Dr Lynda CONSTABLE

Dr Lynda CONSTABLE The University of Aberdeen School of Medicine & Dentistry Trial Manager work +44 (0)1224 438174 pref l.constable@abdn.ac.uk pref Centre for Healthcare Randomised Trials (CHaRT) Health Services Research Unit University of Aberdeen Health Sciences Building Foresterhill ABERDEEN AB25 2ZD

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Biography

Lynda joined the unit in 2012 as a Trial Manager for the VUE trial, two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse.

Lynda graduated from the Robert Gordon University with a BSc in Biosciences and Chemistry and also a PhD in Cancer cell and Molecular biology.

Prior to joining the unit, Lynda worked as a Postdoctoral Research Fellow at Aberdeen University on a range of projects with an emphasis on cancer biomarkers.

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Current Research

VUE Trial

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Qualifications

PhD Cell and Molecular Biology

PgCert Research Methods

BSc(Hons) Applied Biosciences and Chemistry

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Publications

Contributions to Journals

Articles

• Ralton, LD. & Murray, GI. (2011). 'The use of formalin fixed wax embedded tissue for proteomic analysis'. Journal of Clinical Pathology, vol 64, pp. 297-302.
  [Online] DOI: 10.1136/jcp.2010.086835
• O'Dwyer, D., Ralton, LD., O'Shea, A. & Murray, GI. (2011). 'The proteomics of colorectal cancer: Identification of a protein signature associated with prognosis'. PLoS ONE, vol 6, no. 11.
  [Online] DOI: 10.1371/journal.pone.0027718
• Bestwick, CS., Ralton, LD., Milne, L., Lin, PKT. & Duthie, SJ. (2011). 'The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells'. Cell biology and toxicology, vol 27, no. 6, pp. 455-463.
  [Online] DOI: 10.1007/s10565-011-9199-1
• Ralton, LD. & Murray, GI. (2010). 'Biomarkers for Colorectal Cancer: Identification Through Proteomics'. Current Proteomics, vol 7, no. 3, pp. 212-221.
  [Online] DOI: 10.2174/157016410792928116
• Ralton, LD., Bestwick, C., Milne, L., Duthie, SJ. & Lin, PKT. (2009). 'Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells'. Chemico-Biological Interactions, vol 177, no. 1, pp. 1-6.
  [Online] DOI: 10.1016/j.cbi.2008.09.033
• Oliveira, J., Ralton, LD., Tavares, J., Codeiro-da-Silva, A., Bestwick, C., McPherson, A. & Lin, PKT. (2007). 'The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum'. Bioorganic & Medicinal Chemistry, vol 15, no. 1, pp. 541-545.
  [Online] DOI: 10.1016/j.bmc.2006.09.031
• Ralton, L., Bestwick, C. & Kong, PTL. (2007). 'Polyamine Analogues and Derivatives as Potential Anticancer Agents'. Current Bioactive Compounds, vol 3, no. 3, pp. 179-191.
• Dance, AM., Ralton, LD., Fuller, Z., Milne, L., Duthie, SJ., Bestwick, C. & Lin, PKT. (2005). 'Synthesis and biological activities of bisnaphthalimido polyamines derivatives'. Biochemical Pharmacology, vol 69, no. 1, pp. 19-27.
  [Online] DOI: 10.1016/j.bcp.2004.09.020

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