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MOLECULAR BIOLOGY

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MB 3006
MOLECULAR BIOLOGY OF THE CELL
CREDIT POINTS 30

Course Co-ordinator: Dr I Stansfield

Pre-requisite(s): BI 2002, BI 20M3 and BI 25M6.

Co-requisite(s): None

The first part of the course deals with the basic biochemistry of genetic material, including an examination of DNA replication, including cell cycle, chromosome organisation, recombination and repair, and mobile genetic elements (transposons). We progress into the core central dogma by dealing with both prokaryotic and eukaryotic mechanisms for the transcription of DNA into RNA and the subsequent synthesis of proteins encoded in mRNA. The focus then moves first to protein molecules, dealing with protein processing, targeting and turnover, and then to cell biological aspects of protein trafficking, membrane transduction and cell signalling. The course concludes with a discussion of cell structure and cell death. Laboratory work, assignments and tutorials are designed to complement and extend the lecture topics. Additional learning opportunities are provided in the staged series of Workshops, which allow the opportunity to actively employ understanding of a topic in a workshop/small group learning environment.

The formal teaching comprises 4 one-hour lectures per week, 1 two-hour workshop per fortnight, 5 three-hour practicals during the course and 1 two-hour tutorial.

1st Attempt: One 2.5 hour examination (60%) and in-course assessment (40%). Oral examination for borderline candidates.

Resit: One 2.5 hour examination (60%) and in-course assessment (40%). Oral examination for borderline candidates.