Sir Henry Dale fellow. University of Aberdeen (2014-present)
Postdoctoral researcher. Hans Knoell Institute, Jena, Germany (2007-2014).
Doctor of Philosophy. University of Manchester (2003-2006). The role of phosphodiesterases in Candida albicans physiology
Bachelor of Science with Honours in Microbiology. University of Glasgow (1999-2003).
I am interested in how pathogenic fungi compete with their hosts for essential micronutrients. Certain trace minerals, such as iron and zinc, are actively withheld from pathogens in a process called nutritional immunity. Therefore, pathogenic microbes must have evolved specialised uptake systems in order to proliferate in their hosts and cause disease. I am using a combination of molecular and cellular biology, together with models of host-pathogen interactions, to dissect the mechanisms of micronutrient assimilation by the major human fungal pathogen, Candida albicans. I am particularly interested in the molecular mechanisms of zinc scavenging by this fungus during interactions with host cells.
Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society.
Overcoming nutritional immunity: micronutrient acquisition mechanisms of pathogenic fungi.
May 2014 - April 2019.
Dhara Malavia, Aaron Crawford, Duncan Wilson, Omran Alamir & Laura Lehtovirta.
Aaron Crawford, PhD student. Project: The role of endosomal zinc trafficking in fungal adaptation to nutritional immunity.
Dhara Malavia, PhD student. Project: A giant impact: the role of Candida albicans Goliath cells on host-pathogen interactions.
Omran Alamir, PhD student. Project: Candida albicans vacuolar zinc flux.
Bader Alawfi, MSc student. Project: Environmental regulation of zinc transporters in Candida albicans.
Herbert Itabngi, MRes student. Project: Zinc uptake and homeostasis in Candida albicans.
Anna da Cost, Visiting scientist. Project: Candida albicans unique genes in biofilm formation and antifungal drug resistance.