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Dr Leslie Noble

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Personal Details

Telephone:

+44 (0)1224 272392

E-mail:

l.r.noble@abdn.ac.uk


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Research Interests

My group's research focus has the evolution of host-parasite interactions as its underlying theme - studying models which allow us to determine the evolutionary interactions of host and parasite from the molecular to the population level. Various aspects of an organism's life history will make it more or less susceptible to parasite/pathogen attack, and several of our interests (such as mate choice and paternity assessment - in an ascidian Diplosoma listerianum and in the squid Loligo forbesi ; inbreeding assessment - in tropical freshwater snails; and population structure - in the great white shark) reflect this consideration.

Our studies of the genetic basis of parasite resistance employ four model systems which have been used to investigate expression analysis of resistance genes, population genetics, phylogenetics, and in some species their identification and evolution. Our main model is the tropical freshwater snail-schistosome association. But more recently, in response to the rapid progress made by the Salmon Genome Project, our research interests have expanded to include immune gene expression and parasite resistance in three fish-parasite systems, sealice (Lepeophtheirus salmonis) and Gyrodactylus salaris resistance in Atlantic salmon and resistance to Tetracapsula bryosalmonae, PKX, causative agent of Proliferative Kidney Disease, PKD in trout. The synergy produced by studying these systems in parallel is proving particularly helpful in defining general key determinants of host-parasite interactions.  

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Research Grants

2001/2004 MAFF. Immune Gene Expression during PKD infection. (With Prof. C. Secombes & Dr C. Jones).

2001/2004 EU Aberdeen University as Coordinators. (SALMOGYRO) The genetic basis of Gryrodactylus salaris Resistance in Altantic salmon (Salmo salar). (With Dr C. Jones).

1999/ 2003 NERC Link Aquaculture / Scottish Salmon Growers/ Marine Harvest Scotland Identification of disease resistance genes and markers in Atlantic salmon differing in their susceptibility to sealice infection. (With Dr C. Jones & Prof. C. Secombes).

1997/ 2002 Wellcome Trust Biodiversity Prize Studentship Molecular systematics & ecology of Bulinus Africanus group snails in Tanzania. (With Dr D. Rollinson, NHM, London).

1999/ 2002. Wellcome Trust Biodiversity Prize Studentship Population structure and speciation in tropical freshwater snails of the genus Bulinus from Cameroon. (With Dr C. Jones & Dr D. Rollinson, NHM, London).

1999/2003; World Bank Genetic diversity of Cichlid fish from Tanzania.; (With Dr C. Jones & Prof Monty Preide).

2001 Leverhulme Trust Development and evaluation of Molecular Paternity Markers for an Ascidian. (With Dr C. Jones & Dr J. Bishop, MBA, Plymouth).  

