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Professor Chris Secombes, FIBiol, FRSE

School of Biological Sciences
Email: c.secombes@abdn.ac.uk

Professor Secombes has studied fish immunology since 1977 and has over 290 publications on this subject. He is currently on the Executive Committee of the International Society for Developmental and Comparative Immunology, an editor of Fish & Shellfish Immunology and on the editorial board of "Veterinary Immunology and Immunopathology".

Current research includes:

The isolation of fish cytokine genes (e.g. interleukins, interferons and colony stimulating factors) and production of the recombinant proteins for bioactivity testing.
The elucidation of bactericidal pathways, with emphasis on a number of the newly discovered antibacterial peptide genes.
The use of functional-genomics methods (eg gene chips) to give a more holistic approach to how vaccines or immune stimulants can induce disease resistance in fish.

Recent publications:

Wang, T., Hanington, P.C., Belosevic, M. & Secombes, C.J. (2008). Two macrophage colony-stimulating factor genes exist in fish that differ in gene organisation and are differentially expressed. J. Immunol. 181: 3310-3322.
Martin, S.A.M., Zou, J., Houlihan, D.F. & Secombes, C.J. (2007). Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-11 macrophage cells as revealed by transcriptome profiling. BMC Genomics 8: 150.
Wang, T., Holland, J., Bols, N. & Secombes, C.J. (2007). Molecular and functional characterisation of interleukin-15 in rainbow trout Oncorhynchus mykiss: A potent inducer of interferon-gamma expression in spleen leucocytes. J. Immunol. 179: 1475-1488.
Zou, J., Tafalla, C., Truckle, J. & Secombes, C.J. (2007). Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates. J. Immunol. 179: 3859-3871.
Laing, K.J., Zou, J.J., Purcell, M.K., Phillips, R., Secombes, C.J. & Hansen, J.D. (2006). Evolution of the CD4 family: teleost fish possess two divergent forms of CD4 in addition to lymphocyte activation gene-3. J. Immunol. 177: 3939-3951.
Bird, S., Zou, J & Secombes, C. (2006). Advances in fish cytokine biology give clues to the evolution of a complex network. Current Pharmaceutical Design 12: 3051-3069.
Zou, J., Carrington, A., Collet, B., Dijkstra, J.M., Bols, N. & Secombes, C.J. (2005). Identification and bioactivities of interferon gamma in rainbow trout Oncorhynchus mykiss: the first Th1 type cytokine characterised functionally in fish. J. Immunol. 175: 2484-2494.
Chang, C.-I., Pleguezuelos, O., Zhang, Y.-A., Zou, J. & Secombes, C.J. (2005). Identification of a novel cathelicidin gene in the rainbow trout, Oncorhynchus mykiss. Infection and Immunity 73: 5053-5064.

Page last updated: Wednesday, 20-Aug-2008 15:52:43 BST

Scottish Fish Immunology Research Centre
Zoology Building · University of Aberdeen · Aberdeen AB24 2TZ
Telephone +44 (0)1224-272857 · Fax +44 (0)1224-272396 · Email: sfirc@abdn.ac.uk

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