Dr Jun Zou

Dr Jun Zou The University of Aberdeen School of Biological Sciences Dr Jun Zou Senior Research Fellow work +44 (0)1224 273796 work fax +44 (0)1224 272396 pref Room 214 Zoology Building University of Aberdeen Aberdeen AB24 2TZ

Senior Research Fellow

Dr Jun Zou

Personal Details

Telephone: +44 (0)1224 273796
Fax: +44 (0)1224 272396
Email: j.j.zou@abdn.ac.uk
Address: Room 214
Zoology Building
University of Aberdeen
Aberdeen AB24 2TZ
hCard

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http://www.abdn.ac.uk/sfirc/staff/zou.shtml


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Biography

1987, BSc, Peking University.

1990, MSc, Chinese Academy of Sciences.

1998, PhD, University of Aberdeen.

1990-1992, Research Assistant, Chinese Academy of Sciences.

1992-2008, Research Fellow, University of Aberdeen.

2008-present, Senior Research Fellow, University of Aberdeen.


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Research Interests

I am interested in comparative immunology and in particular fish immunology. My main research interests are to study:

1) Molecular mechanisms of fish antiviral defence.

2) The role of Leucocytes in antigen presentation.

3) Chemokines and chemokine-directed leucocyte trafficking.


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Research Grants

Cytokine Biology. 2010. 18k. Leverhulme Trust Visiting Fellowship. 

Development of leucocyte cell lines for immunological research in teleost fish. 2009-2011. £254k. National Centre for the Replacement, Refinement and Reduction of Animals in Research. (Lead PI, with Prof C Secombes).

Bioinformatic discovery of fish chemokines and expression modulation by pathogenic and environmental bacteria. 2008-2010. £12k. The Royal Society of Edinburgh. (Lead PI, with Prof C Secombes and Dr S Bird).

Study of MHC and gamma interferon genotype and disease susceptibility to viral pathogens in farmed fish species. 2007-2008. £12k. The Royal Society of Edinburgh. (Co-PI, with Prof C Secombes).

Do cell mediated immune responses equivalent to the Th1 responses exist in fish? 2004-2007. £325k. BBSRC. (Lead PI, with Prof C Secombes and Prof S Adams at the Univ. of Stirling).


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External Responsibilities

Member of editorial board of Fish & Shellfish Immunology, 2006-present. 

Research Manager of Scottish Fish Immunology Research Centre, 2004-present.


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Current Research Projects

Development of leucocyte cell lines for immunological research in teleost fish (Funded by NC3R, 2009-2011)

Whilst many fish cell lines have been developed over the years, and are widely used in many aspects of biological studies in virology, physiology and toxicology, most have a fibroblast or epithelial cell phenotype. Cytokines are important growth factors for leucocyte development and differentiation. The promgramme is focused on establishing a number of rainbow trout leucocyte cell lines, using cytokines as growth factors, and on phenotyping the cells that grow in response to these factors, to enable their subsequent use by the research community. These cell lines will provide a permanent platform for basic research of the fish immune system and have potential application for testing of aquaculture drugs/reagents to complement the use of live fish, and to evaluate the impact of chemicals/pollutants or other factors in the environment that may impact on fish health and welfare. Postdoctoral Research Fellow: Dr Yolanda Corripio Miyar. 

Characterising immune functions of chemokines in rainbow trout (Funded by the Royal Society of Edinburgh and the Leverhulme Trust Visiting Scholarship, 2009-2010)

Chemokines are a large family of soluble peptides directing cell migration in vertebrates. They play an important role in leucocyte trafficking and activation of the immune system. Chemokines are small in size, typically 8-10 kDa and can be classified into two major subfamilies, CXC and CC, based on the distinctive cysteine patterns at the N terminal region. As in mammals, fish appear to have a large repertoire of chemokines; with many having no apparent homology to mammalian molecules. This project is to focus on phylogenetic analysis and functional characterisation of trout chemokines, and on evaluation of the impact of bacteria and virus derived compounds on their gene expression. Visiting researcher: Dr Jun Chen.


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Publications

Contributions to Journals

Articles

  • Corripio-Miyar, Y., Secombes, CJ. & Zou, J. (2012). 'Long-term stimulation of trout head kidney cells with the cytokines MCSF, IL-2 and IL-6: Gene expression dynamics'. Fish & Shellfish Immunology, vol 32, no. 1, pp. 35-44.
    [Online] DOI: 10.1016/j.fsi.2011.10.016
  • Shewring, DM., Zou, J., Corripio-Miyar, Y. & Secombes, CJ. (2011). 'Analysis of the cathelicidin 1 gene locus in Atlantic cod (Gadus morhua)'. Molecular Immunology, vol 48, no. 5, pp. 782-787.
    [Online] DOI: 10.1016/j.molimm.2010.11.006
  • Monte, M., Zou, J., Wang, T., Carrington, AC. & Secombes, CJ. (in press). 'Cloning, expression analysis and bioactivity studies of rainbow trout (Onchorhynchus mykiss) interleukin-22'. Cytokine.
  • Castro, R., Zou, J., Secombes, C. & Martin, S. (2011). 'Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line'. Fish & Shellfish Immunology, vol 30, no. 1, pp. 215-223.
    [Online] DOI: 10.1016/j.fsi.2010.10.010
  • Zou, J. & Secombes, CJ. (2011). 'Teleost fish interferons and their role in immunity'. Developmental and Comparative Immunology, vol 35, no. 12, pp. 1376-1387.
    [Online] DOI: 10.1016/j.dci.2011.07.001
  • Sun, B., Skjaeveland, I., Svingerud, T., Zou, J., Jorgensen, J. & Robertsen, B. (2011). 'Antiviral Activity of Salmonid Gamma Interferon against Infectious Pancreatic Necrosis Virus and Salmonid Alphavirus and Its Dependency on Type I Interferon'. Journal of Virology, vol 85, no. 17, pp. 9188-9198.
    [Online] DOI: 10.1128/JVI.00319-11
  • Chang, M., Collet, B., Nie, P., Lester, K., Campbell, S., Secombes, CJ. & Zou, J. (2011). 'Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss)'. Journal of Virology, vol 85, no. 16, pp. 8403-8412.
    [Online] DOI: 10.1128/JVI.00445-10
  • Chang, M., Wang, T., Nie, P., Zou, J. & Secombes, CJ. (2011). 'Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains'. Fish & Shellfish Immunology, vol 30, no. 1, pp. 118-127.
    [Online] DOI: 10.1016/j.fsi.2010.09.014
  • Castro, R., Martin, S., Zou, J. & Secombes, C. (2010). 'Establishment of an IFN-gamma specific reporter cell line in fish'. Fish & Shellfish Immunology, vol 28, no. 2, pp. 312-319.
    [Online] DOI: 10.1016/j.fsi.2009.11.010
  • Chen, WQ., Xu, QQ., Chang, MX., Zou, J., Secombes, CJ., Peng, KM. & Nie, P. (2010). 'Molecular characterization and expression analysis of the IFN-gamma related gene (IFN-gamma rel) in grass carp Ctenopharyngodon idella'. Veterinary Immunology and Immunopathology, vol 134, no. 3-4, pp. 199-207.
    [Online] DOI: 10.1016/j.vetimm.2009.09.007
  • Qi, Z., Nie, P., Secombes, CJ. & Zou, J. (2010). 'Intron-containing type I and type III IFN coexist in amphibians'. Journal of Immunology, vol 184, no. 9, pp. 5038-5046.
    [Online] DOI: 10.4049/jimmunol.0903374
  • Chaves-Pozo, E., Zou, J., Secombes, CJ., Cuesta, A. & Tafalla, C. (2010). 'The rainbow trout (Oncorhynchus mykiss) interferon response in the ovary'. Molecular Immunology, vol 47, no. 9, pp. 1757-1764.
    [Online] DOI: 10.1016/j.molimm.2010.02.030
  • Casadei, E., Wang, T., Zou, J., Vecino, JLG., Wadsworth, S. & Secombes, CJ. (2009). 'Characterization of three novel beta-defensin antimicrobial peptides in rainbow trout (Oncorhynchus mykiss)'. Molecular Immunology, vol 46, no. 16, pp. 3358-3366.
    [Online] DOI: 10.1016/j.molimm.2009.07.018
  • Diaz-Rosales, P., Bird, S., Wang, T., Fujiki, K., Davidson, WS., Zou, J. & Secombes, CJ. (2009). 'Rainbow trout interleukin-2'. Fish & Shellfish Immunology, vol 27, no. 3, pp. 414-422.
    [Online] DOI: 10.1016/j.fsi.2009.06.008
  • Wang, T., Bird, S., Koussounadis, A., Holland, JW., Carrington, AC., Zou, J. & Secombes, CJ. (2009). 'Identification of a Novel IL-1 Cytokine Family Member in Teleost Fish'. Journal of Immunology, vol 183, no. 2, pp. 962-974.
    [Online] DOI: 10.4049/jimmunol.0802953
  • Gao, Q., Nie, P., Thompson, K., Adams, A., Wang, T., Secombes, CJ. & Zou, J. (2009). 'The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss'. Developmental and Comparative Immunology, vol 33, no. 8, pp. 920-931.
