Ms Seonaidh Cotton

Ms Seonaidh Cotton The University of Aberdeen School of Medicine & Dentistry Trial Manager work +44 (0)1224 438178 work +44 (0)1224 438437 work +44 (0)1224 438438 work fax 01224 554580 pref s.c.cotton@abdn.ac.uk pref Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

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Biography

Seonaidh Cotton joined HSRU in 2007 as a trial manager.  She graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, Seonaidh worked in the Department of Public Health at the University of Aberdeen. 

Seonaidh works as a trial manager across a number of different trials.  These include FOCCUS (a multicentre trial looking at whether fluid loading reduces the risks associated with major surgery in high-risk patients), REFLUX (a national multicentre trial that aims to look at the best form of treatment for gastro-oesophageal reflux disease, and is now in long-term follow-up) and CLASS (a multicentre trial comparing two minimally invasive treatments for varicose veins with conventional surgery). 

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Current Research

FOCCUS

REFLUX

CLASS

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Publications

Contributions to Journals

Articles

• Sharp, L., Cotton, S., Gray, NM., Avis, M., Russell, I., Walker, L., Waugh, N., Whynes, D., Woolley, C., Thornton, A., Smart, L., Cruickshank, M., Little, J. & TOMBOLA Grp (2011). 'Long-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial'. British Journal of Cancer, vol 104, no. 2, pp. 255-264.
  [Online] DOI: 10.1038/sj.bjc.6606042
• Sharp, L., Cotton, S., Thornton, A., Gray, NM., Whynes, D., Smart, L., Waugh, N., Duncan, I., Cruickshank, M. & Little, J. (in press). 'Which women default from follow-up cervical cytology tests?: A cohort study within the TOMBOLA trial'. Cytopathology.
  [Online] DOI: 10.1111/j.1365-2303.2011.00848.x
• TOMBOLA Group (2011). 'Human Papillomavirus Infection and Anxiety: Analyses in Women with Low-Grade Cervical Cytological Abnormalities Unaware of Their Infection Status'. PLoS one, vol 6, no. 6.
  [Online] DOI: 10.1371/journal.pone.0021046
• Cotton, S., Sharp, L., Cochran, C., Gray, N., Cruickshank, M., Smart, L., Thornton, A. & Little, J. (2011). 'After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trial'. British Journal of General Practice, vol 61, no. 587, pp. e333-e339.
  [Online] DOI: 10.3399/bjgp11X578007
• Cuthbertson, BH., Campbell, MK., Stott, SA., Elders, A., Hernández, R., Boyers, D., Norrie, J., Kinsella, J., Brittenden, J., Cook, J., Rae, D., Cotton, SC., Alcorn, D., Addison, J., Grant, A. & the FOCCUS study group (2011). 'A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study'. Critical Care, vol 15, no. 6, pp. R296.
  [Online] DOI: 10.1186/cc10592
  [Online] AURA: Cuthbertson_2011.pdf
• Cotton, SC., Sharp, L., Little, J., Cruickshank, ME., Seth, R., Smart, L., Duncan, I., Harrild, KA., Neal, K., Waugh, NR. & The TOMBOLA Group (2010). 'The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial'. BJOG-An International Journal of Obstetrics and Gynaecology, vol 117, no. 6, pp. 645-659.
  [Online] DOI: 10.1111/j.1471-0528.2010.02519.x
• Whynes, D., Philips, Z., Woolley, C., Cotton, SC., Cruickshank, ME., Harrild, KA., Little, J., Sharp, L., Waugh, NR. & The TOMBOLA Group (2009). 'Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial'. British Medical Journal, vol 339, pp. b2546.
  [Online] DOI: 10.1136/bmj.b2546
• Sharp, L., Cotton, SC., Cochran, C., Gray, NM., Little, J., Neal, K., Cruickshank, ME. & The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group (2009). 'After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial'. BJOG: An International Journal of Obstetrics and Gynaecology, vol 116, no. 11, pp. 1506-1514.
  [Online] DOI: 10.1111/j.1471-0528.2009.02263.x
• Sharp, L., Cruickshank, ME., Little, J., Cotton, SC., Harrild, KA., Cochran, C., Waugh, NR., Smart, L. & TOMBOLA Group (2009). 'Biopsy and selective recall is as effective as immediate LLETZ in the management of women with low-grade smears referred for colposcopy'. British Medical Journal, vol 339, pp. 2548.
• Whynes, D., Philips, Z., Woolley, C., Cotton, SC., Harrild, KA., Cruickshank, ME., Little, J., Smart, L., Waugh, NR. & TOMBOLA group (2009). 'Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study'. British Medical Journal, vol 339, pp. 2549.
  [Online] DOI: 10.1136/bmj.b2549
• Sharp, L., Little, J., Brockton, NT., Cotton, SC., Masson, LF., Haites, NE. & Cassidy, J. (2008). 'Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake'. British Journal of Nutrition, vol 99, pp. 379-389.
  [Online] DOI: 10.1017/S0007114507801073
  [Online] AURA: MTHFR_Bvits_CRC.pdf
• Cotton, SC., Sharp, L., Seth, R., Masson, LF., Little, J., Cruickshank, ME., Neal, K. & Waugh, NR. (2007). 'Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK women'. British Journal of Cancer, vol 97, no. 1, pp. 133-139.
