Wiring and Firing Neuronal Networks: Endocannabinoids Take Centre Stage
Monday 3 November, 6.00pm Location
Auditorium, Polwarth Building, Foresterhill.
In the developing brain, an amazing variety of neurons are produced and organised into complex neuronal networks to control higher brain functions that make us distinctly human. Neuronal development is strictly regulated by signalling molecules that control the identification of neuronal subtypes
This lecture will highlight newly discovered principles of neuronal specification and wiring into networks by discussing fundamental roles of endocannabinoids in controlling the acquisition of neuronal identity during nervous system development. Endocannabinoids are endogenous compounds similar in function to delta-9-tetrahydropcannbinol found in cannabis. Recent findings about the roles of endocannabinoids as developmental signalling cues has advanced our understanding of the detrimental affects of maternal cannabis smoking on the developing brain of the unborn baby.
Professor Tibor Harkany is a developmental neurophysiologist who has gained international reputation with his work on identifying unique factors affecting the organisation and functions of the cerebral cortex. He has also identified novel means to feedback control synapic efficacy and plasticity in cortical neuronal network. His present work is focused on understanding cell biology principles of how maternal cannabis use affects the identity of neurons, and alters neural pathways such that there are permanent effects on the cognitive functions and emotional control of offspring.
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