    [Online] DOI: 10.1016/j.dci.2009.03.001
  • Corripio Miyar, Y., Zou, J., Richmond, H. & Secombes, CJ. (2009). 'Identification of interleukin-22 in gadoids and examination of its expression level in vaccinated fish'. Molecular Immunology, vol 46, no. 10, pp. 2098-2106.
    [Online] DOI: 10.1016/j.molimm.2009.01.024
  • Zou, J., Chang, M., Nie, P. & Secombes, CJ. (2009). 'Origin and evolution of the RIG-I like RNA helicase gene family'. BMC Evolutionary Biology, vol 9, pp. 85-98.
    [Online] DOI: 10.1186/1471-2148-9-85
  • Chang, M., Nie, P., Collet, B., Secombes, CJ. & Zou, J. (2009). 'Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts'. Immunogenetics, vol 61, no. 4, pp. 315-325.
    [Online] DOI: 10.1007/s00251-009-0366-y
  • Su, J., Zhu, Z., Wang, Y., Zou, J., Wang, N. & Jang, S. (2009). 'Grass carp reovirus activates RNAi pathway in rare minnow, Gobiocypris rarus'. Aquaculture, vol 289, no. 1-2, pp. 15.
    [Online] DOI: 10.1016/j.aquaculture.2008.12.027
  • Casani, D., Randelli, E., Costantini, S., Facchiano, AM., Zou, J., Martin, SAM., Secombes, CJ., Scapigliati, G. & Buonocore, F. (2009). 'Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.)'. Molecular Immunology, vol 46, no. 5, pp. 943-952.
    [Online] DOI: 10.1016/j.molimm.2008.09.016
  • Holland, JW., Bird, S., Williamson, B., Woudstra, C., Mustafa, A., Wang, T., Zou, J., Blaney, SC., Collet, B. & Secombes, CJ. (2008). 'Molecular characterization of IRF3 and IRF7 in rainbow trout, Oncorhynchus mykiss: Functional analysis and transcriptional modulation'. Molecular Immunology, vol 46, no. 2, pp. 269-285.
    [Online] DOI: 10.1016/j.molimm.2008.08.265
  • Buonocore, F., Randelli, E., Casani, D., Guerra, L., Picchietti, S., Costantini, S., Facchiano, AM., Zou, J., Secombes, CJ. & Scapigliati, G. (2008). 'A CD4 homologue in sea bass (Dicentrarchus labrax): Molecular characterization and structural analysis'. Molecular Immunology, vol 45, no. 11, pp. 3168-3177.
    [Online] DOI: 10.1016/j.molimm.2008.02.024
  • Harun, NO., Zou, J., Zhang, YY., Nie, P. & Secombes, CJ. (2008). 'The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8'. Developmental and Comparative Immunology, vol 32, no. 6, pp. 673-681.
    [Online] DOI: 10.1016/j.dci.2007.10.005
  • Skjaeveland, I., Iliev, DB., Zou, J., Jorgensen, T. & Jorgensen, JB. (2008). 'A TLR9 homolog that is up-regulated by IFN-gamma in Atlantic salmon (Salmo salar)'. Developmental and Comparative Immunology, vol 32, no. 6, pp. 603-607.
    [Online] DOI: 10.1016/j.dci.2007.10.011
  • Su, J., Zhu, Z., Wang, Y., Zou, J. & Hu, W. (2008). 'Toll-like receptor 3 regulates Mx expression in rare minnow Gobiocypris rarus after viral infection'. Immunogenetics, vol 60, no. 3-4, pp. 195-205.
    [Online] DOI: 10.1007/s00251-007-0264-0
  • Martin, SAM., Zou, J., Houlihan, DF. & Secombes, CJ. (2007). 'Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-II macrophage cells as revealed by transcriptome profiling'. BMC Genomics, vol 8.
    [Online] DOI: 10.1186/1471-2164-8-150
  • Wang, T., Holland, JW., Carrington, AC., Zou, J. & Secombes, CJ. (2007). 'Molecular and Functional Characterization of IL-15 in Rainbow Trout Oncorhynchus mykiss: A Potent Inducer of IFN-¿ Expression in Spleen Leukocytes'. Journal of Immunology, vol 179, no. 3, pp. 1475-1488.
  • Nascimento, DS., do Vale, A., Raduma Tomas, MA., Zou, J., Secombes, CJ. & dos Santos, NMS. (2007). 'Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits'. Molecular Immunology, vol 44, no. 9, pp. 2277-2291.
    [Online] DOI: 10.1016/j.molimm.2006.11.006
  • Zou, J., Mercier, C., Koussounadis, A. & Secombes, CJ. (2007). 'Discovery of multiple beta-defensin like homologues in teleost fish'. Molecular Immunology, vol 44, no. 4, pp. 638-647.
    [Online] DOI: 10.1016/j.molimm.2006.01.012
  • Robertsen, B., Zou, J., Secombes, CJ. & Leong, J. (2006). 'Molecular and expression analysis of an interferon-gamma-inducible guanylate-binding protein from rainbow trout (Oncorhynchus mykiss)'. Developmental and Comparative Immunology, vol 30, no. 11, pp. 1023-1033.
