MSc (University of Groningen, The Netherlands; 2002); PhD (University of Groningen, The Netherlands; 2007)
Whole animal energetics & physiology in the context of Obesity and Ageing
During my PhD I studied the relationship between energetics and ageing. I manipulated energy expenditure by exposing mice (Mus muscullus) to cold or by using mice with high spontaneous activity and looked at effects on body composition, oxidative stress and life span. These studies showed that the assumption from the 'rate of living' theory, that there is an inverse relationship between energy expenditure and life span did not hold up within species. I also studied behavioural and physiological consequences of increased foraging effort, and responses in energy balance to high-fat feeding in mice selectively-bred for high wheel-running activity.
The extent of diet-induced weight loss varies substantially between individuals. We know little however about why certain individuals are prone to weight loss whereas others are resistant. Understanding the mechanisms underlying this individual variability in dieting-induced weight loss will be important for developing intervention strategies that are more suitable for individual treatment.
I received a Rubicon grant from the Dutch Science Organisation (NWO) in july 2008 to study causes of individual variability in diet-induced weight loss and have shown that about 50% of the variation in body mass and fat mass loss could be predicted by pre-existing differences in food intake, resting metabolic rate (RMR), and general activity, where body mass loss was greater when food intake was lower and activity and RMR were higher. Compensatory changes in activity and body temperature together explained ~50% of the variation in body mass and fat mass loss in both sexes. I Currently I am investigating the expression of various neuropeptides involved in the regulation of food intake in mice that are prone or resistant to weight loss and whether animals that are prone/resistant to weight loss are also prone/resistant to high-fat diet induced weight gain.
Rubicon grant from NWO july 2008
I am involved in teaching lectures and practicals in the Diversity of Life and Animal Physiology courses at the School of Biological Sciences.
- Vaanholt, LM., Magee, V. & Speakman, JR. Factors Predicting Individual Variability in Diet-Induced Weight Loss in MF1 Mice, Article, 2012, Obesity, 20, 2, pp285 - 294, ISSN/ISBN: 1930-7381
- Meakin, PJ., Harper, AJ., Hamilton, DL., Gallagher, J., McNeilly, AD., Burgess, LA., Vaanholt, LM., Bannon, KA., Latcham, J., Hussain, I., Speakman, JR., Howlett, DR. & Ashford, MLJ. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice, Article, 2012, Biochemical Journal, 441, pp285 - 296, ISSN/ISBN: 0264-6021
- Simons, MJP., Reimert, I., van der Vinne, V., Hambly, C., Vaanholt, LM., Speakman, JR. & Gerkema, MP. Ambient temperature shapes reproductive output during pregnancy and lactation in the common vole (Microtus arvalis), Article, 2011, Journal of Experimental Biology, 214, 1, pp38 - 49, ISSN/ISBN: 0022-0949
- Schubert, KA., Boerema, AS., Vaanholt, LM., de Boer, SF., Strijkstra, AM. & Daan, S. Daily torpor in mice, Article, 2010, Biology Letters, 6, 1, pp132 - 135, ISSN/ISBN: 1744-9561
- JÃ³nÃ¡s, I., Vaanholt, LM., Doornbos, M., Garland, T., Scheurink, AJW., Nyakas, C. & van Dijk, G. Effects of selective breeding for increased wheel-running behavior on circadian timing of substrate oxidation and ingestive behavior, Article, 2010, Physiology and Behavior, 99, 5, pp549 - 54, ISSN/ISBN: 0031-9384
- Vaanholt, LM., Daan, S., Garland, T. & Visser, GH. Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities, Article, 2010, Physiological and Biochemical Zoology, 83, 2, pp239 - 51, ISSN/ISBN: 1522-2152
- Duarte, LC., Vaanholt, LM., Sinclair, R., Gamo, Y. & Speakman, JR. Limits to sustained energy intake XII, Article, 2010, Journal of Experimental Biology, 213, 2, pp278 - 87, ISSN/ISBN: 0022-0949
- Schubert, KA., de Vries, G., Vaanholt, LM., Meijer, HAJ., Daan, S. & Verhulst, S. Maternal energy allocation to offspring increases with environmental quality in house mice, Article, 2009, The American Naturalist, 173, 6, pp831 - 840, ISSN/ISBN: 0003-0147
- Vaanholt, LM., Daan, S., Schubert, KA. & Visser, GH. Metabolism and aging, Article, 2009, Physiological and Biochemical Zoology, 82, 4, pp314 - 324, ISSN/ISBN: 1522-2152
- Schubert, KA., Vaanholt, LM., Stavasius, F., Demas, GE., Daan, S. & Visser, GH. Female mice respond differently to costly foraging versus food restriction, Article, 2008, Journal of Experimental Biology, 211, 14, pp2214 - 2223, ISSN/ISBN: 0022-0949
- Vaanholt, LM., Jonas, I., Doornbos, M., Schubert, KA., Nyakas, C., Garland, T., Visser, GH. & van Dijk, G. Metabolic and behavioral responses to high-fat feeding in mice selectively bred for high wheel-running activity, Article, 2008, International Journal of Obesity, 32, 10, pp1566 - 1575, ISSN/ISBN: 0307-0565
- Vaanholt, LM., Speakman, JR., Garland, T., Lobley, G. & Visser, GH. Protein synthesis and antioxidant capacity in aging mice, Article, 2008, Physiological and Biochemical Zoology, 81, pp148 - 157, ISSN/ISBN: 1522-2152
- Vaanholt, LM., De Jong, B., Garland Jr, T., Daan, S. & Visser, GH. Behavioural and physiological responses to increased foraging effort in male mice, Article, 2007, Journal of Experimental Biology, 210, 11, pp2013 - 2024, ISSN/ISBN: 0022-0949
- Vaanholt, LM., Meerlo, P., Garland, T., Visser, GH. & van Dijk, G. Plasma Adiponectin is Increased in Mice Selectively Bred for High Wheel-running Activity, but not by Wheel Running per sÃ©, Article, 2007, Hormone and Metabolic Research, 39, 5, pp377 - 383, ISSN/ISBN: 0018-5043
- Vaanholt, LM., Garland, T., Daan, S. & Visser, GH. Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity, Article, 2007, Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, 177, 1, pp109 - 118, ISSN/ISBN: 0174-1578
- Vaanholt, LM., Turek, FW. & Meerlo, P. Beta-endorphin modulates the acute response to a social conflict in male mice but does not play a role in stress-induced changes in sleep, Article, 2003, Brain Research, 978, 1-2, pp169 - 176, ISSN/ISBN: 0006-8993