Dr Jonathan Cook

Dr Jonathan Cook The University of Aberdeen School of Medicine & Dentistry Research Fellow work +44 (0)1224 438166 work fax +44 (0)1224 554580

Methodologist

Personal Details

Telephone: +44 (0)1224 438166
Fax: +44 (0)1224 554580
Email: j.a.cook@abdn.ac.uk
hCard

Jump to:

Biography

Jonathan Cook joined the Unit in October 2000 as a PhD student conducting research on the statistical assessment of learning curve effects in randomised controlled trials. He graduated from the University of Aberdeen earlier that year in Statistics.  Upon completed of his doctoral research he became a staff member in the Unit working as a Statistical research assistant and later research fellow. He contributed to numerous projects including both trials and systematic reviews in a variety of clinical areas. In August 2007, he started a MRC UK Fellowship focusing upon methodology related the design, conduct and analysis of surgical randomised trials. As part of the fellowship, he spent 12 months working at the Ottawa Hospital Research Institute in Canada before returned to the Unit in August 2009 to take up a Methodologist position. He lead a programme of methodological research within the Unit and has responsibility for methodological research within the Unit.


^ top

Research Interests

Surgical trial methodology and statistical methods for meta-analysis

 


^ top

Current Research

 


^ top

External Responsibilities


^ top

Qualifications

  • BSc Statistics
  • Grad Stat 
  • PhD Public Health Medicine

^ top

Publications

Contributions to Journals

Articles

  • Mowatt, G., N'Dow, J., Vale, L., Nabi, G., Boachie, C., Cook, JA., Fraser, C., Griffiths, TRL. & Aberdeen Technology Assessment Review (TAR) Group (2011). 'Photodynamic diagnosis of bladder cancer compared with white light cystoscopy: Systematic review and meta-analysis'. International Journal of Technology Assessment in Health Care, vol 27, no. 1, pp. 3-10.
    [Online] DOI: 10.1017/S0266462310001364
    [Online] AURA: Mowatt 2010.pdf
  • Cuthbertson, BH., Campbell, MK., Stott, SA., Elders, A., Hernández, R., Boyers, D., Norrie, J., Kinsella, J., Brittenden, J., Cook, J., Rae, D., Cotton, SC., Alcorn, D., Addison, J., Grant, A. & the FOCCUS study group (2011). 'A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study'. Critical Care, vol 15, no. 6, pp. R296.
    [Online] DOI: 10.1186/cc10592
    [Online] AURA: Cuthbertson_2011.pdf
  • McKenzie, L., De Verteuil, R., Cook, JA., Shanmugam, V., Loudon, M., Watson, A. & Vale, LD. (2010). 'Economic evaluation of the treatment of grade II haemorrhoids: a comparison of stapled haemorrhoidopexy and rubber band ligation'. Colorectal Disease, vol 12, no. 6, pp. 587-593.
    [Online] DOI: 10.1111/j.1463-1318.2009.01889.x
    [Online] AURA: McKenzie 2010.pdf
  • Imamura, M., Abrams, P., Bain, C., Buckley, B., Cardozo, L., Cody, DJ., Cook, JA., Eustice, S., Glazener, CMA., Grant, AM., Hay-Smith, EJC., Hislop, JM., Jenkinson, DJ., Kilonzo, MM., Nabi, G., N'Dow, JM.O, Pickard, R., Ternent, L., Wallace, SA., Wardle, J., Zhu, S. & Vale, LD. (2010). 'Systematic review and economic modelling of the effectiveness and efficiency of non-surgical treatments for women with stress urinary incontinence'. Health Technology Assessment, vol 14, no. 40.
    [Online] DOI: 10.3310/hta14400
    [Online] AURA: Imamura 2010.pdf
  • Mowatt, G., Zhu, S., Kilonzo, MM., Boachie, C., Fraser, CM., Griffiths, TRL., N'Dow, JMO., Nabi, G., Cook, JA. & Vale, LD. (2010). 'Systematic review of the clinical and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer'. Health Technology Assessment, vol 14, no. 4, pp. 1-353.
