Professor TIBOR HARKANY
SULSA Professor and Sixth Century Chair in Cell Biology, EMBO Young Investigator
Ph.D
Personal Details
| Telephone: | +44 (0)1224 555904 |
| Fax: | +44 1224 555915 |
| E-mail: | t.harkany@abdn.ac.uk |
| Address: | Institute of Medical Sciences School of Medical Sciences University of Aberdeen Foresterhill Ashgrove Road West AB25 2ZD, Aberdeen Scotland, United Kingdom |
Web Links
http://www.mbb.ki.se/molneuro/ (Division of Molecular Neurbiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute Stockholm, Sweden)
Current Research
Research topics:
i) Developmental functions of endocannabinoid signaling during corticogenesis,
ii) Context-dependent assembly of endocannabinoid signaling networks,
iii) Genetic and epigenetic factors controlling neuronal network formation,
iv) Developmental consequences of maternal cannabis smoking,
v) Endocannabinoid signaling in aging and Alzheimer's disease,
vi) Novel cannabinoid receptors,
The Harkany lab focuses on understanding the developmental organization and functions of the endocannabinoid system by using a combination of molecular genetics, neuroimaging, neuroanatomy and electrophysiology approaches. Besides focusing on physiological developmental programs controlled by endocannabinoid signaling during corticogenesis, substantial resources are dedicated to elucidating the neuronal basis of cannabis-induced developmental deficits in the central nervous system. Through our studies, we hope to identify organizing principles of endocannabinoid signaling in the developing brain with particular emphasis on the roles of endocannabinoids in establishing neuronal diversity and connectivity patterns.
Collaborations
Ken Mackie, Departments of Psychological & Brain Sciences, PY 363, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USA
Yasmin Hurd, Departments of Psychiatry and Pharmacology & Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place - Box 1215, New York, New York 10029-6574, USA
Yuri Zilberter, Institut de Neurobiologie de la Méditerranée (INMED), INSERM U29, Parc Scientifique de Luminy, 13273 MARSEILLE Cedex 09, France
Andrew J. Irving, Molecular Imaging Group, Centre For Neuroscience, Division of Medical Sciences, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY, United Kingdom
Research Grants
Alzheimer's Association; Alzheimer's Research Trust UK; EMBO Young Investigator Programme; Swedish Medical Research Council; European Union - 7th Framework; Scottish Universities Life Science Alliance; National Institutes of Health; Medical Research Council - Integrative Toxicolgy Training Programme.
External Responsibilities
Professor Harkany is actively involved in coordinating research projects at the Department of Medical Biochemistry and Biophysics of the Karolinska Institute, Stockholm, Sweden. He is editorial board member of Current Signal Transduction Therapy and The European Journal of Neuroscience; and ad-hoc reviewer for various neuroscience and cell biology jounrnals and granting agencies.
Current members of the Harkany laboratory
Dr. Jan Mulder - Alzheimer's Research Trust fellow (j.mulder@abdn.ac.uk)
Dr. Klaudia Barabas - SULSA postdoctoral research fellow (k.barabas@abdn.ac.uk)
Dr. Giuseppe Tortoriello - postdoctoral research fellow (g.tortoriello@abdn.ac.uk)
Dr. Misha Zilberter - postdoctoral research fellow (misha.zilberter@ki.se)
Drs. Erik Keimpema - graduate student (e.keimpema@abdn.ac.uk)
Drs. Adele Swanson - MRC-ITTP fellow/graduate student (a.swanson@abdn.ac.uk)
Drs. Ashley Dorning - SULSA graduate student (A.J.Dorning@dundee.ac.uk)
Ms. Lauren Spence - research technician (l.spence@abdn.ac.uk)
Ms. Orsolya K. Penz - research coordinator (o.penz@abdn.ac.uk)
Selected Publications
Original Papers:
Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 2009, 29:3453-3462.
Zilberter M, Holmgren C, Shemer I, Silberberg G, Grillner S, Harkany T*, Zilberter Y*. Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells. Cereb Cortex 2009, available online: February 4, 2009.
Fettisov SO, Bensing S, Mulder J, Le Maitre E, Hulting A-L, Harkany T, Ekwall O, Sköldberg F, Husebye E, Perheentupa J, Rorsman F, Kampe O, Hökfelt T. Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems. J Comp Neurol 2009, 513:1-20; cover image: 513(1): spc1.
