Professor John Norrie

Professor John Norrie The University of Aberdeen School of Medicine & Dentistry CHART Director work +44 (0)1224 438149 work fax +44 (0)1224 554580

CHART Director

Personal Details

Telephone: +44 (0)1224 438149
Fax: +44 (0)1224 554580
Email: j.norrie@abdn.ac.uk
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Biography

I graduated from Kings College London in Mathematics in 1985. After 3 years research at University College London, I took a Masters in Statistics at the London School of Economics in 1989. I joined the Robertson Centre for Biostatistics at Glasgow University as a statistician in 1990, the last 4 years as Assistant Director, before moving to the Health Services Research Unit as Trials Director in September 2003. My research interests generally involve the application of statistical methods to the design, conduct (e.g. sequential monitoring), analysis (e.g. risk modelling) and reporting of randomised clinical trials. 


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Current Research

CHaRT was formally launched in November 2004, and has developed a portfolio of RCT. I am leading the 4 year £1.2 million Scottish Funding Council Strategic Research Development Grant ‘The Scottish Collaboration of Trialists (SCoT)’ in collaboration with academic trials units at the Universities of Dundee, Edinburgh and Glasgow, to support excellence and build capacity for multicentre clinical network based RCT led from Scotland. SCoT started in November 2005. 