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Publications

  • Cauwelier, E., Gilbey, J., Jones, CS., Noble, LR. & Verspoor, E. Asymmetrical viability in backcrosses between highly divergent populations of Atlantic salmon (Salmo salar), Article, 2012, Conservation Genetics, 13, 6, pp1665 - 1669, ISSN/ISBN: 1566-0621
  • Lockyer, AE., Emery, AM., Kane, RA., Walker, AJ., Mayer, CD., Mitta, G., Coustau, C., Adema, CM., Hanelt, B., Rollinson, D., Noble, LR. & Jones, CS. Early Differential Gene Expression in Haemocytes from Resistant and Susceptible Biomphalaria glabrata Strains in Response to Schistosoma mansoni, Article, 2012, PLoS ONE, 7, 12, ISSN/ISBN: 1932-6203
  • Noble, LR., Queiroz, NM., Humphries, NE., santos, a. & Sims, DW. Spatial Dynamics and Expanded Vertical Niche of Blue Sharks in Oceanographic Fronts Reveal Habitat Targets for Conservation, Article, 2012, PLoS ONE, 7, 2, ISSN/ISBN: 1932-6203
  • Gubili, C., bilgin, r., kalkan, e., Karhan, U., Jones, CS., Sims, DW., kabasakal, h., martin, a. & Noble, LR. Antipodean white sharks on a Mediterranean walkabout?, Article, 2011, Proceedings of the Royal Society of London. B, Biological Sciences, 278, 1712, pp1679 - 1686, ISSN/ISBN: 0962-8452
  • Cauwelier, E., Gilbey, J., Jones, CS., Noble, LR. & Verspoor, E. Genotypic and phenotypic correlates with proliferative kidney disease-induced mortality in Atlantic salmon, Article, 2010, Diseases of Aquatic Organisms, 89, 2, pp125 - 135, ISSN/ISBN: 0177-5103
  • Campbell, G., Noble, LR., Rollinson, D., Southgate, VR., Webster, JP. & Jones, CS. Low genetic diversity in a snail intermediate host (Biomphalaria pfeifferi Krass, 1848) and schistosomiasis transmission in the Senegal River Basin, Article, 2010, Molecular Ecology, 19, 2, pp241 - 256, ISSN/ISBN: 0962-1083
  • Thieltges, DW., Ferguson, MA., Jones, CS., Noble, LR. & Poulin, R. Biogeographical patterns of marine larval trematode parasites in two intermediate snail hosts in Europe, Article, 2009, Journal of Biogeography, 36, 8, pp1493 - 1501, ISSN/ISBN: 0305-0270
  • Gubili, C., Johnson, R., Gennari, E., Oosthuizen, WH., Kotze, D., Meyer, M., Sims, DW., Jones, CS. & Noble, LR. Concordance of genetic and fin photo identification in the great white shark, Carcharodon carcharias, off Mossel Bay, South Africa, Article, 2009, Marine Biology, 156, 10, pp2199 - 2207, ISSN/ISBN: 0025-3162
  • Thieltges, DW., Ferguson, MA., Jones, CS., Krakau, M., de Montaudouin, X., Noble, LR., Reise, K. & Poulin, R. Distance decay of similarity among parasite communities of three marine invertebrate hosts, Article, 2009, Oecologia, 160, 1, pp163 - 173, ISSN/ISBN: 0029-8549
  • Pade, NG., Queiroz, NM., Humphries, NE., Witt, MJ., Jones, CS., Noble, LR. & Sims, DW. First results from satellite-linked archival tagging of porbeagle shark, Lamna nasus, Article, 2009, Journal of Experimental Marine Biology and Ecology, 370, 1-2, pp64 - 74, ISSN/ISBN: 0022-0981
  • Searle, JB., Jones, CS., Gunduz, I., Scascitelli, M., Jones, EP., Herman, JS., Rambau, RV., Noble, LR., Berry, RJ., Gimenez, MD. & Johannesdottir, F. Of mice and (Viking?) men, Article, 2009, Proceedings of the Royal Society of London. B, Biological Sciences, 276, 1655, pp201 - 207, ISSN/ISBN: 0962-8452
  • Gilbey, J., Cauwelier, E., Jones, CS., Mclay, A., Noble, LR. & Verspoor, E. Size-dependent growth of individual Atlantic salmon Salmo salar alevins from hatch to first feeding, Article, 2009, Journal of Fish Biology, 75, 10, pp2820 - 2831, ISSN/ISBN: 0022-1112
  • Lockyer, AE., Spinks, J., Kane, RA., Hoffmann, KF., Fitzpatrick, JM., Rollinson, D., Noble, LR. & Jones, CS. Biomphalaria glabrata transcriptome, Article, 2008, BMC Genomics, 9 - 634, ISSN/ISBN: 1471-2164
  • Collins, CA., Olstad, K., Sterud, E., Jones, CS., Noble, LR., Mo, TA. & Cunningham, CO. Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris, Article, 2007, Fish & Shellfish Immunology, 23, 4, pp793 - 807, ISSN/ISBN: 1050-4648
