Research facilities are mainly clinically based and there is an increasing output of high quality research papers together with the production of several textbooks over the last few years. The Health Services Research Unit plus several other Research Units are sited in Aberdeen and provide excellent help for widely based radiology research projects.
- Breast imaging including Screening, PET, Magnetic Resonance Imaging (Prof FJ Gilbert, Dr H Deans and Dr K Duncan, Prof G Needham)
- Low Back Pain (Prof FJ Gilbert)
- Implementations of Guidelines (Prof F J Gilbert, Prof G Needham)
- Ovarian Screening (Dr H Deans, Prof F J Gilbert)
- Avascular Necrosis (Prof F J Gilbert)
- Head and Neck Imaging (Dr D McAteer, Dr M Brooks, Prof G Needham)
- Teleradiology and Teleultrasound (Dr A Thompson, Prof F J Gilbert, Prof J Weir)
- Interventional Radiology (Dr J Hussey, Dr P Thorpe)
- Neuroimaging including SPECT (Dr A D Murray, Dr O Robb)
- Ophthalmology (Dr K Goatman)
- Oncology Imaging (Prof F J Gilbert, Dr D McAteer, Dr S Yule, Dr M Brooks, Prof G Needham)
- Pain Imaging (Prof FJ Gilbert, Dr A D Murray)
There is a successful programme of functional imaging research concentrating on both MRI and PET. Prof Gilbert heads the oncological imaging programme investigating angiogenesis using a breast cancer model using both dynamic MRI information and metabolic data from PET.
Dr Murray is a neuroradiologist and uses MRI, PET and Nuclear Medicine techniques to investigate various neurological conditions including stoke, the ageing brain, white matter changes in divers and the immediate postoperative period in divers.
Grants have been obtained from the MRC, EPSRC, HTA board, CRC and Scottish Office to support staff and infrastructure costs.
Current Grants
Breast Imaging
Evaluation of mammographic surveillance services in women under 50 with a family history of breast cancer. Gilbert FJ. NHS Health Technology Assessment Programme. £8100, 2005-2007.
Further investigation of the early changes in the vascular characteristics of primary breast cancer physiology to predict response to chemotherapy, using dynamic MRI. Semple SIK. CSO. £14,400, 2005-2006
CADET II: Computer Aided detection in the NHS breast screening programme – a prospective evaluation. Gilbert FJ, Duffy S, Gillan M, Astley S et al. CRUK, NHS Breast Screening Programme. £443,000, 2005-2007.
Cardiac
Prediction of functional recovery following acute myocardial infarction: a comparison of echocardiography and cardiac MRI. Hillis G, Norton M, Walton S, Redpath TW, Gilbert FJ. Chest, Heart and Stroke Association Scotland. £68,193, 2004-2006.
Prediction of functional recovery following acute myocardial infarction: a comparison of echocardiography and cardiac magnetic resonance imaging, Hillis G, Norton M, Redpath TW, Walton S, Gilbert FJ. British Heart Foundation, £72,885, 2004-2006.
Musculoskeletal
A pragmatic randomised trial to evaluate direct access to MRI versus referral to orthopaedic surgeons for GP patients with continuing knee problems (DAMASK). Russell I, Wilkinson C, Gilbert FJ, Bryan S, King D, Houston H. Medical Research Council. £554,122, 2002-2006.
CSL in Rheumatology - Sports and Soft Tissue Medicine. Reid DM, Hutchison JD, MacDonald AG, Ledingham WM, Gilbert FJ, Pope MH, Hukins DWL, Ralston SH. Arthritis Research Campaign. £292,808, 2003-2008.
Neuro Imaging
Anatomical and functional brain correlates of cognitive ageing and their relationships to progression to Alzheimer’s disease. Whalley LJ, Staff RT, Deary IJ, Murray AD, Starr JM & Riedel G. Alzheimer’s Research Trust. £302,260, 2003-2006.
