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MT5003
Drug Metabolism & Toxicology
CREDIT POINTS 15

Course Co-ordinator: Prof. Gay M. Hawksworth

Pre-requisite(s): A degree or equivalent in Medicine, Pharmacy or a relevant science subject.

Lectures, tutorials and practical classes. Topics - absorption, distribution, metabolism and excretion of drugs. Human drug metabolism - cytochrome P450. Induction/inhibition of cytochrome P450. Identification of cytochrome P450 at an early stage in drug discovery. Pharmacogenetics of human drug metabolism - implication for drug safety in clinical practice. Mechanisms of drug induced toxicity: reactive metabolites; glutathoine conjugate-mediated toxicity; cytoprotective mechanisms; agents conferring protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis. Target organ toxicity. Toxicology of specified organ systems. Clinical biochemistry of drug toxicity. Pathology of drug toxicity. Haematological indices of drug toxicity.

2 x 1 hour lectures per week.
2 x lab practicals during weeks 1-2.

1 written exam paper (75%)
3 assignments for continuous assessment (25%)

MT5004
Therapeutics
CREDIT POINTS 10

Course Co-ordinator: Dr James McLay

Pre-requisite(s): A degree or equivalent at the prescribed standard in Medicine, Pharmacy or a relevant science subject.

Lectures and tutorials. Beta Adrenonreceptor Antagonists, Calcium Channel Antagonists, Lip Lowering Agents, Psychotic Illnesses and their treatment, Depression and its treatment, Angiotensin Converting Enzyme Inhibitors/Angiotensin Antagonists, Adverse Drug Reactions, Drug Interactions, Antibiotic Drugs used in the treatment of Asthma, Pharmacy Aspects of Safe Prescribing and Delivery of Drugs, Formulary Management, Drug Delivery Systems, Patient Compliance.

2x 1 or 1.5 hour lectures per week.
4 tutorials throughout the module.

1 written exam (75%)
2 assignments for continuous assessment (25%)

MT5007
Human Nutrition Core Course
CREDIT POINTS 50

Course Co-ordinator: Dr Janet Kyle

Pre-requisite(s): The course is restricted to students on the MSc Human Nutrition and Metabolism, MSc Public Health Nutrition, or PG Diploma in Human Nutrition programmes. A second class honours degree or equivalent in biological sciences such as biochemistry, physiology, nutrition or medicine

Lectures, seminars and practical classes on dietary assessment, macronutrients, energy balance and metabolism, micronutrients, nutritional status and body composition, nutrition throughout the life cycle, and diet and disease

Approximately ten 1-hour lectures per week. Laboratory practical classes.

Two 2 hour examinations (70%) and continuous assessment (30%)

MT5008
Molecular Pharmacology
CREDIT POINTS 20

Course Co-ordinator: Dr Heather M Wallace

Pre-requisite(s): A degree or equivalent qualification in Medicine, Pharmacy or relevant Science subject.

Lectures, seminars, tutorials and practical classes. Receptor pharmacology, immunopharmacology, cancer biology, molecular carcinogenesis, chemotherapy and ethics.

3 x 1 hour lectures per week.
1 tutorial or seminar per week.
1 lab practical throughout the course.

1 written examination paper (80%).
2 assignments for continuous assessment (20%)

MT5010
Basic Skills - Induction
CREDIT POINTS 0

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s): A degree or equivalent qualification, at the prescribed standard in Medicine, Pharmacy or relevant Science subject (eg. Biochemistry, Biology, or Pharmacy).

Lectures, Basic Laboratory Techniques, Library Facilities and how to use them, Working in Teams.

1x 2-hour lecture once every two weeks.

MT5011
Molecular Pharmacology, Immunology and Oncology
CREDIT POINTS 15

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s):

Overview of receptor pharmacology
Cellular communication
Basic Immunology, immunopharmacology
Drug targeting and gene therapy
Cancer biology, chemotherapy, chemoprevention and drug resistance
Molecular carcinogenesis
Clinical indices of malignancy
Clinical therapy

3 x 1 hour lecture per week; 3 x tutorials; 1 x practical class

1 formative essay, 1 practical report (10%), 1 essay, 1 x 1.5 hour written examination (65%)

MT5012
Human Drug Metabolism and Molecular Toxicology
CREDIT POINTS 20

Course Co-ordinator: Professor Gabrielle Hawksworth

Pre-requisite(s): IIi Honours degree in relevant discipline or MBChB

Human drug metabolism, induction/inhibition of metabolism, pharmacogenetics, molecular mechanisms of drug-induced toxicity, developmental toxicology, immunotoxicology, neurotoxicology, risk assessment, regulation of pharmaceuticals/pesticides, mutagenesis, carcinogenesis, discovery toxicology, biomarkers in pre-clinical toxicology.