  [Online] DOI: 10.1038/SJ.BJC.6603822
• Cotton, SC., Sharp, L., Seth, R., Masson, LF., Little, J., Cruickshank, ME., Neal, K., Waugh, NR. & TOMBOLA Group (2007). 'Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women'. British Journal of Cancer, vol 97, no. 1, pp. 133-139.
  [Online] DOI: 10.1038/sj.bjc.6603822
• Gray, NM., sharp, L., Cotton, SC., Masson, LF., little, J., Walker, LG., Avis, M., Philips, Z., Russell, I., Whynes, DK., Cruickshank, ME., Woolley, CM. & The TOMBOLA Group (2006). 'Psychological effects of a low-grade abnormal cervical smear test result:anxiety and associated factors'. British Journal of Cancer, vol 94, pp. 1253-1262.
  [Online] DOI: 10.1038/sj.bjc.6603086
• Bentley, E., Cotton, SC., Cruickshank, ME., Duncan, I., Gray, NM., Jenkins, D., little, J., Neal, K., Philips, Z., Russell, I., Seth, R., sharp, L. & Waugh, NR. (2006). 'Refining the management of low-grade cervical abnormailities in the UK National Health Service and defining the potential for human papillomavirus testing: A commentary on emerging evidence'. Journal of Lower Genital Tract Disease, vol 10, no. 1, pp. 26-38.
  [Online] DOI: 10.1097/01.lgt.0000192695.93172.75
• Cotton, SC., Sharp, L., Little, J., Cruickshank, ME. & TOMBOLA Group (2006). 'Trial of management of borderline and other low grade abnormal smears (TOMBOLA): Trial design'. Contemporary Clinical Trials, vol 27, no. 5, pp. 449-471.
  [Online] DOI: 10.1016/j.cct.2006.04.001
• Sharp, L., Cotton, SC., Alexander, L., Williams, E., Gray, NM., Reid, JM. & TOMBOLA Grp (2006). 'Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)'. Clinical Trials, vol 3, pp. 431-442.
  [Online] DOI: 10.1177/1740774506070812
• Sharp, L., Cochran, C., Cotton, SC., Gray, NM., Gallagher, ME. & TOMBOLA grp (2006). 'Enclosing a pen with a postal questionnaire can significantly increase the response rate'. Journal of Clinical Epidemiology, vol 59, no. 7, pp. 747-754.
  [Online] DOI: 10.1016/j.jclinepi.2005.10.014
• Little, J., Sharp, L., Masson, LF., Brockton, NT., Cotton, SC., Haites, NE. & Cassidy, J. (2006). 'Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1'. International Journal of Cancer, vol 119, no. 9, pp. 2155-2164.
  [Online] DOI: 10.1002/ijc.22093
• Masson, LF., Sharp, L., Cotton, SC. & Little, J. (2005). 'Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review'. American Journal of Epidemiology, vol 161, no. 10, pp. 901-915.
  [Online] DOI: 10.1093/aje/kwi121
• Gray, NM., Sharp, L., Cotton, SC., Avis, M., Philips, Z., Russell, I., Walker, LG., Whynes, DK. & Little, J. (2005). 'Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) trial'. Quality of Life Research, vol 14, no. 6, pp. 1553-1562.
  [Online] DOI: 10.1007/s11136-004-8146-5
• Cotton, SC., Sharp, L. & Seth, R. (2004). 'Are lifestyle factors associated with infection with high risk human papilloma virus? results from TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)'. Journal of Epidemiology and Community Health, vol 58, no. Supplement II.
• Sharp, L., Cardy, AH., Cotton, SC. & Little, J. (2004). 'CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review'. American Journal of Epidemiology, vol 160, no. 8, pp. 729-740.
  [Online] DOI: 10.1093/aje/kwh287
• Sharp, L., Little, J., Schofield, AC., Pavlidou, E., Cotton, SC., Miedzybrodzka, ZH., Baird, J., Haites, NE., Heys, SD. & Grubb, DA. (2002). 'Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)'. Cancer Letters, vol 181, no. 1, pp. 65-71.
  [Online] DOI: 10.1016/S0304-3835(02)00030-7
• Sharp, L., Little, J., Brockton, NT., Cotton, SC., Haites, NE. & Cassidy, J. (2002). 'Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population based case-control study in Scotland'. Journal of Nutrition, vol 132 Supplement 11.
• Gray, NM., Sharp, L., Cotton, SC., Little, J., Avis, M., Philips, Z., Walker, LG. & Duncan, I. (2002). 'Women’s experiences of having an abnormal smear result: qualitative analyses from TOMBOLA'. Journal of Obstetrics and Gynaecology, vol 22, pp. 107-111.
  [Online] DOI: 10.1080/01443610211113
• Sharp, L., Little, J., Brockton, NT., Cotton, SC., Haites, NE. & Cassidy, J. (2001). 'Genetic polymorphisms in folate metabolism, dietary folate intake and colorectal cancer: a population-based case-control study'. Journal of Epidemiology and Community Health, vol 55, no. Supplement 1.

Books and Reports

Commissioned Reports

• Cuthbertson, B., Campbell, MK., Stott, S., Vale, LD., Norrie, JDT., Kinsella, J., Cook, JA., Brittenden, J., Grant, AM., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, GC., McDonald, AM., Cotton, SC., Elders, AS., MacLennan, GS., Boyers, D. & Hernández, RA. (2010). 'Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery'. Chief Scientist Office, Edinburgh, United Kingdom.

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