Dr Leslie Noble

Dr Leslie Noble The University of Aberdeen School of Biological Sciences Dr Leslie Noble Reader work +44 (0)1224 272392

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Dr Leslie Noble

Personal Details

Telephone: +44 (0)1224 272392
Email: l.r.noble@abdn.ac.uk
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Research Interests

My group's research focus has the evolution of host-parasite interactions as its underlying theme - studying models which allow us to determine the evolutionary interactions of host and parasite from the molecular to the population level. Various aspects of an organism's life history will make it more or less susceptible to parasite/pathogen attack, and several of our interests (such as mate choice and paternity assessment - in an ascidian Diplosoma listerianum and in the squid Loligo forbesi ; inbreeding assessment - in tropical freshwater snails; and population structure - in the great white shark) reflect this consideration.

Our studies of the genetic basis of parasite resistance employ four model systems which have been used to investigate expression analysis of resistance genes, population genetics, phylogenetics, and in some species their identification and evolution. Our main model is the tropical freshwater snail-schistosome association. But more recently, in response to the rapid progress made by the Salmon Genome Project, our research interests have expanded to include immune gene expression and parasite resistance in three fish-parasite systems, sealice (Lepeophtheirus salmonis) and Gyrodactylus salaris resistance in Atlantic salmon and resistance to Tetracapsula bryosalmonae, PKX, causative agent of Proliferative Kidney Disease, PKD in trout. The synergy produced by studying these systems in parallel is proving particularly helpful in defining general key determinants of host-parasite interactions.  


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Research Grants

2001/2004 MAFF. Immune Gene Expression during PKD infection. (With Prof. C. Secombes & Dr C. Jones).

2001/2004 EU Aberdeen University as Coordinators. (SALMOGYRO) The genetic basis of Gryrodactylus salaris Resistance in Altantic salmon (Salmo salar). (With Dr C. Jones).

1999/ 2003 NERC Link Aquaculture / Scottish Salmon Growers/ Marine Harvest Scotland Identification of disease resistance genes and markers in Atlantic salmon differing in their susceptibility to sealice infection. (With Dr C. Jones & Prof. C. Secombes).

1997/ 2002 Wellcome Trust Biodiversity Prize Studentship Molecular systematics & ecology of Bulinus Africanus group snails in Tanzania. (With Dr D. Rollinson, NHM, London).

1999/ 2002. Wellcome Trust Biodiversity Prize Studentship Population structure and speciation in tropical freshwater snails of the genus Bulinus from Cameroon. (With Dr C. Jones & Dr D. Rollinson, NHM, London).

1999/2003; World Bank Genetic diversity of Cichlid fish from Tanzania.; (With Dr C. Jones & Prof Monty Preide).

2001 Leverhulme Trust Development and evaluation of Molecular Paternity Markers for an Ascidian. (With Dr C. Jones & Dr J. Bishop, MBA, Plymouth).  


