Dr Janice Drew

Dr_Janice_Drew

Dr Janice Drew

Inter-individual responses to nutrition and lifestyle

Improving diet and lifestyle is a key strategy to maintaining metabolic health and preventing risk of diseases such as cancer, heart disease and diabetes that are major contributors to reduced healthspan.

At the Rowett I am involved in nutrition studies, using human volunteers, to assess health status and inter-individual variation in responses to diet and lifestyle changes to maintain health.
 
The research we are doing can help the food industry to make their products healthier and provide appropriated and effective advice to the public on how best to ensure they maintain good health throughout their lifespan.

 


Diet and lifestyle are critical factors in maintaining health. However, research has established that responses to diet and lifestyle interventions to restore, maintain or improve health differ between individuals. This is thought in part to be a consequence of our genes and the different ways in which our genes determine interactions with diet and lifestyle factors and how the confer risk or protection from diet and lifestyle related diseases.

My current research is focused on identifying the molecular and cellular effects of diet and exercise on our bodies and how these effects impact on metabolic health, biological aging, healthspan. Comprehensive strategies have been developed to interrogate inter-individual variation in biological samples. Strategies incorporate transcriptomics, including the novel gene expression technology, the GenomeLab System, proteomics, together with biochemical analyses of plasma and tissue samples to assess correlated changes in the cell defence systems, immunity, inflammation, redox regulation, metabolism and DNA repair that maintain health.  

Biological samples range from cultured human tissue explants, whole blood gene expression profiling (bloodomics), liver, muscle and adipose to assess correlated changes in the cell defence systems that maintain health. This approach is revealing predictive molecular signatures of health status and modulation by diet and lifestyle interventions making it feasible for nutrition scientist to contemplate monitoring and surveying the impact of diet and lifestyle factors to generate evidence for effective translation of research on food, drink and health in individuals.


