Dr STUART GRAY


Dr STUART GRAY The University of Aberdeen School of Medical Sciences Dr STUART GRAY Senior Lecturer work +44 (0)1224 438026 pref Room 106 Health Science Building Institute of Medical Sciences School of Medical Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD

Senior Lecturer

BSc PhD

Dr STUART GRAY

Personal Details

Telephone: +44 (0)1224 438026
Email:

s.r.gray@abdn.ac.uk

Address: Room 106 Health Science Building
Institute of Medical Sciences
School of Medical Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD
hCard

Jump to:

Musculoskeletal Programme: http://www.abdn.ac.uk/ims/research/musculoskeletal-175.php 


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Biography

Stuart graduated in Physiology and Sports Science from the University of Glasgow before undertaking a PhD entitled "Temperature and in vivo human skeletal muscle function and metabolism" at the University of Strathclyde(2007). During his doctoral studies Stuart was awarded the Pfizer Prize from the Physiological Society in 2005. Stuart remained at the University of Strathclyde as a Post-Doctoral Research Fellow before moving to Loughborough University to take up a Senior Research-Associate position. Stuart joined the institute of medical sciences in November 2008 as a Lecturer in Exercise Physiology.


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Research Interests

 

Stuart has two main areas of interest.

With age there is a natural loss of muscle mass that is termed sarcopenia and this can have major effects on physical function and quality of life in the elderly. The precise cause of the loss of muscle mass is not yet known, but we do know that elderly muscles exhibit an anabolic resistance to exercise and food intake. We are currently investigating whether an increase in n3 PUFA consumption, particularly fish oils, can augment the adaptive response to resistance exercise in the elderly. Preliminary results have shown that fish oils can retard the loss of muscle mass with age in a rat model and that this effect is potentially mediated through an increase activity of p70s6k, a key regulator of protein synthesis.

We are also interested in determining the effects of high intensity exercise on post prandial lipaemia and activation of the immune system. Upon the consumption of a high fat meal triglycerides enter the blood stream and can trigger a series of inflammatory reactions that ultimately results in endothelial dysfunction, a precursor for the development of atherosclerosis. It is known that exercise can reduce the magnitude of this response but the optimal and most time efficient form of exercise has yet to be determined. We are also interested in extending this research to patient populations where post prandial lipaemia is a contributing factor to disease progression.


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Collaborations

Dr Henning Wackerhage

Dr Aivaras Ratkevicius

Dr Arimantas Lionikas 

Dr Frank Thies

Professor Michael Frenneaux

 


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Research Grants

2010-11 NHS Grampian Endowments. Gray SR and Frenneaux M. The effect of short duration high intensity interval exercise on post-prandial lipaemia and adhesion molecules. £4,025

2010-11 Tenovus Scotland. Gray SR and Thies F. The effect of fish oil supplementation on immune function and inflammatory responses to execise. £7,575

2010-2013 Saltire Energy Studentship. Gray SR and Ratkevicius A. High intensity exercise and metabolic regulation. £85,896

2012-13 NHS Grampian Endowments. Ratkevicius A and Gray SR. Citrate synthase as a target in the treatment of lipotoxicity in skeletal muscle cells. £8,000

2012-2015 BBSRC New Investigator. Gray SR. Overcoming the blunted response to resistance exercise with fish oil to maximise the maintenance of muscle mass in older people. £330,684


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Teaching Responsibilities

I currently teach on the following courses.

SR1002

SR1502

SR2501 (Course Co-ordinator)

SR2002

SM3003

SR3506

BM3501

PY3002 (Course Co-ordinator)

SR4301

BM4006

SR4004/5 (Course Co-ordinator)


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External Responsibilities

Ad Hoc reviewer for the Cytokine, Endocrine, Acta Physiologica, Journal of Sports Sciences, International Journal of Sports Nutrition and Exercise Metabolism, Preventive Medicine, Applied Physiology Nutrtion and Metabolism, Scandinavian Journal of Medicine and Science in Sports, PLoS ONE, AGE, Obesity, British Journal of Pharmacology, Metabolism, Molecular Nutrition and Food Research, Lipids, BMC Research Notes, Clinical Science and the European Journal of Applied Physiology.

