Dr Samuel Martin

Dr Samuel Martin The University of Aberdeen School of Biological Sciences Dr Samuel Martin Senior Lecturer work +44 (0)1224 272867

Senior Lecturer, Fish Physiology

Dr Samuel Martin

Personal Details

Telephone: +44 (0)1224 272867
Email: sam.martin@abdn.ac.uk
Personal website:
hCard

Jump to:

Salmon TRAITS Microarray http://www.abdn.ac.uk/sfirc/salmon/

LIFECYCLES EU project http://www.lifecycle.gu.se/

Fish Proteomics http://www.abdn.ac.uk/fishprom/

River Don Trust http://www.riverdon.org.uk/welcome.asp

Journal of Aquaculture Research and Development http://www.omicsonline.org/jardhome.php


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Biography

2007-Present Lecturer, Institute of Biological and Environmental Sciences, University of Aberdeen

1999- 2007 Research Fellow, School of Biological Sciences, University of Aberdeen

1996-1999 Senior Research Officer, National Diagnostics Centre, NUI, Galway, Ireland

1993-1996 Postdoctoral RA, Department of Veterinary Parasitology, University of Glasgow

PhD Queens University Belfast 1993

BSc (Hons) Queens University Belfast 1989


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Research Interests

1. Genomics in Aquaculture
2. Atlantic salmon transcriptomics
3. Proteomics in salmonid fish
4. Immune Responses in salmon
5. Protein degradation by the ubiquitin proteasome pathway

My main research interests are related to two key physiological processes in salmonid fish, namely the control of protein deposition and immune responses. A major research gap is the relation between metabolism and immune competence in fish and the related expression of genes.

Protein metabolism:

The rate of protein deposition during growth is a balance between protein synthesis and degradation. These two processes are under tight control and evidence suggests that in fish the control of degradation may be key to efficient protein growth. There are two main cellular pathways that can degrade cellular proteins, the energy dependant ubiquitin proteasome pathway and the lysosomal degradation of proteins. Both theses processes are tightly regulated and their regulation in fish may be very different to what is known about mammals, as ecto and endothermic animals have different strategies for controlling protein mobilization. To address these questions I have used a combination of biochemical, microarray and proteomics approaches.

Immune responses:

The coordinated response of a fish to either a pathogen or vaccine requires the correct identification of the foreign material. Signalling pathways result in gene expression changes and the fish can then mount the desired response to eliminate the disease or have protection by the vaccination. We have developed a 17,000 gene microarray (see link to salmon TRAITS) from which we have identified gene expression profile changes for both bacterial infection and specific response to recombinant fish cytokines.  More recently we have moved to use custom designed Agilent 4 x 44K Atlantic salmon and rainbow trout microarray slides.


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Research Grants

 

2011-2015 Development of protein-rich and starch-rich fractions from faba beans for salmon and terrestrial animal production respectively.  Technology Strategy Board, UK. (Coordinated by Dr Crampton, EWOS)

2011-2014:  Nutritional requirements during viral induced muscle wasting in Atlantic salmon (Industrial PhD studentship CLSM & BioMar)

2011-2014 : Selenium as an antiviral agent in farmed fish (Industrial PhD studentship with Alltech, with Prof Secombes and Dr Wang)

2010-2014    Application of nutrigenomics to develop new diets that reduce lice burden in Atlantic salmon (With Dr A Bowman & Dr JMO Fernandes, Bodo University College, Norway) Industrial PhD studentship with BioMar

2010-2014   Farm animal proteomics

EU COST, Coordinated Prof D. Eckersall, University of Glasgow, UK

2010-2014: The physiological and genomic basis to the timing of life history transitions in Atlantic salmon.

BBSRC (with Prof Hazlerigg and Dr W.C. Jordan, IOZ, London) 

2008-2011: Evolutionary dynamics of major histocompatibility genes in Arctic charr

NERC (with Dr W.C. Jordan, IOZ London)

2009-2013: LIFECYCLES: Building a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture

Coordinated Prof T. Bjornsson, University of Gotenburg, Sweden, CoPI with Prof Secombes

2009-2012: A systems biology based approach to functionally annotate and analyse the genome of the fish pathogenic oomycete Saprolegnia parasitica 

BBSRC (with Prof Secombes & Dr P. Van West)

2008-2011: Molecular basis of improved feed quality for aquaculture

Industrial PhD studentship with BioMar

2009-2010: Modulation of muscle atrophy gene expression in Atlantic salmon following an inflammatory response.

Royal Society

2009-2012: The molecular basis endocrine and immune modulation of protein metabolism in salmonid fish, a model for ectothermic animals

BBSRC studentship.

2009-2010: Ubiquitin E3 ligases as controllers of protein wastage in fish.

CLSM Pump priming

2009: Immune control of energy reallocation in fish  (with Dr S Bird)

British Society of Animal Science/Genesis Faraday 2009


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Teaching Responsibilities

Lecturer:

1st year BUGS (BI1006), 

1st year Organismal Biology (BI1004), guest lecturer

2nd year Diversity of life, (BI2008, Course Coordinator)

3rd year Aquatic Biology, Conservation and Exploitation  (ZO3809)

4th year Sustainable Aquaculture (ZO4811, Course Coordinator)

4th year Bioethics (ZO4805)

MSc Applied Marine and Fisheries Ecology, Aquaculture  (ZI5505, Unit Coordinator)

Outreach to Schools: "Trout in the Classroom". I teach about ecology and fish in the river Don by growing fish from eggs to fry in the classroom. (Kemnay Academy 2008, Inverurie Academy 2009, Strathburn School 2010).


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External Responsibilities

Coordinator for "New technologies in fish nutrition" European Aquaculture Technology Implementation Platform

Editorial Board Member : Journal of Aquaculture and Development

Board of Directors, River Don Trust


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Research Projects

 Research Projects

Molecular basis of improved feed quality for aquaculture 2008-2011, PhD CASE Studentship, Co funded with BioMar

The replacement of fish meal and fish oils using vegetable proteins and vegetable oils is hampered by "antinutritional factors" that can be co purified, leading to metabolic dysfunction in the fish.  This results in undesirable affects including reduced digestibility, reduced food conversion, gut inflammation, altered immune function and reduction in growth.  This project will examine the resulting gene expression modifications in fish fed alternate diets, and help identify key molecular markers which will assist in the selection of new diets regarding performance and health of the fish. Student: Luca Tacchi.

IMAQUANIM   Improved immunity of aquacultured animals (EU 2006-2011)

EU funded project: Based on important disease models, this project concerns development of a technological knowledge platform for a future improved immunity to infectious pathogens in the major aquacultured species in Europe (Atlantic salmon, rainbow trout, sea bream, sea bass, carp, mussel and oyster). Focus will be put on use of vaccines, immuno-stimulants, immuno-diagnostic surveillance as well as markers for selection of the most immuno- competent individuals.

Web link http://imaquanim.dfvf.dk/info/

Evolutionary dynamics of major histocompatibility genes in Arctic charr,  

NERC 2007-2010, PI Dr W.C Jordan Institute of Zoology, London.

 Arctic charr (Savelinus alpinus), in common with many salmonid species, show great variability within and across localities. A number of morphotypes of charr coexist in various freshwater systems and differ in characteristics such as body size and spawning coloration, external and internal morphology and parasite fauna. Differences in parasite faunas are likely to create differences in the types of natural selection experienced by different morphs and subsequent differentiation at loci involved in the immune response. The highly polymorphic major histocompatibility (MH) genes are likely targets for such selection. MH class I and class II molecules are instrumental in eliciting an immune response, which results in elimination or control of the pathogen. We will isolate and characterize the MH class I and class II genes from Arctic charr and use the cDNA sequence information to genotype charr populations from different localities.  

Post Doctoral Fellow   Dr Jolene G. M. Slothouber-Galbreath

 


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Publications

BOOK CHAPTERS

Samuel A.M. Martin.  (2009) Proteomics in aquaculture. (Book Chapter) In Molecular Research in Aquaculture. Ed Ken Overturf.  Wiley-Blackwell ISBN-13:978-0-8138-1851-1/2009

Vilhelmsson, O.T., Martin, S.A.M., & D.F. Houlihan. (2005) Application of Proteomics to Fish Processing and Quality Issues. (Book chapter) In: Food biochemistry and food processing. Ed. Y. H. Hui, W. Nip, L.M.L. Nollet, and G.Paliyath. Blackwell Publishing. ISBN-13: 978-0813803784

  Peer reviewed publications

  1. Tacchi, L., Casadei, E.,Bickerdike, R., Secombes, C.J. and Martin, S.A.M. 2011  Mitochondrial Ubiquitin Ligase Activator of NF-kB (MULAN) in Atlantic salmon (Salmo salar) and its role in the immune response. Molecular Immunology (In Press)

  2. Król, E., Douglas, A., Martin, S.A.M., Huhtaniemi I.T. and John R. Speakman. 2011 Lactating mice with greater downregulation of genes linked to thermogenesis in brown adipose tissue produce more milk. Journal of Experimental Biology (In Press)

  3. Nøstbakken, O.J., Goksøyr, A,  Martin, S.A.M., Cash, P. and Torstensen, B.E. 2011. Marine n-3 FAs alter the proteomic response to methylmercury in Atlantic salmon Kidney (ASK) cells.  Aquatic Toxicology In Press)

  4. Tacchi, L., Bron, J.E., Taggart, J.B., Secombes, C.J., Bickerdike, R., Adler, M.A., Takle, H. and Martin, S.A.M.  (2011) Multiple tissue transcriptomic responses to Piscirickettsia salmonis in Atlantic salmon (Salmo salar).  Physiol. 10.1152/physiolgenomics.00086.2011

  5. Nøstbakken, O.J., Martin, S.A.M., Cash, P., Torstensen, B.E., Amlund, H., & Olsvik P.A. (2011) Dietary methylmercury alters the proteome in Atlantic salmon (Salmo salar) kidney. Aquatic Toxicology (In Press) DOI:10.1016/j.aquatox.2011.08.017

  6. Tacchi, L., Bickerdike, R., Secombes, C.J., Martin, S.A.M. (2011)   Muscle-Specific RING Finger (MuRF) cDNAs in Atlantic Salmon (Salmo salar) and Their Role as Regulators of Muscle Protein Degradation.  Martine Biotechnology. (In Press) DOI: 10.1007/s10126-011-9385-4

  7. Tacchi, L., Bickerdike, R., Douglas, A., Secombes, C.J. and Martin, S.A.M. 2011. Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar). Fish and Shellfish Immunology. (In Press DOI: 10.1016/j.fsi.2011.02.023)

  8. Castro, R., Zou, J., Secombes, C.J. and Martin, S.A.M. (2011) Cortisol interference in the modulation of inflammatory gene expression by cytokines in macrophages.  Fish and Shellfish Immunology30: 215-23

  9. Wang, T., Wenshu Huang, W., Costa, M.M., Martin, S.A.M. and Secombes, C.J.  (2011). Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Ralpha, IL-13Ralpha1 and IL-13Ralpha2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation.  Immunogenetics   63(4): 235-253

  10. Martin, S.A.M., Douglas, A,. Houlihan, D.F. and Secombes, C.J. (2010). Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar).  BMC Genomics  11: 418