Martens H, Weston MC, Boulland JL, Grřnborg M, Grosche J, Kacza J, Hoffmann A, Matteoli M, Takamori S, Harkany T, Chaudhry F, Rosenmund C, Erck C, Jahn R, Härtig W. Unique luminal localization of vesicular GABA transporter carboxy-terminus allows for selective labelling of active cortical GABAergic synapses. J Neurosci 2008, 28:13125-13131.
Jenstad M, Quazi AZ, Zilberter M, Haglerřd C, Berghuis P, Saddique N, Goiny M, Buntup D, Ottersen OP, Davanger S, Haug F-MS, Barnes CA, McNaughton BL, Storm-Mathisen J, Harkany T, Chaudhry FA. System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate. Cereb Cortex 2009, 19:1092-1106.
Grumelli C, Berghuis P, Pozzi D, Caleo M, Antonucci F, Bonanno G, Carmignoto G, Dobszay MB, Harkany T, Matteoli M, Verderio C. Calpain activity contributes to the control of SNAP-25 levels in neurons. Mol Cell Neurosci 2008, 39:314-323.
Mulder J, Augado T, Keimpema E, Barabas K, Ballaster Rosado CJ, Nguyen L, Monory K, Marsicano G, Di Marzo V, Hurd YL, Guillemot F, Mackie K, Lutz B, Guzman M, Lu H-C, Galve-Roperh I*, Harkany T*. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci USA 2008, 105:8760-8765.
Martin MG, Perga S, Trovň L, Rasola A, Holm P, Rantamäki T, Harkany T, Castrén E, Chiara F, Dotti CG. Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol Biol Cell 2008, 19:2101-2112.
Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Monory K, Marsicano G, Matteoli M, Canty A, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T. Hardwiring the brain: Endocannabinoids shape neuronal connectivity, Science 2007, 316:1212-1216.
Berghuis P, Agerman K, Dobszay MB, Minichiello L, Harkany T, Ernfors P. Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCγ pathway. J Neurobiol 2006, 66:1437-1451.
Shemer I, Holmgren C, Min R, Fülöp L, Zilberter M, Sousa KM, Farkas T, Härtig W, Burnashev N, Tanila H, Zilberter Y, Harkany T. Non-fibrillar β-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting AMPA receptors. Eur J Neurosci 2006, 23:2035-2047.
Martin-Ibanez R, Jenstad M, Berghuis P, Edwards RH, Hioki H, Kaneko T, Mulder J, Canals JM, Ernfors P, Chaudhry F, Harkany T. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci 2006, 23:1063-1070.
Siegemund T, Paulke B-R, Schmiedel H, Bordag N, Hoffmann A, Harkany T, Tanila H, Kacza J, Härtig W. Thioflavins released from nanoparticles target fibrillar amyloid β in the hippocampus of APP/PS1 transgenic mice. Int J Devl Neurosci 2006, 4:195-201.
Berghuis P, Dobszay MB, Wang X, Spano S, Ledda F, Sousa KM, Schulte G, Ernfors P, Mackie K, Paratcha G, Hurd YL, Harkany T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci USA, 2005, 102:19115-19120.
Harkany T, Dobszay MB, Cayetanot F, Härtig W, Aujard F, Mackie K. Redistribution of CB1 cannabinoid receptors during evolution of cholinergic basal forebrain territories and their cortical projection areas: A comparison between the grey mouse lemur (Microcebus murnius) and rat. Neuroscience 2005, 135:595-609,.
Mulder J, Harkany T, Czollner K, Cremers TIFH, Keijser JN, Nyakas C, Luiten PGM. Galantamine-induced behavioral recovery after sublethal excitotoxic lesions to cholinergic neurons of the rat medial septum. Behav Brain Res 2005, 166:33-41.
Berghuis P, Dobszay MB, Sousa KM, Schulte G, Mager PP, Härtig W, Görcs TJ, Zilberter Y, Ernfors P, Harkany T. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons. Eur J Neurosci, 2004; 20:1290-1306.
Horvath KM, Harkany T, Mulder J, Koolhaas JM, Luiten PGM, Meerlo P. Neonatal handling increases sensitivity to acute neurodegeneration in adult rats. J Neurobiol 2004; 60:463-472.
Harkany T, Holmgren CD, Härtig W, Qureshi T, Chaudhry FA, Storm-Mathisen J, Sousa KM, Schulte G, Berghuis P, Dobszay MB, Fremeau RT JR, Edwards RH, Mackie K, Ernfors P, Zilberter Y. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: Involvement of vesicular glutamate transporter 3. J Neurosci 2004; 24:4978-4988.