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Publications

Contributions to Journals

Articles

  • Cauwelier, E., Gilbey, J., Jones, CS., Noble, LR. & Verspoor, E. (2010). 'Genotypic and phenotypic correlates with proliferative kidney disease-induced mortality in Atlantic salmon'. DISEASES OF AQUATIC ORGANISMS, vol 89, no. 2, pp. 125-135.
    [Online] DOI: 10.3354/dao02191
  • Campbell, G., Noble, LR., Rollinson, D., Southgate, VR., Webster, JP. & Jones, CS. (2010). 'Low genetic diversity in a snail intermediate host (Biomphalaria pfeifferi Krass, 1848) and schistosomiasis transmission in the Senegal River Basin'. Molecular Ecology, vol 19, no. 2, pp. 241-256.
    [Online] DOI: 10.1111/j.1365-294X.2009.04463.x
  • Gilbey, J., Cauwelier, E., Jones, CS., Mclay, A., Noble, LR. & Verspoor, E. (2009). 'Size-dependent growth of individual Atlantic salmon Salmo salar alevins from hatch to first feeding'. Journal of Fish Biology, vol 75, no. 10, pp. 2820-2831.
    [Online] DOI: 10.1111/j.1095-8649.2009.02497.x
  • Gubili, C., Johnson, R., Gennari, E., Oosthuizen, WH., Kotze, D., Meyer, M., Sims, DW., Jones, CS. & Noble, LR. (2009). 'Concordance of genetic and fin photo identification in the great white shark, Carcharodon carcharias, off Mossel Bay, South Africa'. Marine Biology, vol 156, no. 10, pp. 2199-2207.
    [Online] DOI: 10.1007/s00227-009-1233-y
  • Thieltges, DW., Ferguson, MA., Jones, CS., Noble, LR. & Poulin, R. (2009). 'Biogeographical patterns of marine larval trematode parasites in two intermediate snail hosts in Europe'. Journal of Biogeography, vol 36, no. 8, pp. 1493-1501.
    [Online] DOI: 10.1111/j.1365-2699.2008.02066.x
  • Thieltges, DW., Ferguson, MA., Jones, CS., Krakau, M., de Montaudouin, X., Noble, LR., Reise, K. & Poulin, R. (2009). 'Distance decay of similarity among parasite communities of three marine invertebrate hosts'. Oecologia, vol 160, no. 1, pp. 163-173.
    [Online] DOI: 10.1007/s00442-009-1276-2
  • Pade, NG., Queiroz, NM., Humphries, NE., Witt, MJ., Jones, CS., Noble, LR. & Sims, DW. (2009). 'First results from satellite-linked archival tagging of porbeagle shark, Lamna nasus: Area fidelity, wider-scale movements and plasticity in diel depth changes'. Journal of Experimental Marine Biology and Ecology, vol 370, no. 1-2, pp. 64-74.
    [Online] DOI: 10.1016/j.jembe.2008.12.002
  • Searle, JB., Jones, CS., Gunduz, I., Scascitelli, M., Jones, EP., Herman, JS., Rambau, RV., Noble, LR., Berry, RJ., Gimenez, MD. & Johannesdottir, F. (2009). 'Of mice and (Viking?) men: phylogeography of British and Irish house mice'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 276, no. 1655, pp. 201-207.
    [Online] DOI: 10.1098/rspb.2008.0958
  • Lockyer, AE., Spinks, J., Kane, RA., Hoffmann, KF., Fitzpatrick, JM., Rollinson, D., Noble, LR. & Jones, CS. (2008). 'Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni'. BMC Genomics, vol 9, pp. 634.
    [Online] DOI: 10.1186/1471-2164-9-634
  • Cauwelier, E., Jones, CS., Noble, LR. & Verspoor, E. (2006). 'The genetical architecture of outbreeding depression in Atlantic salmon'. Journal of Fish Biology, vol 69, pp. 240.
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. (2005). 'A High incidence of clustered microsatellite mutations revealed by parent-offpring analysis in an African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)'. Genetica, vol 124, pp. 77-83.
    [Online] DOI: 10.1007/s10709-005-0204-6
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. (2005). 'High levels of selfing are revealed by a parent-offspring analysis of the medically-important freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)'. Journal of Molluscan Studies, vol 71, pp. 175-180.
