Dr Mirela Delibegovic
Senior Research Fellow
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+44 (0)1224 437587
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+44 (0)1224 437411
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fax
+44 1224 437465
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m.delibegovic@abdn.ac.uk
http://www.abdn.ac.uk/ims/profiles/m.delibegovic
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University of Aberdeen
College of Life Sciences and Medicine
School of Medical Sciences
Institute of Medical Sciences (IMS), office 6:34, lab 6:50
Foresterhill
Aberdeen AB25 2ZD, UK
TEL: +44 1224 437587
Lab: +44 1224 437411
Senior Research Fellow
Ph.D.
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Personal Details
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WE CURRENTLY HAVE AN OPENING FOR A PhD POSITION IN OUR LABORATORY; FOR MORE DETAILS PLEASE FOLLOW INSTRUCTIONS ON:
http://www.findaphd.com/search/ProjectDetails.aspx?PJID=44771&LID=15
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Biography
EDUCATION
Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, USA
Post-Doctoral Fellow in the Division of Medicine, Cancer Biology Programme, in the laboratory of Professor Benjamin G. Neel (2003 –2007)
University of Dundee, MRC Protein Phosphorylation Unit, Dundee, UK
PhD in Biochemistry. Supervisor Professor Patricia T.W. Cohen (1999 –2003).
University of Edinburgh, Edinburgh, UK
BSc in Biological Sciences with Honours in Pharmacology (1995 –1999).
Secondary education: George Heriot's School, Edinburgh, UK (1994 –1995);
Mesa Selimovic Grammar School, Tuzla, Bosnia & Hercegovina (1990-1994).
EMPLOYMENT HISTORY
2012: University of Aberdeen, Promotion to Grade 8 Senior Research Fellow; School of Medical Sciences, Institute of Medical Sciences (IMS)
2010: University of Aberdeen, Promotion to Grade 7 (Lecturer grade): School of Biological Sciences, Institute of Biological and Environmental Sciences
2007 - 2012: University of Aberdeen, RCUK Fellowship (5 year tenure track); School of Biological Sciences, Institute of Biological and Environmental Sciences
2003 - 2007: Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, USA; Post-Doctoral Fellowship (personal fellowship from the American Heart Association) in the Division of Medicine, Cancer Biology Programme
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Research Interests
RESEARCH INTERESTS
My main interests of study are the role of tyrosine phosphorylation and dephosphorylation in cell signaling and disease, such as type 2 diabetes, cardiovascular disease, Alzheimer's disease, Hungtington's disease and non-alcoholic fatty liver disease (NAFLD). Through the combined use of biochemical, cellular and gene knockout mouse models, my research focuses on the function of protein-tyrosine phosphatases (PTPs) in regulating insulin and leptin signalling pathways in whole body metabolism, and how deregulation of these pathways leads to the development of these diseases. Understanding the pathways regulating metabolic processes is of critical importance because these diseases are reaching epidemic proportions.
LAB PHOTOS
A group photo in our Institute prior to going out for lunch (April 2013); LR: Carl, Emma, Louise, Kirsty, Mirela; top: Nimesh, George.
Diabetes UK conference - Manchester, March 2013 (LR: Louise, Kirsty, Mirela)
Abdel's leaving drinks and cakes - Abdel is off to take up his lecturship at
the University of Surrey - we'll miss him! Abdel is the one holding the card!
Ela and Jenny's leaving dinner, 2012 (LR: Jenny, Emma, Ela)
Petros and Claire finish their projects (LR: Petros, Carl, Claire, George, Nimesh, Mirela)
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Current Research
Carl Owen, who obtained his MSc at the University of Aberdeen, is a BBSRC funded PhD student (2009-2013) in my lab investigating the role of PTP1B in body mass regulation and insulin sensitivity. Carl is currently writing up his thesis.
Dr. Louise Grant is a research fellow working on a BHF-funded project grant (2011-2014) investigating the role of adipocyte and macrophage PTP1B in metabolism.
Ms. Emma Lees is a BBSRC funded PhD student (2011-2015), co-supervised by Dr. Nimesh Mody, elucidating the role of tyrosine phosphorylation in diabetes, obesity and cardiovascular disease.