Flow-sensitive alternating inversion recovery (FAIR) technique: application to neonatal brain magnetic resonance imaging. Redpath, TW, Ries M, Waiter, G, Murray AD. Cerebra. £99,700, 2003-2006.
Electroconvulsive therapy and the brain: Neuroprotective effects. Reid IC, Murray AD. Chief Scientist Office via Grampian Universities Hospitals Trust. £15,000, 2004-2006.
Development of functional imaging of pain processing in patients with chronic wide spread pain. Waiter GD, Jones GT, Murray AD, Macfarlane G. NHS R D. £17,255, 2005-2006.
The relative contributions of cerebrovasclar disease and Alzheimer’s Disease to cognitive decline and dementia in the 1921 Aberdeen Birth Cohort Study. Murray AD, Staff RT, Whalley L. NHS R&D. £14,000, 2005-2006
Novel MRI contrast agents. Riedel G, Redpath TW, Seton HC. TauRx Therapeutics Pte Lts. circa £204,264, 2005-2007
Gordon's CV Lawrie SM, Gountouna EV, Ahrean TS, Brennan D, Cavanagh J, Condon B, Hadley DM, Job DE, Lymer K, McGonigle DJ, McIntosh A, Marshall I, Moorhead TWJ, Murray AD, Steele JD, Waiter GD, Whalley HC. CaliBrain: Multicentre structural and functional MRI in Scotland. CSO, 2006–2007, £172,386
Gordon's CV Scott C, Ietswart M, Waiter GD, Mon-Williams M, Johnston M, Hamilton S. Can motor imagery enhance recovery of hand function after stroke? Evaluation of functional redistribution following motor imagery training. NHS Grampian Research Endowments, 2006, £9755
Ophthalmology
The role of automated level-two grading within the Diabetic Retinopathy Screening Collaborative Network. Olson J, Sharp P, Goatman K, Fleming A, McNamee P, Prescott G, Williams G, Leese G, Swa K, Virdi M, Wykes W. Scottish Chief Scientists Office. £183,743, 2005-2007.
Oncology
Development of magnetic drug delivery devices: a novel approach to enhance delivery of chemotherapeutic agents for the treatment of cancer. AC Schofield, N Strachan, I Brown, SD Heys, Gilbert FJ, Rotariu O. NHSG Endowments. £6,560, 2005-2006.
Cancer of the Oesophagus or Gastricus: New Assessment of the Technology of Endosonography (COGNATE). Park KGM, Russell IT, Gilbert FJ, Sculpher MJ, Fullarton G, Kind P, Attwood S, Campbell S, Thompson AM. NHS Health Technology Assessment Programme. £1,079,256, 2004-2009.
Functional assays for prediction of response to chemotherapy in metastatic rectal cancer. Samuel L, Petty R, Collie-Duguid E, Yule S, Gilbert FJ, Semple S, Redpath TW, Royal College of Radiologists . £13,000, 2004-2006
Functional assays for prediction of responses to chemotherapy in metastatic rectal cancer. Samual L, Petty R, Collie-Duguid E, Yule S, Gilbert FJ, Semple SIK, Redpath TW. Chief Scientist Office, £15,000, 2005-2006.
Physics
Planar T-ray Gunn diodes. Dunn G, Redpath TW, Cumming D, Thayne I, Stanley C. Scottish Enterprise – Proof of Concept Fund. £199,845, 2004-2006.
Previous Grants
Breast Imaging
CADET - Computer Aided Detection in Mammography. Gilbert FJ, Astley S, Duffy S, McGee M, Gillan M. Cancer Research UK. £76,561, 2003-2004
Magnetic resonance imaging (MRI) breast screening in women at increased risk from mantle and mediastinal irradiation for Hodgkin's disease - a pilot. Gilbert FJ, Ratcliffe MA. GUHT Endowment Grant. £6,000, 2000.
