Dr Thomas Baddeley

Dr Thomas Baddeley

PhD, BSc Hons

Senior Research Fellow

About

Telephone Number: +44 (0)1224 274238
School/Department: School of Natural and Computing Sciences

Google Scholar

Pure

North East Analytical Research (NEAR) Symposium

Link to the NEAR Symposium Website

NEAR Symposium

Qualifications

PhD Chemistry
2002 - University of Aberdeen
BSc Hons Chemistry
1998 - University of Aberdeen

External Memberships

Head of DMPK / Analytical Chemistry for TauRx Therapeutics
Cofounder of the North East Analytical Research (NEAR) Symposium

Latest Publications

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
2023 - Published
Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
International Journal of Molecular Sciences, vol. 24, no. 13, 10810
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms241310810
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f25eee8a-d88e-4932-8d2f-6574bcb547cf/download
Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography
2022 - Published
Delbono, V., Larch, C. P., Newlands, K. C., Rhydderch, S., Baddeley, T. C., Storey, J. M. D.
International journal of analytical chemistry, vol. 2022, 9171836
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1155/2022/9171836
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/30d761b6-cd1d-41b8-9a27-332deb2c1c20/download
- [ONLINE] View publication in Scopus
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
2022 - Published
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
Biomedicines, vol. 10, no. 4, 867
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/biomedicines10040867
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/161666d1-4323-45bc-9b3c-26c075dc2edd/download
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020 - Published
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-191173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/53b6ee0c-d5be-45c3-90a0-1afea8f620c4/download
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019 - Published
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190772
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4bb2ba91-6ed8-4d4f-92e5-d6879822bf25/download

View My Publications

Research

Research Overview

My focus is on the analytical pathways involved in pharmaceutical drug development.

This starts early during R and D looking at physical chemical testing of novel compounds and early analytical development to determine material purity and its impurities.
As the candidates progress further, bioanalytical methods, initial metabolism and material characterisation are developed.
Once into non clinical and clinical development validation according to ICH Q3 is required for material assays and ICH M7 for bioanalytical methods

Current Research

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The development and use of bioanalytical methods used in clinical and non clinical studies

DMPK studies supporting novel pharmaceutical development

Past Research

The synthesis and study of novel organic compounds for use as potential drug candidates and excipients.

The study of the physical properties of novel oligosaccharides

Knowledge Exchange

Speaker at NEAR Symposium 2024 in Aberdeen

Speaker at REID bioanalytical Forum 2019, Cambridge

Speaker at INFORM 2018 in Copenhagen

Publications

Page 1 of 4 Results 1 to 10 of 35

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
2023 - Published
Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
International Journal of Molecular Sciences, vol. 24, no. 13, 10810
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms241310810
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f25eee8a-d88e-4932-8d2f-6574bcb547cf/download
Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography
2022 - Published
Delbono, V., Larch, C. P., Newlands, K. C., Rhydderch, S., Baddeley, T. C., Storey, J. M. D.
International journal of analytical chemistry, vol. 2022, 9171836
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1155/2022/9171836
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/30d761b6-cd1d-41b8-9a27-332deb2c1c20/download
- [ONLINE] View publication in Scopus
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
2022 - Published
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
Biomedicines, vol. 10, no. 4, 867
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/biomedicines10040867
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/161666d1-4323-45bc-9b3c-26c075dc2edd/download
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020 - Published
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-191173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/53b6ee0c-d5be-45c3-90a0-1afea8f620c4/download
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019 - Published
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190772
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4bb2ba91-6ed8-4d4f-92e5-d6879822bf25/download
Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives
2019 - Published
Gomes, L. R., Low, J. N., Turner, A. B., Nowicki, A. W., Baddeley, T. C., Wardell, J. L.
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 74, no. 9, pp. 649-663
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1515/znb-2019-0094
- [ONLINE] View publication in Scopus
N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry
2019 - Published
Baddeley, T. C., de Souza, M. V. N., Wardell, J. L., Jotani, M. M., Tiekink, E. R. T.
Acta Crystallographica Section E: Crystallographic Communications, vol. 75, no. 4, pp. 516-523
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1107/S2056989019003980/hb7809Isup3.cml
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4a37bda3-ffb6-4157-89e4-6281bf707eb9/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives
2019 - Published
Pinheiro, A. C., de Souza, M. V. N., Lourenco, M. C. S., da Costa, C. F., Baddeley, T. C., Low, J. N., Wardell, S. M. S. V., Wardell, J. L.
Journal of Molecular Structure, vol. 1178, pp. 655-668
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.molstruc.2018.10.030
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements
2018 - Published
Gomes, L. R., Low, J. N., Turner, A. B., Baddeley, T. C., Wardell, J. L.
Steroids, vol. 140, pp. 92-103
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.steroids.2018.09.010
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
2018 - Published
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2018.08.010
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4a511918-4131-4ebe-8d13-8da584a0ff83/download

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North East Analytical Research (NEAR) Symposium

Qualifications

External Memberships

Latest Publications

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Research Overview

Current Research

Past Research

Knowledge Exchange

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives

N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Refine

Contributions to Journals

Patents

North East Analytical Research (NEAR) Symposium

Qualifications

External Memberships

Latest Publications

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Research Overview

Current Research

Past Research

Knowledge Exchange

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives

N′-(1,3-Benzo­thia­zol-2-yl) benzene­sulfono­hydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Refine

Contributions to Journals

Patents

N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry