Dr COLIN SELMAN
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+44 (0)1224 272399
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+44 (0)1224 272396
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c.selman@abdn.ac.uk
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Room 307
Institute of Biological and Environmental Sciences
University of Aberdeen
Tillydrone Ave
Aberdeen
AB24 2TZ
UK
+44 (0)1224 272399
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Personal Details
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Web Links
High resolution respirometry - http://www.oroboros.at/
British Society for Research in to Ageing - http://www.bsra.org.uk/
Open Longevity Science - http://www.bentham.org/open/toaj/
The European Nutrigenomics Organisation - http://www.nugo.org/everyone/
Scottish Crucible - http://www.hw.ac.uk/scottishcrucible/
Mitofood COST ACTION FA0603- http://www.mitofood.eu/UK/^ top
Biography
Education
1990-1994 BSc- Univ. Glasgow
1994-1998 PhD- Univ. Durham
Employment History
1998-1999 RA- Dept. Biological Sciences, Univ. Durham
1999-2002 PDRA- Dept. Zoology, Univ. Aberdeen
2002-2003 PDRA- Dept. Aging and Geriatrics, Univ. Florida
2003-2007 PDRA- Dept. Medicine, Imperial College/UCL
2007-2010 Lecturer- IBES, Univ. Aberdeen
- 2010-2011 Senior Lecturer, IBES, Univ. Aberdeen
- 2011- Reader- IBES, Univ. Aberdeen
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Research Interests
My research primarily aims to identify the mechanism/s that underlie the ageing process in mammals, using various experimental paradigms that extend lifespan AND healthspan in rodents. To this end, I have considerable experience in using end-point survival analysis, rodent phenotyping, and various molecular, biochemical and transcriptomic techniques to investigate the ageing process. In 1996, it was estimated that 21% of the European Community population was over 60, with this number projected to rise to >33% by 2050. In the UK, the 2001 population census reported that more people are now over the age of 60 than below 16 years of age. These demographic profiles thus present major medical, social and economic challenges for the future. While the economic and social impact of this burgeoning ageing society is evident, the basic mechanisms underlying the ageing process are not understood. Therefore, the major challenge in ageing research is to identify general mechanisms of ageing, with comparative approaches using manipulations which vary in biological ageing and/or lifespan likely to be useful. Several of these manipulations we utilise in our current research e.g. caloric restriction (Physiol Genomics 2006.pdf, Mech Age Dev 2010.pdf, Ann NY Acad Sci 2006.pdf, Mech Age Dev 2006_1.pdf) voluntary exercise (Arch Biochem Biophys 2002.pdf, AMJ 2005.pdf), targeted mutations in the insulin signaling and mTOR signalling pathways (see below), antioxidant supplementation (Rejuv Res 2008.pdf; Mech Age Dev 2006.pdf). The use of model organisms (J Int Med 2008.pdf, ) will hopefully result in the identification of conserved mechanisms (e.g. Genome Biol 2007.pdf) which will benefit our understanding of the ageing process, ultimately helping to extend healthy ageing in humans. For recent review of long-lived mice and healthy ageing see Phil Trans Roy Soc 2011.pdf
We recently showed in Science (Selman et al. Science 2009, Science 2009.pdf) that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity in mice. Deletion of S6K1 induced gene expression patterns similar to those seen in CR or with pharmacological activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a conserved regulator of the metabolic response to CR. A commentary in Science also accompanied this paper (Cell signaling. Aging is a RSKy business; Kaebelein M and Kapahi, P).
Previously, we (Selman et al. FASEB Journal 2008) demonstrated that global deletion of the insulin receptor substrate protein 1 also extends median and maximum lifespan in BOTH female and male mice FASEB 2008.pdf, PLoS One 2011.pdf. However, homozygous deletion of IRS2 significantly shortened lifespan (see also Science 2008.pdf). We have recently been awarded a 3 year grant from the BBSRC to further investigate candidate molecular mechanisms the healthy long-life of Irs1 null mice. This research will be undertaken by Melissa Page (see below).
I am also interested in how acute and long-term CR impacts on whole-animal metabolic rate, mitochondrial respiration, mTOR signalling and mitochondrial biogenesis. Sarah Hempenstall (see below) is examining these parameters during her PhD, using an Oroboros High Resolution Respirometer (above) to determine mitochondrial function in permeabilised skeletal muscle.
Ruth Banks (see below) is examining the transcriptional and biochemical changes following Vitamin E (alpha tocopherol) supplementation in cell culture. Ruth's PhD follows on from our recent finding (Selman et al., 2008 Rejuvenation Res. 11(1):83-96, Rejuvenation Research.pdf) demonstrating that life-long alpha tocopherol supplementation extends lifespan in mice but not apparently through any specific antioxidant effect.
I am also interested in how intraspecific differences in metabolic rate, antioxidant protection and oxidative stress impact on various aspects of life-history in free living and/or novel model organisms. See Biol Lett 2005.pdf, Ecol Lett 2005.pdf, Bioessays 2010.pdf, J Nutr 2002_1.pdf, FRBM 2002.pdf, Biol Lett 2005.pdf, FRBM 2000.pdf, Proc Royal Soc B 2008.pdf
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Current Research
**We are always very interested in hearing from prospective PhD students and from scientists who are keen to collaborate with us through applying for their own grants/fellowships**
CURRENT LAB. MEMBERS:
2010-2013: Dr Melissa Page- BBSRC funded PDRA. Dissecting the mechanisms underlying lifespan extension in insulin mutant mice'. Room 315. Telephone +44(0)1224272288/4396. E-mail: m.page@abdn.ac.uk
Insulin/IGF-1 is a highly conserved signalling pathway that has been shown to regulate lifespan and cellular resistance to physiological stress in both invertebrate and vertebrate animal models. However, what remains to be clearly elucidated is the mechanism(s) that underlie these phenomena. Putative mechanisms have been examined in several long-lived insulin/IGF-1 signalling (IIS) deficient mice, such as Ames, Snell and GHRKO dwarf mice; however these mutant mice are also growth hormone (GH) deficient or resistant, which there is some evidence effects lifespan and stress resistance. Therefore, I am interested in examining cellular stress resistance within long-lived insulin receptor 1 (IRS1) knockout mice, which have normal levels of GH. In addition, I will look at plausible mechanisms that lead to enhanced cellular stress resistance, namely the activities of 1) intracellular antioxidant enzymes and 2) base excision repair (BER) enzymes, which function to repair oxidative damage to DNA. Dietary restriction is a conserved, non-genetic intervention that has also extends lifespan and enhances stress resistance. Evidence, within the Ames dwarf mice, suggests that this pathway is separate from IIS. I am interested to determine if this is also the case for IRS1 KO long-lived mice, at different ages I will place IRS1 KO on a dietary restricted diet to examine lifespan extension and cellular stress resistance.
Publications:
1: Kronenberg G, Gertz K, Overall RW, Harms C, Klein J, Page MM, Stuart JA,Endres M. Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase. Exp Neurol. 2011 Apr;228(2):253-8.
2: Stuart JA, Page MM. Plasma IGF-1 is negatively correlated with body mass in a comparison of 36 mammalian species. Mech Ageing Dev. 2010 Sep;131(9):591-8.
3: Salway KD, Page MM, Faure PA, Burness G, Stuart JA. Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species. Age (Dordr). 2011 Mar;33(1):33-47.
4: Page MM, Richardson J, Wiens BE, Tiedtke E, Peters CW, Faure PA, Burness G,Stuart JA. Antioxidant enzyme activities are not broadly correlated with longevity in 14 vertebrate endotherm species. