Professor TIBOR HARKANYThe University of AberdeenSchool of Medical SciencesChair in the School of Medical Scienceswork+44 (0)1224 437371work+44 (0)1224 437578workfax+44 1224 555915preft.harkany@abdn.ac.ukpref
Institute of Medical Sciences
School of Medical Sciences
University of Aberdeen
Foresterhill
Ashgrove Road West
AB25 2ZD, Aberdeen
Scotland, United Kingdom
Institute of Medical Sciences
School of Medical Sciences
University of Aberdeen
Foresterhill
Ashgrove Road West
AB25 2ZD, Aberdeen
Scotland, United Kingdom
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http://ki.se/ki/jsp/polopoly.jsp?d=40498&l=en (Karolinska Institutet, Stockholm, Sweden)
i) Developmental functions of endocannabinoid signaling during corticogenesis,
ii) Context-dependent assembly of endocannabinoid signaling networks,
iii) Genetic and epigenetic factors controlling neuronal network formation,
iv) Developmental consequences of maternal cannabis smoking,
v) Endocannabinoid signaling in aging and Alzheimer's disease,
vi) Novel cannabinoid receptors,
The Harkany lab focuses on understanding the developmental organization and functions of the endocannabinoid system by using a combination of molecular genetics, neuroimaging, neuroanatomy and electrophysiology approaches. Besides focusing on physiological developmental programs controlled by endocannabinoid signaling during corticogenesis, substantial resources are dedicated to elucidating the neuronal basis of cannabis-induced developmental deficits in the central nervous system. Through our studies, we hope to identify organizing principles of endocannabinoid signaling in the developing brain with particular emphasis on the roles of endocannabinoids in establishing neuronal diversity and connectivity patterns.
Ken Mackie, Departments of Psychological & Brain Sciences, PY 363, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USA
Yasmin Hurd, Departments of Psychiatry and Pharmacology & Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place - Box 1215, New York, New York 10029-6574, USA
Andrew J. Irving, Molecular Imaging Group, Centre For Neuroscience, Division of Medical Sciences, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY, United Kingdom
Alzheimer's Association; Alzheimer's Research Trust UK; EMBO Young Investigator Programme; Swedish Medical Research Council; European Union - 7th Framework; Scottish Universities Life Science Alliance; National Institutes of Health; Medical Research Council - Integrative Toxicolgy Training Programme.
Professor Harkany is actively involved in coordinating research projects at the Department of Medical Biochemistry and Biophysics of the Karolinska Institutet, Stockholm, Sweden.
Attems, J., Alpar, A., Spence, L., McParland, S., Heikenwalder, M., Uhlen, M., Tanila, H., Hokfelt, TGM. & Harkany, T. (2012). 'Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation'. PNAS, vol 109, no. 16, pp. 6259-6264.
[Online]DOI: 10.1073/pnas.1203843109
Mulder, J., Zilberter, M., Pasquare, SJ., Alpar, A., Schulte, G., Ferreira, SG., Koefalvi, A., Martin-Moreno, AM., Keimpema, E., Tanila, H., Watanabe, M., Mackie, K., Hortobagyi, T., de Ceballos, ML. & Harkany, T. (2011). 'Molecular reorganization of endocannabinoid signalling in Alzheimer's disease'. Brain, vol 134, no. 4, pp. 1041-1060.
[Online]DOI: 10.1093/brain/awr046
Keimpema, E., Barabas, K., Morozov, YM., Tortoriello, G., Torii, M., Cameron, G., Yanagawa, Y., Watanabe, M., Mackie, K. & Harkany, T. (2010). 'Differential Subcellular Recruitment of Monoacylglycerol Lipase Generates Spatial Specificity of 2-Arachidonoyl Glycerol Signaling during Axonal Pathfinding'. Journal of Neuroscience, vol 30, no. 42, pp. 13992-14007.
[Online]DOI: 10.1523/JNEUROSCI.2126-10.2010 [Online]AURA: Tibor_Harkany_2010.pdf
Mulder, J., Zilberter, M., Spence, L., Tortoriello, G., Uhlen, M., Yanagawa, Y., Aujard, F., Hokfelt, T. & Harkany, T. (2009). 'Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons'. PNAS, vol 106, no. 52, pp. 22492-22497.
[Online]DOI: 10.1073/pnas.0912484106
Martens, H., Weston, MC., Boulland, J-L, Gronborg, M., Grosche, J., Kacza, J., Hoffmann, A., Matteoli, M., Takamori, S., Harkany, T., Chaudhry, FA., Rosenmund, C., Erck, C., Jahn, R. & Haertig, W. (2008). 'Unique Luminal Localization of VGAT-C Terminus Allows for Selective Labeling of Active Cortical GABAergic Synapses'. Journal of Neuroscience, vol 28, no. 49, pp. 13125-13131.
[Online]DOI: 10.1523/JNEUROSCI.3887-08.2008
Grumelli, C., Berghuis, P., Pozzi, D., Caleo, M., Antonucci, F., Bonanno, G., Carmignoto, G., Dobszay, MB., Harkany, T., Matteoli, M. & Verderio, C. (2008). 'Calpain activity contributes to the control of SNAP-25 levels in neurons'. Molecular and Cellular Neuroscience, vol 39, no. 3, pp. 314-323.
[Online]DOI: 10.1016/j.mcn.2008.07.011
Harkany, T., Mackie, K. & Doherty, P. (2008). 'Wiring and firing neuronal networks: endocannabinoids take center stage'. Current Opinion in Neurobiology, vol 18, no. 3, pp. 338-345.
[Online]DOI: 10.1016/j.conb.2008.08.007
Mulder, J., Aguado, T., Keimpema, E., Barabas, K., Rosado, CJB., Nguyen, L., Monory, K., Marsicano, G., Di Marzo, V., Hurd, YL., Guillemot, F., Mackie, K., Lutz, B., Guzman, M., Lu, H-C, Galve-Roperh, I. & Harkany, T. (2008). 'Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning'. PNAS, vol 105, pp. 8760-8765.
[Online]DOI: 10.1073/pnas.0803545105
Harkany, T., Keimpema, E., Barabas, K. & Mulder, J. (2008). 'Endocannabinoid functions controlling neuronal specification during brain development'. Molecular and Cellular Endocrinology, vol 286, no. 1-2 Suppl. 1, pp. S84-S90.
[Online]DOI: 10.1016/j.mce.2008.02.011
Chair in the School of Medical Sciences
work
+44 (0)1224 437371
work
+44 (0)1224 437578
work
fax
+44 1224 555915
pref
t.harkany@abdn.ac.uk
pref
Institute of Medical Sciences
School of Medical Sciences
University of Aberdeen
Foresterhill
Ashgrove Road West
AB25 2ZD, Aberdeen
Scotland, United Kingdom