  11. Tacchi, L., Bickerdike, R., Secombes, C.J., Pooley, N.J., Urquhart, K.L., Collet, B. and Martin, S.A.M.  2010. Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar), sequence analysis, genomic structure and modulation of expression. Comp. Biochem. Physiol. Part B 157: 364-373

  12. Ostergaard, A.E.,  Lubieniecki, K.P.  Martin, S.A.M., Stet, R.J.M. Davidson, W.S. and Secombes, C.J. 2010. Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family. BMC Genomics, 11:697

  13. Wang, T., Diaz-Rosales, P., Costa M.M., Campbell, S., Snow, M., Collet, B., Martin, S.A.M. and Secombes, C.J. (2011)  Functional Characterization of a Nonmammalian IL-21: Rainbow Trout Oncorhynchus mykiss IL-21 Upregulates the Expression of the Th Cell Signature Cytokines IFN-?, IL-10, and IL-22.  Journal of Immunology  186: 708-721

  14. Wang,T., Holland, J.W., Martin S.A.M. and Secombes, C.J. (2010) Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in  rainbow trout Oncorhynchus mykiss and analysis of their expression during bacterial and parasitic infection.  Fish and Shellfish Immunology. 29: 705-715

  15. Wang, T., Monte, M.M., Huang, W., Boudinot, P., Martin, S.A.M. and Secombes, C.J. (2010). Identification of two FoxP3 genes in rainbow trout (Oncorhynchus mykiss) that are differentially expressed and modulated. Molecular Immunology 47(16):2563-74

  16. Castro R., Martin S.A.M., Zou, J and Secombes C.J. (2010). Establishment of an IFN-g specific reporter cell line in fish.  Fish and Shellfish Immunology 28: 312-319

  17. Wang T, Martin S.A.M., Secombes C.J (2010). Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated.  Dev Comp Immunol. 34: 491-500

  18. Sissener, N.H., Martin, S.A.M., Cash, P., Hevrøy, E.M., Sanden, M., Hemre, G.-I. 2010). Proteomic Profiling of Liver from Atlantic Salmon (Salmo salar) Fed Genetically Modified Soy Compared to the Near-Isogenic non-GM Line.  Marine Biotechnology, 12: 273-283

  19. Wang, T, Díaz-Rosales, P., Martin, S.A.M.  and Secombes, C.J. (2009). Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family.  Developmental & Comparative Immunology  34: 158–167

  20. Østergaard, A.E., Martin, S.A.M., Wang, T., Stet, R.J.M. & Secombes, C.J.  (2008) Multiple genes and alternative splicing of novel immunoglobulin-1 like transcripts in rainbow trout (Oncorhynchus mykiss) containing either an ITAM or ITIMs. Developmental and Comparative Immunology 33:525-32.

  21. Casania, D,. Randelli, E., Costantini, S., Facchiano, A. M., Zou, J. Martin, S.A.M., Secombes, C.J., Scapigliati, G., Buonocore, F. 2008. Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.).  Molecular Immunology 46(5):943-52

  22. Martin, S.A.M., Collet, B., MacKenzie, S., Evensen O., & Secombes C.J. (2008). Genomic tools for examining immune gene function in salmonid fish. Reviews in Fisheries Sciences 16(S1): 155-164.

  23. Taggart, J.B. Bron, J.E. Martin, S.A.M. Seear, P.J. Høyheim, B. Talbot, R. Carmichael, S.N. Villeneuve, L.A.N. Sweeney, G.E. Houlihan, D.F. Secombes, C.J. Tocher, D.R. Teale, A.J. (2008). A description of the origins D. F, design and performance of the TRAITS-SGP Atlantic salmon Salmo salar L. cDNA microarray.  Journal of Fish Biology 72 (9) , 2071–2094

  24. Castro R, Martin SAM, Bird S, Lamas J, Secombes CJ. (2008) Characterisation of gamma-interferon responsive promoters in fish. Molecular Immunology. 45(12):3454-62

  25. Martin S.A.M, J.B. Taggart, P. Seear, J.E Bron, R. Talbot, A.J. Teale, G Sweeney, B, Hoyheim D.F. Houlihan and C.J. Secombes (2007). Interferon type 1 and type II responses in an Atlantic salmon (Salmo salar) cell line SHK-1 using the salmon TRAITS/SGP microarray. Physiological Genomics  19;32(1):33-44. 

  26. Martin, S.A.M., B Mohanty, P Cash, D.F. Houlihan & C.J. Secombes 2007. Proteome analysis of Atlantic salmon (Salmo salar) SHK-1 cells following recombinant interferon gamma stimulation. Proteomics 13: 2275-2286

  27. Martin, S.A.M., Zou, J. Houlihan, D.F., &. Secombes, C.J. 2007. Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS 11 macrophage cells as revealed by transcriptome profiling.  BMC Genomics 8:150

  28. Kause, A., Tobin, D., E. A. Mäntysaari, S.A.M. Martin, D. F. Houlihan, A. Dobly, A. Kiessling, K. Rungruansak-Torrissen, O. Ritola, K. Ruohonen (2007).  Genetic potential for simultaneous selection of growth and body composition in rainbow trout depend on the dietary protein and lipid content: Phenotypic and genetic correlations on two diets.  Aquaculture 271: 162-172.

  29. Martin, S.A.M. Blaney, S.C. Houlihan, D.F. &. Secombes, C.J.(2006). Transcriptome response following administration of a live bacterial vaccine in Atlantic salmon (Salmo salar).  Molecular Immunology. 43:1900-1911.

