Mrs Claire COCHRAN
Trial Manager
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+44 (0)1224 438171
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fax
+44 (0)1224 554580
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claire.cochran@abdn.ac.uk
Trial Manager
Bsc Geography (Hons), MsC Public Health (Medicine)
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Personal Details
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Biography
Claire Cochran joined the Unit in October 2006, and took up position as the trial manager on the MAPS (Men After Prostate Surgery) trial. MAPS is a £1.3 million project (Funded by NHS R&D Health Technology Assessment (HTA) Programme) to investigate incontinence in men who have had prostate surgery. MAPS aimed to explore whether physiotherapy can help men who have had these kinds of surgery.
Claire graduated from
In 2008 Claire began a new position in HSRU as the trial manger of EAGLE. EAGLE is an MRC funded international multi-centre pragmatic randomised controlled trial (RCT) to establish whether removal of the lens of the eye (lens extraction) for newly diagnosed Primary Angle Closure Glaucoma results in better patient reported health, vision, lower IOP and other outcomes compared with standard management.
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Current Research
EAGLE is an international multi-centre pragmatic randomised controlled trial (RCT) to establish whether removal of the lens of the eye (lens extraction) for newly diagnosed Primary Angle Closure Glaucoma results in better patient reported health, vision, lower IOP and other outcomes compared with standard management.
The current standard care for PACG is a stepped approach of a combination of surgery (laser or incisional) and medical management. Initial surgery uses a laser to make a small hole in the iris (laser iridotomy [LI]) to open the drainage angle, and often eye drops are required as an adjunct to LI to further reduce the IOP. There are several types of drops used to lower IOP but prostaglandin and beta-blocker treatments are the most commonly used. If the drainage pathway is still closed after LI, alternative laser treatment whereby iris tissue is pulled away from the drainage angle, laser peripheral iridoplasty (LPI) is an option. If these first line treatments fail glaucoma filtration surgery (trabeculectomy) is then indicated. Trabeculectomy may fail to control the IOP, and in PACG complications are more likely (such as flat anterior chamber and malignant glaucoma) than for other types of glaucoma. These standard approaches to PACG management have been noted to have variable success.
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Publications
Contributions to Journals
Articles
- Cotton, S., Sharp, L., Cochran, C., Gray, N., Cruickshank, M., Smart, L., Thornton, A. & Little, J. (2011). 'After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trial'. British Journal of General Practice, vol 61, no. 587, pp. e333-e339.
[Online] DOI: 10.3399/bjgp11X578007 - Azuara-Blanco, A., Burr, JM., Cochran, C., Ramsay, C., Vale, L., Foster, P., Friedman, D., Quayyum, Z., Lai, J., Nolan, W., Aung, T., Chew, P., McPherson, G., McDonald, A., Norrie, JDT. & Effectiveness in Angle-closure Glaucoma of Lens Extraction (EAGLE) Study Group (2011). 'The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial'. Trials, vol 12, pp. 133.
[Online] DOI: 10.1186/1745-6215-12-133
[Online] AURA: Azuara_Blanco_2011.pdf - Glazener, C., Boachie, C., Buckley, B., Cochran, C., Dorey, G., Grant, A., Hagen, S., Kilonzo, M., McDonald, A., McPherson, G., Moore, K., Norrie, J., Ramsay, C., Vale, L. & N'Dow, J. (2011). 'Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trials'. Lancet, vol 378, no. 9788, pp. 328-337.
[Online] DOI: 10.1016/S0140-6736(11)60751-4
[Online] AURA: Glazener_2011.pdf - Glazener, CMA., Boachie, C., Buckley, B., Cochran, C., Dorey, G., Grant, AM., Hagen, S., Kilonzo, M., McDonald, AM., McPherson, G., Moore, K., N'Dow, J., Norrie, JDT., Ramsay, C. & Vale, L. (2011). 'Conservative treatment for urinary incontinence in Men After Prostate Surgery (MAPS): two parallel randomised controlled trials'. Health Technology Assessment, vol 15, no. 24, pp. 1-290, iii-iv.
[Online] DOI: 10.3310/hta15240
[Online] AURA: Glazener_2011.pdf - Sharp, L., Cotton, SC., Cochran, C., Gray, NM., Little, J., Neal, K., Cruickshank, ME. & The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group (2009). 'After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial'. BJOG: An International Journal of Obstetrics and Gynaecology, vol 116, no. 11, pp. 1506-1514.
[Online] DOI: 10.1111/j.1471-0528.2009.02263.x - Dorey, G., Glazener, C., Buckley, B., Cochran, C. & Moore, K. (2009). 'Developing a pelvic floor muscle training regimen for use in a trial intervention'. Physiotherapy, vol 95, no. 3, pp. 199-208.
[Online] DOI: 10.1016/j.physio.2009.03.003 - Sharp, L., Cruickshank, ME., Little, J., Cotton, SC., Harrild, KA., Cochran, C., Waugh, NR., Smart, L. & TOMBOLA Group (2009). 'Biopsy and selective recall is as effective as immediate LLETZ in the management of women with low-grade smears referred for colposcopy'. British Medical Journal, vol 339, pp. 2548.
- TOMBOLA group & Cochran, C. (2009). 'Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial'. British Medical Journal, vol 339, pp. b24546-.
[Online] DOI: 10.1136/bmj.b2546 - Sharp, L., Cochran, C., Cotton, SC., Gray, NM., Gallagher, ME. & TOMBOLA grp (2006). 'Enclosing a pen with a postal questionnaire can significantly increase the response rate'. Journal of Clinical Epidemiology, vol 59, no. 7, pp. 747-754.
[Online] DOI: 10.1016/j.jclinepi.2005.10.014
Books and Reports
Commissioned Reports
- Glazener, CMA., Boachie, C., Buckley, B., Cochran, C., Dorey, G., Grant, AM., Hagen, S., Kilonzo, MM., McDonald, AM., McPherson, GC., Moore, K., N'Dow, JMO., Ramsay, CR. & Vale, LD. (2010). 'Conservative treatment for urinary incontinence in men after prostate surgery (MAPS)'. NIHR Health Technology Assessment programme, Southampton, United Kingdom.
[Online] AURA: Glazener_2011.pdf
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