  • Drew, JE., Farquharson, AJ., Horgan, GW. & Williams, LM. 'Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding'. The Journal of Nutritional Biochemistry, vol 37, pp. 20-29.
    [Online] DOI: 10.1016/j.jnutbio.2016.07.013
  • Hirschey, MD., DeBerardinis, RJ., Diehl, AME., Drew, JE., Frezza, C., Green, MF., Jones, LW., Ko, YH., Le, A., Lea, MA., Locasale, JW., Longo, VD., Lyssiotis, CA., McDonnell, E., Mehrmohamadi, M., Michelotti, G., Muralidhar, V., Murphy, MP., Pedersen, PL., Poore, B., Raffaghello, L., Rathmell, JC., Sivanand, S., Vander Heiden, MG., Wellen, KE. & Target Validation Team (2015). 'Dysregulated metabolism contributes to oncogenesis'. Seminars in cancer biology, vol 35, no. Suppl., pp. S129-150.
    [Online] DOI: 10.1016/j.semcancer.2015.10.002
    [Online] AURA: 1_s2.0_S1044579X15000991_main.pdf
  • Drew, JE., Farquharson, AJ., Vase, H., Carey, FA., Steele, RJC., Ross, RA. & Bunton, DC. (2015). 'Molecular Profiling of Multiplexed Gene Markers to Assess Viability of Ex Vivo Human Colon Explant Cultures'. BioResearch open access, vol 4, no. 1, pp. 425-430.
    [Online] DOI: 10.1089/biores.2015.0029
    [Online] AURA: biores_2E2015_2E0029.pdf
  • Block, KI., Gyllenhaal, C., Lowe, L., Amedei, A., Amin, AR.MR., Amin, A., Aquilano, K., Arbiser, J., Arreola, A., Arzumanyan, A., Ashraf, SS., Azmi, AS., Benencia, F., Bhakta, D., Bilsland, A., Bishayee, A., Blain, SW., Block, PB., Boosani, CS., Carey, TE., Carnero, A., Carotenuto, M., Casey, SC., Chakrabarti, M., Chaturvedi, R., Chen, GZ., Chen, H., Chen, S., Chen, YC., Choi, BK., Ciriolo, MR., Coley, HM., Collins, AR., Connell, M., Crawford, S., Curran, CS., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, RJ., Decker, WK., Dhawan, P., Diehl, AME., Dong, J-T, Dou, QP., Drew, JE., Elkord, E., El-Rayes, B., Feitelson, MA., Felsher, DW., Ferguson, LR., Fimognari, C., Firestone, GL., Frezza, C., Fujii, H., Fuster, MM., Generali, D., Georgakilas, AG., Gieseler, F., Gilbertson, M., Green, MF., Grue, B., Guha, G., Halicka, D., Helferich, WG., Heneberg, P., Hentosh, P., Hirschey, MD., Hofseth, LJ., Holcombe, RF., Honoki, K., Hsu, H-Y, Huang, GS., Jensen, LD., Jiang, WG., Jones, LW., Karpowicz, PA., Keith, WN., Kerkar, SP., Khan, GN., Khatami, M., Ko, YH., Kucuk, O., Kulathinal, RJ., Kumar, NB., Kwon, BS., Le, A., Lea, MA., Lee, H-Y, Lichtor, T., Lin, L-T, Locasale, JW., Lokeshwar, BL., Longo, VD., Lyssiotis, CA., MacKenzie, KL., Malhotra, M., Marino, M., Martinez-Chantar, ML., Matheu, A., Maxwell, C., McDonnell, E., Meeker, AK., Mehrmohamadi, M., Mehta, K., Michelotti, GA., Mohammad, RM., Mohammed, SI., Morre, DJ., Muralidhar, V., Muqbil, I., Murphy, MP., Nagaraju, GP., Nahta, R., Niccolai, E., Nowsheen, S., Panis, C., Pantano, F., Parslow, VR., Pawelec, G., Pedersen, PL., Poore, B., Poudyal, D., Prakash, S., Prince, M., Raffaghello, L., Rathmell, JC., Rathmell, WK., Ray, SK., Reichrath, J., Rezazadeh, S., Ribatti, D., Ricciardiello, L., Robey, RB., Rodier, F., Rupasinghe, HPV., Russo, GL., Ryan, EP., Samadi, AK., Sanchez-Garcia, I., Sanders, AJ., Santini, D., Sarkar, M., Sasada, T., Saxena, NK., Shackelford, RE., Shantha Kumara, HM.C, Sharma, D., Shin, DM., Sidransky, D., Siegelin, MD., Signori, E., Singh, N., Sivanand, S., Sliva, D., Smythe, C., Spagnuolo, C., Stafforini, DM., Stagg, J., Subbarayan, PR., Sundin, T., Talib, WH., Thompson, SK., Tran, PT., Ungefroren, H., Vander Heiden, MG., Venkateswaran, V., Vinay, DS., Vlachostergios, PJ., Wang, Z., Wellen, KE., Whelan, RL., Yang, ES., Yang, H., Yang, X., Yaswen, P., Yedjou, C., Yin, X., Zhu, J. & Zollo, M. (2015). 'Designing a broad-spectrum integrative approach for cancer prevention and treatment'. Seminars in cancer biology, vol 35, no. Supplement, pp. S276-304.
    [Online] DOI: 10.1016/j.semcancer.2015.09.007
    [Online] AURA: 1_s2.0_S1044579X15000887_main.pdf
  • Drew, JE., Farquharson, AJ., Horgan, GW., Duthie, SJ. & Duthie, GG. (2014). 'Postprandial cell defense system responses to meal formulations: Stratification through gene expression profiling'. Molecular Nutrition & Food Research, vol 58, no. 10, pp. 2066-2079.
    [Online] DOI: 10.1002/mnfr.201400331
  • Williams, LM., Campbell, FM., Drew, JE., Koch, C., Hoggard, N., Rees, WD., Kamolrat, T., Thi Ngo, H., Steffensen, I-L, Gray, SR. & Tups, A. (2014). 'The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases'. PloS one, vol 9, no. 8, e106159.
    [Online] DOI: 10.1371/journal.pone.0106159
    [Online] AURA: 2014Williamsetal_PLOSone_.pdf

Research briefs for the Knowledge Scotland web site

Rowett Institute of Nutrition and Health MSc/PgDip Molecular Nutrition

Dr Drew coordinates the Molecular Nutrition course within MSc Molecular/Human Nutrition programme at the University of Aberdeen. If you are require further information: MSc Human Nutrition

