Dr Mirela Delibegovic
Research Councils UK (RCUK) tenure-track fellow
Ph.D.
|
Personal Details
|
Biography
EDUCATION
Harvard Medical School
and Beth Israel
Deaconess Medical
Center, Boston, USA
Post-Doctoral Fellow in the Division of Medicine, Cancer Biology
Programme, in the laboratory of Professor Benjamin G. Neel (2003 –2007)
University
of Dundee, MRC Protein Phosphorylation
Unit, Dundee, UK
PhD in Biochemistry. Supervisor
Professor Patricia T.W. Cohen (1999 –2003).
University
of Edinburgh, Edinburgh, UK
BSc in Biological Sciences with Honours in Pharmacology (1995 –1999).
Secondary education: George
Heriot's School, Edinburgh,
UK (1994 –1995);
Mesa
Selimovic Grammar
School, Tuzla,
Bosnia &
Hercegovina (1990-1994).
« top
Research Interests
RESEARCH INTERESTS
My main interests of study are the role of tyrosine phosphorylation and dephosphorylation in cell signaling and disease. Through the combined use of biochemical, cellular and gene knockout mouse models, my research focuses on the function of protein-tyrosine phosphatases (PTPs) in regulating insulin and leptin signaling pathways in whole body metabolism, and how deregulation of these pathways leads to the development of diseases such as Type 2 diabetes and obesity. Understanding the pathways regulating metabolic processes is of critical importance because these diseases are reaching epidemic proportions.
LAB PHOTO
Abdel's leaving drinks and cakes - Abdel is off to take up his lecturship at
the University of Surrey - we'll miss him!
« top
Current Research
Carl Owen, who obtained his MSc at the University of Aberdeen, is a BBSRC funded PhD student (2009-2013) in my lab investigating the role of PTP1B in body mass regulation and insulin sensitivity.
Dr. Louise Grant is a research fellow working on a BHF-funded project grant (2011-2014) investigating the role of adipocyte and macrophage PTP1B in metabolism.
Ms. Emma Lees is a BBSRC funded PhD student (2011-2015), co-supervised by Dr. Nimesh Mody, elucidating the role of tyrosine phosphorylation in diabetes, obesity and cardiovascular disease.
Dr. Ela Krol is research fellow currently funded by Diabetes UK (2012); working on the role of liver and adipose PTP1B in inflammation, glucose metabolism and ageing.
Previous members of Delibegovic lab:
Dr. Abdelali Agouni was a research fellow in my laboratory working on a 3 year Diabetes UK project grant (2009-2012) to study the role of protein tyrosine phosphatase 1B (PTP1B) in inflammatory pathways in liver and adipose tissue. PTP1B has been identified as an important potential anti-diabetic, anti-obesity drug target and understanding its role and mechanism of action in control of glucose homeostasis, inflammation and body mass regulation is essential for future therapeutics. Abdel is now a lecturer in cardiovascular biology at the University of Surrey.
Dr. Alicja Czopek was a postdoctoral research fellow working on a British Heart Foundation funded project (2009-2010) grant furthering our understanding of the role of macrophage- and adipocyte-PTP1B in glucose homeostasis, lipid metabolism and adiposity. She is now a postdoctoral research fellow at the University of Edinburgh.
2011-2012 Mr James Workman - Honours student working on the role of macrophages in inflammation and glucose homeostasis.
2010-2011 Mr Jay Aaron Hutchison - undergraduate student volunteer in our lab since Feb 2010. He was awarded the Medical Research Scotland vacation studentship to investigate mechanisms of PTP1B action in AMPK signaling.
2010-2011 Ms Katie Towle - Honours student, co-supervised by Dr. Nimesh Mody, working on the role of sex hormones in body mass regulation in mice.
2009-2010 Ms. Lindsey Hasler - Honours student working in the area of adipocyte biology and examining the effects of different fasting regimens on insulin sensitivity in adipose tissue.
