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Dr Samuel Martin

Senior Lecturer, Fish Physiology

Personal Details

Telephone:

+44 (0)1224 272867

E-mail:

sam.martin@abdn.ac.uk

Personal website:


Jump to:

Web Links

Salmon TRAITS Microarray http://www.abdn.ac.uk/sfirc/salmon/

LIFECYCLES EU project http://www.lifecycle.gu.se/

Fish Proteomics http://www.abdn.ac.uk/fishprom/

River Don Trust http://www.riverdon.org.uk/welcome.asp

Journal of Aquaculture Research and Development http://www.omicsonline.org/jardhome.php

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Biography

2012-Reader, Institute of Biological and Environmental Sciences (IBES), University of Aberdeen

2010-2012 Senior lecturer, IBES, University of Aberdeen

2007-2010 Lecturer IBES, University of Aberdeen

1999- 2007 Research Fellow, School of Biological Sciences, University of Aberdeen

1996-1999 Senior Research Officer, National Diagnostics Centre, NUI, Galway, Ireland

1993-1996 Postdoctoral RA, Department of Veterinary Parasitology, University of Glasgow

PhD Queens University Belfast 1993

BSc (Hons) Queens University Belfast 1989

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Research Interests

1. Genomics in Aquaculture
2. Atlantic salmon transcriptomics
3. Proteomics in salmonid fish
4. Immune Responses in salmon
5. Protein degradation by the ubiquitin proteasome pathway

My main research interests are related to two key physiological processes in salmonid fish, namely the control of protein deposition and immune responses. A major research gap is the relation between metabolism and immune competence in fish and the related expression of genes.

Protein metabolism:

The rate of protein deposition during growth is a balance between protein synthesis and degradation. These two processes are under tight control and evidence suggests that in fish the control of degradation may be key to efficient protein growth. There are two main cellular pathways that can degrade cellular proteins, the energy dependant ubiquitin proteasome pathway and the lysosomal degradation of proteins. Both theses processes are tightly regulated and their regulation in fish may be very different to what is known about mammals, as ecto and endothermic animals have different strategies for controlling protein mobilization. To address these questions I have used a combination of biochemical, microarray and proteomics approaches.

Immune responses:

The coordinated response of a fish to either a pathogen or vaccine requires the correct identification of the foreign material. Signalling pathways result in gene expression changes and the fish can then mount the desired response to eliminate the disease or have protection by the vaccination. We have developed a 17,000 gene microarray (see link to salmon TRAITS) from which we have identified gene expression profile changes for both bacterial infection and specific response to recombinant fish cytokines.  More recently we have moved to use custom designed Agilent 4 x 44K Atlantic salmon and rainbow trout microarray slides.

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Research Grants

 

2011-2015 Development of protein-rich and starch-rich fractions from faba beans for salmon and terrestrial animal production respectively.  Technology Strategy Board, UK. (Coordinated by Dr Crampton, EWOS)

2011-2014:  Nutritional requirements during viral induced muscle wasting in Atlantic salmon (Industrial PhD studentship CLSM & BioMar)

2011-2014 : Selenium as an antiviral agent in farmed fish (Industrial PhD studentship with Alltech, with Prof Secombes and Dr Wang)

2010-2014    Application of nutrigenomics to develop new diets that reduce lice burden in Atlantic salmon (With Dr A Bowman & Dr JMO Fernandes, Bodo University College, Norway) Industrial PhD studentship with BioMar

2010-2014   Farm animal proteomics

EU COST, Coordinated Prof D. Eckersall, University of Glasgow, UK

2010-2014: The physiological and genomic basis to the timing of life history transitions in Atlantic salmon.

BBSRC (with Prof Hazlerigg) 

2008-2011: Evolutionary dynamics of major histocompatibility genes in Arctic charr

NERC (with Dr W.C. Jordan, IOZ London)

2009-2013: LIFECYCLES: Building a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture

Coordinated Prof T. Bjornsson, University of Gotenburg, Sweden, CoPI with Prof Secombes

2009-2012: A systems biology based approach to functionally annotate and analyse the genome of the fish pathogenic oomycete Saprolegnia parasitica 

BBSRC (with Prof Secombes & Dr P. Van West)

2008-2011: Molecular basis of improved feed quality for aquaculture

Industrial PhD studentship with BioMar

2009-2010: Modulation of muscle atrophy gene expression in Atlantic salmon following an inflammatory response.

Royal Society

2009-2012: The molecular basis endocrine and immune modulation of protein metabolism in salmonid fish, a model for ectothermic animals

BBSRC studentship.

2009-2010: Ubiquitin E3 ligases as controllers of protein wastage in fish.

CLSM Pump priming

2009: Immune control of energy reallocation in fish  (with Dr S Bird)

British Society of Animal Science/Genesis Faraday 2009

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Teaching Responsibilities

Lecturer:

1st year BUGS (BI1006), 

1st year Organismal Biology (BI1004), guest lecturer

2nd year Diversity of life, (BI2008, Course Coordinator)

3rd year Aquatic Biology, Conservation and Exploitation  (ZO3809)

3rd year Skills, Bioinformatics unit (BI3010)

4th year Sustainable Aquaculture (ZO4811, Course Coordinator)

4th year Bioethics (ZO4805)

MSc Applied Marine and Fisheries Ecology, Aquaculture  (ZI5505, Unit Coordinator)

MSci  Degree programme coordinator

 

Outreach to Schools: "Trout in the Classroom". I teach about ecology and fish in the river Don by growing fish from eggs to fry in the classroom. (Kemnay Academy 2008, Inverurie Academy 2009, Strathburn School 2010).