  30. Kause, A., D. Tobin, D.F. Houlihan, S.A.M. Martin,  E.A. Mäntysaari, O. Ritola, and K. Ruohonen (2006).  Feed efficiency of rainbow trout can be improved through selection: Different genetic potential on alternative diets.  Journal of Animal Science 84: 807-817.

  31. Kause, A., D. Tobin, A. Dobly D.F. Houlihan, S.A.M. Martin,  E.A. Mäntysaari, O. Ritola, and K. Ruohonen.  (2006) Selective breeding of long-term feed intake recorded using the X-ray method in rainbow trout.  Genetics Selection Evolution 38 (4): 389-409

  32. Tobin, D., A. Kause, E. A. Mäntysaari, S.A.M. Martin, D. F. Houlihan, A. Dobly, A. Kiessling, K. Rungruansak-Torrissen, O. Ritola, K. Ruohonen (2006). Fat or lean? Selection strategies for lipid or protein composition traits in fish breeding schemes. A quantitative genetic analysis of rainbow trout. Aquaculture 261: 510-521.

  33. Jordan, W.C., T.F. Cross, W.W. Crozier, A. Ferguson, P. Galvin, R.H. Hurrell, P.McGinnity,  S.A.M. Martin, I.J.J. Moffett, D.J. Price, A.F. Youngson and E. Verspoor. (2005). Allozyme variation in Atlantic salmon (Salmo salar) from the British Isles: associations with geography and the environment. Journal of Fish Biology.67: (Supplement A), 146-168.

  34. Vilhelmsson, O.T., Martin, S.A.M., Médale, F., Kaushik, S.J. & Houlihan, D.F. (2004). Dietary plant protein substitution affects hepatic metabolism, in rainbow trout (Oncorhynchus mykiss).  British Journal of Nutrition 92: 71-81.

  35. Dobly, A., Martin S.A.M., Blaney, S. & Houlihan, D.F. (2004).  Efficiency of Conversion of ingested Proteins into Growth; Protein Degradation Assessed by 20S Proteasome Activity in Rainbow Trout, Oncorhynchus mykiss. Comparative Biochemistry and Physiology, Part A 137: 75-85.

  36. Gómez-Requeni, P., Mingarro, M., Calduch-Giner, J.A., Médale, F., Martin, S.A.M. Houlihan, D.F., Kaushik, S. & Pérez-Sánchez, J. (2004). Protein growth performance, amino acid utilisation and somatotropic axis responsiveness to fish meal replacement by plant protein sources in gilthead sea bream (Sparus aurata). Aquaculture232: 493-510.

  37. Gómez-Requeni, P., Mingarro, M., Kirchner, S., Calduch-Giner, J.A., Médale, F., Corraze, G., Panserat, S., Martin, S.A.M., Houlihan, D.F., Kaushik, S., & Pérez-Sánchez, J. (2003). Effects of dietary amino acid profile on growth performance, key metabolic enzymes and somatotropic axis responsiveness of gilthead sea bream (Sparus aurata).  Aquaculture 220 (1-4): 749-767.

  38. Martin S.A.M, Vilhelmsson O.T., Médale, F.Watt, P. Kaushik, S., & Houlihan D.F. (2003).  Proteomic sensitivity to dietary manipulations in rainbow trout. Biochimica et Biophysica Acta (Proteins and Proteomics), 1651:17-29.

  39. Martin S.A.M., Blaney, S., Bowman, A., & Houlihan, D.F. (2002).  Ubiquitin-proteasome dependant proteolysis in rainbow trout Oncorhynchus mykiss: Effect of food deprivation.  Pflügers Archiv, European Journal of Physiology 445: 257-266.

  40. Martin S.A.M., Cash, P., Blaney, S., & Houlihan, D.F. (2001).  Proteome analysis of rainbow trout (Oncorhynchus mykiss) liver proteins during short term starvation.  Fish Physiology and Biochemistry 24 (3): 259-270.

  41. Sangrador-Vegas, A., Martin, S.A.M., O'Dea, P.G., & Smith, T.J. (2000).  Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin-1 receptor cDNA.  European Journal of Biochemistry.  267: 7031-7037

  42. Nolan, D.V., Martin, S.A.M., Kelly, Y., Glennon. K., Palmer, R., Smith, T., McCormack, G.P., & Powell, R. (2000).  Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis (Kroyer).  Aquaculture Research31: 815-822

  43. Guiguen, Y., Baroiller, J.F., Ricordel, M.J., Iseki, K., McMeel, O.M., Martin, S.A.M. & Fostier, A. (1999).  Involvement of estrogens in the process of sex differentiation in two fish species: The rainbow trout (Oncorhynchus mykiss) and a Tilapia (Oreochromis niloticus).  Molecular Reproduction and Development. 54: 154-162.

  44. Davidson, J., Smith, T., & Martin, S.A.M. (1999).  Cloning and sequence analysis of rainbow trout LMP 2 cDNA and differential expression of the mRNA.  Fish and Shellfish Immunology 9: 621-632.

  45. Hunter, S.J., Martin, S.A.M., Thompson, F.J., Tetley, L., & Devaney, E. (1999).  The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi.  Parasitology. 119: 189-198.

  46. Martin, S. A. M., Wallner, W., Youngson, A.F., & Smith, T. (1998).  Differential expression of Atlantic salmon (Salmo salar) thyrotropin b subunit mRNA and its cDNA sequence.  Journal of Fish Biology 54: 757-766.

  47. Martin, S.A.M., Youngson, A.F., & Ferguson, A. (1998).  Atlantic salmon (Salmo salar) prolactin cDNA sequence and its mRNA expression after transfer of fish between salinities.  Fish Physiology and Biochemistry 20: 351-359

  48. Anant, S*., Martin, S.A.M*., Yu, H., MacGinnite, A.J., Devaney, E., & Davidson, N.O. (1997).  *Equal contribution.  A Cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding activity.  Molecular and Biochemical Parasitology.  88: 105-114.