  • Cauwelier, E., Jones, CS., Noble, LR. & Verspoor, E. The genetical architecture of outbreeding depression in Atlantic salmon, Article, 2006, Journal of Fish Biology, 69 - 240, ISSN/ISBN: 0022-1112
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. A High incidence of clustered microsatellite mutations revealed by parent-offpring analysis in an African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)., Article, 2005, Genetica, 124, pp77 - 83, ISSN/ISBN: 0016-6707
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. High levels of selfing are revealed by a parent-offspring analysis of the medically-important freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)., Article, 2005, Journal of Molluscan Studies, 71, pp175 - 180, ISSN/ISBN: 0260-1230
  • Lockyer, AE., Jones, CS., Noble, LR. & Rollinson, D. Trematodes and snails: an intimate association, Article, 2004, Canadian Journal Of Zoology/Revue Canadien De Zoologie, 82, 2, pp251 - 269, ISSN/ISBN: 0008-4301
  • Foucher, AFL., Bongers, T., Noble, LR. & Wilson, MJ. Assessment of nematode biodiversity using DGGE of 18S rDNA following extraction of nematodes from soil, Article, 2004, Soil Biology and Biochemistry, 36, 12, pp2027 - 2032, ISSN/ISBN: 0038-0717
  • Gow, J., Noble, LR., Rollinson, D., Mimpfoundi, R. & Jones, CS. Breeding system and demography shape population genetic structure across ecological and climatic zones in the African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata), intermediate host for schistosomes, Article, 2004, Molecular Ecology, 13, 11, pp3561 - 3573, ISSN/ISBN: 0962-1083
  • Pemberton, AJ., Sommerfeldt, AD., Wood, CA., Flint, HC., Noble, LR., Clarke, KR. & Bishop, JDD. Plant-like mating in an animal:sexual compatibility and allocation trade-offs in a simultaneous hermaphrodite with remote transfer of sperm, Article, 2004, Journal of Evolutionary Biology, 17, 3, pp506 - 518, ISSN/ISBN: 1010-061X
  • Maclean, L., Pardini, AT., Noble, LR., Bishop, JDD. & Jones, CS. Polymorphic dinucleotide microsatellite loci in the clonal ascidian Diplosoma listerianum: predominance of compound and highly interrupted imperfect repeats., Article, 2004, Molecular Ecology Notes, 4, 2, pp283 - 285, ISSN/ISBN: 1471-8278
  • Lockyer, AE., Noble, LR., Rollinson, D. & Jones, CS. Schistosoma mansoni: Resistant specific infection-induced gene expression in Biomphalaria glabrata identified by fluorescent-based differential display, Article, 2004, Experimental Parasitology, 107, 1-2, pp97 - 104, ISSN/ISBN: 0014-4894
  • Holland, JW., Gould, CRW., Jones, CS., Noble, LR. & Secombes, CJ. The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD), Article, 2003, Parasitology, 126, ppS95 - 102, ISSN/ISBN: 1469-8161
  • Gowland, F., Boyle, PR. & Noble, LR. Asymmetry in the embryonic chromatophore pattern of the squid Loligo forbesi (Mollusca: Cephalopoda): a proxy for developmental instability, Article, 2003, Journal of the Marine Biological Association of the United Kingdom, 83, 5, pp1101 - 1105, ISSN/ISBN: 0025-3154
  • Pemberton, AJ., Noble, LR. & Bishop, JDD. Frequency dependence in matings with water-borne sperm, Article, 2003, Journal of Evolutionary Biology, 16, 2, pp289 - 301, ISSN/ISBN: 1010-061X
  • Parsons, KM., Durban, J., Claridge, DE., Balcombe, KC., Noble, LR. & Thompson, PM. Kinship as a basis for alliance formation between male bottlenose dolphins, Tursiops truncatus, in the Bahamas, Article, 2003, Animal Behaviour, 66, pp185 - 194, ISSN/ISBN: 0003-3472
  • Emery, AM., Loxton, NJ., Stothard, R., Jones, CS., Spinks, J., Llewellyn-Hughes, J., Noble, LR. & Rollinson, D. Microsatellites in the freshwater snail Bulinus globosus (Gastropoda : Planorbidae) from Zanzibar, Article, 2003, Molecular Ecology Notes, 3, 1, pp108 - 110, ISSN/ISBN: 1471-8278
  • Noble, LR., Jones, CS., Lockyer, AE., Spinks, J. & Rollinson, D. Molluscs, molecules and man: Towards new perspectives in Host-parasite interactions and future control strategies, Other contribution, 2003
  • Holland, JW., Gould, CRW., Jones, CS., Noble, LR. & Secombes, CJ. The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD), Article, 2003, Parasitology, 126, ppS95 - 102, ISSN/ISBN: 0031-1820