Dr. Kirsty Shearer is a postdoctoral fellow working on the EFSD/Lilly Programme grant (2012-2013) investigating the role of macrophages in insulin resistance, cholesterol synthesis and organ size.
Petros Stathakos (University of Aberdeen undergraduate student) - summer project in the lab working on the link between insulin sensitivity and Alzheimer's disease (AD) (summer 2012); previously summer student in the lab of Dr. Nimesh Mody and my lab working on the role of tyrosine phosphatases and ER stress (summer 2010, summer 2011). Petros will be starting his PhD studies on Parkinson's disease in Bristol in autumn 2013.
Ms. Samantha le Sommer has recently been awarded a 3-year competitive Institute of Medical Sciences PhD studentship in my lab (2013-2016) to work on the effects of myeloid-PTP1B deficiency on cell proliferation and migration. Dr. Cristina Martin-Granados is her second supervisor. Samantha obtained her undergraduate degree in Immunology from the University of Edinburgh.
Mr. Armin Oskooi (University of Aberdeen undergraduate student) was awarded a Medical Research Scotland vacation studentship (2013) to study the link between obesity, insulin resistance and inflammation.
PREVIOUS LAB MEMBERS:
Dr. Abdelali Agouni; Diabetes UK funded postdoctoral fellow 2009-2011 (current position: Lecturer in Cardiovascular Biology, University of Surrey)
Dr. Alicja Czopek; BHF funded postdoctoral fellow 2009-2011 (current position: postdoctoral fellow at the University of Edinburgh)
Dr. Ela Krol; Diabetes UK funded postdoctoral fellow 2011-2012 (current position: postdoctoral fellow, University of Aberdeen)
Undergraduate Students:
Miss Olga Kochman (2012-2013)
Miss Sonia Pawelek (2012-2013)
Mr Jay Hutchinson (2009-2012) - obtained a Medical Research Scotland vacation studentship in 2011
Ms. Jenny Reekie (2011-2012)
Mr. James Workman (2011-2012)
Ms. Katie Towle (2010-2011)
Ms. Lindsey Hasler (2009-2010)
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Collaborations
EXTERNAL
Prof. Benjamin Neel; Ontario Cancer Institute; Toronto; Canada
Prof. Barbara Kahn: BIDMC and Harvard Medical School; Boston; USA
Prof. Thomas Gettys; Penningtom Biomedical Research Center; Baton Rouge; USA
Dr. Kendra Bence; University of Pennsylvania; Philadelphia; USA
Dr. Maria Kontaridis; BIDMC and Harvard Medical School; Boston, USA
Prof. Kei Sakamoto; Head of Division of Diabetes Research, Nestle Institute of Health Sciences and Professor at EPFL, Lausanne; Switzerland
Dr. Olga Göransson, Lund University , Protein Phosphorylation Research Group, Sweden
Dr. Frederic Preitner; University of Lausanne; Switzerland
Prof. Colin Selman, Professor of Biogerontology, University of Glasgow
INTERNAL
Prof. Bettina Platt, Institute of Medical Sciences, University of Aberdeen
Dr. Nimesh Mody; BHF career development fellow, University of Aberdeen
Prof. Micheal Frenneaux, Regius Chair of Medicine, University of Aberdeen
Dr. Dana Dawson; Senior Clinical Lecturer, IMS, University of Aberdeen
Prof. Alison Murray, Chair in Radiology, IMS, UoA
Dr. Zofia Miedzybrodzka, Reader in Medical Genetics, IMS, UoA
Dr. Perry Barrett; Rowett Institute of Nutrition and Health, UoA
Dr. Nigel Hoggard; Rowett Institute of Nutrition and Health, UoA
Prof. Andy Welch; Chair in School of Medical Sciences, UoA
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Research Grants
Medical Research Scotland, Vacation Scholarship 2013, Principal Investigator
Tenovus Scotland, 1-year Research Grant (2012-2013) "Protein X and Dementia Risk" co-applicant (with Dr. A. Murray as lead PI, Dr. Staff - coapplicant, Dr. McNeil - coapplicant).