The cost effectiveness of bone mass assessment in post-menopausal women: can it be enhanced by detection of breast cancer risk. Gilbert FJ, Reid D., National Osteoporosis Society. £5,000, 1999-2000.
Transvaginal scanning – Endometrium of patients on long term Tamoxifen SHHD Gilbert FJ, Campbell-Brown C, Kitchener H, Eremin O. £2,000, 1992.
Development of correlative and analytical techniques for MRI and PET imaging in breast cancer. Ah-See AK, Gilbert FJ, Heys SD, Hutcheon A, Redpath TW, Sharp P, Smith I. EPSRC. £165,769, 1999-2002.
Development of correlative analytical techniques for MRI and PET imaging in breast cancer. Redpath TW, Sharp PF, Gilbert FJ, Heys SD, Smith IC, Hutcheon AW, Ah-See AK. Engineering and Physical Sciences Research Council, £165,769: 1999-2002.
Breast cancer, dietary retinol intake and genetic factors in retinol metabolism: a pilot study. Sharp L, Little J, Haites N, Broom I, Eremin O, Gilbert FJ., ARHT Endowment Grant. £5,455, 1998-1999.
National Multi-Centre Study of MRI in Women at Genetic Risk of Breast Cancer. Leach M, Gilbert FJ, Turnbull LW, Walker LG, The Institute of Cancer Research - The Royal Marsden MRC. £64,917, 1998-2001.
PET, in vivo tumour cell metabolism and breast cancer: novel assessment of tumour volume, metastatic spread, response to chemotherapy and prediction of prognosis. Eremin O, Sharp P, Welch AE, Hutcheon AW, Smith IC, Walker LG, Heys SD, Miller I, Gilbert FJ, Ah-See AK, Payne S, Smith FW, Cancer Research Campaign £249,135 1997-2000 ARH NHS Trust Endowments. £10,000, 1997-2000.
Dynamic Gadolinium - DPTA enhanced magnetic resonance imaging of axillary lymph nodes in women with breast cancer comparison with pathology of excised nodes. Murray AD, Redpath TW, Gilbert FJ, Needham G, Smith FW, Eremin O, Ah-See AK, Heys SD.,
ARH NHS Trust. £12,930, 1995-1996.
RCR Pump Primer Grant. £4,310, 1997.Induction of neo-vascularisation and potentiation of chemotherapy by hyperbaric oxygen in patients with large breast cancers (>5cm) Heys SD, Ross A, Hutcheon AW, Miller ID, Gilbert FJ, Eremin O., Scottish Home & Health Department. £64,641, 1996-1998.
Gadolinium enhanced Magnetic Resonance Mammography As a Predictor of Response to Chemotherapy in Breast Cancer.Gilbert FJ, Needham G, Redpath TW, Ah-See AK, Heys SD, Eremin O, Sarkar T, Hutcheon AK, Miller I., ARH NHS Trust. £10,985, 1996-1997.
International Breast Interventional Study (IBIS) F J Gilbert and N Haites, Imperial Cancer Research Fund and Cancer Research Campaign £87,500 1995-2002 R & D Grampian Health Care Endowment. £10,000, 1995-1998.
Comparison of Breast Screening, Cervical Screening and Immunistation uptakes and GP attitudes. Ruddiman R, Gilbert FJ., Scottish Acceptability Group NHSBSP. £895, 1993.
MR Mammography with Needham G, Ah-See A, Heys SD, Sarkar T, Hutcheon AW, Eremin O, Gilbert FJ. ARHT Endowment Fund. £15,000, 1993-1994.
Psychological Aspects of Attendance and Recall to Breast Screening. C M Cordiner, L G Walker, A Ah-See, O Eremin and F J Gilbert. Scottish Acceptability Group NHSBP and GHB Endowments. £7,000, 1992-1994.
ACTR Research Fellowship in Medical Genetics de Silva D, Haites N, Gilbert FJ. £80,000, 1992-1994.
Mammography and HRT F J Gilbert (part of £200,000 grant to Reid D and Jandial V), Wyeth. £8,000, 1991-1994.