  • Jones, CS., Lockyer, AE., Verspoor, E., Secombes, CJ. & Noble, LR. Towards selective breeding of Atlantic salmon for sea louse resistance: approaches to identify trait markers, Article, 2002, Pest Management Science, 58, pp559 - 568, ISSN/ISBN: 1526-498X
  • Martin, AP., Pardini, AT., Noble, LR. & Jones, CS. Conservation of a dinucleotide simple sequence repeat locus in sharks, Article, 2002, Molecular Phylogenetics and Evolution, 23, 2, pp205 - 213, ISSN/ISBN: 1055-7903
  • Hatton-Ellis, TW., Hope, A., Noble, LR. & Okamura, B. Genetic variation in a freshwater bryozoan, Article, 2002, Archiv für Hydrobiologie, 154, pp293 - 309, ISSN/ISBN: 0003-9136
  • Parsons, KM., Noble, LR., Reid, RJ. & Thompson, PM. Mitochondrial genetic diversity and population structuring of UK bottlenose dolphins (Tursiops truncatus): is the NE Scotland Population demographically and geographically isolated?, Article, 2002, Biological Conservation, 108, pp175 - 182, ISSN/ISBN: 0006-3207
  • Gowland, F., Boyle, PR. & Noble, LR. Morphological variation provides a method of estimating thermal niche in hatchlings of the squid Loligo forbesi (Mollusca: Cephalopoda), Article, 2002, Journal of Zoology, 258, pp505 - 513, ISSN/ISBN: 0952-8369
  • Emery, AM., Wilson, IJ., Craig, S., Boyle, PR. & Noble, LR. Assignment of paternity groups without access to parental genotypes: multiple mating and developmental plasticity in squid, Article, 2001, Molecular Ecology, 10, 5, pp1265 - 1278, ISSN/ISBN: 0962-1083
  • Boyle, PR., Noble, LR., Emery, A., Craig, S., Black, KD. & Overnell, J. Development and hatching in cephalopod eggs: A model system for partitioning environmental and genetic effects on development, Chapter, 2001, In: Animal Developmental Biology (eds. Atkinson,D.;Thorndyke,M.) BIOS Scientific Publishers Ltd
  • Lockyer, AE., Jones, CS., Noble, LR., Verspoor, E., Holland, JW. & Secombes, CJ. Isolation and characterisation of a putative interleukin 13 receptor a2 sequence from rainbow trout (Oncorhynchus mykiss), Article, 2001, Fish & Shellfish Immunology, 11, pp541 - 546, ISSN/ISBN: 1050-4648
  • Jones, CS., Lockyer, AE., Rollinson, D. & Noble, LR. Molecular approaches in the study of Biomphalaria glabrata - Schistosoma mansoni interactions: linkage analysis and gene expression profiling, Article, 2001, Parasitology, 123, ppS181 - S196, ISSN/ISBN: 0031-1820
  • Jones, CS., Lockyer, AE., Rollinson, D. & Noble, LR. Molecular approaches in the study of Biomphalaria glabrata - Schistosoma mansoni interactions: linkage analysis and gene expression profiling, Article, 2001, Parasitology, 123, ppS181 - S196, ISSN/ISBN: 1469-8161
  • Jones, CS., Rollinson, D., Mimpfoundi, R., Ouma, J. & Noble, LR. Molecular evolution of freshwater snail intermediate hosts within the Bulinus forskalii group, Article, 2001, Parasitology, 123, ppS277 - S292, ISSN/ISBN: 0031-1820
  • Jones, CS., Rollinson, D., Mimpfoundi, R., Ouma, J. & Noble, LR. Molecular evolution of freshwater snail intermediate hosts within the Bulinus forskalii group, Article, 2001, Parasitology, 123, ppS277 - S292, ISSN/ISBN: 1469-8161
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. Polymorphic microsatellites in the African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata), Article, 2001, Molecular Ecology Notes, 1, pp237 - 241, ISSN/ISBN: 1471-8278
  • Pardini, AT., Jones, CS., Noble, LR., Kreiser, B., Malcolm, H., Bruce, BD., Stevens, JD., Cliff, G., Scholl, MC., Francis, M., Duffy, CAJ. & Martin, AP. Sex-biased dispersal of great white sharks, Article, 2001, Nature, 412, pp139 - 140, ISSN/ISBN: 0028-0836
  • Webster, JP., Davies, CM., Ndamba, J., Jones, CS., Noble, LR. & Woolhouse, MM. Spatio-temporal population genetics of Biomphalaria pfeifferi in the Zimbabwean Highveld using RAPD markers, Article, 2001, American Journal of Tropical Medicine and Hygiene, 95, pp515 - 527, ISSN/ISBN: 0002-9637