    [Online] DOI: 10.1016/j.dci.2006.01.003
  • Benedetti, S., Randelli, E., Buonocore, F., Zou, J., Secombes, CJ. & Scapigliati, G. (2006). 'Evolution of cytokine responses'. Cytokine, vol 34, no. 1-2, pp. 916.
    [Online] DOI: 10.1016/j.cyto.2006.03.009
  • Kono, T., Zou, J., Bird, S., Savan, R., Sakai, M. & Secombes, CJ. (2006). 'Identitication and expression analysis of lymphotoxin-beta like hornologues in rainbow trout Oncorhynchus mykiss'. Molecular Immunology, vol 43, no. 9, pp. 1390-1401.
    [Online] DOI: 10.1016/j.molimm.2005.07.037
  • Chang, C., Zhang, Y., Zou, J., Nie, P. & Secombes, CJ. (2006). 'Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar)'. Antimicrobial Agents and Chemotherapy, vol 50, no. 1, pp. 185-195.
    [Online] DOI: 10.1128/AAC.50.1.185-195.2006
  • Zou, J., Carrington, AC., Collet, B., Dijkstra, JM., Yoshiura, Y., Bols, N. & Secombes, CJ. (2005). 'Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: The First Th1-Type Cytokine Characterized Functionally in Fish'. Journal of Immunology, vol 175, no. 4, pp. 2484-2494.
  • Chang, C., Pleguezuelos, O., Zhang, A., Zou, J. & Secombes, CJ. (2005). 'Identification of a novel cathelicidin gene in the rainbow trout, Oncorhynchus mykiss'. Infection and Immunity, vol 73, no. 8, pp. 5053-5064.
    [Online] DOI: 10.1128/IAI.73.8.5053-5064.2005
  • Bird, S., Zou, J., Savan, R., Kono, T., Sakai, M., Woo, J. & Secombes, CJ. (2005). 'Characterisation and expression analysis of an interleukin 6 hornologue in the Japanese pufferfish, Fugu rubripes'. Developmental and Comparative Immunology, vol 29, no. 9, pp. 775-789.
    [Online] DOI: 10.1016/j.dci.2005.01.002
  • Zhang, Y., Zou, J., Chang, C. & Secombes, CJ. (2004). 'Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout'. Veterinary Immunology and Immunopathology, vol 101, no. 3-4, pp. 259-269.
    [Online] DOI: 10.1016/j.vetimm.2004.05.005
  • Zou, J., Yasutoshi, YB., Dijkstra, JM., Sakai, M., Ototake, M. & Secombes, CJ. (2004). 'Identification of an interferon gamma homologue in Fugu, Takifugu rubripes'. Fish & Shellfish Immunology, vol 17, no. 4, pp. 403-409.
    [Online] DOI: 10.1016/j.fsi.2004.04.015
  • Zou, J., Bird, S., Truckle, JW., Bols, N., Horne, M. & Secombes, CJ. (2004). 'Identification and expression analysis of an IL-18 homologue and its alternatively spliced form in rainbow trout (Oncorhynchus mykiss)'. European Journal of Biochemistry, vol 271, no. 10, pp. 1913-1923.
    [Online] DOI: 10.1111/j.1432-1033.2004.04101.x
  • Wang, T., Johnson, N., Zou, J., Bols, N. & Secombes, CJ. (2004). 'Sequencing and expression of the second allele of the interleukin-1 beta 1 gene in rainbow trout (Oncorhynchus mykiss)'. Fish & Shellfish Immunology, vol 16, no. 3, pp. 335-358.
    [Online] DOI: 10.1016/S1050-4648(03)00114-1
  • Hong, SH., Zou, J., Collet, B., Bols, NC. & Secombes, CJ. (2004). 'Analysis and characterisation of IL-1 beta processing in rainbow trout, Oncorhynchus mykiss'. Fish & Shellfish Immunology, vol 16, no. 3, pp. 453-459.
    [Online] DOI: 10.1016/j.fsi.2003.08.002
  • Buonocore, F., Mazzini, M., Forlenza, M., Randelli, E., Secombes, CJ., Zou, J. & Scapigliati, G. (2004). 'Expression in Escherchia coli and purification of sea bass (Dicentrarchus labrax) interleukin 1 beta, a possible immunoadjuvant in aquaculture'. Marine Biotechnology, vol 6, no. 1, pp. 53-59.
    [Online] DOI: 10.1007/s10126-003-0011-y
  • Zou, J., Clark, MS. & Secombes, CJ. (2003). 'Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes'. Immunogenetics, vol 55, no. 5, pp. 325-335.
    [Online] DOI: 10.1007/s00251-003-0580-y
  • Zou, J., Secombes, CJ., Long, S., Miller, N., Clem, LW. & Chinchar, VG. (2003). 'Molecular identification and expression analysis of tumor necrosis factor in channel catfish (Ictalurus punctatus)'. Developmental and Comparative Immunology, vol 27, no. 10, pp. 845-858.
    [Online] DOI: 10.1016/S0145-305X(03)00085-5
  • Zou, J., Peddie, S., Scapigliati, G., Zhang, Y., Bols, NC., Ellis, A. & Secombes, CJ. (2003). 'Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss'. Developmental and Comparative Immunology, vol 27, no. 9, pp. 813-822.
    [Online] DOI: 10.1016/S0145-305X(03)00077-6
  • Peddie, S., Zou, J. & Secombes, CJ. (2002). 'A biologically active IL-1 beta derived peptide stimulates phagocytosis and bactericidal activity in rainbow trout, Oncorhynchus mykiss (Walbaum), head kidney leucocytes in vitro'. Journal of Fish Diseases, vol 25, no. 6, pp. 351-360.
    [Online] DOI: 10.1046/j.1365-2761.2002.00380.x
  • Wang, T., Zou, J., Cunningham, C. & Secombes, CJ. (2002). 'Cloning and functional characterisation of the interleukin-1 beta 1 promoter of rainbow trout (Oncorhynchus mykiss)'. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol 1575, no. 1-3, pp. 108-116.
    [Online] DOI: 10.1016/S0167-4781(02)00235-X
  • Subramaniam, S., Stansberg, C., Olsen, L., Zou, J., Secombes, CJ. & Cunningham, C. (2002). 'Cloning of a Salmo salar interleukin-1 receptor-like cDNA'. Developmental and Comparative Immunology, vol 26, no. 5, pp. 415-431.
    [Online] DOI: 10.1016/S0145-305X(01)00091-X
  • Peddie, S., Zou, J. & Secombes, CJ. (2002). 'Immunostimulation in the rainbow trout (Oncorhynchus mykiss) following intraperitoneal administration of Ergosan'. Veterinary Immunology and Immunopathology, vol 86, no. 1-2, pp. 101-113.
    [Online] DOI: 10.1016/S0165-2427(02)00019-3
  • Bird, S., Wang, T., Zou, J., Cunningham, C. & Secombes, CJ. (2002). 'The first cytokine sequence within cartilaginous fish: IL-1 beta in the small spotted catshark (Scyliorhinus canicula)'. Journal of Immunology, vol 168, no. 7, pp. 3329-3340.
  • Zou, J., Wang, T., Hirono, I., Aoki, T., Inagawa, H., Honda, T., Soma, GI., Ototake, M., Nakanishi, T., Ellis, BE. & Secombes, CJ. (2002). 'Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss'. Developmental and Comparative Immunology, vol 26, no. 2, pp. 161-172.
    [Online] DOI: 10.1016/S0145-305X(01)00058-1
  • Jorgensen, JB., Zou, J., Johansen, A. & Secombes, CJ. (2001). 'Immunostimulatory CpG oligodeoxynucleotides stimulate expression of IL-1 beta and interferon-like cytokines in rainbow trout macrophages via a chloroquine-sensitive mechanism'. Fish & Shellfish Immunology, vol 11, no. 8, pp. 673-682.
    [Online] DOI: 10.1006/fsim.2001.0344
  • Peddie, S., Zou, J., Cunningham, C. & Secombes, CJ. (2001). 'Rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta and derived peptides induce migration of head-kidney leucocytes in vitro'. Fish & Shellfish Immunology, vol 11, no. 8, pp. 697-709.
    [Online] DOI: 10.1006/fsim.2001.0348
  • Scapigliati, G., Buonocore, F., Bird, S., Zou, J., Pelegrin, P., Falasca, C., Prugnoli, D. & Secombes, CJ. (2001). 'Phylogeny of cytokines: molecular cloning and expression analysis of sea bass Dicentrarchus labrax interleukin-1 beta'. Fish & Shellfish Immunology, vol 11, no. 8, pp. 711-726.
    [Online] DOI: 10.1006/fsim.2001.0347
  • Secombes, CJ., Wang, T., Hong, S., Peddie, S., Crampe, M., Laing, KJ., Cunningham, C. & Zou, J. (2001). 'Cytokines and innate immunity of fish'. Developmental and Comparative Immunology, vol 25, no. 8-9, pp. 713-723.
    [Online] DOI: 10.1016/S0145-305X(01)00032-5
  • Hong, S., Zou, J., Crampe, M., Peddie, S., Scapigliati, G., Bols, N., Cunningham, C. & Secombes, CJ. (2001). 'The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta'. Veterinary Immunology and Immunopathology, vol 81, no. 1-2, pp. 1-14.
    [Online] DOI: 10.1016/S0165-2427(01)00328-2
  • Secombes, CJ., Bird, S., Hong, S., Laing, KJ. & Zou, J. (2001). 'Phylogeny of vertebrate cytokines'. Advances in Experimental Medicine and Biology, vol 484, pp. 89-94.
  • Laing, KJ., Wang, T., Zou, J., Holland, JW., Hong, SH., Bols, N., Hirono, I., Aoki, T. & Secombes, CJ. (2001). 'Cloning and expression analysis of rainbow trout Oncorhynchus mykiss tumour necrosis factor-alpha'. European Journal of Biochemistry, vol 268, no. 5, pp. 1315-1322.
    [Online] DOI: 10.1046/j.1432-1327.2001.01996.x