Cardiac
The use of MRI in the assessment of left ventricular impairment and its recovery: a PET-MRI comparative study. Redpath TW, Al-Mohammad A, Walton S, Sharp PF. Dr James Alexander Mearns' Trust, £72,084: 1998-2000.
The use of a novel MRI technique in the study of myocardial perfusion and prediction of hibernating myocardium: a PET comparative study. Walton S, AlL-Mhammad A, Redpath TW, Welch A, Sharp P. Chest, Heart and Stroke Scotland, £26,050: 1998-2000.
Validation of positron emission tomography (PET) surrogate markers for hibernating myocardium. Walton S, Al-Mohammad A, Welch AE, Redpath TW, Sharp PF. British Heart Foundation, £75,000: 1998-2000.
The study of T2* MRI in the diagnosis of myocardial ischaemia in comparison with nuclear perfusion imaging in patients with ischaemic heart disease. Walton S, Egred M, Metcalfe M, Redpath TW. Chief Scientist Office, Scottish Executive, £31,265 (including NHS costs): 2001-2002.
Assessment of T2* BOLD MRI in the detection of myocardial ischaemia in comparison to 13NH3 PET imaging in patients with coronary heart disease. Egred M, Walton S, Redpath TW, Waiter G, Norton M. Chest, Heart and Stroke Scotland, £21,941: 2001-2002.
Delayed enhancement magnetic resonance imaging to detect peri-operative myocardial damage in patients undergoing major vascular surgery. Hillis G, Brittenden J, Cuthbertson B, Bachoo P, Croal B, Redpath TW, Gilbert FJ. Grampian University Hospitals Trust Research Endowments, £12,000: 2002-2003.
Cardiovascular involvement in myotonic dystrophy: prevalence, genetic influences and non-invasive predictors of outcome. Hillis G, Dean J, Broadhurst P, Norton M, Redpath TW, Walton S, Gilbert FJ. Muscular Dystrophy Campaign, £50,000: 2003-2005.
A comparison of the incidence of post operative cerebral ischaemic change as detected by MRI between on (CABG) and off (OPCAB) coronary artery bypass surgery groups. Flynn S, Keston P, Gilbert FJ, El-Shafei H, Buchan K, Cockburn R., RCR. £5,300, 2003-2004.
Delayed enhancement MRI to detect peri-operative myocardial damage in patients undergoing major vascular surgery. Hillis G, Brittenden J, Cuthbertson B, Bachoo P, Croal B, Redpath TW, Gilbert FJ. GUHT. £12,000, 2003-2004.
Fetal
Non invasive detection of oxygenation in utero using BOLD-MRI in normal and small for date fetuses. Redpath TW, Haggerty P, Abramovich DR, Ross JA, Semple SIK, Gilbert FJ. Chief Scientist's Office. £117,919, 2001-2003.
Infrastructure
Quantitative Magnetic Resonance Imaging in Cancer, Ischaemic Heart Disease and Neurology. Gilbert FJ, Redpath TW, Murray AD. Tenovus Grampian. £100,000, 1998-2000.
A high performance MR scanner for the quantitative functional imaging programme in cancer, heart disease and neurology. Gilbert FJ, Redpath TW, Murray AM, Sharp P. SHEFC. £641,000, 1999-2002.
Donation for MRI Building, Roland Sutton Trust. £250,000, 2000.
Donation for MRI Building, GUHT Endowments. £350,000, 2000.
Musculoskeletal
Systematic Review of Musculoskeletal Radiology Guidelines. Gilbert FJ, Grimshaw JM, Watt I. The Royal College of Radiologists. £6,500, 2000.
"Does early sophisticated imaging influence management and improve outcome in patients with low back pain". Gilbert FJ, Grant A, Porter RA, Hutchison J, Wardlaw D, Smith FW., NHS Health Technology Assessment Programme. £408,074, 1996-2001.
Neuro Imaging
Functional neuroimaging studies of action, facial and object-directed imitation. Williams JHG, Whiten A, Perrett D, Murray AD, Waiter GD. National Alliance for Autism Research. $119,977 (approx) £71,986, 2003-2005.
Proton spectroscopy upgrade for GE clinical research MRI system. Murray AD, Reid IC. Chief Scientist Office via Grampian Universities Hospitals Trust. £35,900, 2004-2005.
The value of FP-CIT and IBZM brain isotope scans in the diagnosis of patients with newly diagnosed Parkinsonian syndromes early in their disease course. Counsell C, Murray AD, Staff RT. GUHT Endowments. £11,365, 2004-2005.
Contribution In Support of MRI Data Analysis. Murray AD, Staff RT. Millar-MacKenzie Trust. £5,000, 2005.
Trans-National access to the Centre for BioMedical Functional Imaging "FUNCIMAGE". Sharp P, Gilbert FJ, Forrester I, Logie R. CEC. £629,468, 2001-2004.
The role of FDG PET in the staging of advanced (stage III-IV) malignant melanoma. Murray AD Davies M, Holmes JD, Welch A, RCR X-Appeal Pump Priming Grant Scheme. £5,000, 2003-2004.
The value of FP-CIT and IBZM brain isotope scans in the diagnosis of patients with the newly diagnosed parkinsonian syndromes early in their disease course. Counsell C, Murray AD.,
GHUT Endowments. £15,000, 2003-2004
£11,365, 2004-2005.Web based tools for brain SPECT.Staff RT, Murray AD, Gemmell HG. Amersham. £61,000, 2003-2004.
The development of a population based study of the incidence and long-term outcome of Parkinsons's disease in Grampian. Counsell C, Hannaford P, Smith C, Murray AD. British Medical Association. £17,443, 2002-2003.
A comparison of the incidence of post operative cerebral ischaemic change as detected by MRI between on (CABG) and off (OPCAB) coronary artery bypass surgery groups. Flynn S, Keston P, Gilbert FJ, El-Shafei H, Buchan K, Cockburn R. RCR. £5,300, 2003-2004.
The role of FDG PET in the staging of advanced (stage III-IV) malignant melanoma. Murray AD Davies M, Holmes JD, Welch A, RCR X-Appeal Pump Priming Grant Scheme. £5,000, 2003-2004.
A pilot study using fMRI to image imitation in autistic spectrum disorders. William HG, Whiten A, Murray AD, Gilchrist A, Perrett DI. Chief Scientists Office. £66,165, 2001-2002.
Co-ordination functions in healthy and impaired working memory: experimental and neuroimaging investigations. Logie R, Della Sala S, Redpath TW. Medical Research Council, £136,426: 2001-2004.
Imaging cognitive effort in ageing. Royal College of Radiologists Murray AD, Venneri A, Shanks M, X-Appeal Research Scheme (Old Age). £5,500 2000-2001 GUHT Endowments. £15,000, 2000-2001.
The clinical significance of brain cortical atrophy and white matter lesions detected by MRI in a well characterised cohort of old people. Whalley LJ, Deary I, Murray AD, Staff RT. Chief Scientist’s Office. £160,510, 2000–2002.
Evaluation of magnetic resonance renography as a “one-stop” investigation for renal artery stenosis. Murray AD, Thorpe AP, Webster J, Khan I. GUHT Endowments. £9,250, 2000–2001.
Hyperprolactinaemia in Hodgkin’s Disease and Non-Hodgkin’s Lymphoma. Shaw JAM, Abraham P, Bevan JS, Duncan M, Meiklejohn D, Culligan D, Watson H, Murray AD, Gilbert FJ. GUHT Endowments. £2,200, 1998–1999.
Effect of glyceryl trinitate on blood pressure and regional cerebral blood flow in acute ischaemic stroke. Dijkhuizen RS, Gemmell H, Murray AD, Kerr S. GUHT Endowments. £10,000, 1999-2000.