3/4 one-hour lectures, 1 one-hour tutorial per week; 3 all-day practicals.

1 two-hour written examination (70%); continuous assessment (30%).

MT5013
Therapeutics for Scientists
CREDIT POINTS 5

Course Co-ordinator: Dr J S McLay

Pre-requisite(s): MBChB or good Honours degree in Pharmacology, Pharmacy, Biochemistry or a related discipline.

Aspects described above for selected drug groups e.g. beta adrenoceptor antagonists, Ca channel antagonists, lip lowering drugs.
Adverse drug reactions.
Drug interactions.
Drug delivery systems.

Oral presentations by students to peers with supporting summaries and references collated and distributed by lecturer.

1.5 hour written examination (75%); continuous assessment essay (25%).

MT5014
Molecular Pharmacology, Drug Discovery and Development
CREDIT POINTS 20

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s):

Basics of receptors, cancer biology and therapy, immunology, drug development and discovery, molecular biology, cancer treatment, cell signalling.

2 one-hour lectures per week, 4 tutorials, 1 six-hour practical class

1 two-hour written examination, 1 presentation, 1 practical report, 1 formative essay, 1 essay

MT5015
Research Skills
CREDIT POINTS 20

Course Co-ordinator: Dr Georgina Hold

Pre-requisite(s): MBChB or equivalent and acceptance onto the Aberdeen Academic Foundation Program.

The content will cover a theoretical and evidence-based background to generic research skills within the context of clinical research. Taught by a multi-disciplinary team from the College of Life Sciences and Medicine, specific topics to be covered include:
- Epidemiology
- Data handling and statistics
- Questionnaire design
- Literature search strategies
- Critical review
- The role of ethics
- Scientific writing skills

Teaching for this course will be delivered in 2 parts. The first part of the course teaching will be provided through a taught research course which will be held in September/October 2010 (dates to be confirmed). This is a 3-day full-time course containing six 3-hour workshops (2 per day) comprising small group teaching and interactive learning. The workshops will cover ethics and good clinical practice training, scientific writing and how to prepare fundable grant applications. There will also be a workshop on critical review. Coursework relating to this taught course will be due in by 21 December 2010. However, a second critical review assignment comprising tutorials and additional coursework will be instigated in January 2011 and completed by end of February 2011.

The second part of the course will be provided through a taught research course which will be held in March 2011 (date to be confirmed). The workshops will cover epidemiology, data handling and statistics, questionnaire design and literature search strategies. This is a 1-week full-time course containing ten 3-hour workshops (2 per day) comprising lectures, small group work and interactive sessions, with coursework due in by 10 June 2011.

Participants are expected to draw on and share their personal experiences of the topics covered and small group activities will be a prominent feature of this course. Formal lectures will be used to introduce new material, but these will be complemented by focussed discussion, practical exercises and group work.

Assessment will comprise preparation of research protocol for taught research course (20%), continuous assessment (60%) and oral presentation (20%). The continuous assessment marking will comprise:
1. Scientific writing assessment (10%)
2. Critical appraisal (20%)
3. Data handling assignment (20%)
4. Library based literature searching assessment (10%)

MT5016
Bench to bedside
CREDIT POINTS 10

Course Co-ordinator: Dr Julie Crockett

Pre-requisite(s): MBChB or equivalent and acceptance onto the Aberdeen Academic Foundation Program.

The content will cover a theoretical and evidence-based background to bench to bedside practical research skills. This will be followed by practical demonstrations of laboratory techniques and then students will undertake sample analysis using the various laboratory approaches in order to identify a series of 'patient' samples. This set of samples will have been generated by the course organiser and do not reflect genuine patient samples - there are no ethical considerations. Once laboratory analysis is complete, students will prepare reports summarising their findings. Taught by a multi-disciplinary team from the College of Life Sciences & Medicine, specific topics to be covered include:
- Laboratory safety
- Laboratory note keeping
- Practical demonstration of microbiology and molecular biological techniques
- Performing of the microbiology and molecular biological techniques by all students
- Data handling/results assimilation
- Scientific writing skills
- Scientific presentation skills

Teaching for this course will be delivered in 2 parts. The first part of the course teaching will be provided through a practical course which will be held in October 2010 (date to be confirmed). This is a 2-day full-time course containing three 3-hour laboratory sessions (two on day 1 and one in the morning of day 2) comprising small group teaching and interactive learning within the laboratory. The laboratory sessions will cover safety, effective note keeping, demonstrations of the various laboratory techniques within the course, performing of the techniques by the students and assessment of the laboratory findings. There will also be a tutorial in the afternoon of day 2 in which students will present their findings to a panel of senior academics. Coursework relating to this laboratory course (written summary and laboratory note books) will be due in by 21 December 2010.