Scientific Reviews

  • Zou, J., Bird, S. & Secombes, C. (2010). 'Antiviral Sensing in Teleost Fish'. Current Pharmaceutical Design, vol 16, no. 38, pp. 4185-4193.
  • Bird, S., Zou, J. & Secombes, CJ. (2006). 'Advances in fish cytokine biology give clues to the evolution of a complex network'. Current Pharmaceutical Design, vol 12, no. 24, pp. 3051-3069.
  • Bird, S., Zou, J., Kono, T., Sakai, M., Dijkstra, JM. & Secombes, CJ. (2005). 'Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny'. Immunogenetics, vol 56, no. 12, pp. 909-923.
    [Online] DOI: 10.1007/s00251-004-0741-7
  • Bird, S., Zou, J., Wang, T., Munday, B., Cunningham, C. & Secombes, CJ. (2002). 'Evolution of interleukin-1 beta'. Cytokine & Growth Factor Reviews, vol 13, no. 6, pp. 483-502.
  • Secombes, C., Zou, J., Daniels, G., Cunningham, C., Koussounadis, A. & Kemp, G. (1998). 'Rainbow trout cytokine and cytokine receptor genes'. Immunological Reviews, vol 166, pp. 333-340.

Chapters in Books, Reports and Conference Proceedings

Chapters

  • Secombes, CJ., Zou, J. & Collet, B. (2003). 'Fish cytokine genes'. in N Shimizu, T Aoki, I Hirono & F Takashima (eds), Aquatic Genomics: Steps towards a great future SPRINGER-VERLAG TOKYO, Tokyo; London.

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