31 January 2014

Heart attack drug proven to have no rebound effect

University of Aberdeen scientists have analysed clopidogrel - a drug prescribed following a heart attack
University of Aberdeen scientists have analysed clopidogrel - a drug prescribed following a heart attack

Clopidogrel, a drug prescribed to thousands of people who have had a heart attack, can be safely withdrawn with no 'rebound effect', according to a study by Aberdeen scientists.

The drug works by lowering the stickiness of platelets and preventing clots forming. Heart attacks occur when platelets in the blood form clots in the coronary artery.

Current guidelines recommend that patients are prescribed clopidogrel for up to 12 months following a heart attack.

However, recent reports had shown that a higher than expected number of patients experienced blood clots within a short time of stopping this drug.

Concerns were raised that the drug may be causing platelets within the blood to become more active.

Our study is the first to show that platelet activity after stopping clopidogrel is not any higher than it would have been without the drug." Dr Isobel Ford from the University of Aberdeen's Institute of Medical Sciences

But a three year study of patients who had a heart attack or blocked leg artery, performed by experts from the University of Aberdeen’s Institute of Medical Sciences, has found no evidence for increased blood platelet activity after planned discontinuation of the drug.

The findings of the research, which was funded by Heart Research UK, are published in the Journal of the American College of Cardiology (JACC).

Dr Isobel Ford from the University of Aberdeen’s Institute of Medical Sciences said: “Our trial recruited 171 patients who had narrowed arteries in their heart or leg arteries. They were given clopidogrel and aspirin, or a placebo capsule and aspirin, to take for one month. We measured blood platelet activity using a range of tests before, during treatment, and after stopping the medicine.

“Our study is the first to show that platelet activity after stopping clopidogrel is not any higher than it would have been without the drug.”

Julie Brittenden, Professor in Vascular Surgery & Deputy Head of Division of Applied Medicine at the University of Aberdeen said:  “Our findings provide reassurance for doctors that they can safely halt therapy using clopidogrel in patients that are stable, as per current guidelines, without leading to a rebound in platelet activity.”

Notes for Editors

Issued by the Communications Team
Office of External Affairs, University of Aberdeen, King's College, Aberdeen
Tel: +44 (0)1224 272014

Contact: Kelly Potts
Issued on: 31 January 2014
Ref: 022HEART


back



    Search News

    Search News

    Browse by Month

    2016

    2016

    Jan
    Feb
    Mar
    Apr
    May
    Jun
    Jul
    Aug
    Sep
    Oct
    Nov
    Dec

    2015

    2014

    2013

    2012

    2011

    2010

    2009