Reviewer for grant applications submitted to BBSRC, BHF and BUPA.

Outreach activities

I have recently acted as a mentor for secondary school pupils taking part in the "Science of Sport: How to Win Gold" competition organised by the Physiological Society. I also recently participated in i'm a scientist get me out of here, where we had online chats with primary school kids who then decided whether we our responses merit their votes. I did not win!


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Admin Responsibilities

Member of the college of life sciences and medicine ethics review board (CERB).

Health and Safety Adviser for HSB labs and RPS for IMS level 2.


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Current Lab

Dr Mariasole Da Boit - Research Fellow working on the BBSRC funded project entitled "the blunted response to resistance exercise with fish oil to maximise the maintenance of muscle mass in older people".

Torkamol Kamolrat - PhD student funded by the Royal Thai government. Torkamol's thesis is investigating the role of EPA/DHA on skeletal muscle anabolic signalling.

Brendan Gabriel - PhD student funded by the Saltire Energy Studentship. Brendan's project is investigating the effect of high intensity exercise on fat metabolism and CV health.

Patrick Gray - Technician/MSc Student. Patrick's thesis is investigating the effect of n3 PUFAs on post exercise immune function.

Nor Aini Jamil - PhD student investigating the role of Vitamin D in bone and muscle health in South East Asian populations living in Aberdeen.


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Publications 

 