  49. Devaney, E.,  Martin, S.A.M., & Thompson, F.J. (1996).  Review:  Stage-specific gene expression in lymphatic filarial nematodes.  Parasitology Today 12:418-424.

  50. Martin, S.A.M., Hunter, S.J., Thompson, F.J., & Devaney, E. (1996).  Stage specific gene expression in the post-infective L3 of the filarial nematode, Brugia pahangi.  Molecular and Biochemical Parasitology. 79: 109-112.

  51. Thompson, F.J., Martin, S.A.M., & Devaney, E.  (1996).  Brugia phangi: Characterization of a small heat shock protein cDNA clone.  Experimental Parasitology. 83: 259-266.

  52. Martin, S.A.M., Thompson, F.J., & Devaney, E. (1995).  The construction of spliced leader cDNA libraries from the filarial nematode Brugia pahangi.  Molecular and Biochemical Parasitology.  70: 241-245

  53. Cox-Singh, J., Paine, M.J.I., Martin, S.A.M., & Devaney, E. (1994).  Stage specific differences in steady state levels of mRNA encoding the major surface glycoprotein of Brugia pahangi.  Tropical Medicine and Parasitology. 45: 352-354.

  54. W.C. Jordan et al., (1992). Genetic Protein variation in Atlantic salmon (Salmo salar) from the British Isles. A report to the Chief Scientists Group and the CFRD Working group on Fisheries Genetics.

  55. Youngson, A.F., Martin, S.A.M., Jordan, W.C. & Verspoor, E. (1991).  Genetic protein variation in Atlantic salmon in Scotland: Comparison of wild and farmed fish.  Aquaculture 98: 231-242.

  56. Youngson, A.F., Martin, S.A.M., Jordan, W.C. & Verspoor, E. (1989). Genetic protein variation in farmed Atlantic salmon in Scotland: comparison of farmed strains with their wild source populations. Scottish Fisheries Research Report. Number 42 ISSN 0308 8022

 

 