The second part of the course will be provided in February 2011 (date to be confirmed). The second part will aim to build on the teaching undertaken in the first course and will provide training in different laboratory techniques. This is also a 2-day full-time course containing three 3-hour laboratory sessions (two on day 1 and one in the morning of day 2) comprising small group teaching and interactive learning within the laboratory. The laboratory sessions will cover safety, effective note keeping, demonstrations of the various laboratory techniques within the course, performing of the techniques by the students, assessment of the laboratory findings. There will also be a tutorial in the afternoon of day 2 in which students will present their findings to a panel of senior academics. Coursework relating to this laboratory course (written summary and laboratory note books) will be due in by end of March 2011.

Small group working and critical evaluation of the literature will be a prominent feature of this module. Practical demonstrations will be used to familiarise the students with various laboratory techniques, which they will perform independently (under supervision) on a series of samples. Once completed the students will be required to work within their groups to collate the laboratory data, compare it with the provided clinical observations and discuss between themselves and refer to the literature in order to define suggested clinical management. Once complete, each group will be expected to present the patient scenarios and individually prepare a written summary of each course.

Assessment will comprise laboratory notebook keeping (10%), written summary (course 1 - 35%), written summary (course 2 - 35%) and oral presentation (20%).

MT5017
Research and Scientific Writing
CREDIT POINTS 30

Course Co-ordinator: Dr Paul Lochhead

Pre-requisite(s): MBChB or equivalent. Acceptance onto the Aberdeen Academic Foundation Program. PgCert Medical Research Skills courses 1 and 2.

1 clinical audit
1 peer reviewed article (for example scientific review or case report)
The content and structure will vary depending on the clinical speciality in which the student is training.

All PgCert students are allocated clinical academic mentors at the beginning of the course. It is these academic mentors who will oversee the successful completion of this module. Over the course of the PgCert second year, opportunities to undertake the various aspects of this module will be identified and instigated. It is expected that in year 2, students will undertaken 1 clinical audit and write 1 peer reviewed article.

Assessment will comprise:
- Clinical audit assessment (30%)
- Peer reviewed article (70%)

MT5401
Human Nutrition & Metabolism
CREDIT POINTS 30

Course Co-ordinator: Dr Janet Kyle

Pre-requisite(s): The course is restricted to students on the MSc Human Nutrition and Metabolism or PG Diploma in Human Nutrition programmes. The Human Nutrition core course (MT5007) and the Applied Statistics course (PU5005) are pre-requisites for this course.

Lectures, seminars and practical classes on epidemiology and study design, laboratory methods, gene-nutrient interactions, tracer methodology and clinical nutrition.

Approximately ten 1-hour lectures per week. Laboratory classes and clinical attachments.

Two 2 hour examinations (70%) and continuous assessment (30%)

MT5501
Pharmacovigilance
CREDIT POINTS 5

Course Co-ordinator: Dr MJ MacLeod

Pre-requisite(s): A degree or equivalent qualification, at the prescribed standard in Medicine, Pharmacy or a relevant Science subject (eg. Biochemistry, Biology or Pharmacy)

Co-requisite(s): None

The 1 week course will comprise lectures, tutorials and seminars. The curriculum will provide an in-depth look at pharmacovigilance using examples from both first and third world countries and will include detection of adverse drug reactions; causality assessment; prevention of adverse drug reactions including correct prescribing, prevention of drug errors and promotion of rational drug use; and communication of risk-benefit information to the general public.

5 x 1 hour lectures
5 tutorials/seminars

1 assignment for continuous assessment (100%)

MT5502
Drug Development to Evidence Based Medicine
CREDIT POINTS 20

Course Co-ordinator: Dr James McLay

Pre-requisite(s): A degree or equivalent qualification at the prescribed standard in Medicine, Pharmacy or a relevant Science subject.

Impact or particular disease states with reference to the pathophysiology, epidemiology, economic cost and current drugs available. Rationale for further drug development and clinical trials. End point measurements. Drug trial design. Critical analysis of 'key' publications on the treatment of disease. Clinical guidelines. Selecting a limited list of medicines. Pharmacovigilance. Ethics. Development of a new medicinal compound from pharmacology to pharmaceutical product.

2 x 1.5 hour lectures per week.
4 tutorials throughout week 15-22.

2 written exam paper (60%)
3 assignments for continuous assessment (40%)

MT5503
Pharmacokinetics
CREDIT POINTS 10

Course Co-ordinator: Prof Gay M. Hawksworth

Pre-requisite(s): A degree or equivalent qualification, at the prescribed standard in Medicine, Pharmacy or a relevant Science subject.

Topics - Pharmacokinetic Principles, Applied Pharmacokinetics, Clinical Relevance of Pharmacokinetics, Therapeutic Drug Monitoring, Clinical Applications of Pharmacokinetics, Pharmacokinetics of Asprin (Practical).

3 x 1 hour lectures per week.
2 tutorials during the module.
1 lab practical during the module.

1 written exam (80%)
1 assignment for continuous assessment (20%)

MT5508
Clinical Pharmacology
CREDIT POINTS 5

Course Co-ordinator: Dr David Williams and Professor John Webster

Pre-requisite(s):

Content will be dictated by the delivery of course material by available lecturers. The content would be broadly based on The Therapeutic aspects of Hypertension, stroke and Cardiovascular medicine. A clear line between the development of drugs in this therapeutic field and assessment of their safety will be emphasised.

7 one-hour lectures/tutorials (to be arranged).

Continuous assessment essay/report (100%).

MT5509
Pharmacokinetics and Toxicokinetics
CREDIT POINTS 10

Course Co-ordinator: Professor Gabrielle Hawksworth

Pre-requisite(s): First Class Honours degree in relevant discipline or MBChB.

Introduction to pharmacokinetics, clinical pharmacokinetics, industrial pharmacokinetics, population kinetics, toxicokinetics.
Practical - aspirin pharmacokinetics and pharmacodynamics, using human volunteers.

3/4 one-hour lectures, 1 hour tutorial per week. One 2.5 day practical. Problem solving sessions using WinNonLin.

One 2h 20min written exam (allows reading time for paper) (70%); continuous assessment (30%).

MT5510
Introduction to Research Methods
CREDIT POINTS 10

Course Co-ordinator: Dr Heather Wallace and Professor Gabrielle Hawksworth

Pre-requisite(s): MBChB or good Honours degree in Pharmacology, Pharmacy, Biochemistry or a related discipline.

Theory of microarray analyses, proteomics, transcriptomics, PCR, protein blotting.
Metabolic profiling.
Key features in the design of a research project.
Basic epidemiology.
Risk assessment in drug development.

12 x 1-hour lectures and 2 x tutorials, 1 x practical class.

100% Continuous assessment: essay (35%); practical (35%); presentation (30%).

MT5511
Molecular Nutrition
CREDIT POINTS 30

Course Co-ordinator: Dr Janice Drew

Pre-requisite(s): The course will be restricted to students on the MSc/PgDip Molecular Nutrition programme. The courses MT5007 and PU5005 are pre-requisites for this course.

Lectures, seminars and practicals on molecular biology theory and methods, molecular nutrition, molecular analysis of human samples, model systems to study molecular nutrition, genomics, proteomics and nutrition research, human genome and polymorphisms, genes and disease, ethical considerations.

8 one-hour lectures (Mon, Tues and Thur am) or 4 two-hour seminars per week.
2 practical classes over the 6 weeks.
Visits to laboratory facilities for 0.5-1 day to be arranged on a group basis.

2 two-hour written examinations (70%), continuous assessment (30%).

MT5512
Research Project - Bio-Business and Medical Sciences
CREDIT POINTS 60

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s): Successful completion of all courses prescribed to date.

Note(s): Restricted to students on the MSc in Bio-business and Medical Sciences

Each project is unique and depends on the interests of the student and ongoing research work within the department. All proposed research topics are reviewed before being offered to the students.

No formal teaching - one to one meetings with supervisor.

100 continuous assessment (presentation, thesis and viva).

MT5514
Introduction to Drug Discovery
CREDIT POINTS 10

Course Co-ordinator: Dr Heather M Wallace

Pre-requisite(s):

Drug discovery, pre clinical toxicology, safety pharmacology

12 x 1 hour lecture and 2 x 1 hour tutorial

Continuous Assessment 100% 1 essay (60%) 4000 words and 1 presentation (40%)

MT5702
Extended Essay in Medical Sciences
CREDIT POINTS 10

Course Co-ordinator: Dr H Wallace

Pre-requisite(s): Degree at 2II or above from an appropriate academic institution in a science discipline. For international students, appropriate level of written and spoken English.

Note(s): For January start students.

The majority of the work carried out will be student directed. Guidance will be given via project supervisors and a series of informal tutorial sessions. Much of the early work will require library research. The students will be provided with a few key references to enable them to begin this task. The early part of the MSc programme will have already equipped the students will all the necessary skills required to tackle hard copy and on-line data and literature retrieval.

100% continuous. A 6500 word extended essay.

MT5801
Dissertation in Clinical Pharmacology
CREDIT POINTS 25

Course Co-ordinator: Dr Keith N Stewart

Pre-requisite(s): Attainment at the appropriate level in the taught courses of the Diploma/MSc Clinical Pharmacology common programme.

Co-requisite(s): Restricted to students on the Diploma in Clinical Pharmacology Programme.

Each dissertation is distinct and dependent on the student's interests and the work being pursued by research groups within the department at the time. All proposed dissertations are reviewed by the course coordinators and committee before being offered to the students.

No formal teaching during the research period. Departmental seminar - 1 hour per week.

Thesis (80%)
Defence of Thesis at Viva (20%)

MT5802
Research Project in Clinical Pharmacology
CREDIT POINTS

Course Co-ordinator: Dr Keith N Stewart

Pre-requisite(s): A Pass in each of the taught courses of the MSc Clinical Pharmacology programme.

Note(s): This course is worth 80 credits

Each project is distinct and is dependent on the work being pursued by research groups within the department at the time. All projects are reviewed by the course coordinators and committee before it is offered to the students.

No formal teaching during the research period. Departmental seminar - 1 hour per week.

Thesis (60%)
Oral Presentation of Work (20%)
Defence of Thesis at Viva (20%)

MT5803
Research Project in Human Nutrition & Metabolism
CREDIT POINTS 90

Course Co-ordinator: Dr Lindsey Masson

Pre-requisite(s): This course is restricted to students on the MSc Human Nutrition & Metabolism programme. The Human Nutrition core course (MT5007), Applied Statistics course (PU5005 and the Human Nutrition and Metabolism (MT5401) taught courses are pre-requisites.

Full-time supervised research project on a topic related to human nutrition and metabolism in laboratory or clinical setting

Full-time research work as dictated by the specific project

Thesis (University Examiner 25%; Rowett Examiner, 25%; External Examiner, 25%), Oral Presentation of Project Results (25%).

MT5804
Diploma Literature Review in Human Nutrition
CREDIT POINTS 30

Course Co-ordinator: Dr Lindsey Masson

Pre-requisite(s): This course is restricted to students on the PG Human Nutrition and Metabolism programme. The Human Nutrition core course and the Human Nutrition and Metabolism taught course are pre-requisites.

Full-time literature review on a topic related to human nutrition chosen by the student in consultation with an appointed supervisor

Full-time research work as dictated by the specific project.

Dissertation 100%

MT5809
Dissertation
CREDIT POINTS 20

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s): A pass in each of the taught courses in the MSc degree programmes for Drug Development and Drug Development and Bio-Business

Dissertation for candidates taking Postgraduate Diploma in Drug Development and Drug Development with Bio-Business

MT5810
Research Project
CREDIT POINTS

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s):

Note(s): Course is worth 65 credit points.

Research Project for Drug Development and Drug Development and Bio-Business MSc

MT5900
Project in Drug Development and Drug Safety
CREDIT POINTS 70

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s): Successful completion of all courses prescribed for MSc in Drug Development and Drug Safety.

Note(s): Restricted to students on the MSc in Drug Development and Drug Safety.

Each project is unique and depends on the interests of the student and ongoing research work within the department. All proposed dissertation topics are reviewed by the committee before being offered to the students.

No formal teaching. One-to-one meetings with supervisor.

Thesis (100%).

MT5901
Research Project in Molecular Nutrition
CREDIT POINTS 90

Course Co-ordinator: Dr Janice Drew

Pre-requisite(s): The course will be restricted to students on the MSc Molecular Nutrition programme. The courses MT5007, PU5005 and the new course "Molecular Nutrition" are pre-requisites for this course.

Research work as dictated by the specific project.

Research work as dictated by the specific project.

Thesis (75%), oral presentation (25%).

MT5902
Medical Sciences Practical
CREDIT POINTS 25

Course Co-ordinator: Dr Heather Wallace

Pre-requisite(s): Successful completion of MSc courses to date.

Laboratory based training with supervisor.

Day-to-day training and supervision with weekly supervisor-student meetings.

Laboratory notebook (40%); written report (20%); presentations (20%); laboratory practical skills (20%).