    [Online] DOI: 10.3310/hta14040
    [Online] AURA: Mowatt2010.pdf
  • Cuthbertson, B., Campbell, MK., Stott, S., Vale, LD., Norrie, JD., Kinsella, J., Cook, JA., Brittenden, J., Grant, AM. & Foccus Study Group (2010). 'A pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol'. Trials, vol 11, no. 41.
    [Online] DOI: 10.1186/1745-6215-11-41
    [Online] AURA: CuthbertsonTrials2010.pdf
  • Imamura, M., Cook, JA., MacLennan, S., N'Dow, JMO., Dahm, P. & Evidence-Based Urology Working Group (2010). 'Evidence-based urology in practice: heterogeneity in a systematic review meta-analysis'. BJU International, vol 105, no. 6, pp. 770-773.
    [Online] AURA: Imamura 2010.pdf
  • Shanmugam, V., Muthukumarasamy, G., Cook, JA., Vale, LD., Watson, A. & Loudon, MA. (in press). 'Randomised controlled trial comparing rubber band ligation with stapled haemorrhoidopexy for grade II circumferential haemorrhoids: long term results'. Colorectal Disease, vol 12, no. 6, pp. 579-586.
    [Online] DOI: 10.1111/j.1463-1318.2009.01841.x
    [Online] AURA: Shanmugam 2010.pdf
  • Kilonzo, MM., Sambrook, AM., Cook, JA., Campbell, MK. & Cooper, KG. (2010). 'A Cost-Utility Analysis of Microwave Endometrial Ablation versus Thermal Balloon Endometrial Ablation'. Value in Health, vol 13, no. 5, pp. 528-534.
    [Online] DOI: 10.1111/j.1524-4733.2010.00704.x
  • Lois, N., Burr, JM., Norrie, J., Vale, L., Cook, JA., McDonald, A., Boachie, C., Ternent, L. & McPherson, G. (2010). 'Internal limiting membrane peeling versus no peeling for idiopathic full thickness macular hole: A pragmatic randomised controlled trial'. Investigative Ophthalmology & Visual Science.
    [Online] DOI: 10.1167/iovs.10-6287
    [Online] AURA: Lois 2010.pdf
  • McNeill, AS., Nabi, G., McLornan, L., Cook, J., Bollina, P. & Stolzenberg, J. (2010). 'Endoscopic extraperitoneal radical prostatectomy: critical analysis of outcomes and learning curve'. BJU International, vol 106, no. 10, pp. 1537-1543.
    [Online] DOI: 10.1111/j.1464-410X.2010.09322.x
  • Treweek, S., Mitchell, E., Pitkethly, M., Cook, J., Kjeldstrøm, M., Taskila, T., Johansen, M., Sullivan, F., Wilson, S., Jackson, C. & Jones, R. (2010). 'Strategies to improve recruitment to randomised controlled trials'. Cochrane Database of Systematic Reviews, no. 1, pp. MR000013.
    [Online] DOI: 10.1002/14651858.MR000013.pub4
  • Sambrook, A., Cooper, K., Campbell, MK. & Cook, JA. (2009). 'Clinical outcomes from a randomised comparison of Microwave Endometrial Ablation with Thermal Balloon endometrial ablation for the treatment of heavy menstrual bleeding'. BJOG-An International Journal of Obstetrics and Gynaecology, vol 116, no. 8, pp. 1038-1045.
    [Online] DOI: 10.1111/j.1471-0528.2009.02181.x
    [Online] AURA: Sambrook 2009.pdf
  • Ergina, PL., Cook, JA., Blazeby, JM., Boutron, I., Clavien, P., Reeves, BC., Seiler, CM. & Balliol Collaboration (2009). 'Challenges in evaluating surgical innovation'. Lancet, vol 374, no. 9695, pp. 1097-1104.
    [Online] DOI: 10.1016/S0140-6736(09)61086-2
  • Cook, JA. (2009). 'The challenges faced in the design, conduct and analysis of surgical randomised controlled trials'. Trials, vol 10, no. 9.
    [Online] DOI: 10.1186/1745-6215-10-9
  • Barkun, JS., Aronson, JK., Feldman, LS., Maddern, GJ., Strasberg, SM., Altman, DG., Barkun, JS., Blazeby, JM., Boutron, IC., Campbell, SB., Clavien, P., Cook, JA., Ergina, PL., Flum, DR., Glasziou, P., Marshall, J., McCulloch, P., Nicholl, J., Reeves, BC., Seiler, CM., Meakins, JL., Ashby, D., Black, N., Bunker, J., Burton, M., Campbell, MK., Chalkidou, K., Chalmers, I., de Leval, M., Deeks, J., Grant, AM., Gray, M., Greenhalgh, R., Jenicek, M., Kehoe, S., Lilford, R., Littlejohns, P., Loke, Y., Madhock, R., McPherson, DK., Rothwell, P., Summerskill, B., Taggart, D., Tekkis, P., Thompson, M., Treasure, T., Trohler, U., Vandenbroucke, J. & Balliol Collaboration (2009). 'Evaluation and stages of surgical innovations'. Lancet, vol 374, no. 9695, pp. 1089-1096.