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Publications

Contributions to Journals

Articles

  • Nøstbakken, O., Martin, S., Goksøyr, A., Cash, P. & Torstensen, B. (2012). 'Marine n-3 fatty acids alter the proteomic response to methylmercury in Atlantic salmon kidney (ASK) cells'. Aquatic Toxicology, vol 106-107, no. 1, pp. 65-75.
    [Online] DOI: 10.1016/j.aquatox.2011.10.008
  • Castro, R., Zou, J., Secombes, C. & Martin, S. (2011). 'Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line'. Fish & Shellfish Immunology, vol 30, no. 1, pp. 215-223.
    [Online] DOI: 10.1016/j.fsi.2010.10.010
  • Wang, T., Huang, W., Costa, M., Martin, S. & Secombes, C. (2011). 'Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Ra, IL-13Ra1 and IL-13Ra2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation'. Immunogenetics, vol 63, no. 4, pp. 235-253.
    [Online] DOI: 10.1007/s00251-010-0508-2
  • Nøstbakken, O., Martin, S., Torstensen, B., Amlund, H., Cash, P. & Olsvik, P. (in press). 'Dietary methylmercury alters the proteome in Atlantic salmon (Salmo salar) kidney'. Aquatic Toxicology.
    [Online] DOI: 10.1016/j.aquatox.2011.08.017
  • Król, E., Martin, S., Douglas, A., Speakman, J. & Huhtaniemi, I. (2011). 'Negative correlation between milk production and brown adipose tissue gene expression in lactating mice'. Journal of Experimental Biology, vol 214, no. 24, pp. 4160-4170.
    [Online] DOI: 10.1242/jeb.061382
  • Tacchi, L., Douglas, A., Secombes, C., Bickerdike, R. & Martin, S. (2011). 'Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar)'. Fish & Shellfish Immunology, vol 31, no. 5, pp. 704-715.
    [Online] DOI: 10.1016/j.fsi.2011.02.023
  • Tacchi, L., Secombes, C., Bron, J., Taggart, J., Bickerdike, R., Adler, M., Takle, H. & Martin, S. (2011). 'Multiple tissue transcriptomic responses to piscirickettsia salmonis in atlantic salmon (salmo salar)'. Physiological Genomics, vol 43, no. 21, pp. 1241-1254.
    [Online] DOI: 10.1152/physiolgenomics.00086.2011
  • Tacchi, L., Secombes, C., Bickerdike, R. & Martin, S. (2011). 'Muscle-Specific RING Finger (MuRF) cDNAs in Atlantic Salmon (Salmo salar) and Their Role as Regulators of Muscle Protein Degradation'. Marine Biotechnology, vol 14, no. 1, pp. 35-45.
    [Online] DOI: 10.1007/s10126-011-9385-4
  • Wang, T., Diaz-Rosales, P., Costa, M., Martin, S., Campbell, S., Snow, M., Collet, B. & Secombes, C. (2011). 'Functional characterization of a nonmammalian IL-21: Rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-¿, IL-10, and IL-22'. Journal of Immunology, vol 186, no. 2, pp. 708-721.
    [Online] DOI: 10.4049/jimmunol.1001203
  • Tacchi, L., Casadei, E., Secombes, C., Bickerdike, R. & Martin, S. (2011). 'Cloning and expression analysis of the Mitochondrial Ubiquitin Ligase Activator of NF-¿B (MULAN) in Atlantic salmon (Salmo salar)'. Molecular Immunology, vol 49, no. 3, pp. 558-565.
    [Online] DOI: 10.1016/j.molimm.2011.10.005
  • Castro, R., Martin, S., Zou, J. & Secombes, C. (2010). 'Establishment of an IFN-gamma specific reporter cell line in fish'. Fish & Shellfish Immunology, vol 28, no. 2, pp. 312-319.
    [Online] DOI: 10.1016/j.fsi.2009.11.010
  • Wang, T., Martin, SAM. & Secombes, CJ. (2010). 'Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated'. Developmental and Comparative Immunology, vol 34, no. 5, pp. 491-500.
    [Online] DOI: 10.1016/j.dci.2009.11.011
  • Wang, T., Diaz-Rosales, P., Martin, SAM. & Secombes, CJ. (2010). 'Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family'. Developmental and Comparative Immunology, vol 34, no. 2, pp. 158-167.
    [Online] DOI: 10.1016/j.dci.2009.09.003
  • Sissener, NH., Martin, SAM., Cash, P., Hevrøy, EM., Sanden, M. & Hemre, G. (2010). 'Proteomic Profiling of Liver from Atlantic Salmon (Salmo salar) Fed Genetically Modified Soy Compared to the Near-Isogenic non-GM Line'. Marine Biotechnology, vol 12, no. 3, pp. 273-281.
    [Online] DOI: 10.1007/s10126-009-9214-1
  • Tacchi, L., Bickerdike, R., Secombes, C., Pooley, N., Urquhart, KL., Collet, B. & Martin, S. (2010). 'Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar): Sequence analysis, genomic structure and modulation of expression'. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, vol 157, no. 4, pp. 364-373.
    [Online] DOI: 10.1016/j.cbpb.2010.08.004
  • Østergaard, A., Lubieniecki, KP., Martin, S., Stet, R., Davidson, WS. & Secombes, C. (2010). 'Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family'. BMC Genomics, vol 11.
    [Online] DOI: 10.1186/1471-2164-11-697
  • Wang, T., Holland, J., Martin, S. & Secombes, C. (2010). 'Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus mykiss and analysis of their expression during bacterial and parasitic infection'. Fish & Shellfish Immunology, vol 29, no. 5, pp. 705-715.
    [Online] DOI: 10.1016/j.fsi.2010.06.016
  • Casani, D., Randelli, E., Costantini, S., Facchiano, AM., Zou, J., Martin, SAM., Secombes, CJ., Scapigliati, G. & Buonocore, F. (2009). 'Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.)'. Molecular Immunology, vol 46, no. 5, pp. 943-952.
    [Online] DOI: 10.1016/j.molimm.2008.09.016
  • Oestergaard, AE., Martin, SAM., Wang, T., Stet, RJM. & Secombes, CJ. (2009). 'Rainbow trout (Oncorhynchus mykiss) possess multiple novel immunoglobulin-like transcripts containing either an ITAM or ITIMs'. Immunology, vol 125, pp. 83-83.
  • Castro, R., Martin, SAM., Bird, S., Lamas, J. & Secombes, CJ. (2008). 'Characterisation of gamma-interferon responsive promoters in fish'. Molecular Immunology, vol 45, pp. 3454-3462.
    [Online] DOI: 10.1016/j.molimm.2008.03.015
  • Taggart, JB., Bron, JE., Martin, SAM., Seear, PJ., Hoyheim, B., Talbot, R., Carmichael, SN., Villeneuve, LAN., Sweeney, GE., Houlihan, DF., Secombes, CJ., Tocher, DR. & Teale, AJ. (2008). 'A description of the origins, design and performance of the TRAITS-SGP Atlantic salmon Salmo salar L. cDNA microarray'. Journal of Fish Biology, vol 72, pp. 2071-2094.
    [Online] DOI: 10.1111/j.1095-8649.2008.01876.x
  • Martin, SAM., Collet, B., Mackenzie, S., Evensen, O. & Secombes, CJ. (2008). 'Genomic Tools for Examining Immune Gene Function in Salmonid Fish'. Reviews in Fisheries Science, vol 16, no. S1, pp. 112-118.
    [Online] DOI: 10.1080/10641260802325476
  • Martin, SAM., Mohanty, BP., Cash, P., Houlihan, DFJ. & Secombes, CJ. (2007). 'Proteome analysis of the Atlantic salmon (Salmo salar) cell line SHK-1 following recombinant IFN-¿ stimulation'. Proteomics, vol 7, no. 13, pp. 2275-2286.
    [Online] DOI: 10.1002/PMIC.200700020
  • Kause, A., Tobin, D., Mantysaari, EA., Martin, SAM., Houlihan, DF., Kiessling, A., Rungruangsak-Torrissen, K., Ritola, O. & Ruohonen, K. (2007). 'Genetic potential for simultaneous selection of growth and body composition in rainbow trout (Oncorhynchus mykiss) depends on the dietary protein and lipid content: Phenotypic and genetic correlations on two diets'. Aquaculture, vol 271, pp. 162-172.
    [Online] DOI: 10.1016/j.aquaculture.2007.06.005
  • Martin, SAM., Zou, J., Houlihan, DF. & Secombes, CJ. (2007). 'Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-II macrophage cells as revealed by transcriptome profiling'. BMC Genomics, vol 8.
    [Online] DOI: 10.1186/1471-2164-8-150
  • Teale, AJ., Archibald, AL., Bron, JE., Burt, DW., Houlihan, DFJ., Høyheim, B., Martin, SAM., Murray, FD., Secombes, CJ., Seear, PJ., Sweeney, GE., Taggart, JB., Talbot, R., Tocher, DR. & Zheng, X. (2007). 'Towards a molecular genetic tool for health and performance monitoring of Atlantic salmon (Salmo salar): The TRAITS 17K cDNA microarray'. Aquaculture, vol 272, no. Supplement 1, pp. S313-S314.
    [Online] DOI: 10.1016/j.aquaculture.2007.07.192