Computing equipment for clinical database handling. Murray AD. Joint Research Equipment Fund. £1,392, 1999-2000.
Identification of hip prosthesis infection by FDG-PET and Sulesomab white cell scanning. Keston P, Ashcroft GP, Brooks M, Murray AD. Royal College of Radiologists Pump Priming Grant. £6000, 1999-2000.
Language mapping using positron emission tomography in normal volunteers and in patients with brain tumours for preoperative planning. Murray AD, Venneri A, Welch A, Currie DG, Kaar GF, Staff R. ARH NHS Trust Endowments. £7500, 1998-1999.
Staging of malignant melanoma: comparison of positron emission tomography (PET) with clinical outcome and histopathology of excised locoregional lymph nodes. Murray AD, Davies M, Holmes J, Blessing K, Welch A, Nicholson M, White M. GUHT Endowments. £9600, 1998-1999.
Dynamic gadolinium – DTPA enhanced magnetic resonance imaging of axillary lymph nodes in women with breast cancer comparison with pathology of excised nodes. Murray AD, Redpath TW, Gilbert FJ, Needham G, Smith FW, Eremin O, Ah-See AK, Heys SD.
ARH NHS Trust. £12,930, 1995-1996
Royal College of Radiologists pump Primer Grant. £4,310, 1997–1998.99m Tc HMPAO SPECT and MRI of the brain following head injury – correlation of imaging findings with neuropsychological assessment. Duddalwar VA, Murray AD, Robb OJ, Moore J, Crawford J, Smith FW, Redpath TW, Gemmell HG, Kaar GF. ARH NHS Trust Endowments. £7500, 1996-1997.
Ophthalmology
The Role of Automated Grading of Diabetic Retinopathy in a Primary Care Screening Programme. Olson J, Sharp P, Goatman K, McNamee P, Prescott G. Scottish Chief Scientists Office. £203,827.
Oncology
European Randomised Trial of Ovarian Screening (ERTOCS) Cancer Research Campaign with H C Kitchener, H E Deans, D Parkin & F J Gilbert,
R & D Grampian Health Care £60,000 1995-1998
Gynaecology Endowment Fund £24,850, 1995-1998
Cancer Research Campaign, £12,000, 1996-1998
£44,049, 1999-2000
£46,636, 2000-2002,Hyperprolactinaemia in Hodgkin's Disease and Non-Hodgkin's Lymphoma. Shaw JAM, Abraham P, Bevan JS, Duncan M, Meiklejohn D, Culligan D, Watson H, Murray AD, Gilbert FJ. ARHT Endowment Grant. £2,200, 1998-1999.
Scottish Audit of Gastro-Oesophageal Cancer. Park K, Gilbert FJ, NPC CRAG SHHD. £280,189, 1997-2000.
Scottish Radiological Society/Scottish Standing Committee Audit Group
a) Audit of investigation and management of testicular teratoma in Scotland
b) CT Planning for Radiotherapy treatment in Scotland
c) Use of contrast media in Scotland
d) Audit of Treatment of the Larynx
e) Audit of Preparation of Children, prior to MRI,
CRAG, £60,000, 1992-1994
£33,000, 1994-1995
£32,000, 1995-1996.Network Resource for the European Randomised Trial of Ovarian Cancer Screening. Wald N, Scott I, Tabor A, Gilbert FJ. EU Contribution - Biomed & Health Research Programme. £85,730, 1996-1999.
Telemedicine
An evaluation of the feasibility and diagnostic acceptability of the tele-ultrasonography for rural areas. Brebner J, Ritchie L, MacLean JR, Gilbert FJ, Thompson A, Smith P. R & D Grampian Healthcare. £71,547, 1996-1998.
Computed Assisted Learning - Radiology for Undergraduates Hamilton N, Weir J, Undrill P, Gilbert FJ. Roland Sutton Academic Trust. £20,000, 1995-1996.
