Dr Janice Drew

Dr_Janice_Drew

Dr Janice Drew

Cellullar defence systems diet and health

Improving diet and lifestyle is a key strategy to maintain metabolic health and prevent risk of developing diseases such as cancer, heart disease and diabetes.

At the Rowett I am involved in nutrition studies, using human volunteers, to assess health status and responses to different foods consumed and lifestyle changes.
 
The research we are doing can help the food industry to make their products healthier and provide advice to the public on how best to ensure they maintain good health.
 


Diet is a critical factor in maintenance of human cellular defence systems, immunity, inflammation, redox regulation, metabolism and DNA repair. Failure to maintain and regulate a co-ordinated cellular defence system leads to a number of chronic diseases and promotes unhealthy aging. Dysregulation of cellular defence systems are a consequence of obesity, now a global epidemic. Obesity is now associated with a significant increased risk of a number of organ specific cancers, colon, breast and oesophageal among others. Cellular defence systems play a significant role in prevention of cancer and metastasis.

My current research is focused on identifying the molecular and cellular effects of diets associated with development of obesity and the impact on cellular defence systems and links to increased cancer risk. Comprehensive strategies have been developed incorporating transcriptomics, including the novel gene expression technology, the GenomeLab System, application to interrogation of cultured human tissue explants, whole blood gene expression profiling (bloodomics) and proteomics, together with biochemical analyses of plasma and tissue samples to assess correlated changes in immunity, inflammation, redox regulation, metabolism and DNA repair and associated pathology. This approach is revealing predictive molecular signatures of health status, pathology and dietary modulation making it feasible for nutrition scientist to contemplate monitoring and survey of the impact of diet and lifestyle factors to generate evidence for effective translation of research on food, drink and health.


  • Drew, JE., Farquharson, AJ., Horgan, GW., Duthie, SJ. & Duthie, GG. (2014). 'Postprandial cell defense system responses to meal formulations: Stratification through gene expression profiling'. Molecular Nutrition & Food Research, vol 58, no. 10, pp. 2066-2079.
    [Online] DOI: 10.1002/mnfr.201400331
  • Williams, LM., Campbell, FM., Drew, JE., Koch, C., Hoggard, N., Rees, WD., Kamolrat, T., Thi Ngo, H., Steffensen, I-L, Gray, SR. & Tups, A. (2014). 'The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases'. PloS one, vol 9, no. 8, e106159.
    [Online] DOI: 10.1371/journal.pone.0106159
    [Online] AURA: 2014Williamsetal_PLOSone_.pdf
  • Drew, JE., Farquharson, AJ., Mayer, CD., Vase, HF., Coates, PJ., Steele, RJ. & Carey, FA. (2014). 'Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma'. PLoS ONE, vol 9, no. 11, 0113071.
    [Online] DOI: 10.1371/journal.pone.0113071
    [Online] AURA: journal.pone.0113071.pdf
  • Hold, GL., Berry, S., Saunders, KA., Drew, J., Mayer, C., Brookes, H., Gay, NJ., El-Omar, EM. & Bryant, CE. (2014). 'The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes'. PloS one, vol 9, no. 11, e111460.
    [Online] DOI: 10.1371/journal.pone.0111460
    [Online] AURA: journal.pone.0111460.pdf
  • Drew, J. (2012). 'Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer'. Molecular Biology Reports, vol 39, no. 5, pp. 5727-5736.
    [Online] DOI: 10.1007/s11033-011-1382-1
  • Padidar, S., Farquharson, A., Williams, L., Kearney, R., Arthur, J. & Drew, J. (2012). 'High-Fat Diet Alters Gene Expression in the Liver and Colon: Links to Increased Development of Aberrant Crypt Foci'. Digestive Diseases and Sciences, vol 57, no. 7, pp. 1866-1874.
    [Online] DOI: 10.1007/s10620-012-2092-9

Research briefs for the Knowledge Scotland web site

Rowett Institute of Nutrition and Health MSc/PgDip Molecular Nutrition

Dr Drew coordinates the Molecular Nutrition course within MSc Molecular/Human Nutrition programme at the University of Aberdeen. If you are require further information: MSc Human Nutrition

