Chair in Pharmaceutical Industrial Chemi
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+44 (0)1224 272926
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j.storey@abdn.ac.uk
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Meston Room G106
Professor of Pharmaceutical Industrial Chemistry
BSc, PhD (KC, London)
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Personal Details
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Research Interests
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
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Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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Teaching Responsibilities
Professor Storey teaches in the following courses:
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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External Responsibilities
Head Chemist for TauRx Therapeutics
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Publications
Contributions to Journals
Articles
- Grant, N., Storey, JMD. & Howe, RF. (2007). 'Semiconductor Oxide Photocatalysis for Organic Synthesis'. Studies in Surface Science and Catalysis, vol 172, pp. 445-448.
- Storey, JMD. & Ladwa, MM. (2006). 'Homolytic aromatic substitution: a radical approach towards the synthesis of 5-azaoxindoles'. Tetrahedron Letters, vol 47, pp. 381-383.
[Online] DOI: 10.1016/j.tetlet.2005.11.004 - Kirsop, P., Storey, JMD. & Harrison, WTA. (2006). '2-Bromo-1,3-bis(bromomethyl)-benzene, with Z ' = 1.5: whole-molecule disorder of one of the two independent molecules'. Acta Crystallographica Section C, Crystal Structure Communications, vol C62, no. 7, pp. o376-o378.
[Online] DOI: 10.1107/S0108270106017707 - Storey, JMD. & Williamson, C. (2005). 'Imidazole based solid-supported catalysts for the benzoin condensation'. Tetrahedron Letters, vol 46, pp. 7337-7339.
[Online] DOI: 10.1016/j.tetlet.2005.08.141 - Simpson, M., Storey, JMD. & Harrison, WTA. (2004). 'Diethyl 9,10-endo-ethano-9,10-dihydroanthracene-11,11-dicarboxylate'. Acta Crystallographica Section E, Structure Reports Online, vol E60, pp. o1081-o1083.
[Online] DOI: 10.1107/S1600536804012279 - Beckwith, ALJ., Bowry, VW., Bowman, WR., Mann, E., Parry, J. & Storey, JMD. (2004). 'The mechanism of Bu 3 SnH-mediated homolytic aromatic substitution'. Angewandte Chemie International Edition, vol 43, pp. 95-98.
[Online] DOI: 10.1002/anie.200352419 - Walji, DVB., Storey, JMD. & Harrison, WTA. (2004). '5-(Bis(cyclopropenecarbonyl)aminol-4,6-dichloro-pyrimidine containing a short cyclopropyl C-H...O interaction'. Acta Crystallographica Section E, Structure Reports Online, vol E60, pp. o1110-o1112.
[Online] DOI: 10.1107/S1600536804012577 - Kirsop, P., Storey, JMD. & Harrison, WTA. (2004). '1,3,5-Tribromo-2,6-dihydroxybenzene'. Acta Crystallographica Section E, Structure Reports Online, vol E60, pp. o222-o224.
[Online] DOI: 10.1107/S1600536804000571 - Kirsop, P., Storey, JMD. & Harrison, WTA. (2004). '1-Bromo-2,6-dihydroxybenzene containing R 4 4 (8) rings and C(2) helices'. Acta Crystallographica Section C, Crystal Structure Communications, vol C60, no. 5, pp. o353-o355.
[Online] DOI: 10.1107/S0108270104006882
Chapters in Books, Reports and Conference Proceedings
Chapters
- Wischik, CM., Wischik, DJ., Storey, JMD. & Harrington, CR. (2010). 'Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies'. in A Martinez (ed.), Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism vol. 1, RSC Drug Discovery Series, Cambridge, pp. 210-232.
[Online] DOI: 10.1039/9781849731065 - Wischik, CM., Rickard, JE., Harrington, CR., Horsley, D., Storey, JMD., Marshall, C. & Sinclair, JP. (2006). 'Case 11 Compounds and uses'. US-CIP US-CIP.
- Wischik, CM., Rickard, JE., Harrington, CR., Horsley, D., Storey, JMD., Marshall, C. & Sinclair, JP. (2006). 'Case 12 US Compounds and uses'. US compounds US compounds.
Patents
- Storey, JMD., Sinclair, JP., Marshall, C., Tan, HW. & Wischik, CM. (2006). 'Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)'. WO 2006/032879 Filed 23.09.04. Published 30 March 2006..
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