    [Online] DOI: 10.1093/mollus/eyi020
  • Gow, J., Noble, LR., Rollinson, D., Mimpfoundi, R. & Jones, CS. (2004). 'Breeding system and demography shape population genetic structure across ecological and climatic zones in the African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata), intermediate host for schistosomes'. Molecular Ecology, vol 13, no. 11, pp. 3561-3573.
    [Online] DOI: 10.1111/J.1365-294X.2004.02339.X
  • Foucher, AFL., Bongers, T., Noble, LR. & Wilson, MJ. (2004). 'Assessment of nematode biodiversity using DGGE of 18S rDNA following extraction of nematodes from soil'. Soil Biology and Biochemistry, vol 36, no. 12, pp. 2027-2032.
    [Online] DOI: 10.1016/j.soilbio.2004.05.021
  • Pemberton, AJ., Sommerfeldt, AD., Wood, CA., Flint, HC., Noble, LR., Clarke, KR. & Bishop, JDD. (2004). 'Plant-like mating in an animal:sexual compatibility and allocation trade-offs in a simultaneous hermaphrodite with remote transfer of sperm'. Journal of Evolutionary Biology, vol 17, no. 3, pp. 506-518.
    [Online] DOI: 10.1111/j.1420-9101.2004.00708.x
  • Lockyer, AE., Noble, LR., Rollinson, D. & Jones, CS. (2004). 'Schistosoma mansoni: Resistant specific infection-induced gene expression in Biomphalaria glabrata identified by fluorescent-based differential display'. Experimental Parasitology, vol 107, no. 1-2, pp. 97-104.
    [Online] DOI: 10.1016/j.exppara.2004.04.004
  • Maclean, L., Pardini, AT., Noble, LR., Bishop, JDD. & Jones, CS. (2004). 'Polymorphic dinucleotide microsatellite loci in the clonal ascidian Diplosoma listerianum : predominance of compound and highly interrupted imperfect repeats'. Molecular Ecology Notes, vol 4, no. 2, pp. 283-285.
    [Online] DOI: 10.1111/j.1471-8286.2004.00643.x
  • Lockyer, AE., Jones, CS., Noble, LR. & Rollinson, D. (2004). 'Trematodes and snails: an intimate association'. Canadian Journal Of Zoology/Revue Canadien De Zoologie, vol 82, no. 2, pp. 251-269.
    [Online] DOI: 10.1139/z03-215
  • Holland, JW., Gould, CRW., Jones, CS., Noble, LR. & Secombes, CJ. (2003). 'The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD)'. Parasitology, vol 126, pp. S95-102.
    [Online] DOI: 10.1017/S0031182003003767
  • Emery, AM., Loxton, NJ., Stothard, R., Jones, CS., Spinks, J., Llewellyn-Hughes, J., Noble, LR. & Rollinson, D. (2003). 'Microsatellites in the freshwater snail Bulinus globosus (Gastropoda : Planorbidae) from Zanzibar'. Molecular Ecology Notes, vol 3, no. 1, pp. 108-110.
    [Online] DOI: 10.1046/j.1471-8286.2003.00368.x
  • Pemberton, AJ., Noble, LR. & Bishop, JDD. (2003). 'Frequency dependence in matings with water-borne sperm'. Journal of Evolutionary Biology, vol 16, no. 2, pp. 289-301.
    [Online] DOI: 10.1046/j.1420-9101.2003.00509.x
  • Parsons, KM., Durban, J., Claridge, DE., Balcombe, KC., Noble, LR. & Thompson, PM. (2003). 'Kinship as a basis for alliance formation between male bottlenose dolphins, Tursiops truncatus , in the Bahamas'. Animal Behaviour, vol 66, pp. 185-194.
    [Online] DOI: 10.1006/anbe.2003.2186
  • Gowland, F., Boyle, PR. & Noble, LR. (2003). 'Asymmetry in the embryonic chromatophore pattern of the squid Loligo forbesi (Mollusca: Cephalopoda): a proxy for developmental instability'. Journal of the Marine Biological Association of the United Kingdom, vol 83, no. 5, pp. 1101-1105.
    [Online] DOI: 10.1017/S0025315403008336h
  • Martin, AP., Pardini, AT., Noble, LR. & Jones, CS. (2002). 'Conservation of a dinucleotide simple sequence repeat locus in sharks'. Molecular Phylogenetics and Evolution, vol 23, no. 2, pp. 205-213.
    [Online] DOI: 10.1016/S1055-7903(02)00001-5