  • Martin, SAM., Blaney, SC., Houlihan, DFJ. & Secombes, CJ. (2006). 'Transcriptome response following administration of a live bacterial vaccine in Atlantic salmon (Salmo salar)'. Molecular Immunology, vol 43, pp. 1900-1911.
    [Online] DOI: 10.1016/j.molimm.2005.10.007
  • Tobin, D., Kause, A., Mantysaari, EA., Martin, SAM., Houlihan, DF., Dobly, A., Kiessling, A., Rungruangsak-Torrissen, K., Ritola, O. & Ruohonen, K. (2006). 'Fat or lean? The quantitative genetic basis for selection strategies of muscle and body composition traits in breeding schemes of rainbow trout (Oncorhynchus mykiss)'. Aquaculture, vol 261, pp. 510-521.
    [Online] DOI: 10.1016/j.aquaculture.2006.07.023
  • Kause, A., Tobin, D., Houlihan, DF., Martin, SAM., Mantysaari, EA., Ritola, O. & Ruohonen, K. (2006). 'Feed efficiency of rainbow trout can be improved through selection: different genetic potential on alternative diets'. Journal of Animal Science, vol 84, pp. 807-817.
  • Kause, A., Mäntysaari, E., Tobin, D., Dobly, A., Houlihan, D., Martin, SAM., Ritola, O. & Ruohonen, K. (2006). 'Recording strategies and selection potential of feed intake measured using the X-ray method in rainbow trout'. Genetics Selection Evolution, vol 38, no. 4, pp. 389-409.
    [Online] DOI: 10.1051/gse:2006011
  • Dobly, A., Ritola, O., Wahlroos, H., Kause, A., Mantysaari, E., Ruohonen, K., Martin, SAM. & Houlihan, DFJ. (2005). 'Genetic correlates of protein growth efficiency in 210 families of rainbow trout assessed by X-rays'. Aquaculture, vol 247, no. 1-4, pp. 12-12.
    [Online] DOI: 10.1016/j.aquaculture.2005.02.001
  • Martin, SAM., Houlihan, DFJ. & Secombes, CJ. (2005). 'Transcriptional analysis of Atlantic salmon (Salmo salar) cDNAs following a disease challenge'. Aquaculture, vol 247, no. 1-4, pp. 24.
  • Martin, SAM., Vilhelmsson, OT. & Houlihan, DFJ. (2005). 'Protein profiles in rainbow trout, Oncorhynchus mykiss'. Aquaculture, vol 247, no. 1-4, pp. 24-25.
  • Vilhelmsson, OT., Martin, SAM., Medale, F., Kaushil, SJ. & Houlihan, DFJ. (2004). 'Dietary plant-protein substitution affects hepatic metabolism in rainbow trout ( Oncorhynchus mykiss )'. British Journal of Nutrition, vol 92, no. 1, pp. 71-80.
    [Online] DOI: 10.1079/BJN20041176
  • Gomez-Requeni, P., Mingarro, M., Calduch-Giner, JA., Medale, F., Corraze, G., Panserat, S., Martin, SAM., Houlihan, DFJ., kaushik, SJ. & Perez-Sanchez, J. (2004). 'Protein growth performance, amino acid utilisation and somatotropic axis responsiveness to fish meal replacement by plant protein sources in gilthead sea bream ( Sparus aurata )'. Aquaculture, vol 232, no. 1-4, pp. 493-510.
    [Online] DOI: 10.1016/S0044-8486(03)00532-5
  • Dobly, A., Martin, S., Blaney, S. & Houlihan, D. (2004). 'Protein growth rate in rainbow trout (Oncorhynchus mykiss) is negatively correlated to liver 20S proteasome activity'. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 137, no. 1, pp. 75-85.
    [Online] DOI: 10.1016/j.cbpb.2003.09.002
  • Martin, SAM., Vilhelmsson, OT., Medale, F., Watt, P., Kaushik, SJ. & Houlihan, DFJ. (2003). 'Proteomic sensitivity to dietary manipulations in rainbow trout'. Biochimica et Biophysica Acta - Proteins and Proteomics, vol 1651, no. 1-2, pp. 17-29.
    [Online] DOI: 10.1016/S1570-9639(03)00231-0
  • Gomez-Requeni, P., Mingarro, M., Calduch-Giner, JA., Medale, F., Martin, SAM., Houlihan, DFJ., Kaushik, SJ. & Perez-Sanchez, J. (2003). 'Effects of dietary amino acid profile on growth performance, key metabolic enzymes and somatotropic axis responsiveness of gilthead sea bream ( Sparus aurata )'. Aquaculture, vol 220, no. 1-4, pp. 749-767.
    [Online] DOI: 10.1016/S0044-8486(02)00654-3
  • Martin, SAM., Vilhelmsson, OT. & Houlihan, DFJ. (2003). 'Rainbow trout liver proteome: dietary manipulation and protein metabolism'. European Association for Animal Production Publication, vol 109, pp. 57-60.
  • Martin, SAM., Blaney, SC., Bowman, AS. & Houlihan, DFJ. (2002). 'Ubiquitin-proteasome dependant proteolysis in rainbow trout Oncorhynchus mykiss : effect of food deprivation'. Pflugers Archiv : European Journal of Physiology, vol 445, pp. 257-266.
    [Online] DOI: 10.1007/s00424-002-0916-8
  • Houlihan, DFJ. & Martin, SAM. (2002). 'Protein metabolism in fish: gambling on proteomics'. Integrative and Comparative Biology, vol 42, no. 6, pp. 1245-1246.
  • Martin, SAM., Cash, P., Blaney, SC. & Houlihan, DFJ. (2001). 'Proteome analysis of rainbow trout ( Oncorhyncus mykiss ) liver proteins during short term starvation'. Fish Physiology and Biochemistry, vol 24, no. 3, pp. 259-270.
    [Online] DOI: 10.1023/A:1014015530045
  • Sangrador-Vegas, A., Martin, SAM., O'Dea, PG. & Smith, TJ. (2000). 'Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin-1 receptor cDNA'. European Journal of Biochemistry, vol 267, no. 24, pp. 7031-7037.
  • Nolan, D., Martin, SAM., Kelly, Y., Glennon, K., Palmer, R., Smith, T., McCormack, GP. & Powell, R. (2000). 'Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis (Kroyer)'. Aquaculture Research, vol 31, no. 11, pp. 815-822.
    [Online] DOI: 10.1046/j.1365-2109.2000.00514.x
  • Guiguen, Y., Baroiller, JF., Ricordel, MJ., Iseki, K., McMeel, OM., Martin, SAM. & Fostier, A. (1999). 'Involvement of estrogens in the process of sex differentiation in two fish species: The rainbow trout (Oncorhynchus mykiss) and a Tilapia (Oreochromis niloticus): The rainbow trout (Oncorhynchus mykiss) and a Tilapia (Oreochromis niloticus)'. Molecular Reproduction and Development, vol 54, no. 2, pp. 154-162.
    [Online] DOI: 10.1002/(SICI)1098-2795(199910)54:2<154::AID-MRD7>3.0.CO;2-5
  • Hunter, SJ., Martin, SAM., Thompson, FJ., Tetley, L. & Devaney, E. (1999). 'The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi'. Parasitology, vol 119, no. 2, pp. 189-198.
    [Online] DOI: 10.1017/S0031182099004576
  • Martin, SAM., Youngson, AF. & Ferguson, A. (1999). 'Atlantic salmon (Salmo salar) prolactin cDNA sequence and its mRNA expression after transfer of fish between salinities'. Fish Physiology and Biochemistry, vol 20, no. 4, pp. 351-359.
    [Online] DOI: 10.1023/A:1007711504712
  • Martin, SAM., Wallner, W., Youngson, AF. & Smith, T. (1999). 'Differential expression of Atlantic salmon thyrotropin beta subunit mRNA and its cDNA sequence'. Journal of Fish Biology, vol 54, no. 4, pp. 757-766.
    [Online] DOI: 10.1111/j.1095-8649.1999.tb02031.x
  • Anant, S., Martin, SAM., Yu, HR., MacGinnitie, AJ., Devaney, E. & Davidson, NO. (1997). 'A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding activity'. Molecular and Biochemical Parasitology, vol 88, no. 1-2, pp. 105-114.
    [Online] DOI: 10.1016/S0166-6851(97)00083-2
  • Thompson, FJ., Martin, SAM. & Devaney, E. (1996). 'Brugia pahangi: characterisation of a small heat shock protein cDNA clone'. Experimental Parasitology, vol 83, no. 3, pp. 259-266.
    [Online] DOI: 10.1006/expr.1996.0073
  • Martin, SAM., Hunter, SJ., Thompson, FJ. & Devaney, E. (1996). 'Stage specific gene expression in the post-infective L3 of the filarial nematode, Brugia pahangi'. Molecular and Biochemical Parasitology, vol 79, no. 1, pp. 109-112.
  • Martin, SAM., Thompson, FJ. & Devaney, E. (1995). 'The construction of spliced leader cDNA libraries from the filarial nematode Brugia pahangi (vol 70, pg 241, 1995)'. Molecular and Biochemical Parasitology, vol 75, no. 1, pp. 129.
  • YOUNGSON, AF., Martin, SAM., JORDAN., WC. & Verspoor, E. (1991). 'Genetic protein variation in Atlantic salmon in Scotland: comparison of wild and farmed fish'. Aquaculture, vol 98, no. 1-3, pp. 231-242.
    [Online] DOI: 10.1016/0044-8486(91)90386-L
  • Martin, SAM. & Stefani, LAJ. (1991). 'Genetic-Regulation of the Pituitary Control of Smolting and Sexual-Maturation in Atlantic Salmon'. Biochemical Society Transactions, vol 19, no. 2, pp. S199.