EFSD/Lilly European Diabetes Research Programme Grant (2012 - 2013) Principal Investigator (with Dr. Nimesh Mody as a co-PI)
British Heart Foundation Project Grant (2011-2014) Principal Investigator
BBSRC Doctoral Training Grant (DTG) (2011-2015) 'Elucidating the role of tyrosine phosphorylation in obesity, diabetes and cardiovascular disease'
Tenovus Scotland, 1-year Research Grant (2011-2012) Principal Investigator
Medical Research Scotland, Vacation Scholarship 2011, Principal Investigator
UKRC for Women in SET, Travel bursary, USA conference and collaboration trip (2010)
British Heart Foundation Project Grant (2009-2010) Principal Investigator
BBSRC Doctoral Training Grant (DTG) (2009-2013) 'Role of Protein Tyrosine Phosphatase 1B (PTP1B) in body mass regulation and glucose homeostasis'
The Royal Society Research Grant (2009-2010) Principal Investigator
Diabetes UK Project Grant (2009-2012) Principal Investigator
College of Life Sciences and Medicine Start-up Fund (2007-2012)
Research Council UK (RCUK) Fellowship to study mouse models of ageing and obesity (2007-2012)
American Heart Association Postdoctoral Fellowship (2005-2007)
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Teaching Responsibilities
- 4th year Molecular Pharmacology; School of Medical Sciences; University of Aberdeen; lectures:
1) Diabetes and Insulin Resistance: current therapies
2) Diabetes and Insulin Resistance: New research
- Course Co-ordinator; final 4th year Honours Bioethics course, ZO 4805, School of Biological Sciences, University of Aberdeen (2010 - 2012). Also teaching (2008- current) on this course:
- Genetic modifications of animals and human beings;
- Ethics and research on human subjects.
- Kindrogan Teambuilding Course - Honours year 2 day teambuilding retreat
- Lecturing in the 2nd year undergraduate Vertebrate Zoology BI20Z1 course; School of Biological Sciences, University of Aberdeen
- Mammals - radiation and adaptations 1.
- Mammals - radiation and adaptations 2.
- Mammals - radiation and adaptations 3.
as well as Vitae (click on the link for full details)
- Outreach and teaching in secondary schools as a part of the Researchers in Residence programme; appointed to Hazlehead Academy in Aberdeen.
For the latest practical class I did in Hazlehead Academy, where the students were learning about DNA go to:
http://www.hazleheadacy.aberdeen.sch.uk/more_news157.htm
In the past, I've given inspirational talks and practical science classes during my postdoctoral fellowship at Harvard, to Science Club For Girls and similar practical "murder mistery" classes as a PhD student in Dundee.
Diabetes UK voluntary group talks - I've been invited by the Moray Voluntary Group, Ribble Valley Voluntary Group and Aberdeen Voluntary Group to talk about my lab's research, and our work is officially adopted by the Moray Voluntary Group and Ribble Valley voluntary group.