Contributions to Journals

Articles

  • Allen, E., Gray, P., Kollias-Pearson, A., Oag, E., Pratt, K., Henderson, J. & Gray, SR. (in press). 'The effect of short-duration sprint interval exercise on plasma postprandial triacylglycerol levels in young men'. Journal of Sports Sciences., http://dx.doi.org/10.1080/02640414.2013.865254
    [Online] DOI: 10.1080/02640414.2013.865254
  • Kamolrat, T., Gray, SR. & Carole Thivierge, M. (2013). 'Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle'. European Journal of Nutrition, vol 52, no. 2, pp. 647-657., http://dx.doi.org/10.1007/s00394-012-0368-7
    [Online] DOI: 10.1007/s00394-012-0368-7
  • Kamolrat, T. & Gray, SR. (2013). 'The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes'. Biochemical and Biophysical Research Communications, vol 432, no. 4, pp. 593-598., http://dx.doi.org/10.1016/j.bbrc.2013.02.041
    [Online] DOI: 10.1016/j.bbrc.2013.02.041
  • Judson, RN., Gray, SR., Walker, C., Carroll, AM., Itzstein, C., Lionikas, A., Zammit, PS., De Bari, C. & Wackerhage, H. (2013). 'Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy'. PloS one, vol 8, no. 3, e59622., http://dx.doi.org/10.1371/journal.pone.0059622
    [Online] DOI: 10.1371/journal.pone.0059622
  • Gray, S. & Da Boit, M. (2013). 'Marine n-3 polyunsaturated fatty acids: a potential role in the treatment of sarcopenia'. Clinical Lipidology, vol 8, no. 2, pp. 187-194., http://dx.doi.org/10.2217/clp.13.10
    [Online] DOI: 10.2217/clp.13.10
  • Gray, SR. & Da Boit, M. (2013). 'Fish oils and their potential in the treatment of sarcopenia'. Journal of Frailty and Aging, vol 2, no. 4, pp. 211-216.
  • McMinn, D., Acharya, R., Rowe, DA., Gray, SR. & Allan, JL. (2013). 'Measuring Activity Energy Expenditure: Accuracy of the GT3X+ and Actiheart Monitors'. International Journal of Exercise Science, vol 6, no. 3, 5, pp. 217-229.
    [Online] AURA: McMinn_2013_GT3X_and_Actiheart_validity.pdf
    [Link] http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=1500&context=ijes
  • Gray, P., Chappell, AJ., Jenkinson, AM., Thies, F. & Gray, SR. (in press). 'Fish Oil Supplementation Reduces Markers of Oxidative Stress But Not Muscle Soreness After Eccentric Exercise'. International Journal of Sport Nutrition & Exercise Metabolism.
    [Link] http://journals.humankinetics.com/ijsnem-in-press/ijsnem-in-press/fish-oil-supplementation-reduces-markers-of-oxidative-stress-but-not-muscle-soreness-after-eccentric-exercise
  • Gabriel, BM., Pugh, J., Pruneta-Deloche, V., Moulin, P., Ratkevicius, A. & Gray, SR. (2013). 'The effect of high intensity interval exercise on postprandial triacylglycerol and leukocyte activation - monitored for 48h post exercise'. PloS one, vol 8, no. 12, pp. e82669., http://dx.doi.org/10.1371/journal.pone.0082669
    [Online] DOI: 10.1371/journal.pone.0082669
    [Online] AURA: 2013Gabrieletal_PLOSOne_.pdf
  • Fitzsimons, CF., Baker, G., Gray, SR., Nimmo, MA. & Mutrie, N. (2012). 'Does physical activity counselling enhance the effects of a pedometer-based intervention over the long-term: 12-month findings from the Walking for Wellbeing in the West study'. BMC Public Health, vol 12, no. 1, pp. 206., http://dx.doi.org/10.1186/1471-2458-12-206
    [Online] DOI: 10.1186/1471-2458-12-206
    [Online] AURA: 2012Fitzsimons_BMCPublicHealth_.pdf
  • Gabriel, B., Ratkevicius, A., Gray, P., Frenneaux, M. & Gray, SR. (2012). 'High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress'. Clinical Science, vol 123, no. 5, pp. 313-321., http://dx.doi.org/10.1042/CS20110600
    [Online] DOI: 10.1042/CS20110600
  • Gray, P., Gabriel, B., Thies, F. & Gray, SR. (2012). 'Fish oil supplementation augments post-exercise immune function in young males'. Brain, Behavior, and Immunity, vol 26, no. 8, pp. 1265-1272., http://dx.doi.org/10.1016/j.bbi.2012.08.002
    [Online] DOI: 10.1016/j.bbi.2012.08.002
    [Online] AURA: GrayetalBBI.docx
  • Gray, SR. & Kamolrat, T. (2011). 'The effect of exercise induced cytokines on insulin stimulated glucose transport in C2C12 cells'. Cytokine, vol 55, no. 2, pp. 221-228., http://dx.doi.org/10.1016/j.cyto.2011.04.019
    [Online] DOI: 10.1016/j.cyto.2011.04.019
    [Online] AURA: Cytokine_Revision_.docx