Recent Presentations

  • EuroSciCon The 2014 Obesity Summit “Obesity and metabolic health status: predictive gene signatures” Drew JE O2 Arena, London, 1 – 3 April 2014.
  • The Nutrition Society Winter Meeting Diet Gut Microbiology and Human Health “Nutritional responses of cellular defence systems to different fats with or without phytochemical rich extracts: molecular markers of health status” Royal College of Surgeons, London 11-12th December, 2013.
  • Unhealthy eating? How to study relationship between diet and health. “Cellular defence systems, diet and health” Global Health Academy, University of Edinburgh, Surgeon’s Hall, Edinburgh 27th Sept 2012
  • Experimental Biology 2012, San Diego, USA April 2012. Precancerous and Cancerous Predictive Signatures Using a Custom Designed Novel Gene Expression Assay Vase HF, Carey FA, Steele RJC, Ross RA, Drew JE
  • Nutrition Society Scottish Section Meeting "Novel multiplex technology platform to assess gene expression signatures in blood: predicting health benefits in response to diet." Drew, J.E, Farquharson, A.J 26th - 28th March University of Aberdeen 2012.
  • The Nutrition Society Summer Meeting 70th Anniversary: From plough through practice to policy “Obesity colon cancer links – adipokine signalling” University of Reading 4 – 6th July 2011
  • Aberdeen Proteomic Applications in Clinical and Life Sciences “Interrogation of the Colon Mitoproteome:  links with obesity related colon cancer. Institute of Medical Sciences University of Aberdeen 13th April 2010.
  • BIT’s 3rd Annual Congress of PepCon2010 “Interrogation of the Colon Mitoproteome:  links with obesity related colon cancer. Beijing, China 21-23rd March 2010.

Blog

Parliament, government and science: Dr Janice Drew spends a week in Westminster 9 December 2013 by Dr Janice Drew blog

Editorials

Autobiography of Editorial Board Members Janice Drew’s work on diet and cancer World Journal of Gastrointestinal Pathophysiology 2011 2:61-64.

Editorial: Obesity cancer links. The Open Obesity Journal Special Issue Obesity 2:10-11, 2010

Books and Reviews

Drew JE (2012) Cellular defence system gene expression signatures in blood: predicting health benefits in response to diet Advances in Nutrition 3:1-7.

Drew JE Molecular mechanisms linking adipokines to obesity related colon cancer: focus on leptin. The Proceedings of the Nutrition Society (2011) Published online doi:10.1017/S0029665111003259

Drew JE, Duthie GG, Farquharson AJ, Padidar S (2007) Combined approaches to investigate pre-pathological colon dysfunction in the pro-oxidant environment.” In: Precancerous Conditions Research Trends, Chapter 9 p203-227 Nova Science Publishers, Inc., New York.

Abstracts

  • Drew, J.E, Farquharson, A.J Novel multiplex technology platform to assess gene expression signatures in blood: predicting health benefits in response to diet. Proc Nut Soc (In press)
  • Vase HF, Carey FA, Steele RJC, Ross RA, Drew JE Precancerous and cancerous predictive signatures using a custom designed novel Gene expression assay The FASEB Journal 2012;26:397.1
  • Vase HF, Farquharson AJ, Carey FA, Steele RJC, Ross RA, Bunton DC, Drew JE Interrogating therapeutic manipulation of the endocannabinoid system in human colon. The FASEB Journal 2012;26:1123.1
  • Spotlight on Prostate Cancer Research, Stirling Management Centre, Stirling, Scotland, UK 28 June 2011. Biomarker profiling of precancerous and cancerous gene targets using a custom designed novel gene expression assay. Vase, HF, Carey, FA, Steele, RJC, Ross, RA, Drew, JE
  • SULSA Symposium, University of Glasgow, Glasgow, 7th June 2010. Novel therapeutics targeting the endocannabinoid system in GI inflammation and cancer. Vase HF, Farquharson FA, Steele RJC, Ross RA, Bunton DC, Drew JE.  AWARDED BEST TRANSLATIONAL BIOLOGY POSTER
  • ENDO 2011June 2011 Boston, Massachusetts, USA. High-fat diet in C57Bl/6 mice induces a rapid decrease in insulin sensitivity and an acute phase response. CampbellF, Drew JE, Tups A, Hoggard N,Nicol PF, Farquharson AJ, Koch C, Grant C, Morris AC, Williams LM
  • SET for BRITAIN 2011 14th March Biological and Biomedical Sciences Session Biomarker profiling of precancerous and cancerous gene targets using a custom designed novel gene expression assay. Vase HF, Farquharson FA, Steele RJC, Ross RA, Bunton DC, Drew JE.House of Commons, London, UK
  • SULSA Symposium, University of St Andrews St Andrews, June 2010. Novel therapeutics targeting the endocannabinoid system in GI inflammation and cancer. Vase HF, Farquharson FA, Steele RJC, Ross RA, Bunton DC, Drew JE.  AWARDED BEST TRANSLATIONAL BIOLOGY POSTER