2009-2010 Mr Callum Wemyss - 6th year Hazlehead Academy student working in the lab on the effects of Orlistat on insulin senstitivity and AMPK signaling in 3T3-L1 adipocytes.
« top
Collaborations
EXTERNAL
Prof. Benjamin Neel; Ontario Cancer Institute; Toronto; Canada
Prof. Barbara Kahn: BIDMC and Harvard Medical School; Boston; USA
Prof. Thomas Gettys; Penningtom Biomedical Research Center; Baton Rouge; USA
Dr. Kendra Bence; University of Pennsylvania; Philadelphia; USA
Dr. Maria Kontaridis; BIDMC and Harvard Medical School; Boston, USA
Prof. Kei Sakamoto; Head of Division of Diabetes Research, Nestle Institute of Health Sciences and Professor at EPFL, Lausanne; Switzerland
Dr. Olga Göransson, Lund University , Protein Phosphorylation Research Group, Sweden
Dr. Frederic Preitner; University of Lausanne; Switzerland
INTERNAL
Prof. Micheal Frenneaux, Regius Chair of Medicine, University of Aberdeen
Dr. Nimesh Mody; BHF career development fellow, University of Aberdeen
Dr. Dana Dawson; Senior Clinical Lecturer, IMS, University of Aberdeen
Dr. Colin Selman, Reader, University of Aberdeen
Prof. Bettina Platt, Institute of Medical Sciences, University of Aberdeen
Dr. Alison Murray, Senior Clinical Lecturer, IMS, UoA
Dr. Zofia Miedzybrodzka, Reader in Medical Genetics, IMS, UoA
Dr. Perry Barrett; Rowett Institute of Nutrition and Health, UoA
Dr. Nigel Hoggard; Rowett Institute of Nutrition and Health, UoA
Prof. Andy Welch; Chair in School of Medical Sciences, UoA
« top
Research Grants
EFSD/Lilly European Diabetes Research Programme Grant (2012 - 2013) Principal Investigator (with Dr. Nimesh Mody as a co-PI)
British Heart Foundation Project Grant (2011-2014) Principal Investigator
BBSRC Doctoral Training Grant (DTG) (2011-2015) 'Elucidating the role of tyrosine phosphorylation in obesity, diabetes and cardiovascular disease'
Tenovus Scotland, 1-year Research Grant (2011-2012) Principal Investigator
Medical Research Scotland, Vacation Scholarship 2011, Principal Investigator
UKRC for Women in SET, Travel bursary, USA conference and collaboration trip (2010)
British Heart Foundation Project Grant (2009-2010) Principal Investigator
BBSRC Doctoral Training Grant (DTG) (2009-2013) 'Role of Protein Tyrosine Phosphatase 1B (PTP1B) in body mass regulation and glucose homeostasis'
The Royal Society Research Grant (2009-2010) Principal Investigator
Diabetes UK Project Grant (2009-2012) Principal Investigator
College of Life Sciences and Medicine Start-up Fund (2007-2012)
Research Council UK (RCUK) Fellowship to study mouse models of ageing and obesity (2007-2012)
American Heart Association Postdoctoral Fellowship (2005-2007)
« top
Teaching Responsibilities
- Course Co-ordinator; final 4th year Honours Bioethics course, ZO 4805, School of Biological Sciences, University of Aberdeen. Also teaching on this course:
- Genetic modifications of animals and human beings;
- Ethics and research on human subjects.
- Kindrogan Teambuilding Course - Honours year 2 day teambuilding retreat
- Lecturing in the 2nd year undergraduate Vertebrate Zoology BI20Z1 course; School of Biological Sciences, University of Aberdeen
- Mammals - radiation and adaptations 1.
- Mammals - radiation and adaptations 2.
- Mammals - radiation and adaptations 3.
as well as Vitae (click on the link for full details)
- Outreach and teaching in secondary schools as a part of the Researchers in Residence programme; appointed to Hazlehead Academy in Aberdeen.