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External Responsibilities
Elected for the Royal Society of Edinburgh (RSE) Young Academy of Scotland
Diabetes UK Professional Member
The American Physiological Society Elected Member
The Biochemical Society Elected Member
European Association for the Study of Diabetes (EASD) Member
Editorial Board Member of Frontiers in Systems and Translational Endocrinology
Editorial Board Member of ISRN Obesity
Reviewer for several peer-reviewed journals and funding bodies (UK and international)
Member of the Ethics Review Board for College of Life Sciences and Medicine (CLSM)
Member of the University of Aberdeen Senatus Academicus (the Senate)
Member of the College BSU Management Group
Athena SWAN Self Assessment Team, University of Aberdeen
Seminars Organiser for the School of Biological Sciences, University of Aberdeen
Member of the Genetically Modified Organisms committee for Old Aberdeen
Elected for the Scottish Crucible 2009 programme
Member of the Scottish Researcher Career Coordination Forum
Member of the Aberdeen Center for Energy Regulation & Obesity (ACERO)
Member of regulatory variation and disease collaborative centre
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Admin Responsibilities
Seminars organiser for School of Biological Sciences, University of Aberdeen (2007-2012)
Project grants budget administration
Undergraduate student examiner
PhD and MSc student examiner
Committee memberships (Senate, CLSM Ethics Review Committee, BSU managment committee, GMO committee, Athena SWAN)
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Invited Conference Speaker
- 20th Anniversary of EFSD/Lilly Research Symposium, Bad Homburg, Germany (May 2013)
- Herrenhausen Symposium on Metabolic Diseases, Hannover, Germany (April 2013)
- Keynote speaker, Cardiovascular Symposium, University of Aberdeen (Jan 2013)
- University of Dundee, Diabetes Research Centre, Dundee (Dec 2012)
- Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland (2011)
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DIABETES UK Annual Professional Conference 2011, London (2011)
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University of Edinburgh, Centre for Cardiovascular Science, Edinburgh, 2010
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Astra Zeneca UK Adipose Tissue Discussion Group, 2009
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University of Angers Medical School, Angers, France (2009)
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ECO 2009 17th European Congress on Obesity (Amsterdam 2009)
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University of Dundee, Neuroscience Department (2008)
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Scottish Society for Experimental Medicine (Edinburgh 2008)
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Keystone conference on Diabetes Mellitus & Energy Metabolism (Vancouver 2006)
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Cold Spring Harbor, Protein Phosphorylation and Cell Signaling conference (2005)
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Retreat with Collaborators
Reatreat - November 2009; Dalmunzie Castle; laboratories of Dr. Kei Sakamoto (University of Dundee), Dr. Olga Goransson (Lund University, Sweden) and Dr. Mirela Delibegovic
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The Royal Society of Edinburgh (RSE) Young Academy of Scotland
An elected member of the RSE Young Academy of Scotland. The Young Academy brings together some of the most able and innovative young academics, entrepreneurs, artists and professionals in Scotland, with the aim of harnessing their creativity to develop a coherent and influential voice on behalf of the most talented people of their generation. The Academy members will work across disciplines to consider many of the most challenging issues facing society either domestically or globally, in fields as diverse as climate change, the economy, ethics or the arts.
The Royal Society of Edinburgh (RSE), Scotland’s National Academy, welcomed all the members of the new “RSE Young Academy of Scotland” to an event on Tuesday 29th November.
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Publications
Contributions to Journals
Articles
- McIlroy, GD., Delibegovic, M., Owen, C., Stoney, PN., Shearer, KD., McCaffery, PJ. & Mody, N. (2013). 'Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver and Hypothalamus'. Diabetes, vol 62, no. 3, pp. 825-836.
[Online] DOI: 10.2337/db12-0458 - Owen, C., Czopek, AJ., Agouni, A., Grant, L., Judson, RN., Lees, EK., McIlroy, GD., Göransson, O., Welch, A., Kendra Bence, K., Kahn, B., Neel, BG., Mody, N. & Delibegovic, M. (2012). 'Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and is a Minor Regulator of Glucose Homeostasis'. PLoS ONE, vol 7, no. 2, pp. e32700.
[Online] DOI: 10.1371/journal.pone.0032700
[Online] AURA: Delibegovic_Adipose1BKO_PLoS_2012.pdf - Hoggard, N., Agouni, A., Mody, N. & Delibegovic, M. (2012). 'Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes'. International Journal of General Medicine, vol 5, pp. 403-411.
[Online] DOI: 10.2147/IJGM.S25879
[Online] AURA: Delibegovic_HumanRBP4_PTP1B_IJGM_2012.pdf - Mody, N., Agouni, A., McIlroy, GD., Platt, B. & Delibegovic, M. (2011). 'Susceptibility to diet-induced obesity and glucose intolerance in the APPSWE/PSEN1A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein'. Diabetologia, vol 54, no. 8, pp. 2143-2151.
[Online] DOI: 10.1007/s00125-011-2160-2 - Agouni, A., Mody, N., Owen, C., Czopek, A., Zimmer, D., Bentirez-Alj, M., Bence, KK. & Delibegovic, M. (2011). 'Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically-induced endoplasmic reticulum stress'. Biochemical Journal, vol 438, no. 2, pp. 369-378.
