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Professor Chris Secombes, DSc, FSB, FRSE

School of Biological Sciences
Email: c.secombes@abdn.ac.uk

Professor Secombes has studied fish immunology since 1977 and has over 350 publications on this subject. He is an editor of Fish & Shellfish Immunology and is on the editorial boards of "Veterinary Immunology and Immunopathology" and "Molecular Immunology".

Current research includes:

Determining the cytokine network in fish to gain an insight into cytokine gene evolution in a highly diverse vertebrate group.
The elucidation of antimicrobial pathways in fish, with emphasis on a number of newly discovered antibacterial peptide genes.
The development of fish vaccines and analysis of their mode of action.

Recent publications:

Wang, T., Kono, T., Monte, M.M., Kuse, H., Costa, M.M., Korenaga, H., Maehr, T., Husain, M., Sakai, M. & Secombes C.J. (in press). Identification of IL-34 in teleost fish: differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor. Molec. Immunol.
Costa, M.M., Wang, T.H., Monte, M.M. & Secombes, C.J. (2012). Molecular characterization and expression analysis of the putative interleukin 6 receptor (IL-6Rα and glycoprotein-130) in rainbow trout (Oncorhynchus mykiss): Salmonid IL-6Rα possesses a polymorphic N-terminal Ig-domain with variable numbers of two repeats. Immunogenetics 64: 229-244.
Wawra, S., Bain, J., Durward, E., de Bruijn, I., Minor, K.L., Matena, A., Löbach, L., Whisson, S.C., Bayer, P., Porter, A.J., Birch, P.R.J., Secombes, C.J. & van West, P. (2012). Host-targetting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner. PNAS 109: 2096-2101.
Secombes, C.J., Wang, T.H. & Bird, S. (2011). The interleukins of fish. Dev. Comp. Immunol. 35: 1336-1345.
Chang, M.X., Collet, B., Nie, P., Lester, K., Campbell, S., Secombes, C.J. & Zou, J. (2011). Expression and functional characterization of the RIG-1-like receptors MDA5 and LGP2 in rainbow trout (Oncorhynchus mykiss). J. Virology 85: 8403-8412.
Wang, T.H., Gorgoglione, B., Maehr, T., Holland, J.W., González Vecino, J.L., Wadsworth, S. & Secombes, C.J. (2011). Fish suppressors of cytokine signaling (SOCS): Gene discovery, modulation of expression and function. J. Signal Transduction, article ID 905813.
Harun, N.O., Wang, T. & Secombes, C.J. (2011). Gene expression profiling in naïve and vaccinated rainbow trout after Yersinia ruckeri infection: Insights into the mechanisms of protection seen in vaccinated fish.Vaccine 29: 4388-4399.
Wang, T., Huang, W., Costa, M.M., Martin, S.A.M. & Secombes, C.J. (2011). Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Rα, IL-13Rα1 and IL-13Rα2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation. Immunogenetics 63: 235-253.
Holland, J.W., Okamura, B., Hartikainen, H. & Secombes, C.J. (2011). A novel minicollagen gene links cnidarians and myxozoans. Proc. Roy. Soc. B. 278: 546-553.
Wang, T., Diaz-Rosales, P., Costa, M.M., Campbell, S., Snow, M., Collet, B., Martin, S.A.M., & Secombes, C.J. (2011). Functional characterisation of a nonmammalian IL-21: Rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-g, IL-10 and IL-22. J. Immunol. 186: 708-721.
Zou, J., Bird, S. & Secombes C.J. (2010). Antiviral sensing in teleost fish. Current Pharmaceutical Design 16: 4185-4193.
Zhitao, Qi., Pin, N., Secombes, C.J. & Zou, J. (2010). Intron-containing type I and III IFN co-exist in amphibians: refuting the concept that a retroposition event gave rise to type I IFNs. J. Immunol. 184: 5038-5046.

Page last updated: Thursday, 27-Sep-2012 16:26:27 BST

Scottish Fish Immunology Research Centre
Zoology Building · University of Aberdeen · Aberdeen AB24 2TZ
Telephone +44 (0)1224-272857 · Fax +44 (0)1224-272396 · Email: sfirc@abdn.ac.uk

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