have. You will attend a Staff-Student Liaison Committee and you should represent the views and concerns of the students within this meeting. As a representative you will also be able to contribute to the agenda. You will then feedback to the students after this meeting with any actions that are being taken.

Training

Training for class representatives will be run by the Students Association. Training will take place in the fourth or fifth week of teaching each half-session. For more information about the Class representative system visit www.ausa.org.uk or email the VP Education & Employability vped@abdn.ac.uk. Class representatives are also eligible to undertake the STAR (Students Taking Active Roles) Award, further information about the co-curricular award is available at: www.abdn.ac.uk/careers

Monitoring Student Progress

The University operates a system for monitoring students' progress to identify students who may be experiencing difficulties in a particular course and who may be at risk of losing their class certificate. If the Course Co-ordinator has concerns about your attendance and/or performance, the Registry will be informed. The Registry will then write to you (by e-mail in term-time) to ask you to contact their office in the first instance. Depending on your reason for absence the Registry will either deal directly with your case or will refer you to your Adviser of Studies or a relevant support service. This system is operated to provide support for students who may be experiencing difficulties with their studies. Students are required to attend such meetings with their Adviser of Studies in accordance with General Regulation 8.
Set criteria are used to determine when a student should be reported in the monitoring system. You will be asked to meet your Adviser if any of the following criteria apply for this course:-
either (i) if you are absent for a continuous period of two weeks or 25% of the course (whichever is less) without good cause being reported;
or (ii) if you are absent from two small group teaching sessions e.g. (laboratory/tutorial classes) without good cause;
or (iii) if you fail to submit a piece of summative or a substantial piece of formative in-course assessment by the stated deadline
If you fail to respond within the prescribed timescale (as set out in the e-mail or letter) you will be deemed to have withdrawn from the course concerned and will accordingly be ineligible to take the end of course assessment or to enter for the resit. The Registry will write to you (by e-mail in term-time) to inform you of this decision. If you wish consideration to be given to reinstating you in the course you will be required to meet the Convener of the Students' Progress Committee.

Class Certificates

Students who attend and complete the work required for a course are considered to have been awarded a ‘Class Certificate’. Being in possession of a valid Class Certificate for a course entitles a student to sit degree examinations for that course. From 2010/11 class certificates will be valid for two years and permit a total of three attempts at the required assessment within that two year period i.e. the first attempt plus up to two resits.

Communication

You will receive a University e-mail account when you register with the University Computing Centre. The University will normally use e-mail to communicate with you during term-time. These e-mails will be sent to your University e-mail account, which you can access using Eudora or SquirrelMail.
It is your responsibility to check your e-mail on a regular (at least weekly) basis and to tidy the contents of your e-mail inbox to ensure that it does not go over quota (see http://www.abdn.ac.uk/diss/email/mailquota.hti for guidance on managing your e-mail quota). It is recommended that you use your University e-mail account to read and respond to University communications. If you already have a non-University e-mail account that you use for personal correspondence, it is possible to set up automatic forwarding of messages from your University e-mail account to your personal e-mail address (see http://www.abdn.ac.uk/local/mail.forward/) but, should you do so, it is your responsibility to ensure that this is done correctly. The University takes no responsibility for delivery of e-mails to non-University accounts.
You should note that failure to check your e-mail or failure to receive e-mail due to being over quota or due to non-delivery of an e-mail forwarded to a non-University e-mail account would not be accepted as a ground for appeal (for further information on appeals procedures, please refer to http://www.abdn.ac.uk/registry/quality/appendix5x17.hti).

Additional Course Information

TurnitinUK
TurnitinUK is an online service which compares student assignments with online sources including web pages, databases of reference material, and content previously submitted by other users across the UK. The software makes no decision as to whether plagiarism has occurred; it is simply a tool which highlights sections of text that have been found in other sources thereby helping academic staff decide whether plagiarism has occurred.

As of Academic Year 2011/12, TurnitinUK will be accessed directly through MyAberdeen. Advice about avoiding plagiarism, the University’s Definition of Plagiarism, a Checklist for Students, Referencing and Citing guidance, and instructions for TurnitinUK, can be found in the following area of the Student Learning Service website www.abdn.ac.uk/sls/plagiarism/.

Absence from Classes on Medical Grounds
Candidates who wish to establish that their academic performance has been adversely affected by their health are required to secure medical certificates relating to the relevant periods of ill health (see General Regulation 17.3).
The University’s policy on requiring certification for absence on medical grounds or other good cause can be accessed at:
www.abdn.ac.uk/registry/quality/appendix7x5.pdf
You are strongly advised to make yourself fully aware of your responsibilities if you are absent due to illness or other good cause. In particular, you are asked to note that self-certification of absence for periods of absence up to and including eleven weekdays is permissible. However, where absence has prevented attendance at an examination or where it may have affected your performance in an element of assessment or where you have been unable to attend a specified teaching session, you are strongly advised to provide medical certification (see section 3 of the Policy on Certification of Absence for Medical Reasons or Other Good Cause).

Feedback Framework

Feedback on assessment:

The University recognises that the provision of timely and appropriate feedback on assessment plays a key part in students learning and teaching. The guiding principles for the provision of feedback within the University are detailed in the Institutional Framework for the Provision of Feedback on Assessment available at:
www.abdn.ac.uk/registry/quality/appendix7x8.pdf

Enhancing Feedback:

The University recognises both the importance of providing timely and appropriate feedback on assessments to students, and of enabling students to voice views on their learning experience through channels such as Student Course Evaluation Forms and Class Representatives. FAQs, guidance and resources about feedback can be found on the University’s ‘Enhancing Feedback’ website at: www.abdn.ac.uk/clt/feedback
Appeals and Complaints
The University’s appeals and complaints procedures provide students with a framework through which to formalise their concerns about aspects of their academic experience or to complain when they feel that standards of non-academic service have fallen short of that which they expected.

The process has been designed to make the appeals and complaints process as accessible and simple as possible and to provide a robust, fair mechanism through which to ensure that all appeals and complaints are considered in the appropriate way at the appropriate level.

A major feature of the process is the emphasis it places on early or informal resolution. All students should note that there is an expectation that they will take responsibility for seeking resolution of their academic or non-academic concerns by raising and discussing them at the earliest possible stage with the relevant individuals in an academic School or administrative Service.

Further details of the processes for making an appeal or complaint, including where to find further help and support in the process, is given at:

www.abdn.ac.uk/registry/appeals
Transcripts at Graduation
It is anticipated that students who commenced their studies in, or after, 2009/10, will receive a more detailed transcript of their studies on graduation. The increased details will include a record of all examination results attained. For students graduating in 2012/13 transcripts will show details of all CAS marks awarded, including marks which are fails. Where a resit has been required as a result of medical circumstances or other good cause (MC/GC) this will not be shown, but all other circumstances (i.e. No Paper ‘NP’) will be included.
MyAberdeen (the University of Aberdeen’s Virtual Learning Environment)
MyAberdeen replaces WebCT as students’ virtual learning environment. This is where you will find learning materials and resources associated with the courses you are studying.

MyAberdeen also provides direct access to TurnitinUK, the online originality checking service, through which you may be asked to submit completed assignments.

You can log in to MyAberdeen by going to www.abdn.ac.uk/myaberdeen and entering your University username and password (which you use to access the University network).

Further information on MyAberdeen including Quick Guides and video tutorials, along with information about TurnitinUK, can be found at: www.abdn.ac.uk/students/myaberdeen.php.

Information about academic writing and how to avoid plagiarism can be found at www.abdn.ac.uk/sls/plagiarism.
Aberdeen Graduate Attributes
Graduate Attributes are a wide-ranging set of qualities which students will develop during their time at Aberdeen in preparation for employment, further study and citizenship.

There are four main areas of the Graduate Attributes:

• Academic excellence
• Critical thinking and communication
• Learning and personal development
• Active citizenship
Students have many opportunities to develop and achieve these attributes. These include learning experiences on credit-bearing courses and co-curricular activities such as work placements, study abroad and volunteering. In accordance with the University’s commitment to Equality and Diversity, students can request support with any aspect of the Graduate Attributes framework.
The ACHIEVE website offers resources that enable students to assess and reflect upon their present skills and development needs. The website also contains resources to help students to improve their skills and links to a range of university services such as the Careers Service and the Student Learning Service. Students can access ACHIEVE from their MyAberdeen site in the ‘My Organisations’ section. More information about Aberdeen Graduate Attributes and ACHIEVE can be found at www.abdn.ac.uk/graduateattributes.
The Co-curriculum
The co-curriculum enhances a student’s employability and provides opportunities to develop and achieve Aberdeen Graduate Attributes. Co-curricular activities complement a student’s degree programme and include: work placements, study abroad, enterprise and entrepreneurship activities, the BP Student Tutoring Scheme, career mentoring and the STAR (Students Taking Active Roles) Award initiative. Below are examples of credit-bearing co-curricular activities. It is anticipated that these types of activity will be included on an enhanced transcript for students graduating in, or after, 2012/13

ERASMUS is an exchange programme funded by the European Commission which enables students to study or work in another European country as part of their degree programme. Eligible students will receive a grant to help with extra costs while abroad and a number of our partner institutions teach through English. For more information, visit www.abdn.ac.uk/erasmus/. The University also has opportunities for students to study in a non-European country as part of their degree through the International Exchange Programme. International partners include universities and colleges in North America, Hong Kong and Japan (www.abdn.ac.uk/undergraduate/international-exchange.php). The University aims to ensure full academic recognition for study periods abroad, therefore the credits gained from study abroad will count towards the Aberdeen degree programme for students participating in both ERASMUS and the International Exchange Programme.