Harkany T, Andäng M, Kingma HJ, Görcs TJ, Holmgren CD, Zilberter Y, Ernfors P. Regions-specific generation of functional neurons from naive embryonic stem cells in adult brain. J Neurochem 2004, 88:1229-1239.
Harkany T, Härtig W, Berghuis P, Dobszay MB, Zilberter Y, Edwards RH, Mackie K, Ernfors P. Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signaling by cholinergic neurons. Eur J Neurosci 2003; 18:1979-1992.
Hortobágyi T, Görlach C, Benyó Z, Lacza Z, Hortobágyi S, Wahl M, Harkany T. Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by aminobenzamide. Neuroscience 2003; 121:983-990.
Härtig W, Riedel A, Grosche J, Edwards RH, Fremeau RT Jr., Harkany T, Brauer K, Arendt T. Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons. J Comp Neurol 2003; 465:1-10.
Hortobágyi T, Szüts Á, Csenki M, Harkany T, Zádor Z, Katona M, Bódi I. Combination of vein of Galen malformation and atrial septal defect in a neonate. Clin Neuropathol 2003; 22:193-198.
Holmgren C, Harkany T, Svennenfors B, Zilberter Y. Pyramidal cell communication within local networks in later 2/3 of rat neocortex. J Physiol 2003; 551:139-153.
Arendt T, Stieler J, Strijkstra AM, Hut RA, Rüdiger J, Van Der Zee EA, Harkany T, Holzer M, Härtig W. Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. J Neurosci 2003; 23:6972-6981.
Varga C, Härtig W, Grosche J, Luiten PGM, Seeger J, Brauer K, Harkany T. The rabbit forebrain cholinergic system: morphological characterization of nuclei and distribution of cholinergic terminals in the cerebral cortex and hippocampus. J Comp Neurol 2003; 460:597-611.
Lucas G, Hendolin P, Harkany T, Agerman K, Paratcha G, Holmgren C, Zilberter Y, Sairanen M, Minichiello L, Castren E, Ernfors P. Reinforcement of morphine-induced analgesia by neurotrophin-4 mediated TrkB activation, Nat Neurosci 2003; 6:221-222.
Härtig W, Paulke B-R, Varga C, Seeger J, Harkany T, Kacza J. Electron microscopic analysis of nanoparticles delivering thioflavin-T in vivo: Implications for targeting β-amyloid in Alzheimer's disease. Neurosci Lett 2003, 338:174-176.
Oosterink BJ, Harkany T, Luiten PGM. Post-lesion administration of 5-HT1A receptor agonist 8-OH-DPAT protects cholinergic nucleus basalis neurons against NMDA excitotoxicity. NeuroReport 2003; 14:57-60.
Mager PP, Penke B, Walter R, Harkany T, Härtig W. Pathological peptide folding in Alzheimer's disease and other conformational disorders. Curr Med Chem 2002; 9:1763-1780.
Härtig W, Varga C, Kacza J, Grosche J, Seeger J, Luiten PGM, Brauer K, Harkany T. In vivo labeling of rabbit cholinergic basal forebrain neurons with fluorochromated antibodies. NeuroReport 2002; 13:1395-1398.
Harkany T, Garzuly F, Nyakas C, Luiten PGM, Linke RP, Virágh S. Cutaneous lymphatic amyloid deposits in Hungarian-type familial transthyretin amyloidosis: A case report. Brit J Dermatol 2002; 146:674-679.
Harkany T, Varga C, Grosche J, Mulder J, Luiten PGM, Hortobágyi T, Penke B, Härtig W. Distinct subsets of nucleus basalis neurons exhibit similar sensitivity to excitotoxicity. NeuroReport 2002; 13:767-772.
Horvath KM, Härtig W, Van der Veen R, Keijser J, Mulder J, Ziegert M, Van der Zee EA, Harkany T, Luiten PGM. 17β-Estradiol enhances cortical cholinergic innervation and preserves synaptic density following excitotoxic lesions to the rat nucleus basalis magnocellularis. Neuroscience 2002; 110:489-504.
Harkany T, Grosche J, Mulder J, Horvath KM, Keijser J, Hortobágyi T, Luiten PGM, Härtig W. Short-term consequences of N-methyl-D-aspartate excitotoxicity in rat magnocellular nucleus basalis: effects on in vivo labelling of cholinergic neurons. Neuroscience 2001; 108:611-627.
Gies U, Görcs TJ, Mulder J, Planz O, Stitz L, Bilzer T, Luiten PGM, Harkany T. Cortical cholinergic decline parallels the progression of Borna virus encephalitis. NeuroReport 2001; 13:3767-3772.
Harkany T, Mulder J, Horvath KM, Meeberg E, Nyakas C, Luiten PGM. Oral post-lesion administration of 5-HT1A agonist Repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis. Neuroscience 2001; 108:629-642.
Harkany T, O'Mahony S, Kelly JP, Kónya C, Keijser J, Borostyánköi ZA, Görcs T, Zarándi M, Penke B, Leonard BE, Luiten PGM. β-Amyloid(1-42)-induced cholinergic lesions in the rat nucleus basalis bi-directionally modulate serotonergic innervation of basal forebrain and cerebral cortex. Neurobiol Dis 2001; 8:667-678.
Hortobágyi T, Hortobágyi S, Görlach C, Harkany T, Benyó Z, Görögh T, Nagel W, Wahl M. A novel brain trauma model in the mouse: effects of dexamethasone treatment. Pflüg Arch – Eur J Physiol 2000; 441:409-415.
Harkany T, Dijkstra IM, Horvath KM, Ábrahám I, Keijser J, Van der Zee EA, Luiten PGM. Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca2+ antagonist nimodipine. Neuroscience 2000; 101:101-114.
Horvath KM, Ábrahám I, Harkany T, Meerlo P, Bohus BGJ, Nyakas C, Luiten PGM. Postnatal treatment with ACTH4-9 analog ORG2766 attenuates NMDA-induced excitotoxicity in rat nucleus basalis in adulthood. Eur J Pharmacol 2000; 405:33-42.
Harkany T, Ábrahám I, Timmerman W, Laskay G, Tóth B, Sasvári M, Kónya C, Sebens JB, Korf J, Nyakas C, Zarándi M, Soós K, Penke B, Luiten PGM. β-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur J Neurosci 2000; 12:2735-2745.
Ábrahám I, Harkany T, Horvath KM, Veenema A, Penke B, Nyakas C, Luiten PGM. Chronic corticosterone administration dose-dependently modulates Aβ(1-42) and NMDA-induced neurodegeneration in rat magnocellular nucleus basalis. J Neuroendocrinol 2000; 12:486-495.
Harkany T, Ábrahám I, Laskay G, Timmerman W, Jost K, Zarándi M, Penke B, Nyakas C, Luiten PGM. Pr-IIGL tetrapeptide antagonizes β-amyloid excitotoxicity in rat nucleus basalis. NeuroReport 1999; 10:1693-1698.
Harkany T, Mulder J, Sasvári M, Ábrahám I, Kónya C, Zarándi M, Penke B, Luiten PGM, Nyakas C. NMDA receptor blockade by MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against β-amyloid neurotoxicity. Neurobiol Dis 1999; 6:109-121.
Hortobágyi T, Harkany T, Reisch R, Urbanics R, Kálmán M, Nyakas C, Nagy Z. Neurotrophin-mediated neuroprotection by fetal telencephalic grafts following focal cerebral ischemia in the rat: a preventive approach. Brain Res Bull 1998; 47:185-191.
Harkany T, O'Mahony S, Kelly JP, Soós K, Törö I, Penke B, Luiten PGM, Nyakas C, Gulya K, Leonard BE. β-Amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation. Behav Brain Res 1998; 90:133-145.
O'Mahony S, Harkany T, Rensink AAM, Ábrahám I, De Jong GI, Varga JL, Zarándi M, Penke B, Nyakas C, Luiten PGM, Leonard BE. β-Amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade. Brain Res Bull 1998; 45:405-411.
Ábrahám I, Veenema AH, Nyakas C, Harkany T, Bohus BGJ, Luiten PGM. Effect of corticosterone and adrenalectomy on NMDA-induced cholinergic cell death in rat magnocellular nucleus basalis. J Neuroendocrinol 1997; 9:713-720.
Harkany T, Sasvari M, Nyakas C. Chronic ethanol ingestion-induced changes in open-field behavior and oxidative stress in the rat. Pharmacol Biochem Behav 1997; 58:195-201.
Harkany T, Lengyel Z, Kása P, Gulya K. Chronic aluminum treatment results in aluminum deposits and affects M1 muscarinic receptors in rat brain. Neurobiology 1996; 4:35-43.
Harkany T, De Jong GI, Soós K, Penke B, Luiten PGM, Gulya K. β-Amyloid(1-42) affects cholinergic but not parvalbumin-containing neurons in the rat medial septum. Brain Res 1995; 698:270-274.
Harkany T, Lengyel Z, Soós K, Penke B, Luiten PGM, Gulya K. Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis. Brain Res 1995; 695:71-75.
Reviews:
Harkany T, Mackie K, Doherty P. Wiring and firing neuronal networks: endocannabinoids take center stage. Curr Opin Neurobiol 2008, 18:338-345.
Matteoli M, Pozzi D, Grumelli C, Condliffe S, Frassoni C, Harkany T, Verderio C. The synaptic split of SNAP-25: Different roles in glutamatergic and GABAergic neurons? Neuroscience 2008, 158:223-230.
Harkany T, Keimpema E, Barabas K, Mulder J. Endocannabinoid functions controlling neuronal specification during brain development. Mol Cell Endocrinol 2008, 286 S1:S84-S90.
Harkany T, Guzman M, Galve-Roperh I, Berghuis P, Devi LA, Mackie K. The emerging functions of endocannabinoid signaling during central nervous system development. Trends Pharmacol Sci 2007, 28:83-92.
Zilberter Y, Harkany T, Holmgren CD. Dendritic release of retrograde messengers controls synaptic transmission in local neocortical networks. Neuroscientist 2005; 11:334-344.
Berghuis P, Dobszay MB, Martin-Ibanez R, Ernfors P, Harkany T. Turning the heterogeneous into homogeneous: studies with isolated GABAergic interneuron subsets. Int J Devl Neurosci, 2004; 22:533-543.
Härtig W, Bauer A, Brauer K, Grosche J, Hortobágyi T, Penke B, Schliebs R, Harkany T. Functional recovery of cholinergic basal forebrain neurons under disease conditions: old problems, new solutions? Rev Neurosci 2002; 13:95-165.
Ábrahám IM, Harkany T, Horvath KM, Luiten PGM. Action of glucocorticoids on survival of nerve cells: promoting neurodegeneration or neuroprotection? J Neuroendocrinol 2001; 13:749-761.
Harkany T, Ábrahám I, Kónya C, Nyakas C, Zarándi M, Penke B, Luiten PGM. Mechanisms of β-amyloid neurotoxicity: perspectives of pharmacotherapy. Rev Neurosci 2000; 11:329-382.
Harkany T, Penke B, Luiten PGM. β-Amyloid excitotoxicity in rat magnocellular nucleus basalis - effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease. Ann NY Acad Sci 2000; 903:374-386.
Harkany T, Hortobágyi T, Sasvári M, Kónya C, Penke B, Luiten PGM, Nyakas C. Neuroprotective approaches in experimental models of β-amyloid neurotoxicity: relevance to Alzheimer's disease. Prog Neuro-Psychopharmacol & Biol Psychiat 1999; 23:963-1008.
Harkany T, Luiten PGM. Experimental models of memory dysfunction. Clin Neurosci 1999; 52:223-224
Book Chapters:
Irving AJ, McDonald N, Harkany T. CB1 cannabinoid receptors: molecular biology, second messenger coupling and polarized trafficking in neurons. In: Cannabinoids and the Brain (ed. A. Köfalvi) Boston MA: Springer: 2007, pp. 59-73.
Harkany T, Guzmán M, Hurd YL. Endocannabinoid functions in neurogenesis, neuronal migration and specification. In: Cannabinoids and the Brain (ed. A. Köfalvi) Boston, MA: Springer: 2007, pp. 237-256.
Berghuis P, Mackie K, Harkany T. Figs. 66 and 72. In: Pansajes Neuronales. Homenaje a Santiago Ramon y Cajal. (eds. J. DeFelipe, H. Markram, J Wagensberg) Consejo Superior de Investigaciones Cientificas, Madrid, 2007.
Zilberter Y, Harkany T. Classical neurotransmitters as retrograde messengers in layer 2/3 of the neocortex: emphasis on glutamate and GABA. In: Dendritic Transmitter Release (ed. M. Ludwig) Springer: Newark 2005; pp. 117-131.
Penke B, Harkany T. Physiological role of amyloid precursor protein (APP) and β-amyloid peptides. In: Molecular Pathomechanisms and New Trends in Drug Research (eds. Keri, G and Toth, I) Taylor and Francis: London 2002; pp. 387-401.
Gulya K, Szikra J, Lengyel Z, Harkány T, Kása P. Interaction between the endogenous opioid system and the aluminium content in rat striatum. Rec Adv Aging Sci (eds. Beregi E, Gergely IA, Rajczi K) Monduzzi: Bologna 1993; pp. 631-635.