    [Online] DOI: 10.1016/S0140-6736(09)61083-7
  • McCulloch, P., Altman, DG., Campbell, WB., Flum, DR., Glasziou, P., Marshall, JC., Nicholl, J., Aronson, JK., Barkun, JS., Blazeby, JM., Boutron, IC., Campbell, SB., Clavien, P., Cook, JA., Ergina, PL., Feldman, LS., Flum, DR., Maddern, GJ., Nicholl, J., Reeves, BC., Seiler, CM., Strasberg, SM., Meakins, JL., Ashby, D., Black, N., Bunker, J., Burton, M., Campbell, MK., Chalkidou, K., Chalmers, I., de Leval, M., Deeks, J., Ergina, PL., Grant, AM., Gray, M., Greenhalgh, R., Jenicek, M., Kehoe, S., Lilford, R., Littlejohns, P., Loke, Y., Madhock, R., McPherson, D., Meakins, J., Rothwell, P., Summerskill, B., Taggart, D., Tekkis, P., Thompson, M., Treasure, T., Trohler, U., Vandenbroucke, J. & Balliol Collaboration (2009). 'No surgical innovation without evaluation: the IDEAL recommendations'. Lancet, vol 374, no. 9695, pp. 1105-1112.
    [Online] DOI: 10.1016/S0140-6736(09)61116-8
  • Avenell, A., Cook, JA., MacLennan, GS., McPherson, GC. & RECORD Trial Grp (2009). 'Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)'. Age and Ageing, vol 38, no. 5, pp. 606-609.
    [Online] DOI: 10.1093/ageing/afp109
  • Mowatt, G., Cook, JA., Hillis, GS., Walker, SM., Fraser, CM., Jia, X. & Waugh, NR. (2008). '64-slice computed tomography angiography in the diagnosis and assessment of coronary artery disease: systematic review and meta-analysis'. Heart, vol 94, no. 11, pp. 1386-1393.
    [Online] DOI: 10.1136/hrt.2008.145292
  • Cook, JA., Ramsay, CR. & Norrie, JD. (2008). 'Recruitment to publicly funded trials: Are surgical trials really different?'. Contemporary Clinical Trials, vol 29, no. 5, pp. 631-634.
    [Online] DOI: 10.1016/j.cct.2008.02.005
  • Fielding, S., MacLennan, GS., Cook, JA. & Ramsay, CR. (2008). 'A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes'. Trials, vol 9, no. 51.
    [Online] DOI: 10.1186/1745-6215-9-51
    [Online] AURA: Trials 2008.pdf
  • Mowatt, G., Burr, JM., Cook, JA., Siddiqui, MAR., Ramsay, C., Fraser, C., Azuara-Blanco, A., Deeks, JJ. & Grp, OAGSP. (2008). 'Screening Tests for Detecting Open-Angle Glaucoma: Systematic Review and Meta-analysis'. Investigative Ophthalmology & Visual Science, vol 49, no. 12, pp. 5373-5385.
    [Online] DOI: 10.1167/iovs.07-1501
  • Campbell, AJ., Cook, JA., Adey, G. & Cuthbertson, B. (2008). 'Predicting death and readmission after intensive care discharge'. British Journal of Anaesthesia, vol 100, no. 5, pp. 656-662.
    [Online] DOI: 10.1093/bja/aen069
  • Lois, N., Burr, JM., Norrie, J., Vale, LD., Cook, JA., McDonald, AM. & FILMS Group (2008). 'Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole: Protocol for a Randomised Controlled Trial: FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study)'. Trials, vol 9, pp. 61-67.
  • McNeill, G., Avenell, A., Campbell, MK., Cook, JA., Hannaford, PC., Kilonzo, MM., Milne, AC., Ramsay, CR., Seymour, DG., Stephen, AI. & Vale, LD. (2007). 'Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: A randomised controlled trial'. Nutrition Journal, vol 6.
    [Online] DOI: 10.1186/1475-2891-6-10
  • Cook, JA., Ramsay, CR. & Fayers, P. (2007). 'Using the literature to quantify the learning curve: A case study'. International Journal of Technology Assessment in Health Care, vol 23, no. 2, pp. 255-260.
    [Online] DOI: 10.1017/S0266462307070341
  • Kilonzo, MM., Vale, LD., Cook, JA., Milne, AC., Stephen, AI., Avenell, A. & MAVIS Trial Group (2007). 'A cost-utility analysis of multivitamin and multimineral supplements in men and women aged 65 years and over'. Clinical Nutrition, vol 26, no. 3, pp. 364-370.
    [Online] DOI: 10.1016/j.clnu.2006.11.002
  • Jia, X., Mowatt, G., Burr, JM., Cassar, K., Cook, JA. & Fraser, CM. (2007). 'Systematic review of the safety and efficacy of foam sclerotherapy for venous disease of the lower limbs'. British Journal of Surgery, vol 94, no. 8, pp. 925-936.
    [Online] DOI: 10.1002/bjs.5891
    [Online] AURA: Jia_Systematic_review_of_foam_sclerotherapy_for_varicose_veins.doc
  • Andrews, PJD., Avenell, A., Noble, DW., Campbell, MK., Battison, CG., Croal, BL., Simpson, WG., Norrie, JD., Vale, LD., Cook, J., De Verteuil, R., Milne, AC. & Trials Management Group (2007). 'Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients: Protocol version 9, 19 February 2007 known as SIGNET (Scottish Intensive Care Glutamine or seleNium Evaluative Trial)'. Trials, vol 8.
    [Online] DOI: 10.1186/1745-6215-8-25
  • Burr, JM., Mowatt, G., Hernández, RA., Siddiqui, MAR., Cook, JA., Lourenco, T., Ramsay, CR., Vale, LD., Fraser, CM., Azuara-Blanco, A., Deeks, J., Cairns, J., Wormald, R., McPherson, S., Rabindranath, K. & Grant, AM. (2007). 'The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: A systematic review and economic evaluation'. Health Technology Assessment, vol 11, no. 41, pp. 1-190.
    [Online] DOI: 10.3310/hta11410
  • Nabi, G., Cook, J., N'Dow, J. & McClinton, S. (2007). 'Outcomes of stenting after uncomplicated ureteroscopy: systematic review and meta-analysis'. BMJ (Clinical research ed.), vol 334, no. 7593, pp. 572.
    [Online] DOI: 10.1136/bmj.39119.595081.55
  • Mowatt, G., Cook, JA., Fraser, CM., McKerrow, WS. & Burr, JM. (2006). 'Systematic review of the safety of electrosurgery for tonsillectomy'. Clinical Otolaryngology and Allied Sciences, vol 31, no. 2, pp. 95-102.
    [Online] DOI: 10.1111/j.1749-4486.2006.01162.x
  • Shaikh, S., Ong, EK., Glavind, K., Cook, J. & N'Dow, JMO. (2006). 'Mechanical devices for urinary incontinence in women'. Cochrane Database of Systematic Reviews, vol 3, pp. CD001756.
    [Online] DOI: 10.1002/14651858.CD001756.pub4
  • McDonald, AM., Knight, RC., Campbell, MK., Entwistle, V., Grant, AM., Cook, JA., Elbourne, DR., Francis, D., Garcia, J., Roberts, I. & Snowdon, C. (2006). 'What influences recruitment to randomised controlled trials? : A review of trials funded by two UK funding agencies'. Trials, vol 7, no. 9.
    [Online] DOI: 10.1186/1745-6215-7-9
  • McCormack, K., Wake, B., Gonzalez Perez, JG., Fraser, CM., Cook, JA., McIntosh, E., Vale, LD. & Grant, AM. (2005). 'Systematic review of the clinical effectiveness and cost-effectiveness of laparoscopic surgery for inguinal hernia repair'. Health Technology Assessment, vol 9, no. 14, pp. 1-218.
    [Online] DOI: 10.3310/hta9140
    [Online] AURA: MacCormack_Systematic_review_of_the_clinical_effectiveness_and_cost-effectiveness_of_laparoscopic_surgery_for_inguinal_hernia_repair_files.pdf
  • Avenell, A., Campbell, MK., Cook, JA., Hannaford, PC., Kilonzo, MM., McNeill, G., Milne, AC., Ramsay, CR., Seymour, DG., Stephen, AI., Vale, LD. & Writing Grp MAVIS Trial (2005). 'Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial'. British Medical Journal, vol 331, no. 7512, pp. 324-329.
    [Online] DOI: 10.1136/bmj.331.7512.324
  • Cook, JA., Ramsay, CR. & Fayers, P. (2004). 'Statistical evaluation of learning curve effects in surgical trials'. Clinical Trials, vol 1, no. 5, pp. 421-427.
    [Online] DOI: 10.1191/1740774504cn042oa