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External Responsibilities

Coordinator for "New technologies in fish nutrition" European Aquaculture Technology Implementation Platform

Editorial Board Member : Journal of Aquaculture and Development

Board of Directors, River Don Trust

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Research Projects

 Research Projects

Molecular basis of improved feed quality for aquaculture 2008-2011, PhD CASE Studentship, Co funded with BioMar

The replacement of fish meal and fish oils using vegetable proteins and vegetable oils is hampered by "antinutritional factors" that can be co purified, leading to metabolic dysfunction in the fish.  This results in undesirable affects including reduced digestibility, reduced food conversion, gut inflammation, altered immune function and reduction in growth.  This project will examine the resulting gene expression modifications in fish fed alternate diets, and help identify key molecular markers which will assist in the selection of new diets regarding performance and health of the fish. Student: Luca Tacchi.

IMAQUANIM   Improved immunity of aquacultured animals (EU 2006-2011)

EU funded project: Based on important disease models, this project concerns development of a technological knowledge platform for a future improved immunity to infectious pathogens in the major aquacultured species in Europe (Atlantic salmon, rainbow trout, sea bream, sea bass, carp, mussel and oyster). Focus will be put on use of vaccines, immuno-stimulants, immuno-diagnostic surveillance as well as markers for selection of the most immuno- competent individuals.

Web link http://imaquanim.dfvf.dk/info/

Evolutionary dynamics of major histocompatibility genes in Arctic charr,  

NERC 2007-2010, PI Dr W.C Jordan Institute of Zoology, London.

 Arctic charr (Savelinus alpinus), in common with many salmonid species, show great variability within and across localities. A number of morphotypes of charr coexist in various freshwater systems and differ in characteristics such as body size and spawning coloration, external and internal morphology and parasite fauna. Differences in parasite faunas are likely to create differences in the types of natural selection experienced by different morphs and subsequent differentiation at loci involved in the immune response. The highly polymorphic major histocompatibility (MH) genes are likely targets for such selection. MH class I and class II molecules are instrumental in eliciting an immune response, which results in elimination or control of the pathogen. We will isolate and characterize the MH class I and class II genes from Arctic charr and use the cDNA sequence information to genotype charr populations from different localities.  

Post Doctoral Fellow   Dr Jolene G. M. Slothouber-Galbreath

 

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Publications

BOOK CHAPTERS

Samuel A.M. Martin.  (2009) Proteomics in aquaculture. (Book Chapter) In Molecular Research in Aquaculture. Ed Ken Overturf.  Wiley-Blackwell ISBN-13:978-0-8138-1851-1/2009

Vilhelmsson, O.T., Martin, S.A.M., & D.F. Houlihan. (2005) Application of Proteomics to Fish Processing and Quality Issues. (Book chapter) In: Food biochemistry and food processing. Ed. Y. H. Hui, W. Nip, L.M.L. Nollet, and G.Paliyath. Blackwell Publishing. ISBN-13: 978-0813803784

  Peer reviewed publications

  1. Tacchi L, Secombes CJ, Bickerdike R, Adler MA, Venegas C, Takle H, Martin SAM. 2012. Transcriptomic and physiological responses to fishmeal substitution with plant proteins in formulated feed in farmed Atlantic salmon (Salmo salar). BMC Genomics. 13(1):363

  2.  Langevin C, Blanco M, Martin SAM, Jouneau L, Bernardet JF, Houel A, Lunazzi A, Duchaud E, Michel C, Quillet E, Boudinot P. 2012.  Transcriptional Responses of Resistant and Susceptible Fish Clones to the Bacterial Pathogen Flavobacterium psychrophilum.  PLoS One.;7(6):e39126

  3. Tacchi, L., Casadei, E., Bickerdike, R., Secombes, C.J. and Martin, S.A.M. 2012. MULAN related gene (MRG): A potential novel ubiquitin ligase activator of NF-kB involved in immune response in Atlantic salmon (Salmo salar). Developmental and Comparative Immunology, (In Press)

  4. Micallef G., Bickerdike R., Reiff C., Fernandes J.M.O., Bowman A.S. and Martin S.A.M. 2012.  Exploring the transcriptome of Atlantic salmon (Salmo salar) skin, a major defense organ. Marine Biotechnology. 14:559–569

  5. Tacchi, L., Casadei, E.,Bickerdike, R., Secombes, C.J. and Martin, S.A.M. 2011  Mitochondrial Ubiquitin Ligase Activator of NF-kB (MULAN) in Atlantic salmon (Salmo salar) and its role in the immune response. Molecular Immunology (In Press)

  6. Król, E., Douglas, A., Martin, S.A.M., Huhtaniemi I.T. and John R. Speakman. 2011 Lactating mice with greater downregulation of genes linked to thermogenesis in brown adipose tissue produce more milk. Journal of Experimental Biology (In Press)

  7. Nøstbakken, O.J., Goksøyr, A,  Martin, S.A.M., Cash, P. and Torstensen, B.E. 2011. Marine n-3 FAs alter the proteomic response to methylmercury in Atlantic salmon Kidney (ASK) cells.  Aquatic Toxicology 106-107: 65-75

  8. Tacchi, L., Bron, J.E., Taggart, J.B., Secombes, C.J., Bickerdike, R., Adler, M.A., Takle, H. and Martin, S.A.M.  (2011) Multiple tissue transcriptomic responses to Piscirickettsia salmonis in Atlantic salmon (Salmo salar).  Physiological Genomics 43 (21), pp. 1241-1254

  9. Nøstbakken, O.J., Martin, S.A.M., Cash, P., Torstensen, B.E., Amlund, H., & Olsvik P.A. (2011) Dietary methylmercury alters the proteome in Atlantic salmon (Salmo salar) kidney. Aquatic Toxicology 108 : 70-77

  10. Tacchi, L., Bickerdike, R., Secombes, C.J., Martin, S.A.M. (2011)   Muscle-Specific RING Finger (MuRF) cDNAs in Atlantic Salmon (Salmo salar) and Their Role as Regulators of Muscle Protein Degradation.  Martine Biotechnology. 14: 35-45

  11. Tacchi, L., Bickerdike, R., Douglas, A., Secombes, C.J. and Martin, S.A.M. 2011. Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar). Fish and Shellfish Immunology. 31 (5), pp. 704-715

  12. Castro, R., Zou, J., Secombes, C.J. and Martin, S.A.M. (2011) Cortisol interference in the modulation of inflammatory gene expression by cytokines in macrophages.  Fish and Shellfish Immunology30: 215-23

  13. Wang, T., Wenshu Huang, W., Costa, M.M., Martin, S.A.M. and Secombes, C.J.  (2011). Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Ralpha, IL-13Ralpha1 and IL-13Ralpha2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation.  Immunogenetics   63(4): 235-253

  14. Martin, S.A.M., Douglas, A,. Houlihan, D.F. and Secombes, C.J. (2010). Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar).  BMC Genomics  11: 418

  15. Tacchi, L., Bickerdike, R., Secombes, C.J., Pooley, N.J., Urquhart, K.L., Collet, B. and Martin, S.A.M.  2010. Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar), sequence analysis, genomic structure and modulation of expression. Comp. Biochem. Physiol. Part B 157: 364-373

  16. Ostergaard, A.E.,  Lubieniecki, K.P.  Martin, S.A.M., Stet, R.J.M. Davidson, W.S. and Secombes, C.J. 2010. Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family. BMC Genomics, 11:697

  17. Wang, T., Diaz-Rosales, P., Costa M.M., Campbell, S., Snow, M., Collet, B., Martin, S.A.M. and Secombes, C.J. (2011)  Functional Characterization of a Nonmammalian IL-21: Rainbow Trout Oncorhynchus mykiss IL-21 Upregulates the Expression of the Th Cell Signature Cytokines IFN-?, IL-10, and IL-22.  Journal of Immunology  186: 708-721

  18. Wang,T., Holland, J.W., Martin S.A.M. and Secombes, C.J. (2010) Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in  rainbow trout Oncorhynchus mykiss and analysis of their expression during bacterial and parasitic infection.  Fish and Shellfish Immunology. 29: 705-715

  19. Wang, T., Monte, M.M., Huang, W., Boudinot, P., Martin, S.A.M. and Secombes, C.J. (2010). Identification of two FoxP3 genes in rainbow trout (Oncorhynchus mykiss) that are differentially expressed and modulated. Molecular Immunology 47(16):2563-74

  20. Castro R., Martin S.A.M., Zou, J and Secombes C.J. (2010). Establishment of an IFN-g specific reporter cell line in fish.  Fish and Shellfish Immunology 28: 312-319

  21. Wang T, Martin S.A.M., Secombes C.J (2010). Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated.  Dev Comp Immunol. 34: 491-500

  22. Sissener, N.H., Martin, S.A.M., Cash, P., Hevrøy, E.M., Sanden, M., Hemre, G.-I. 2010). Proteomic Profiling of Liver from Atlantic Salmon (Salmo salar) Fed Genetically Modified Soy Compared to the Near-Isogenic non-GM Line.  Marine Biotechnology, 12: 273-283

  23. Wang, T, Díaz-Rosales, P., Martin, S.A.M.  and Secombes, C.J. (2009). Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family.  Developmental & Comparative Immunology  34: 158–167

  24. Østergaard, A.E., Martin, S.A.M., Wang, T., Stet, R.J.M. & Secombes, C.J.  (2008) Multiple genes and alternative splicing of novel immunoglobulin-1 like transcripts in rainbow trout (Oncorhynchus mykiss) containing either an ITAM or ITIMs. Developmental and Comparative Immunology 33:525-32.

  25. Casania, D,. Randelli, E., Costantini, S., Facchiano, A. M., Zou, J. Martin, S.A.M., Secombes, C.J., Scapigliati, G., Buonocore, F. 2008. Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.).  Molecular Immunology 46(5):943-52

  26. Martin, S.A.M., Collet, B., MacKenzie, S., Evensen O., & Secombes C.J. (2008). Genomic tools for examining immune gene function in salmonid fish. Reviews in Fisheries Sciences 16(S1): 155-164.

  27. Taggart, J.B. Bron, J.E. Martin, S.A.M. Seear, P.J. Høyheim, B. Talbot, R. Carmichael, S.N. Villeneuve, L.A.N. Sweeney, G.E. Houlihan, D.F. Secombes, C.J. Tocher, D.R. Teale, A.J. (2008). A description of the origins D. F, design and performance of the TRAITS-SGP Atlantic salmon Salmo salar L. cDNA microarray.  Journal of Fish Biology 72 (9) , 2071–2094

  28. Castro R, Martin SAM, Bird S, Lamas J, Secombes CJ. (2008) Characterisation of gamma-interferon responsive promoters in fish. Molecular Immunology. 45(12):3454-62

  29. Martin S.A.M, J.B. Taggart, P. Seear, J.E Bron, R. Talbot, A.J. Teale, G Sweeney, B, Hoyheim D.F. Houlihan and C.J. Secombes (2007). Interferon type 1 and type II responses in an Atlantic salmon (Salmo salar) cell line SHK-1 using the salmon TRAITS/SGP microarray. Physiological Genomics  19;32(1):33-44. 

  30. Martin, S.A.M., B Mohanty, P Cash, D.F. Houlihan & C.J. Secombes 2007. Proteome analysis of Atlantic salmon (Salmo salar) SHK-1 cells following recombinant interferon gamma stimulation. Proteomics 13: 2275-2286

  31. Martin, S.A.M., Zou, J. Houlihan, D.F., &. Secombes, C.J. 2007. Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS 11 macrophage cells as revealed by transcriptome profiling.  BMC Genomics 8:150

  32. Kause, A., Tobin, D., E. A. Mäntysaari, S.A.M. Martin, D. F. Houlihan, A. Dobly, A. Kiessling, K. Rungruansak-Torrissen, O. Ritola, K. Ruohonen (2007).  Genetic potential for simultaneous selection of growth and body composition in rainbow trout depend on the dietary protein and lipid content: Phenotypic and genetic correlations on two diets.  Aquaculture 271: 162-172.

  33. Martin, S.A.M. Blaney, S.C. Houlihan, D.F. &. Secombes, C.J.(2006). Transcriptome response following administration of a live bacterial vaccine in Atlantic salmon (Salmo salar).  Molecular Immunology. 43:1900-1911.

  34. Kause, A., D. Tobin, D.F. Houlihan, S.A.M. Martin,  E.A. Mäntysaari, O. Ritola, and K. Ruohonen (2006).  Feed efficiency of rainbow trout can be improved through selection: Different genetic potential on alternative diets.  Journal of Animal Science 84: 807-817.

  35. Kause, A., D. Tobin, A. Dobly D.F. Houlihan, S.A.M. Martin,  E.A. Mäntysaari, O. Ritola, and K. Ruohonen.  (2006) Selective breeding of long-term feed intake recorded using the X-ray method in rainbow trout.  Genetics Selection Evolution 38 (4): 389-409

  36. Tobin, D., A. Kause, E. A. Mäntysaari, S.A.M. Martin, D. F. Houlihan, A. Dobly, A. Kiessling, K. Rungruansak-Torrissen, O. Ritola, K. Ruohonen (2006). Fat or lean? Selection strategies for lipid or protein composition traits in fish breeding schemes. A quantitative genetic analysis of rainbow trout. Aquaculture 261: 510-521.

  37. Jordan, W.C., T.F. Cross, W.W. Crozier, A. Ferguson, P. Galvin, R.H. Hurrell, P.McGinnity,  S.A.M. Martin, I.J.J. Moffett, D.J. Price, A.F. Youngson and E. Verspoor. (2005). Allozyme variation in Atlantic salmon (Salmo salar) from the British Isles: associations with geography and the environment. Journal of Fish Biology.67: (Supplement A), 146-168.

  38. Vilhelmsson, O.T., Martin, S.A.M., Médale, F., Kaushik, S.J. & Houlihan, D.F. (2004). Dietary plant protein substitution affects hepatic metabolism, in rainbow trout (Oncorhynchus mykiss).  British Journal of Nutrition 92: 71-81.

  39. Dobly, A., Martin S.A.M., Blaney, S. & Houlihan, D.F. (2004).  Efficiency of Conversion of ingested Proteins into Growth; Protein Degradation Assessed by 20S Proteasome Activity in Rainbow Trout, Oncorhynchus mykiss. Comparative Biochemistry and Physiology, Part A 137: 75-85.

  40. Gómez-Requeni, P., Mingarro, M., Calduch-Giner, J.A., Médale, F., Martin, S.A.M. Houlihan, D.F., Kaushik, S. & Pérez-Sánchez, J. (2004). Protein growth performance, amino acid utilisation and somatotropic axis responsiveness to fish meal replacement by plant protein sources in gilthead sea bream (Sparus aurata). Aquaculture232: 493-510.

  41. Gómez-Requeni, P., Mingarro, M., Kirchner, S., Calduch-Giner, J.A., Médale, F., Corraze, G., Panserat, S., Martin, S.A.M., Houlihan, D.F., Kaushik, S., & Pérez-Sánchez, J. (2003). Effects of dietary amino acid profile on growth performance, key metabolic enzymes and somatotropic axis responsiveness of gilthead sea bream (Sparus aurata).  Aquaculture 220 (1-4): 749-767.

  42. Martin S.A.M, Vilhelmsson O.T., Médale, F.Watt, P. Kaushik, S., & Houlihan D.F. (2003).  Proteomic sensitivity to dietary manipulations in rainbow trout. Biochimica et Biophysica Acta (Proteins and Proteomics), 1651:17-29.

  43. Martin S.A.M., Blaney, S., Bowman, A., & Houlihan, D.F. (2002).  Ubiquitin-proteasome dependant proteolysis in rainbow trout Oncorhynchus mykiss: Effect of food deprivation.  Pflügers Archiv, European Journal of Physiology 445: 257-266.

  44. Martin S.A.M., Cash, P., Blaney, S., & Houlihan, D.F. (2001).  Proteome analysis of rainbow trout (Oncorhynchus mykiss) liver proteins during short term starvation.  Fish Physiology and Biochemistry 24 (3): 259-270.

  45. Sangrador-Vegas, A., Martin, S.A.M., O'Dea, P.G., & Smith, T.J. (2000).  Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin-1 receptor cDNA.  European Journal of Biochemistry.  267: 7031-7037

  46. Nolan, D.V., Martin, S.A.M., Kelly, Y., Glennon. K., Palmer, R., Smith, T., McCormack, G.P., & Powell, R. (2000).  Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis (Kroyer).  Aquaculture Research31: 815-822

  47. Guiguen, Y., Baroiller, J.F., Ricordel, M.J., Iseki, K., McMeel, O.M., Martin, S.A.M. & Fostier, A. (1999).  Involvement of estrogens in the process of sex differentiation in two fish species: The rainbow trout (Oncorhynchus mykiss) and a Tilapia (Oreochromis niloticus).  Molecular Reproduction and Development. 54: 154-162.

  48. Davidson, J., Smith, T., & Martin, S.A.M. (1999).  Cloning and sequence analysis of rainbow trout LMP 2 cDNA and differential expression of the mRNA.  Fish and Shellfish Immunology 9: 621-632.

  49. Hunter, S.J., Martin, S.A.M., Thompson, F.J., Tetley, L., & Devaney, E. (1999).  The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi.  Parasitology. 119: 189-198.

  50. Martin, S. A. M., Wallner, W., Youngson, A.F., & Smith, T. (1998).  Differential expression of Atlantic salmon (Salmo salar) thyrotropin b subunit mRNA and its cDNA sequence.  Journal of Fish Biology 54: 757-766.

  51. Martin, S.A.M., Youngson, A.F., & Ferguson, A. (1998).  Atlantic salmon (Salmo salar) prolactin cDNA sequence and its mRNA expression after transfer of fish between salinities.  Fish Physiology and Biochemistry 20: 351-359

  52. Anant, S*., Martin, S.A.M*., Yu, H., MacGinnite, A.J., Devaney, E., & Davidson, N.O. (1997).  *Equal contribution.  A Cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding activity.  Molecular and Biochemical Parasitology.  88: 105-114.

  53. Devaney, E.,  Martin, S.A.M., & Thompson, F.J. (1996).  Review:  Stage-specific gene expression in lymphatic filarial nematodes.  Parasitology Today 12:418-424.

  54. Martin, S.A.M., Hunter, S.J., Thompson, F.J., & Devaney, E. (1996).  Stage specific gene expression in the post-infective L3 of the filarial nematode, Brugia pahangi.  Molecular and Biochemical Parasitology. 79: 109-112.

  55. Thompson, F.J., Martin, S.A.M., & Devaney, E.  (1996).  Brugia phangi: Characterization of a small heat shock protein cDNA clone.  Experimental Parasitology. 83: 259-266.

  56. Martin, S.A.M., Thompson, F.J., & Devaney, E. (1995).  The construction of spliced leader cDNA libraries from the filarial nematode Brugia pahangi.  Molecular and Biochemical Parasitology.  70: 241-245

  57. Cox-Singh, J., Paine, M.J.I., Martin, S.A.M., & Devaney, E. (1994).  Stage specific differences in steady state levels of mRNA encoding the major surface glycoprotein of Brugia pahangi.  Tropical Medicine and Parasitology. 45: 352-354.

  58. W.C. Jordan et al., (1992). Genetic Protein variation in Atlantic salmon (Salmo salar) from the British Isles. A report to the Chief Scientists Group and the CFRD Working group on Fisheries Genetics.

  59. Youngson, A.F., Martin, S.A.M., Jordan, W.C. & Verspoor, E. (1991).  Genetic protein variation in Atlantic salmon in Scotland: Comparison of wild and farmed fish.  Aquaculture 98: 231-242.

  60. Youngson, A.F., Martin, S.A.M., Jordan, W.C. & Verspoor, E. (1989). Genetic protein variation in farmed Atlantic salmon in Scotland: comparison of farmed strains with their wild source populations. Scottish Fisheries Research Report. Number 42 ISSN 0308 8022

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Publications

  • Pacitti, D., Wang, T., Page, M., Martin, S., Sweetman, J., Feldmann, J. & Secombes, C. Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure, Article, 2013, Aquatic Toxicology, 130-131, pp97 - 111, ISSN/ISBN: 0166-445X
  • Langevin, C., Blanco, M., Martin, SAM., Jouneau, L., Bernardet, J., Houel, A., Lunazzi, A., Duchaud, E., Michel, C., Quillet, E. & Boudinot, P. Transcriptional responses of resistant and susceptible fish clones to the bacterial pathogen Flavobacterium psychrophilum, Article, 2012, PloS one, 7, 6, ISSN/ISBN: 1932-6203
  • Tacchi, L., Secombes, CJ., Bickerdike, R., Adler, M., Venegas, C., Takle, H. & Martin, SAM. Transcriptomic and physiological responses to fishmeal substitution with plant proteins in formulated feed in farmed Atlantic salmon (Salmo salar), Article, 2012, BMC Genomics, 13 - 363, ISSN/ISBN: 1471-2164
  • Nøstbakken, O., Martin, S., Torstensen, B., Amlund, H., Cash, P. & Olsvik, P. Dietary methylmercury alters the proteome in Atlantic salmon (Salmo salar) kidney, Article, 2012, Aquatic Toxicology, 108, pp70 - 77, ISSN/ISBN: 0166-445X
  • Micallef, G., Bickerdike, R., Reiff, C., Fernandes, JMO., Bowman, AS. & Martin, SAM. Exploring the Transcriptome of Atlantic Salmon (Salmo salar) Skin, a Major Defense Organ, Article, 2012, Marine Biotechnology, 14, 5, pp559 - 569, ISSN/ISBN: 1436-2228
  • Nøstbakken, O., Martin, S., Goksøyr, A., Cash, P. & Torstensen, B. Marine n-3 fatty acids alter the proteomic response to methylmercury in Atlantic salmon kidney (ASK) cells, Article, 2012, Aquatic Toxicology, 106-107, 1, pp65 - 75, ISSN/ISBN: 0166-445X
  • Król, E., Martin, S., Huhtaniemi, I., Douglas, A. & Speakman, J. Negative correlation between milk production and brown adipose tissue gene expression in lactating mice, Article, 2011, Journal of Experimental Biology, 214, 24, pp4160 - 4170, ISSN/ISBN: 0022-0949
  • Tacchi, L., Douglas, A., Secombes, C., Bickerdike, R. & Martin, S. Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar), Article, 2011, Fish & Shellfish Immunology, 31, 5, pp704 - 715, ISSN/ISBN: 1050-4648
  • Wang, T., Huang, W., Costa, M., Martin, S. & Secombes, C. Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Ra, IL-13Ra1 and IL-13Ra2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation, Article, 2011, Immunogenetics, 63, 4, pp235 - 253, ISSN/ISBN: 0093-7711
  • Tacchi, L., Casadei, E., Secombes, C., Bickerdike, R. & Martin, S. Cloning and expression analysis of the Mitochondrial Ubiquitin Ligase Activator of NF-kB (MULAN) in Atlantic salmon (Salmo salar), Article, 2011, Molecular Immunology, 49, 3, pp558 - 565, ISSN/ISBN: 0161-5890
  • Castro, R., Zou, J., Secombes, C. & Martin, S. Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line, Article, 2011, Fish & Shellfish Immunology, 30, 1, pp215 - 223, ISSN/ISBN: 1050-4648
  • Wang, T., Diaz-Rosales, P., Costa, M., Martin, S., Campbell, S., Snow, M., Collet, B. & Secombes, C. Functional characterization of a nonmammalian IL-21, Article, 2011, The journal of immunology, 186, 2, pp708 - 721, ISSN/ISBN: 0022-1767
  • Tacchi, L., Secombes, C., Bron, J., Taggart, J., Bickerdike, R., Adler, M., Takle, H. & Martin, S. Multiple tissue transcriptomic responses to Piscirickettsia salmonis in Atlantic salmon (Salmo salar), Article, 2011, Physiological Genomics, 43, 21, pp1241 - 1254, ISSN/ISBN: 1094-8341
  • Tacchi, L., Secombes, C., Bickerdike, R. & Martin, S. Muscle-Specific RING Finger (MuRF) cDNAs in Atlantic Salmon (Salmo salar) and Their Role as Regulators of Muscle Protein Degradation, Article, 2011, Marine Biotechnology, 14, 1, pp35 - 45, ISSN/ISBN: 1436-2228
  • Sissener, NH., Martin, SAM., Cash, P., Hevrøy, EM., Sanden, M. & Hemre, G. Proteomic Profiling of Liver from Atlantic Salmon (Salmo salar) Fed Genetically Modified Soy Compared to the Near-Isogenic non-GM Line, Article, 2010, Marine Biotechnology, 12, 3, pp273 - 281, ISSN/ISBN: 1436-2228
  • Wang, T., Holland, J., Martin, S. & Secombes, C. Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus mykiss and analysis of their expression during bacterial and parasitic infection, Article, 2010, Fish & Shellfish Immunology, 29, 5, pp705 - 715, ISSN/ISBN: 1050-4648
  • Martin, SAM., Douglas, A., Houlihan, DFJ. & Secombes, CJ. Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar), Article, 2010, BMC Genomics, 11, July, ISSN/ISBN: 1471-2164
  • Wang, T., Martin, SAM. & Secombes, CJ. Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated, Article, 2010, Developmental and Comparative Immunology, 34, 5, pp491 - 500, ISSN/ISBN: 0145-305X
  • Tacchi, L., Bickerdike, R., Secombes, C., Pooley, N., Urquhart, KL., Collet, B. & Martin, S. Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar), Article, 2010, Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 157, 4, pp364 - 373, ISSN/ISBN: 1096-4959
  • Wang, T., Diaz-Rosales, P., Martin, SAM. & Secombes, CJ. Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family, Article, 2010, Developmental and Comparative Immunology, 34, 2, pp158 - 167, ISSN/ISBN: 0145-305X
  • Castro, R., Martin, S., Zou, J. & Secombes, C. Establishment of an IFN-gamma specific reporter cell line in fish, Article, 2010, Fish & Shellfish Immunology, 28, 2, pp312 - 319, ISSN/ISBN: 1050-4648
  • Østergaard, A., Lubieniecki, KP., Martin, S., Stet, R., Davidson, WS. & Secombes, C. Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family, Article, 2010, BMC Genomics, 11, -, ISSN/ISBN: 1471-2164
  • Wang, T., Monte, M., Huang, W., boudinot, P., Martin, SAM. & Secombes, CJ. Identification of two FoxP3 genes in rainbow trout (Oncorhynchus mykiss) with differential induction patterns, Article, 2010, Molecular Immunology, 47, 16, pp2563 - 2574, ISSN/ISBN: 0161-5890
  • Taggart, JB., Bron, JE., Martin, SAM., Seear, PJ., Hoyheim, B., Talbot, R., Carmichael, SN., Villeneuve, LAN., Sweeney, GE., Houlihan, DF., Secombes, CJ., Tocher, DR. & Teale, AJ. A description of the origins, design and performance of the TRAITS-SGP Atlantic salmon Salmo salar L. cDNA microarray, Article, 2008, Journal of Fish Biology, 72, 9, pp2071 - 2094, ISSN/ISBN: 0022-1112
  • Castro, R., Martin, SAM., Bird, S., Lamas, J. & Secombes, CJ. Characterisation of gamma-interferon responsive promoters in fish., Article, 2008, Molecular Immunology, 45, 12, pp3454 - 3462, ISSN/ISBN: 0161-5890
  • Martin, SAM., Collet, B., Mackenzie, S., Evensen, O. & Secombes, CJ. Genomic Tools for Examining Immune Gene Function in Salmonid Fish, Article, 2008, Reviews in Fisheries Science, 16, S1, pp112 - 118, ISSN/ISBN: 1064-1262
  • Martin, SAM., Mohanty, BP., Cash, P., Houlihan, DFJ. & Secombes, CJ. Proteome analysis of the Atlantic salmon (Salmo salar) cell line SHK-1 following recombinant IFN-¿ stimulation, Article, 2007, Proteomics, 7, 13, pp2275 - 2286, ISSN/ISBN: 1615-9853
  • Teale, AJ., Archibald, AL., Bron, JE., Burt, DW., Houlihan, DFJ., Høyheim, B., Martin, SAM., Murray, FD., Secombes, CJ., Seear, PJ., Sweeney, GE., Taggart, JB., Talbot, R., Tocher, DR. & Zheng, X. Towards a molecular genetic tool for health and performance monitoring of Atlantic salmon (Salmo salar), Article, 2007, Aquaculture, 272, Supplement 1, ppS313 - S314, ISSN/ISBN: 0044-8486
  • Martin, SAM., Zou, J., Houlihan, DF. & Secombes, CJ. Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-II macrophage cells as revealed by transcriptome profiling, Article, 2007, BMC Genomics, 8, ISSN/ISBN: 1471-2164
  • Kause, A., Tobin, D., Mantysaari, EA., Martin, SAM., Houlihan, DF., Kiessling, A., Rungruangsak-Torrissen, K., Ritola, O. & Ruohonen, K. Genetic potential for simultaneous selection of growth and body composition in rainbow trout (Oncorhynchus mykiss) depends on the dietary protein and lipid content, Article, 2007, Aquaculture, 271, 1-4, pp162 - 172, ISSN/ISBN: 0044-8486
  • Martin, SAM., Taggart, JB., Seear, P., Bron, JE., Talbot, R., Teale, AJ., Sweeney, GE., Hoyheim, B., Houlihan, DF., Tocher, DR., Zou, J. & Secombes, CJ. Interferon type I and type II responses in an Atlantic salmon (Salmo salar) SHK-1 cell line by the salmon TRAITS/SGP microarray, Article, 2007, Physiological Genomics, 32, 1, pp33 - 44, ISSN/ISBN: 1094-8341
  • Kause, A., Tobin, D., Dobly, A., Houlihan, D., Martin, SAM., Mäntysaari, E., Ritola, O. & Ruohonen, K. Recording strategies and selection potential of feed intake measured using the X-ray method in rainbow trout, Article, 2006, Genetics Selection Evolution, 38, 4, pp389 - 409, ISSN/ISBN: 0999-193X
  • Martin, SAM., Blaney, SC., Houlihan, DFJ. & Secombes, CJ. Transcriptome response following administration of a live bacterial vaccine in Atlantic salmon (Salmo salar), Article, 2006, Molecular Immunology, 43, 11, pp1900 - 1911, ISSN/ISBN: 0161-5890
  • Tobin, D., Kause, A., Mantysaari, EA., Martin, SAM., Houlihan, DF., Dobly, A., Kiessling, A., Rungruangsak-Torrissen, K., Ritola, O. & Ruohonen, K. Fat or lean?, Article, 2006, Aquaculture, 261, 2, pp510 - 521, ISSN/ISBN: 0044-8486
  • Kause, A., Tobin, D., Houlihan, DF., Martin, SAM., Mantysaari, EA., Ritola, O. & Ruohonen, K. Feed efficiency of rainbow trout can be improved through selection, Article, 2006, Journal of Animal Science, 84, pp807 - 817, ISSN/ISBN: 0021-8812
  • Martin, SAM., Vilhelmsson, OT. & Houlihan, DFJ. Protein profiles in rainbow trout, Oncorhynchus mykiss, Article, 2005, Aquaculture, 247, 1-4, pp24 - 25, ISSN/ISBN: 0044-8486
  • Martin, SAM., Houlihan, DFJ. & Secombes, CJ. Transcriptional analysis of Atlantic salmon (Salmo salar) cDNAs following a disease challenge, Article, 2005, Aquaculture, 247, 1-4 - 24, ISSN/ISBN: 0044-8486
  • Dobly, A., Ritola, O., Wahlroos, H., Kause, A., Mantysaari, E., Ruohonen, K., Martin, SAM. & Houlihan, DFJ. Genetic correlates of protein growth efficiency in 210 families of rainbow trout assessed by X-rays, Article, 2005, Aquaculture, 247, 1-4, pp12 - 12, ISSN/ISBN: 0044-8486
  • Gomez-Requeni, P., Mingarro, M., Calduch-Giner, JA., Medale, F., Martin, SAM., Houlihan, DFJ., Kaushik, SJ. & Perez-Sanchez, J. Protein growth performance, amino acid utilisation and somatotropic axis responsiveness to fish meal replacement by plant protein sources in gilthead sea bream (Sparus aurata), Article, 2004, Aquaculture, 232, 1-4, pp493 - 510, ISSN/ISBN: 0044-8486
  • Dobly, A., Martin, SAM., Blaney, SC. & Houlihan, DFJ. Protein growth rate in rainbow trout (Oncorhynchus mykiss) is negatively correlated to liver 20S proteasome activity, Article, 2004, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 137, 1, pp75 - 85, ISSN/ISBN: 1095-6433
  • Martin, SAM., Vilhelmsson, OT. & Houlihan, DFJ. Rainbow trout liver proteome, Chapter, 2004, Progress in Research on Energy and Protein Metabolism , 109, pp57 - 60
  • Vilhelmsson, OT., Martin, SAM., Medale, F., Kaushik, SJ. & Houlihan, DFJ. Dietary plant-protein substitution affects hepatic metabolism in rainbow trout (Oncorhynchus mykiss), Article, 2004, British Journal of Nutrition, 92, 1, pp71 - 80, ISSN/ISBN: 0007-1145
  • Martin, SAM., Vilhelmsson, OT., Medale, F., Watt, P., Kaushik, SJ. & Houlihan, DFJ. Proteomic sensitivity to dietary manipulations in rainbow trout, Article, 2003, Biochimica et Biophysica Acta - Proteins and Proteomics, 1651, 1-2, pp17 - 29, ISSN/ISBN: 1570-9639
  • Martin, SAM., Vilhelmsson, OT. & Houlihan, DFJ. Rainbow trout liver proteome, Article, 2003, European Association for Animal Production Publication, 109, pp57 - 60, ISSN/ISBN: 0071-2477
  • Gomez-Requeni, P., Mingarro, M., Calduch-Giner, JA., Medale, F., Martin, SAM., Houlihan, DFJ., Kaushik, SJ. & Perez-Sanchez, J. Effects of dietary amino acid profile on growth performance, key metabolic enzymes and somatotropic axis responsiveness of gilthead sea bream (Sparus aurata)., Article, 2003, Aquaculture, 220, 1-4, pp749 - 767, ISSN/ISBN: 0044-8486
  • Houlihan, DFJ. & Martin, SAM. Protein metabolism in fish, Article, 2002, Integrative and Comparative Biology, 42, 6, pp1245 - 1246, ISSN/ISBN: 1540-7063
  • Martin, SAM., Blaney, SC., Bowman, AS. & Houlihan, DFJ. Ubiquitin-proteasome dependant proteolysis in rainbow trout Oncorhynchus mykiss: effect of food deprivation, Article, 2002, Pflugers Archiv : European Journal of Physiology, 445, pp257 - 266, ISSN/ISBN: 0031-6768
  • Martin, SAM., Cash, P., Blaney, SC. & Houlihan, DFJ. Proteome analysis of rainbow trout (Oncorhyncus mykiss) liver proteins during short term starvation, Article, 2001, Fish Physiology and Biochemistry, 24, 3, pp259 - 270, ISSN/ISBN: 0920-1742
  • Sangrador-Vegas, A., Martin, SAM., O'Dea, PG. & Smith, TJ. Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin-1 receptor cDNA, Article, 2000, European Journal of Biochemistry, 267, 24, pp7031 - 7037, ISSN/ISBN: 0014-2956
  • Nolan, D., Martin, SAM., Kelly, Y., Glennon, K., Palmer, R., Smith, T., McCormack, GP. & Powell, R. Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis (Kroyer), Article, 2000, Aquaculture Research, 31, 11, pp815 - 822, ISSN/ISBN: 1355-557X
  • Hunter, SJ., Martin, SAM., Thompson, FJ., Tetley, L. & Devaney, E. The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi, Article, 1999, Parasitology, 119, 2, pp189 - 198, ISSN/ISBN: 0031-1820
  • Hunter, SJ., Martin, SAM., Thompson, FJ., Tetley, L. & Devaney, E. The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi, Article, 1999, Parasitology, 119, 2, pp189 - 198, ISSN/ISBN: 1469-8161
  • Martin, SAM., Youngson, AF. & Ferguson, A. Atlantic salmon (Salmo salar) prolactin cDNA sequence and its mRNA expression after transfer of fish between salinities, Article, 1999, Fish Physiology and Biochemistry, 20, 4, pp351 - 359, ISSN/ISBN: 0920-1742
  • Martin, SAM., Wallner, W., Youngson, AF. & Smith, T. Differential expression of Atlantic salmon thyrotropin beta subunit mRNA and its cDNA sequence, Article, 1999, Journal of Fish Biology, 54, 4, pp757 - 766, ISSN/ISBN: 0022-1112
  • Guiguen, Y., Baroiller, JF., Ricordel, MJ., Iseki, K., McMeel, OM., Martin, SAM. & Fostier, A. Involvement of estrogens in the process of sex differentiation in two fish species: The rainbow trout (Oncorhynchus mykiss) and a Tilapia (Oreochromis niloticus), Article, 1999, Molecular Reproduction and Development, 54, 2, pp154 - 162, ISSN/ISBN: 1040-452X
  • Anant, S., Martin, SAM., Yu, HR., MacGinnitie, AJ., Devaney, E. & Davidson, NO. A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding activity, Article, 1997, Molecular and Biochemical Parasitology, 88, 1-2, pp105 - 114, ISSN/ISBN: 0166-6851
  • Martin, SAM., Hunter, SJ., Thompson, FJ. & Devaney, E. Stage specific gene expression in the post-infective L3 of the filarial nematode, Brugia pahangi, Article, 1996, Molecular and Biochemical Parasitology, 79, 1, pp109 - 112, ISSN/ISBN: 0166-6851
  • Devaney, E., Martin, SAM. & Thompson, FJ. Stage-specific gene expression in lymphatic filarial nematodes, Scientific review, 1996, Parasitology Today, 12, 11, pp418 - 424, ISSN/ISBN: 0169-4758
  • Thompson, FJ., Martin, SAM. & Devaney, E. Brugia pahangi, Article, 1996, Experimental Parasitology, 83, 3, pp259 - 266, ISSN/ISBN: 0014-4894
  • Martin, SAM., Thompson, FJ. & Devaney, E. The construction of spliced leader cDNA libraries from the filarial nematode Brugia pahangi (vol 70, pg 241, 1995), Article, 1995, Molecular and Biochemical Parasitology, 75, 1 - 129, ISSN/ISBN: 0166-6851
  • Martin, SAM., THOMPSON, FJ. & DEVANEY, E. The construction of spliced leader cDNA libraries from the filarial nematode Brugia pahangi, Comment/debate, 1995, Molecular and Biochemical Parasitology, 70, 1-2, pp241 - 245, ISSN/ISBN: 0166-6851
  • COXSINGH, J., PAINE, MJI., Martin, SAM. & DEVANEY, E. Stage-Specific Differences in Steady-State Levels of Messenger-RNA Encoding the Major Surface Glycoprotein of Brugia-Pahangi, Comment/debate, 1994, Annals of Tropical Medicine and Parasitology, 45, 4, pp352 - 354, ISSN/ISBN: 0003-4983
  • YOUNGSON, AF., Martin, SAM., JORDAN, WC. & Verspoor, E. Genetic protein variation in Atlantic salmon in Scotland, Article, 1991, Aquaculture, 98, 1-3, pp231 - 242, ISSN/ISBN: 0044-8486
  • Martin, SAM. & Stefani, LAJ. Genetic-Regulation of the Pituitary Control of Smolting and Sexual-Maturation in Atlantic Salmon, Article, 1991, Biochemical Society Transactions, 19, 2 - S199, ISSN/ISBN: 0300-5127

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