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Qualifications

BSc (Hons) Mathematics
MSc (Econ) Statistics


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Publications

Contributions to Journals

Articles

  • Glazener, C., Boachie, C., Buckley, B., Cochran, C., Dorey, G., Grant, A., Hagen, S., Kilonzo, M., McDonald, A., McPherson, G., Moore, K., Norrie, J., Ramsay, C., Vale, L. & N'Dow, J. (2011). 'Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trials'. Lancet, vol 378, no. 9788, pp. 328-337.
    [Online] DOI: 10.1016/S0140-6736(11)60751-4
    [Online] AURA: Glazener_2011.pdf
  • Cuthbertson, B., Campbell, MK., Stott, S., Vale, LD., Norrie, JD., Kinsella, J., Cook, JA., Brittenden, J., Grant, AM. & Foccus Study Group (2010). 'A pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol'. Trials, vol 11, no. 41.
    [Online] DOI: 10.1186/1745-6215-11-41
    [Online] AURA: CuthbertsonTrials2010.pdf
  • Campbell, MK., Skea, ZC., Sutherland, AG., Cuthbertson, B., Entwistle, V., McDonald, AM., Norrie, JD., Carlson, RV., Bridgman, S. & KORAL study group (2010). 'Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study)'. Health Technology Assessment, vol 14, no. 5, pp. 1-180.
    [Online] DOI: 10.3310/hta14040
    [Online] AURA: Campbell2010.pdf
  • Cook, JA., Ramsay, CR. & Norrie, JD. (2008). 'Recruitment to publicly funded trials: Are surgical trials really different?'. Contemporary Clinical Trials, vol 29, no. 5, pp. 631-634.
    [Online] DOI: 10.1016/j.cct.2008.02.005
  • Cuthbertson, B., Rattray, JE., Johnston, M., Wildsmith, JAW., Wilson, E., Hernandez, RA., Ramsay, CR., Hull, AM., Norrie, JD., Campbell, MK. & PRACTICAL Study Group (2007). 'A Pragmatic Randomised, Controlled Trial of Intensive Care follow up programmes in improving Longer-term outcomes from critical illness: the PRACTICAL study'. BMC Health Services Research, vol 7.
    [Online] DOI: 10.1186/1472-6963-7-116
  • Andrews, PJD., Avenell, A., Noble, DW., Campbell, MK., Battison, CG., Croal, BL., Simpson, WG., Norrie, JD., Vale, LD., Cook, J., De Verteuil, R., Milne, AC. & Trials Management Group (2007). 'Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients: Protocol version 9, 19 February 2007 known as SIGNET (Scottish Intensive Care Glutamine or seleNium Evaluative Trial)'. Trials, vol 8.
    [Online] DOI: 10.1186/1745-6215-8-25
  • Bower, DJ., Barry, N., Reid, M. & Norrie, JD. (2005). 'Devising and implementing e-health application in the UK's National Health Service'. Journal of Health Communication, vol 10, no. 8, pp. 733-750.
    [Online] DOI: 10.1080/10810730500326732
  • Berry, C., Norrie, JD. & McMurray, J. (2005). 'Ximelagatran compared with Warfarin for the prevention of stroke and systemic embolism. An imputed placebo analysis'. Cardiovascular Drugs and Therapy, vol 19, no. 2, pp. 149-151.
    [Online] DOI: 10.1007/s10557-005-3405-4
  • Griffith, D., Hamilton, K., Norrie, JD. & Isles, CG. (2005). 'Early and late mortality after myocardial infarction in men and women: prospective observational study'. Heart, vol 91, no. 3, pp. 305-307.
    [Online] DOI: 10.1136/hrt.2003.033035
  • Berry, C., Hogg, K., Norrie, JD., Stevenson, K., Brett, M. & McMurray, J. (2005). 'Heart failure with preserved left ventricular systolic function: a hospital cohort study'. Heart, vol 91, no. 7, pp. 907-913.
    [Online] DOI: 10.1136/hrt.2004.041996
  • Birnie, D., Vickers, L., Norrie, JD. & Cobbe, SM. (2005). 'Elevated titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute chest pain'. Heart, vol 91, no. 9, pp. 1148-1153.
    [Online] DOI: 10.1136/hrt.2004.040485
  • Mckinnon, B., Deighan, CJ., Norrie, JD., Boulton-Jones, JM., Sattar, N. & Fox, JG. (2005). 'The link between circulating markers of endothelial function and proteinuria in patients with primary glomerulonephritis'. Clinical Nephrology, vol 63, no. 3, pp. 173-180.
  • Balachandran, KP., Berry, C., Norrie, JD., Vallance, BD., Malekianpour, M., Gilbert, TJ., Pell, ACH. & Oldroyd, KG. (2004). 'Relation between coronary derived collateral flow, myocardial perfusion grade, and outcome in left ventricular function after rescue percutaneous coronary intervention'. Heart, vol 90, no. 12, pp. 1450-1454.
    [Online] DOI: 10.1136/hrt.2003.023606
  • Wellwood, I., Egerton, T., Langhorne, P., Norrie, JD. & GAPS Grp (2004). 'Can augmented physiotherapy input enhance recovery of mobility after stroke? A randomised controlled trial'. Clinical Rehabilitation, vol 18, no. 5, pp. 529-537.
    [Online] DOI: 10.1191/0269215504cr768oa
  • Jhund, PS., Dawson, N., Davie, AP., Norrie, JD., O'Kane, KPJ. & McMurray, JJV. (2004). '17 beta oestradiol does not attenuate the response to angiotensin I and II during long term therapy in postmenstral women'. Cardiovascular Drugs and Therapy, vol 18, no. 1, pp. 31-36.
    [Online] DOI: 10.1023/B:CARD.0000025753.20686.2b
  • Freeman, DJ., McManus, F., Brown, EA., Cherry, L. & Norrie, JD. (2004). 'Short and long term changes in plasma inflammatory markters associated with pre-eclampsia'. Hypertension, vol 44, no. 5, pp. 708-714.
    [Online] DOI: 10.1161/01.HYP.0000143849.67254.ca
  • Hunter, R., McLean, J., Peck, D., Pullen, I., Greenfield, A., McArthur, W., Quinn, C., Eaglesham, J., Hagen, S. & Norrie, JD. (2004). 'The Scottish 700 Outcomes Study: A comparative evaluation of the Health of the Nation Outcome Scale (HoNOS), the Avon Mental Health Measure (AVON), and an idiographic scale (OPUS) in adult mental health'. Journal of Mental Health, vol 13, no. 1, pp. 93-105.
    [Online] DOI: 10.1080/09638230410001654594
  • Bowie, P., McKay, J., Norrie, JD. & Lough, M. (2004). 'Awareness and analysis of a significant event by general practitioners: a cross sectional survey'. Quality and Safety in Health Care, vol 13, no. 2, pp. 102-107.
    [Online] DOI: 10.1136/qshc.2003.006734
  • MacFarlane, PW., Norrie, JD. & WOSCOPS Executive Committtee (2004). 'Looking for prognostic information in the ST-T segment - is it really worth it?'. Journal of Electrocardiography, vol 3, pp. 209-213.
    [Online] DOI: 10.1016/j.jelectrocard.2004.08.059
  • Smith, LN., Norrie, JD., Kerr, SM., Lawrence, IM., Langhorne, P. & Lees, KR. (2004). 'Impact and influences on caregiver outcomes at one-year post-stroke'. Cerebrovascular Diseases, vol 18, pp. 145-153.
    [Online] DOI: 10.1159/000079268
  • Lees, KR., Muir, KW., Ford, I., Reid, J., Mendelow, AD., Sandercock, P., Bath, PMW., Chen, C., Davis, S., Phillips, SJ., Saver, J., Vanhooren, G., Forbes, C., Murray, G., Bone, I., Norrie, JD., Kean, S., Robertson, M., Murray, H., Mcilvenna, Y., Gardner, A., Bradford, A., Fenton, J., Sakhri, A., Rodger, M., Sanmuganathan, P., Milia, P., Chong, V., Teasdale, E. & IMAGES Study Investigators (2004). 'Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial'. Lancet, vol 363, no. 9407, pp. 439-445.
    [Online] DOI: 10.1016/S0140-6736(04)15490-1
  • Daly, C., Norrie, JD., Murdoch, DL., Ford, I., Dargie, HJ., Fox, K. & TIBET study Grp (2003). 'The value of routine non-invasive tests to predict clinical outcome in stable angina'. European Heart Journal, vol 24, no. 6, pp. 534-542.
    [Online] DOI: 10.1016/S0195-668X(02)00820-5
  • McFadzean, E., Isles, CG., Moffat, J., Norrie, JD. & Stewart, DL. (2003). 'Is there a role for a prescribing pharmacist in preventing prescribing errors in a medical admission unit?'. Pharmaceutical Journal, vol 270, pp. 896-899.
  • MacKenzie, S., Norrie, JD., Vella, M., Drummond, I., Walker, AE. & Molloy, R. (2003). 'Randomized clinical trial comparing consultant-led or open access investigation for large bowel symptoms'. British Journal of Surgery, vol 90, no. 8, pp. 941-947.
    [Online] DOI: 10.1002/bjs.4212
  • Gumley, A., O'Grady, M., McNay, L., Reilly, J., Power, K. & Norrie, JD. (2003). 'Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy'. Psychological Medicine, vol 33, no. 3, pp. 419-431.
    [Online] DOI: 10.1017/S0033291703007323
  • Hughes, M., MacKirdy, FN., Ross, J., Norrie, JD., Grant, IS. & Scottish Intensive Care Soc (2003). 'Acute respiratory distress syndrome: an audit of incidence and outcome in Scottish intensive care units'. Anaesthesia, vol 58, no. 9, pp. 838-845.
    [Online] DOI: 10.1046/j.1365-2044.2003.03287.x
  • Stirling, C., Houston, J., Robertson, S., Boyle, J., Allan, A., Norrie, JD. & Isles, CG. (2003). 'Diarrhoea, vomiting and ACE inhibitors: an important cause of acute renal failure'. Journal of Human Hypertension, vol 17, pp. 419-423.
    [Online] DOI: 10.1038/sj.jhh.1001571
  • Barron, FA., Ball, DR., Jefferson, P. & Norrie, JD. (2003). ''Airway Alerts'. How UK anaesthetists organise, document and communicate difficult airway management'. Anaesthesia, vol 58, no. 1, pp. 73-77.
    [Online] DOI: 10.1046/j.1365-2044.2003.02788_6.x
  • Robertson, S., Newbigging, K., Isles, CG., Brammah, A., Allan, A. & Norrie, JD. (2002). 'High incidence of renal failure requiring short-term dialysis: a prospective observational study'. QJM, vol 95, no. 9, pp. 585-590.
    [Online] DOI: 10.1093/qjmed/95.9.585
  • Blauw, GJ., Murphy, MB., Bollen, LEM., Buckley, BM., Cobbe, SM., Ford, I., Gaw, A., Hyland, M., Jukema, JW., Kamper, AM., MacFarlane, PW., Meinders, AE., Norrie, JD., Packard, CJ., Perry, IJ., Stott, DJ., Sweeney, BJ., Twomey, G., Westendorp, RGJ. & PROPSER Study Grp (2002). 'Pravastatin in elderly individuals at risk of vascular disease (PROSPER) : a randomised controlled trial'. Lancet, vol 360, no. 9346, pp. 1623-1630.
    [Online] DOI: 10.1016/S0140-6736(02)11600-X
  • Freeman, D., Norrie, JD., Caslake, MJ. & W Scotland Coronary Prevention Stu (2002). 'C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study'. Diabetes, vol 51, no. 5, pp. 1596-1600.
  • Ford, I. & Norrie, JD. (2002). 'A prospective study of pravastatin in the elderly at risk PROSPER: Screening experience and baseline characteristics'. Current Controlled Trials in Cardiovascular Medicine, vol 3.
    [Online] DOI: 10.1186/1468-6708-3-8
  • Houx, PJ. & Norrie, JD. (2002). 'Testing cognitive function in elderly populations: the PROSPER study'. Journal of Neurology, Neurosurgery & Psychiatry, vol 73, no. 4, pp. 385-389.
    [Online] DOI: 10.1136/jnnp.73.4.385
  • Ford, I. & Norrie, JD. (2002). 'The role of covariates in estimating treatment effects and risk in long-term clinical trials'. Statistics in Medicine, vol 21, pp. 2899-2908.
    [Online] DOI: 10.1002/sim.1294
  • Workman, AJ., Kane, KA., Russell, JA., Norrie, JD. & Rankin, AC. (2002). 'Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling'. Cardiovascular Research, vol 58, no. 3, pp. 518-525.
    [Online] DOI: 10.1016/S0008-6363(03)00263-3
  • Scoular, A., Norrie, JD., Gillespie, G., Mir, N. & Carman, WF. (2002). 'Longitudinal stud of genital infection by herpes simplex virus type 1 in western Scotland over 15 years'. British Medical Journal, vol 324, pp. 1366-1367.
    [Online] DOI: 10.1136/bmj.324.7350.1366
  • Liaquat, I., Dunn, LT., Nicoll, JAR., Teasdale, GM. & Norrie, JD. (2002). 'Effect of apolipoprotein E genotype on hematoma volume after trauma'. Journal of Neurology, Neurosurgery & Psychiatry, vol 96, no. 1, pp. 90-96.
    [Online] DOI: 10.3171/jns.2002.96.1.0090
  • Hussien, M., Lee, S., Malyon, A., Norrie, JD. & Webster, M. (2001). 'The impact of intraoperative hypotension on the development of wound haematoma after breast reduction'. British Journal of Plastic Surgery, vol 54, no. 6, pp. 517-522.
    [Online] DOI: 10.1054/bjps.2001.3662
  • Bannerman, A., Hamilton, K. & Norrie, JD. (2001). 'Myocardial infarction in men and women under 65 years of age: No evidence of gender bias'. Scottish Medical Journal, vol 46, no. 3, pp. 73-78.
  • Freeman, D., Norrie, JD., Sattar, N., Neely, RDG., Cobbe, SM., Ford, I., Isles, CG., Lorimer, AR., MacFarlane, PW., McKillop, JH., Packard, CJ. & Gaw, A. (2001). 'Pravastatin and the development of diabetes mellitus – Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study'. Circulation, vol 103, no. 3, pp. 357-362.
  • Scott, NB., Turfrey, DJ. & Norrie, JD. (2001). 'A prospective ransomised study of the potential benefits of thoracic epidural anesthesia and analgesia in patients undergoing coronary bypass grafting'. Anesthesia and Analgesia, vol 93, no. 3, pp. 528-535.
    [Online] DOI: 10.1097/00000539-200109000-00003
  • Berry, C., Montgomery, C., Sattar, N., Norrie, JD. & Weaver, LT. (2001). 'Fatty acid status of women of reproductive age'. European Journal of Clinical Nutrition, vol 55, no. 7, pp. 518-524.
    [Online] DOI: 10.1038/sj.ejcn.1601176
  • Pell, JP., Walsh, D. & Norrie, JD. (2001). 'Outcomes following coronary artery bypass grafting and percutaneous transluminal coronary angioplasty in the stent era: a prospective study of all 9890 consecutive patients operated on in Scotland over a two year period'. Heart, vol 85, no. 6, pp. 662-666.
    [Online] DOI: 10.1136/heart.85.6.662
  • Blue, L. & Norrie, JD. (2001). 'Randomised controlled trial of specialist nurse intervention in heart failure'. British Medical Journal, vol 323, pp. 715-718.
    [Online] DOI: 10.1136/bmj.323.7315.715
  • Jhund, PS., Dawson, N., Davie, AP., Sattar, N., Norrie, JD., O'Kane, KPJ. & McMurray, JJV. (2001). 'Attenuation of endothelin-1 induced vasoconstriction by 17 beta estradiol is not sustained during long-term therapy in postmenopausal women with coronary heart disease'. Journal of the American College of Cardiology, vol 37, no. 5, pp. 1367-1373.
    [Online] DOI: 10.1016/S0735-1097(01)01168-8
  • Hughes, M., MacKirdy, FN., Norrie, JD. & Grant, IS. (2001). 'Outcome of long-stay intensive care patients'. Intensive Care Medicine, vol 27, no. 4, pp. 779-782.
    [Online] DOI: 10.1007/s001340100896
  • Berry, C., Norrie, JD., McMurray, JJV. & Norrie, JD. (2001). 'Are angiotensin II receptor blockers more efficious than placebo in heart failure'. American Journal of Cardiology, vol 87, no. 5, pp. 606-607.
    [Online] DOI: 10.1016/S0002-9149(00)01439-9
  • Burton, CD., Hamilton, KES., Isles, CG. & Norrie, JD. (2001). 'Warfarin for nonvalvular atrial fibrillation in primary care - another example of age paradox?'. Journal of Cardiovascular Risk, vol 323, pp. 715-718.

Books and Reports

Commissioned Reports

  • Cuthbertson, B., Campbell, MK., Stott, S., Vale, LD., Norrie, JDT., Kinsella, J., Cook, JA., Brittenden, J., Grant, AM., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, GC., McDonald, AM., Cotton, SC., Elders, AS., MacLennan, GS., Boyers, D. & Hernández, RA. (2010). 'Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery'. Chief Scientist Office, Edinburgh, United Kingdom.
  • Lois, N., Burr, J., Norrie, JDT., McDonald, AM., Cook, JA., Boachie, C., Ternent, L., McPherson, GC. & Vale, LD. (2009). 'Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole'. Focus on Research, no. CZH/4/235, Chief Scientist Office, Edinburgh, United Kingdom.

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