Letters

  • Taylor, KSM., Cook, JA. & Counsell, CE. (2007). 'Heterogeneity in male to female risk for Parkinson's disease'. Journal of Neurology, Neurosurgery & Psychiatry, vol 78, no. 8, pp. 905-906.
    [Online] DOI: 10.1136/jnnp.2006.104695
  • Avenell, A., Cook, JA., MacLennan, GS. & MacPherson, GC. (2007). 'Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)'. Age and Ageing, vol 36, no. 5, pp. 574-577.
    [Online] DOI: 10.1093/ageing/afm091

Comments and Debates

  • Cook, JA. & Kolehmainen, N. (2010). 'Commentary on “Methodological issues arising from a pilot RCT investigating the effectiveness of joint protection”'. International Journal of Therapy and Rehabilitation, vol 17, no. 12, pp. 654-664.
    [Online] AURA: Comm_draft_4_IJTR_Final_1_.docx

Chapters in Books, Reports and Conference Proceedings

Chapters

  • Cook, JA. (2003). 'Analysis of variance (ANOVA)'. In: Key topics in clinical research (eds. Smith,F. G.;Smith,J. E.), BIOS, Oxford In: Key topics in clinical research (eds. Smith,F. G.;Smith,J. E.), BIOS, Oxford, pp. 133-139.

Books and Reports

Commissioned Reports

  • Cuthbertson, B., Campbell, MK., Stott, S., Vale, LD., Norrie, JDT., Kinsella, J., Cook, JA., Brittenden, J., Grant, AM., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, GC., McDonald, AM., Cotton, SC., Elders, AS., MacLennan, GS., Boyers, D. & Hernández, RA. (2010). 'Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery'. Chief Scientist Office, Edinburgh, United Kingdom.
  • Mowatt, G., Cook, JA., Fraser, CM., McKerrow, WS. & Burr, JM. (2005). 'Systematic review of the safety and efficacy of electrosurgery for tonsillectomy'. University of Aberdeen, Interventional Procedures Programme, National Institute for Health and Clinical Excellence.
  • McCormack, K., Wake, B., Gonzalez-Perez, J., Fraser, CM., Cook, JA., Vale, LD. & Grant, A. (2004). 'Laparoscopic surgery for inguinal hernia repair: systematic review of effectiveness and economic evaluation'. National Institute for Health and Clinical Excellence, London, United Kingdom.

Other Reports

  • McCormack, K., Fraser, CM., Cook, JA., Vale, LD., Grant, AM. & Gonzalez Perez, JG. (2003). 'Systematic review of the clinical effectiveness and cost-effectiveness of laparoscopic surgery for inguinal hernia repair'. Unknown Publisher, Technology Assessment Review submitted to the National Institute of Clinical Excellence. University of Aberdeen, Health Services Research Unit, 2003. Available from: http://www.nice.org.uk/page.aspx?o=108156.

^ top

update

‹ back