Lecturer
work
+44 (0)1224 272953
pref
h.deng@abdn.ac.uk
pref
Room 019, Meston Building, Meston Walk, Old Aberdeen AB24 3UE
Lecturer
|
|
Personal Details
|
||||||||||
Jump to:
Web Links
^ top
Biography
10/2008- Lecturer, University of Aberdeen, UK
06/2002-09/2008 Postdoctoral fellow, University of St Andrews, UK
1999-2002 Ph.D. University of Wales Swansea, UK
^ top
Research Interests
Our projects are generally on the organic chemistry/biochemistry interface. We are interested in isolating novel bioactives, tracing biosynthesis pathways and identifying novel enzyme activities in secondary metabolism. These interests inevitably take us towards designing novel substrates for enzymes (biotransformations) and inhibiting enzymes.
^ top
Current Research
1. New biosynthetic pathways of various bioactive natural products for potential lead compound discovery, such as the potential antibacterial natural product holomycin (Process Biochem., 2011) - (Mr Zhiwei Qin), the potential antitumour agent actinomycin G (- Mrs Xiaoling Wang), the potential anticancer and antileishmania agent acivicin (Mr Zhiwei Qin/Mrs Xiaoling wang) and the antibacterial natural product monamycin (Mr Zhiwei Qin). (with Professor Zixin Deng, Dr Yi Yu (China)). We gratefully thank Royal Society, Tenovus Scotland for financial support.
2. Understanding potential synergism of novel natural products from previously underexplored cyanobacterial strains for lead compound discovery (- Mr Zhiwei Qin) (with Professor Marcel Jaspars and Professor Frithjoff Kuepper). Carnegie Trust and EC FP7 Assemble Call are gratefully thanked.
3. New antibacterial natural product discovery of new bacterial strains from various natural sources (with Professor Marcel Jaspars, Dr Rainer Ebel, (J Nat Prod, 2011)). Royal Society and Leverhulm Trust are gratefully appreciated.
^ top
Research Grants
We gratefully thank the funding bodies below for financial supports of our research
^ top
Teaching Responsibilities
CM4518 Biological origin of natural products
CM1018 Fundamental chemistry
CM4027 Professional Skills
^ top
External Responsibilities
External referees for funding bodies such as BBSRC and FCT (Fundação para a Ciência e a Tecnologia in the field of Chemistry and Biochemistry, 2010-2011) and international peer reviewed journal such as ChemBioChem.
^ top
Recent invited lectures
Natural product symposium. Aberdeen. Dec. 03. 2008. "In vitro biosynthesis of 4-fluorothreonine"
Scottish Perkin Meeting. Aberdeen. Dec. 17. 2008. "Duf62 protein is a SAM hydroxide adenosyltransferase: A new SAM enzyme"
Zing Natural product conference, Antigua and Barbuda. March 1-4, 2009. "New halogenated natural products from the Atacama Desert, Chile"
^ top
Publications
Contributions to Journals
Articles
- Huang, S., Zhao, Y., Qin, Z., Wang, X., Onega, M., Chen, L., He, J., Yu, Y., Deng, H. & Hai Deng (2011). 'Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus'. Process Biochemistry, vol 46, no. 3, pp. 811-816.
[Online] DOI: doi:10.1016/j.procbio.2010.11.024 - Rateb, ME., Houssen, WE., Arnold, M., Abdelrahman, MH., Deng, H., Harrison, WTA., Okoro, CK., Asenjo, JA., Andrews, BA., Ferguson, G., Bull, AT., Goodfellow, M., Ebel, R. & Jaspars, M. (2011). 'Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp'. Journal of Natural Products, vol 74, no. 6, pp. 1491-1499.
[Online] DOI: 10.1021/np200320u - Onega, M., Domarkas, J., Deng, H., Schweiger, LF., Smith, TAD., Welch, A., Plisson, C., Gee, AD. & O'Hagan, D. (2010). 'An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging'. Chemical Communications, vol 46, no. 1, pp. 139-141.
[Online] DOI: 10.1039/B919364B - Deng, H., McMahon, S., Eustaquio, A., Moore, B., Naismith, J. & O'Hagan, D. (2009). 'Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf62)'. ChemBioChem, vol 10, pp. 2455.
[Online] DOI: DOI: 10.1002/cbic.200900369 - Deng, H., Cross, SM., McGlinchey, RP., Hamilton, JT. & O'Hagan, D. (2008). 'In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: Application of the fluorinase'. Chemistry & Biology, vol 15, no. 12, pp. 1268-1276.
[Online] DOI: 10.1016/j.chembiol.2008.10.012 - Deng, H., Botting, CH., Hamilton, JTG., Russell, RJM. & O'Hagan, D. (2008). 'S-Adenosyl-L-methionine:hydroxide adenosyltransferase: a SAM enzyme'. Angewandte Chemie International Edition, vol 47, no. 29, pp. 5357-5361.
[Online] DOI: 10.1002/anie.200800794 - Deng, H. & O’Hagan, D. (2008). 'The fluorinase, the chlorinase and the duf62 enzymes'. Current Opinion in Chemical Biology, vol 12, no. 5, pp. 582-592.
[Online] DOI: 10.1016/j.cbpa.2008.06.036
^ top
‹ back