For the latest practical class I did in Hazlehead Academy, where the students were learning about DNA go to:
http://www.hazleheadacy.aberdeen.sch.uk/more_news157.htm
In the past, I've given inspirational talks and practical science classes during my postdoctoral fellowship at Harvard, to Science Club For Girls and similar practical "murder mistery" classes as a PhD student in Dundee.
Diabetes UK voluntary group talks - I've been invited by the Moray Voluntary Group, Ribble Valley Voluntary Group and Aberdeen Voluntary Group to talk about my lab's research, and our work is officially adopted by the Moray Voluntary Group and Ribble Valley voluntary group.
« top
External Responsibilities
Elected for the Royal Society of Edinburgh (RSE) Young Academy of Scotland
Diabetes UK Professional Member
The American Physiological Society Elected Member
The Biochemical Society Elected Member
Editorial Board Member of Frontiers in Systems and Translational Endocrinology
Editorial Board Member of ISRN Obesity
Reviewer for several peer-reviewed journals and funding bodies (UK and international)
Member of the Ethics Review Board for College of Life Sciences and Medicine (CLSM)
Member of the University of Aberdeen Senatus Academicus (the Senate)
Member of the College BSU Management Group
Seminars Organiser for the School of Biological Sciences, University of Aberdeen
Member of the Genetically Modified Organisms committee for Old Aberdeen
Elected for the Scottish Crucible 2009 programme
Member of the Scottish Researcher Career Coordination Forum
Member of the Aberdeen Center for Energy Regulation & Obesity (ACERO)
Member of regulatory variation and disease collaborative centre
« top
Invited Conference Speaker
-
Cold Spring Harbor, Protein Phosphorylation and Cell Signaling conference (2005)
-
Keystone conference on Diabetes Mellitus & Energy Metabolism (Vancouver 2006)
-
Scottish Society for Experimental Medicine (Edinburgh 2008)
-
University of Dundee, Neuroscience Department (2008)
-
ECO 2009 17th European Congress on Obesity (Amsterdam 2009)
-
University of Angers Medical School, Angers, France (2009)
-
Astra Zeneca UK Adipose Tissue Discussion Group, 2009
-
University of Edinburgh, Centre for Cardiovascular Science, Edinburgh, 2010
-
DIABETES UK Annual Professional Conference 2011, London (2011)
-
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland (2011)
« top
Retreat with Collaborators
Reatreat - November 2009; Dalmunzie Castle; laboratories of Dr. Kei Sakamoto (University of Dundee), Dr. Olga Goransson (Lund University, Sweden) and Dr. Mirela Delibegovic
« top
The Royal Society of Edinburgh (RSE) Young Academy of Scotland
I am an elected member of the RSE Young Academy of Scotland. The Young Academy brings together some of the most able and innovative young academics, entrepreneurs, artists and professionals in Scotland, with the aim of harnessing their creativity to develop a coherent and influential voice on behalf of the most talented people of their generation. The Academy members will work across disciplines to consider many of the most challenging issues facing society either domestically or globally, in fields as diverse as climate change, the economy, ethics or the arts.
The Royal Society of Edinburgh (RSE), Scotland’s National Academy, welcomed all the members of the new “RSE Young Academy of Scotland” to an event on Tuesday 29th November.
« top
Publications
- Owen, C., Czopek, AJ., Agouni, A., Grant, L., Judson, RN., Lees, EK., McIlroy, GD., Göransson, O., Welch, A., Kendra Bence, K., Kahn, B., Neel, BG., Mody, N. & Delibegovic, M. Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and is a Minor Regulator of Glucose Homeostasis, Article, 2012, PLoS one, 7, 2 - e32700
- Hoggard, N., Agouni, A., Mody, N. & Delibegovic, M. Serum Levels of RBP4 and Adipose Tissue Expression Levels of PTP1B are Increased in Obese Men Resident in North East of Scotland Without Associated Changes in ER Stress Response Marker Genes, Article, 2012, International Journal of General Medicine, 2012:5, pp403 - 411
- Agouni, A., Mody, N., Owen, C., Czopek, A., Zimmer, D., Bentirez-Alj, M., Bence, KK. & Delibegovic, M. Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically-induced endoplasmic reticulum stress., Article, 2011, Biochemical Journal, 438, 2, pp369 - 378, ISSN/ISBN: 0264-6021
- Agouni, A., Ducluzeau, P., Benameur, T., Faure, S., Sladkova, M., Duluc, L., Leftheriotis, G., Pechanova, O., Delibegovic, M., Martinez, MC. & Andriantsitohaina, R. Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice, Article, 2011, PLoS one, 6, 11
- Mody, N., Agouni, A., McIlroy, GD., Platt, B. & Delibegovic, M. Susceptibility to diet-induced obesity and glucose intolerance in the APPSWE/PSEN1A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein, Article, 2011, Diabetologia, 54, 8, pp2143 - 2151, ISSN/ISBN: 0012-186X
- Bence, K., Delibegovic, M., Hotamisligil, G., Kahn, B. & Neel, B. Addendum, Comment/debate, 2010, Nature Medicine, 16, 237
- Matsuo, K., Delibegovic, M., Matsuo, I., Nagata, N., Liu, S., Bettaieb, A., Xi, Y., Araki, K., Young, W., Kahn, BB., Neel, BG. & Haj, FG. Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2, Article, 2010, Journal of Biological Chemistry, 285, 51, pp39750 - 39758, ISSN/ISBN: 0021-9258
- Agouni, A., Owen, C., Czopek, AJ., Mody, N. & Delibegovic, M. In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues, Article, 2010, Biochemical and Biophysical Research Communications, 401, 1, pp104 - 111, ISSN/ISBN: 0006-291X
- Delibegovic, M., Zimmer, D., Kauffman, C., Rak, K., Hong, E., Cho, Y., Kim, JK., Kahn, BB., Neel, BG. & Bence, KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress, Article, 2009, Diabetes, 58, 3, pp590 - 9, ISSN/ISBN: 0012-1797
- Xue, B., Pulinilkunnil, T., Murano, I., Bence, KK., He, H., Minokoshi, Y., Asakura, K., Lee, A., Haj, F., Furukawa, N., Catalano, KJ., Delibegovic, M., Balschi, JA., Cinti, S., Neel, BG. & Kahn, BB. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues, Article, 2009, Molecular and Cellular Biology, 29, 16, pp4563 - 4573, ISSN/ISBN: 0270-7306
- Delibegovic, M. & Mody, N. Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes., Article, 2009, Acta Medica Saliniana, 38, 1, pp2 - 7, ISSN/ISBN: 0350-364X
- Delibegovic, M., Bence, KK., Mody, N., Hong, E., Ko, HJ., Kim, JK., Kahn, BB. & Neelt, BG. Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B, Article, 2007, Molecular and Cellular Biology, 27, 21, pp7727 - 7734, ISSN/ISBN: 0270-7306
- Bence, KK., Delibegovic, M., Xue, B., Gorgun, CZ., Hotamisligil, GS., Neel, BG. & Kahn, BB. Neuronal PTP1B regulates body weight, adiposity and leptin action, Article, 2006, Nature Medicine, 12, 8, pp917 - 924
- Cohen, PT., Browne, GJ., Delibegovic, M. & Munro, S. Assay of protein phosphatase 1 complexes, Article, 2003, Methods in Enzymology, 366, pp135 - 44, ISSN/ISBN: 0076-6879
- Delibegovic, M., Armstrong, CG., Dobbie, L., Watt, PW., Smith, AJH. & Cohen, PTW. Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance, Article, 2003, Diabetes, 52, 3, pp596 - 604, ISSN/ISBN: 0012-1797
- Browne, GJ., Delibegovic, M., Keppens, S., Stalmans, W. & Cohen, PTW. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats, Article, 2001, Biochemical Journal, 360, 2, pp449 - 459, ISSN/ISBN: 0264-6021
« top
« back