Comments and Debates

  • Martin, SAM., THOMPSON., FJ. & DEVANEY, E. (1995). 'The construction of spliced leader cDNA libraries from the filarial nematode Brugia pahangi'. Molecular and Biochemical Parasitology, vol 70, no. 1-2, pp. 241-245.
    [Online] DOI: 10.1016/0166-6851(95)00032-V
  • COXSINGH, J., PAINE, MJI., Martin, SAM. & DEVANEY, E. (1994). 'Stage-Specific Differences in Steady-State Levels of Messenger-RNA Encoding the Major Surface Glycoprotein of Brugia-Pahangi'. Annals of Tropical Medicine and Parasitology, vol 45, no. 4, pp. 352-354.

Scientific Reviews

  • Devaney, E., Martin, SAM. & Thompson, FJ. (1996). 'Stage-specific gene expression in lymphatic filarial nematodes'. Parasitology Today, vol 12, no. 11, pp. 418-424.
    [Online] DOI: 10.1016/0169-4758(96)10065-X

Chapters in Books, Reports and Conference Proceedings

Chapters

  • Martin, SAM., Vilhelmsson, OT. & Houlihan, DFJ. (2004). 'Rainbow trout liver proteome: dietary manipulation and protein metabolism'. in W Souffrant & C Metges (eds), Progress in Research on Energy and Protein Metabolism : EAAP Scientific vol. 109, FAO agricultural development paper., no. 109, Purdue University Press, pp. 57-60.

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