[Online] DOI: 10.1042/BJ20110373
[Online] AURA: Paper_Agouni_version_BJ_mAY_vs3.doc - Agouni, A., Ducluzeau, P-H, Benameur, T., Faure, S., Sladkova, M., Duluc, L., Leftheriotis, G., Pechanova, O., Delibegovic, M., Martinez, MC. & Andriantsitohaina, R. (2011). 'Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice'. PLoS ONE, vol 6, no. 11, e27809.
[Online] DOI: 10.1371/journal.pone.0027809
[Online] AURA: Delibegovic_Abdel_microparticles_Plosone_2011.pdf - Agouni, A., Owen, C., Czopek, AJ., Mody, N. & Delibegovic, M. (2010). 'In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues'. Biochemical and Biophysical Research Communications, vol 401, no. 1, pp. 104-111.
[Online] DOI: 10.1016/j.bbrc.2010.09.018 - Matsuo, K., Delibegovic, M., Matsuo, I., Nagata, N., Liu, S., Bettaieb, A., Xi, Y., Araki, K., Young, W., Kahn, BB., Neel, BG. & Haj, FG. (2010). 'Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2'. Journal of Biological Chemistry, vol 285, no. 51, pp. 39750-39758.
[Online] DOI: 10.1074/jbc.M110.153734 - Xue, B., Pulinilkunnil, T., Murano, I., Bence, KK., He, H., Minokoshi, Y., Asakura, K., Lee, A., Haj, F., Furukawa, N., Catalano, KJ., Delibegovic, M., Balschi, JA., Cinti, S., Neel, BG. & Kahn, BB. (2009). 'Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues'. Molecular and Cellular Biology, vol 29, no. 16, pp. 4563-4573.
[Online] DOI: 10.1128/MCB.01914-08 - Delibegovic, M., Zimmer, D., Kauffman, C., Rak, K., Hong, E-G, Cho, Y-R, Kim, JK., Kahn, BB., Neel, BG. & Bence, KK. (2009). 'Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress'. Diabetes, vol 58, no. 3, pp. 590-9.
[Online] DOI: 10.2337/db08-0913 - Delibegovic, M. & Mody, N. (2009). 'Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes'. Acta Medica Saliniana, vol 38, no. 1, pp. 2-7.
- Delibegovic, M., Bence, KK., Mody, N., Hong, E-G, Ko, HJ., Kim, JK., Kahn, BB. & Neelt, BG. (2007). 'Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B'. Molecular and Cellular Biology, vol 27, no. 21, pp. 7727-7734.
[Online] DOI: 10.1128/MCB.00959-07 - Bence, KK., Delibegovic, M., Xue, B., Gorgun, CZ., Hotamisligil, GS., Neel, BG. & Kahn, BB. (2006). 'Neuronal PTP1B regulates body weight, adiposity and leptin action'. Nature Medicine, vol 12, no. 8, pp. 917-924.
[Online] DOI: 10.1038/NM1435 - Delibegovic, M., Armstrong, CG., Dobbie, L., Watt, PW., Smith, AJH. & Cohen, PTW. (2003). 'Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance'. Diabetes, vol 52, no. 3, pp. 596-604.
[Online] DOI: 10.2337/diabetes.52.3.596 - Cohen, PT., Browne, GJ., Delibegovic, M. & Munro, S. (2003). 'Assay of protein phosphatase 1 complexes'. Methods in Enzymology, vol 366, pp. 135-44.
[Online] DOI: 10.1016/S0076-6879(03)66012-X - Browne, GJ., Delibegovic, M., Keppens, S., Stalmans, W. & Cohen, PTW. (2001). 'The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats'. Biochemical Journal, vol 360, no. 2, pp. 449-459.
[Online] DOI: 10.1042/0264-6021:3600449
Comments and Debates
- Bence, K., Delibegovic, M., Hotamisligil, G., Kahn, B. & Neel, B. (2010). 'Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action'. Nature Medicine, vol 16, no. 237.
[Online] DOI: 10.1038/nm0210-237b
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