  • Gray, SR., Soderlund, K., Watson, M. & Ferguson, RA. (2011). 'Skeletal muscle ATP turnover and single fibre ATP and PCr content during intense exercise at different muscle temperatures in humans'. Pflugers Archiv : European Journal of Physiology, vol 462, no. 6, pp. 885-893., http://dx.doi.org/10.1007/s00424-011-1032-4
    [Online] DOI: 10.1007/s00424-011-1032-4
    [Online] AURA: PflugersFINALDRAFT_revision2_.docx
  • Robinson, M., Gray, SR., Watson, MS., Kennedy, G., Hill, A., Belch, JJF. & Nimmo, MA. (2010). 'Plasma IL-6, its soluble receptors and F-isoprostanes at rest and during exercise in chronic fatigue syndrome'. Scandinavian Journal of Medicine & Science in Sports, vol 20, no. 2, pp. 282-290., http://dx.doi.org/10.1111/j.1600-0838.2009.00895.x
    [Online] DOI: 10.1111/j.1600-0838.2009.00895.x
  • Ratkevicius, A., Carroll, AM., Kilikevicius, A., Venckunas, T., McDermott, KT., Gray, SR., Wackerhage, H. & Lionikas, A. (2010). 'H55N polymorphism as a likely cause of variation in citrate synthase activity of mouse skeletal muscle'. Physiological Genomics, vol 42A, no. 2, pp. 96-102., http://dx.doi.org/10.1152/physiolgenomics.00066.2010
    [Online] DOI: 10.1152/physiolgenomics.00066.2010
  • Gray, SR., Clifford, M., Lancaster, R., Leggate, M., Davies, M. & Nimmo, MA. (2009). 'The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men'. Cytokine, vol 47, no. 2, pp. 98-102., http://dx.doi.org/10.1016/j.cyto.2009.05.011
    [Online] DOI: 10.1016/j.cyto.2009.05.011
  • Gray, SR., Ratkevicius, A., Wackerhage, H., Coats, P. & Nimmo, MA. (2009). 'The effect of interleukin-6 and the interleukin-6 receptor on glucose transport in mouse skeletal muscle'. Experimental Physiology, vol 94, no. 8, pp. 899-905., http://dx.doi.org/10.1113/expphysiol.2009.048173
    [Online] DOI: 10.1113/expphysiol.2009.048173
  • Gray, SR., Baker, G., Wright, A., Fitzsimons, CF., Mutrie, N., Nimmo, MA. & Scottish Physical Activity Research Collaboration (2009). 'The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation'. Preventive Medicine, vol 48, no. 1, pp. 39-44., http://dx.doi.org/10.1016/j.ypmed.2008.10.013
    [Online] DOI: 10.1016/j.ypmed.2008.10.013
  • Baker, G., Gray, SR., Wright, A., Fitzsimons, C., Nimmo, M., Lowry, R., Mutrie, N. & Scottish Physical Activity Research Collaboration (SPARColl) (2008). 'The effect of a pedometer-based community walking intervention "Walking for Wellbeing in the West" on physical activity levels and health outcomes: a 12-week randomized controlled trial'. The International Journal of Behavioral Nutrition and Physical Activity, vol 5, no. 1, pp. 44., http://dx.doi.org/10.1186/1479-5868-5-44
    [Online] DOI: 10.1186/1479-5868-5-44
  • Gray, SR., Söderlund, K. & Ferguson, RA. (2008). 'ATP and phosphocreatine utilization in single human muscle fibres during the development of maximal power output at elevated muscle temperatures'. Journal of Sports Sciences, vol 26, no. 7, pp. 701-707., http://dx.doi.org/10.1080/02640410701744438
    [Online] DOI: 10.1080/02640410701744438
  • Gray, SR., Robinson, M. & Nimmo, MA. (2008). 'Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men'. Cell Stress & Chaperones, vol 13, no. 2, pp. 247-251., http://dx.doi.org/10.1007/s12192-008-0019-3
    [Online] DOI: 10.1007/s12192-008-0019-3
  • Patterson, S., Reid, S., Gray, SR. & Nimmo, M. (2008). 'The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans'. Journal of Sports Sciences, vol 26, no. 9, pp. 927-933., http://dx.doi.org/10.1080/02640410801885941
    [Online] DOI: 10.1080/02640410801885941
  • Gray, SR., De Vito, G., Nimmo, MA., Farina, D. & Ferguson, RA. (2005). 'Skeletal muscle ATP turnover and muscle fiber conduction velocity are elevated at higher muscle temperatures during maximal power output development in humans'. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol 290, no. 2, pp. R376-382., http://dx.doi.org/10.1152/ajpregu.00291.2005
    [Online] DOI: 10.1152/ajpregu.00291.2005

Other Contributions

  • Jenkinson, AM., Gray, SR. & Mavroeidi, A. (2012). 'Nutrition for Sport and Performance: Summary review of the literature. Food and Health Innovation Service'.

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