Recent Presentations

  • EuroSciCon The 2014 Obesity Summit “Obesity and metabolic health status: predictive gene signatures” Drew JE O2 Arena, London, 1 – 3 April 2014.
  • The Nutrition Society Winter Meeting Diet Gut Microbiology and Human Health “Nutritional responses of cellular defence systems to different fats with or without phytochemical rich extracts: molecular markers of health status” Royal College of Surgeons, London 11-12th December, 2013.
  • Unhealthy eating? How to study relationship between diet and health. “Cellular defence systems, diet and health” Global Health Academy, University of Edinburgh, Surgeon’s Hall, Edinburgh 27th Sept 2012
  • Experimental Biology 2012, San Diego, USA April 2012. Precancerous and Cancerous Predictive Signatures Using a Custom Designed Novel Gene Expression Assay Vase HF, Carey FA, Steele RJC, Ross RA, Drew JE
  • Nutrition Society Scottish Section Meeting "Novel multiplex technology platform to assess gene expression signatures in blood: predicting health benefits in response to diet." Drew, J.E, Farquharson, A.J 26th - 28th March University of Aberdeen 2012.
  • The Nutrition Society Summer Meeting 70th Anniversary: From plough through practice to policy “Obesity colon cancer links – adipokine signalling” University of Reading 4 – 6th July 2011
  • Aberdeen Proteomic Applications in Clinical and Life Sciences “Interrogation of the Colon Mitoproteome:  links with obesity related colon cancer. Institute of Medical Sciences University of Aberdeen 13th April 2010.
  • BIT’s 3rd Annual Congress of PepCon2010 “Interrogation of the Colon Mitoproteome:  links with obesity related colon cancer. Beijing, China 21-23rd March 2010.

Blog

Parliament, government and science: Dr Janice Drew spends a week in Westminster 9 December 2013 by Dr Janice Drew blog

Editorials

Autobiography of Editorial Board Members Janice Drew’s work on diet and cancer World Journal of Gastrointestinal Pathophysiology 2011 2:61-64.

Editorial: Obesity cancer links. The Open Obesity Journal Special Issue Obesity 2:10-11, 2010

Books and Reviews

Drew JE (2012) Cellular defence system gene expression signatures in blood: predicting health benefits in response to diet Advances in Nutrition 3:1-7.

Drew JE Molecular mechanisms linking adipokines to obesity related colon cancer: focus on leptin. The Proceedings of the Nutrition Society (2011) Published online doi:10.1017/S0029665111003259

Drew JE, Duthie GG, Farquharson AJ, Padidar S (2007) Combined approaches to investigate pre-pathological colon dysfunction in the pro-oxidant environment.” In: Precancerous Conditions Research Trends, Chapter 9 p203-227 Nova Science Publishers, Inc., New York.

Abstracts

  • Drew, J.E, Farquharson, A.J Novel multiplex technology platform to assess gene expression signatures in blood: predicting health benefits in response to diet. Proc Nut Soc (In press)
  • Vase HF, Carey FA, Steele RJC, Ross RA, Drew JE Precancerous and cancerous predictive signatures using a custom designed novel Gene expression assay The FASEB Journal 2012;26:397.1
  • Vase HF, Farquharson AJ, Carey FA, Steele RJC, Ross RA, Bunton DC, Drew JE Interrogating therapeutic manipulation of the endocannabinoid system in human colon. The FASEB Journal 2012;26:1123.1
  • Spotlight on Prostate Cancer Research, Stirling Management Centre, Stirling, Scotland, UK 28 June 2011. Biomarker profiling of precancerous and cancerous gene targets using a custom designed novel gene expression assay. Vase, HF, Carey, FA, Steele, RJC, Ross, RA, Drew, JE
  • SULSA Symposium, University of Glasgow, Glasgow, 7th June 2010. Novel therapeutics targeting the endocannabinoid system in GI inflammation and cancer. Vase HF, Farquharson FA, Steele RJC, Ross RA, Bunton DC, Drew JE.  AWARDED BEST TRANSLATIONAL BIOLOGY POSTER
  • ENDO 2011June 2011 Boston, Massachusetts, USA. High-fat diet in C57Bl/6 mice induces a rapid decrease in insulin sensitivity and an acute phase response. CampbellF, Drew JE, Tups A, Hoggard N,Nicol PF, Farquharson AJ, Koch C, Grant C, Morris AC, Williams LM
  • SET for BRITAIN 2011 14th March Biological and Biomedical Sciences Session Biomarker profiling of precancerous and cancerous gene targets using a custom designed novel gene expression assay. Vase HF, Farquharson FA, Steele RJC, Ross RA, Bunton DC, Drew JE.House of Commons, London, UK
  • SULSA Symposium, University of St Andrews St Andrews, June 2010. Novel therapeutics targeting the endocannabinoid system in GI inflammation and cancer. Vase HF, Farquharson FA, Steele RJC, Ross RA, Bunton DC, Drew JE.  AWARDED BEST TRANSLATIONAL BIOLOGY POSTER