Work placements can also form an integral part of a degree programme and attract academic credit. Placements are available locally, nationally and internationally, lasting from a few weeks to a full year and are generally paid. Visit the Careers Service website for further placement information and to find available work placements.
Further information about the co-curriculum is available at: www.abdn.ac.uk/careers

Transition into level 3

As students progress through their degree programme, they will notice a change in the style and approach of teaching and the expectations upon them as learners. This is particularly marked as students move into level 3 and beyond. To help with this transition into level 3, a number of activities will be planned to address any new challenges faced by students at level 3. The level 3 co-ordinator - Dr Steve Tucker (s.j.tucker@abdn.ac.uk; 01224 437491) will organise such events and should be a first point of contact for any level 3 SMS students facing any kind of difficulty. Regular activities and workshops will be designed around key issues faced by new level 3 students e.g. new exam format, time management, but guidance and support will also be provided on request for individuals or groups with any other problem relating to level 3. In addition, Dr Tucker will hold regular, advertised drop-in surgeries for students to raise any issues face to face and all level 3 SMS students will have access to a WebCT site that will offer information, feedback, guidance and discussion forums designed to enable all students to achieve the most from level 3.

School of Medical Sciences - Guide to Citing and Referencing

This guide should be used to assist you when completing any work for disciplines in the School of Medical Sciences. All work should include citations at appropriate places in the text, with a complete reference list at the end of the assignment. If diagrams/ graphs/ tables are copied or adapted from other publications/ websites, the sources must also be cited in the legend for that item, and included in your reference list.

Good citing and referencing not only improves the quality of your work, but it gives credit to the authors of original work, and makes it less likely that you can be accused of plagiarism. Further guidance on writing and plagiarism may be found at http://www.abdn.ac.uk/writing/ . When you submit work for marking, you are declaring that YOU are the author, that you have not copied it or plagiarised any material from other sources, AND that all sources of information have been acknowledged in your text. Students may be penalised by the University if found guilty of plagiarism.

Students are warned to be careful if using websites as sources of information. These may be inaccurate and are often not peer-reviewed. You are strongly encouraged to use advanced textbooks, peer-reviewed papers or reviews as the sources of your information in your work. Students are also advised to avoid quoting chunks of text in their work. Just because you put quotation marks around some text does not mean that you have not plagiarised it. Try and explain ideas and concepts in your own words.

The referencing style used here is Harvard, similar to that recommended by the University Library (see their factsheet for further information on referencing). Students must use this style of citing and referencing for all work. Other styles are not acceptable. Marks may be deducted if students do not cite or reference properly (see specific marking schemes for details).

Citing references within the text
You must provide citations in the text at the appropriate places by putting the author’s surname and year of publication in round brackets immediately after the relevant text (author, date method).

Author, date method
Jones et al. (1999) has argued that….
Studies have produced conflicting results…..(Bloggs, 2000; MacDuff et al., 1993)
Smith stated (1990)…..and then later work confirmed this (2003)…..
Bloggs (2001) investigated…..
One author (Bloggs, 2000)
Two authors (Smith & Jones, 1982)
Three or more authors (Chesterfield et al., 1995)
If the same author(s) wrote two or more papers in the same year Thwaites et al. stated (1990a)…..and then provided further evidence (1990b)…..
N.B. “et al.” should be in italics, as should all other Latin words/phrases in your text (e.g. in vitro). There is also a full stop after “et al.”, since it is an abbreviation of “et alia” (“and others”).

Listing your references at the end of your work
Your list of references must place the surnames of the first authors in alphabetical order. List all authors of a piece of work unless there are a large number.

Format of references at the end of your work
Book – whole Rang, H.P., Dale, M.M., Ritter, J.M. & Flower, R.J. (2007) Pharmacology. 6th Ed. Edinburgh: Churchill Livingstone.
Book – article or chapter within Johnson, D. & Smart, J.S. (1983) Advanced techniques in measuring athletic performance. In: S. Roberts, ed., Sports Science in the Laboratory. London: Macmillan, pp. 3-28.
Journal – article within Furchgott, R.F., Zawadzki, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288(5789), 373-6.
Website Department for Education and Employment (2000). Student loans: guidance on terms and conditions from April 2000. [online]. Available from: http://www.dfee.gov.uk/loan2000/index.html [Accessed 23rd March 2006]

 

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