  • Campbell, G., Jones, CS., Lockyer, AE., Hughes, S., Brown, D., Noble, LR. & Rollinson, D. Molecular evidence supports an African affinity of the Neotropical freshwater gastropod, Biomphalaria glabrata, Say 1818, an intermediate host for Schistosoma mansoni, Article, 2000, Proceedings of the Royal Society of London. B, Biological Sciences, 267, pp2351 - 2358, ISSN/ISBN: 0962-8452
  • Bishop, JDD., Pemberton, AJ. & Noble, LR. Sperm precedence in a novel context, Article, 2000, Proceedings of the Royal Society of London. B, Biological Sciences, 267, pp1107 - 1113, ISSN/ISBN: 0962-8452
  • Hatton-Ellis, TW., Noble, LR. & Okamura, B. Genetic variation in a freshwater bryozoan. I: Populations in the Thames basin, UK, Article, 1998, Molecular Ecology, 7, 11, pp1575 - 1585, ISSN/ISBN: 0962-1083
  • Rollinson, D., Stothard, JR., Jones, CS., Lockyer, AE., de Souza, CP. & Noble, LR. Molecular characterisation of intermediate snail hosts and the search for resistance genes, Article, 1998, Memorias do Instituto Oswaldo Cruz, 93, pp111 - 116, ISSN/ISBN: 0074-0276
  • Goostrey, A., Carss, DN., Noble, LR. & Piertney, SB. Population introgression and differentiation in the great cormorant Phalacrocorax carbo in Europe, Article, 1998, Molecular Ecology, 7, 3, pp329 - 338, ISSN/ISBN: 0962-1083
  • Jones, CS., Noble, LR., Lockyer, AE., Brown, DS. & Rollinson, D. Species-specific primers discriminate schistosome intermediate hosts: unambiguous PCR diagnosis of Bulinus forskalii group taxa (Gastropoda: Planorbidae), Article, 1997, Molecular Ecology, 6, 9, pp843 - 849, ISSN/ISBN: 0962-1083
  • Noble, LR. & Jones, CS. A molecular and ecological investigation of the large arionid slugs of North-West Europe: The potential for new pests, Chapter, 1996, Ecology of Agricultural Pests, pp93 - 131
  • Bishop, JDD., Jones, CS. & Noble, LR. Female control of paternity in the internally fertilizing compound ascidian Diplosoma listerianum .2. Investigation of male mating success using RAPD markers, Article, 1996, Proceedings of the Royal Society of London. B, Biological Sciences, 263, 1369, pp401 - 407, ISSN/ISBN: 0962-8452
  • Rollinson, D., Jones, CS. & Noble, LR. New approaches to the identification of medically important freshwater snails associated with irrigated agriculture in Africa, Article, 1996, SLUGS, 66 - 312, ISSN/ISBN: 0306-3941
  • Vernon, JG., Okamura, B., Jones, CS. & Noble, LR. Temporal patterns of clonality and parasitism in a population of freshwater bryozoans, Article, 1996, Proceedings of the Royal Society of London. B, Biological Sciences, 263, 1375, pp1313 - 1318, ISSN/ISBN: 0962-8452
  • Jones, CS., Noble, LR., JONES, JS., TEGELSTROM, H., TRIGGS, GS. & BERRY, RJ. DIFFERENTIAL MALE GENETIC SUCCESS DETERMINES GENE FLOW IN AN EXPERIMENTALLY MANIPULATED MOUSE-POPULATION, Article, 1995, Proceedings of the Royal Society of London. B, Biological Sciences, 260, 1359, pp251 - 256, ISSN/ISBN: 0962-8452
  • VERNON, JG., Jones, CS. & Noble, LR. RANDOM AMPLIFIED POLYMORPHIC DNA (RAPD) MARKERS REVEAL CROSS-FERTILIZATION IN BIOMPHALARIA-GLABRATA (PULMONATA, BASOMMATOPHORA), Article, 1995, Journal of Molluscan Studies, 61, pp455 - 465, ISSN/ISBN: 0260-1230
  • Jones, CS., OKAMURA, B. & Noble, LR. PARENT AND LARVAL RAPD FINGERPRINTS REVEAL OUTCROSSING IN FRESH-WATER BRYOZOANS, Article, 1994, Molecular Ecology, 3, 3, pp193 - 199, ISSN/ISBN: 0962-1083
  • OKAMURA, B., Jones, CS. & Noble, LR. RANDOMLY AMPLIFIED POLYMORPHIC DNA ANALYSIS OF CLONAL POPULATION-STRUCTURE AND GEOGRAPHIC-VARIATION IN A FRESH-WATER BRYOZOAN, Article, 1993, Proceedings of the Royal Society of London. B, Biological Sciences, 253, 1337, pp147 - 154, ISSN/ISBN: 0962-8452
  • Noble, LR. DIFFERENTIATION OF LARGE ARIONID SLUGS (MOLLUSCA, PULMONATA) USING LIGULA MORPHOLOGY, Article, 1992, Zoologica Scripta, 21, 3, pp255 - 263, ISSN/ISBN: 0300-3256
  • BERRY, RJ., TRIGGS, GS., KING, P., NASH, HR. & Noble, LR. HYBRIDIZATION AND GENE FLOW IN HOUSE MICE INTRODUCED INTO AN EXISTING POPULATION ON AN ISLAND, Article, 1991, Journal of Zoology, 225, pp615 - 632, ISSN/ISBN: 0952-8369

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