  • Parsons, KM., Noble, LR., Reid, RJ. & Thompson, PM. (2002). 'Mitochondrial genetic diversity and population structuring of UK bottlenose dolphins ( Tursiops truncatus ): is the NE Scotland Population demographically and geographically isolated?'. Biological Conservation, vol 108, pp. 175-182.
    [Online] DOI: 10.1016/S0006-3207(02)00103-9
  • Gowland, F., Boyle, PR. & Noble, LR. (2002). 'Morphological variation provides a method of estimating thermal niche in hatchlings of the squid Loligo forbesi (Mollusca: Cephalopoda)'. Journal of Zoology, vol 258, pp. 505-513.
    [Online] DOI: 10.1017/S0952836902001668
  • Jones, CS., Lockyer, AE., Verspoor, E., Secombes, CJ. & Noble, LR. (2002). 'Towards selective breeding of Atlantic salmon for sea louse resistance: approaches to identify trait markers'. Pest Management Science, vol 58, pp. 559-568.
    [Online] DOI: 10.1002/ps.511
  • Hatton-Ellis, TW., Hope, A., Noble, LR. & Okamura, B. (2002). 'Genetic variation in a freshwater bryozoan: II: The effect of increasing spatial scale'. Archiv für Hydrobiologie, vol 154, pp. 293-309.
  • Emery, AM., Wilson, IJ., Craig, S., Boyle, PR. & Noble, LR. (2001). 'Assignment of paternity groups without access to parental genotypes: multiple mating and developmental plasticity in squid'. Molecular Ecology, vol 10, no. 5, pp. 1265-1278.
    [Online] DOI: 10.1046/j.1365-294X.2001.01258.x
  • Jones, CS., Lockyer, AE., Rollinson, D. & Noble, LR. (2001). 'Molecular approaches in the study of Biomphalaria glabrata - Schistosoma mansoni interactions: linkage analysis and gene expression profiling'. Parasitology, vol 123, pp. S181-S196.
    [Online] DOI: 10.1017/S0031182001008174
  • Webster, JP., Davies, CM., Ndamba, J., Jones, CS., Noble, LR. & Woolhouse, M. (2001). 'Spatio-temporal population genetics of Biomphalaria pfeifferi in the Zimbabwean Highveld using RAPD markers'. American Journal of Tropical Medicine and Hygiene, vol 95, pp. 515-527.
  • Jones, CS., Rollinson, D., Mimpfoundi, R., Ouma, J. & Noble, LR. (2001). 'Molecular evolution of freshwater snail intermediate hosts within the Bulinus forskalii group'. Parasitology, vol 123, pp. S277-S292.
    [Online] DOI: 10.1017/S0031182001008381
  • Lockyer, AE., Jones, CS., Noble, LR., Verspoor, E., Holland, JW. & Secombes, CJ. (2001). 'Isolation and characterisation of a putative interleukin 13 receptor a2 sequence from rainbow trout ( Oncorhynchus mykiss)'. Fish & Shellfish Immunology, vol 11, pp. 541-546.
    [Online] DOI: 10.1006/fsim.2001.0355
  • Pardini, AT., Jones, CS., Noble, LR., Kreiser, B., Malcolm, H., Bruce, BD., Stevens, JD., Cliff, G., Scholl, MC., Francis, M., Duffy, CAJ. & Martin, AP. (2001). 'Sex-biased dispersal of great white sharks'. Nature, vol 412, pp. 139-140.
    [Online] DOI: 10.1038/35084125
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. (2001). 'Polymorphic microsatellites in the African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)'. Molecular Ecology Notes, vol 1, pp. 237-241.
  • Campbell, G., Jones, CS., Lockyer, AE., Hughes, S., Brown, D., Noble, LR. & Rollinson, D. (2000). 'Molecular evidence supports an African affinity of the Neotropical freshwater gastropod, Biomphalaria glabrata, Say 1818, an intermediate host for Schistosoma mansoni'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 267, pp. 2351-2358.
  • Bishop, JDD., Pemberton, AJ. & Noble, LR. (2000). 'Sperm precedence in a novel context: mating in a sessile marine invertebrate with dispersing sperm'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 267, pp. 1107-1113.
  • Hatton-Ellis, TW., Noble, LR. & Okamura, B. (1998). 'Genetic variation in a freshwater bryozoan. I: Populations in the Thames basin, UK'. Molecular Ecology, vol 7, no. 11, pp. 1575-1585.
  • Rollinson, D., Stothard, JR., Jones, CS., Lockyer, AE., de Souza, CP. & Noble, LR. (1998). 'Molecular characterisation of intermediate snail hosts and the search for resistance genes'. Memorias do Instituto Oswaldo Cruz, vol 93, pp. 111-116.
  • Goostrey, A., Carss, DN., Noble, LR. & Piertney, SB. (1998). 'Population introgression and differentiation in the great cormorant Phalacrocorax carbo in Europe'. Molecular Ecology, vol 7, no. 3, pp. 329-338.
  • Jones, CS., Noble, LR., Lockyer, AE., Brown, DS. & Rollinson, D. (1997). 'Species-specific primers discriminate schistosome intermediate hosts: unambiguous PCR diagnosis of Bulinus forskalii group taxa (Gastropoda: Planorbidae)'. Molecular Ecology, vol 6, no. 9, pp. 843-849.
  • Rollinson, D., Jones, CS. & Noble, LR. (1996). 'New approaches to the identification of medically important freshwater snails associated with irrigated agriculture in Africa'. SLUGS, no. 66, pp. 312.
  • Bishop, JDD., Jones, CS. & Noble, LR. (1996). 'Female control of paternity in the internally fertilizing compound ascidian Diplosoma listerianum .2. Investigation of male mating success using RAPD markers'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 263, no. 1369, pp. 401-407.
  • Vernon, JG., Okamura, B., Jones, CS. & Noble, LR. (1996). 'Temporal patterns of clonality and parasitism in a population of freshwater bryozoans'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 263, no. 1375, pp. 1313-1318.
  • VERNON, JG., Jones, CS. & Noble, LR. (1995). 'RANDOM AMPLIFIED POLYMORPHIC DNA (RAPD) MARKERS REVEAL CROSS-FERTILIZATION IN BIOMPHALARIA-GLABRATA (PULMONATA, BASOMMATOPHORA)'. Journal of Molluscan Studies, vol 61, pp. 455-465.
  • Jones, CS., Noble, LR., JONES., JS., TEGELSTROM., H., TRIGGS, GS. & BERRY, RJ. (1995). 'DIFFERENTIAL MALE GENETIC SUCCESS DETERMINES GENE FLOW IN AN EXPERIMENTALLY MANIPULATED MOUSE-POPULATION'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 260, no. 1359, pp. 251-256.
  • Jones, CS., OKAMURA., B. & Noble, LR. (1994). 'PARENT AND LARVAL RAPD FINGERPRINTS REVEAL OUTCROSSING IN FRESH-WATER BRYOZOANS'. Molecular Ecology, vol 3, no. 3, pp. 193-199.
  • OKAMURA, B., Jones, CS. & Noble, LR. (1993). 'RANDOMLY AMPLIFIED POLYMORPHIC DNA ANALYSIS OF CLONAL POPULATION-STRUCTURE AND GEOGRAPHIC-VARIATION IN A FRESH-WATER BRYOZOAN'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 253, no. 1337, pp. 147-154.
  • Noble, LR. (1992). 'DIFFERENTIATION OF LARGE ARIONID SLUGS (MOLLUSCA, PULMONATA) USING LIGULA MORPHOLOGY'. Zoologica Scripta, vol 21, no. 3, pp. 255-263.
  • BERRY, RJ., TRIGGS., GS., KING., P., NASH, HR. & Noble, LR. (1991). 'HYBRIDIZATION AND GENE FLOW IN HOUSE MICE INTRODUCED INTO AN EXISTING POPULATION ON AN ISLAND'. Journal of Zoology, vol 225, pp. 615-632.

Chapters in Books, Reports and Conference Proceedings

Chapters

  • Boyle, PR., Noble, LR., Emery, A., Craig, S., Black, KD. & Overnell, J. (2001). 'Development and hatching in cephalopod eggs: A model system for partitioning environmental and genetic effects on development'. In: Animal Developmental Biology (eds. Atkinson,D.;Thorndyke,M.) BIOS Scientific Publishers Ltd In: Animal Developmental Biology (eds. Atkinson,D.;Thorndyke,M.) BIOS Scientific Publishers Ltd.
  • Noble, LR. & Jones, CS. (1996). 'A molecular and ecological investigation of the large arionid slugs of North-West Europe: The potential for new pests'. in WOC Symondson & JE Liddell (eds), Ecology of Agricultural Pests: Biochemical Approaches The Systematics Association Special Volume Series, Springer, pp. 93-131.

Other Contributions

  • Noble, LR., Jones, CS., Lockyer, AE., Spinks, J. & Rollinson, D. (2003). 'Molluscs, molecules and man: Towards new perspectives in Host-parasite interactions and future control strategies'.

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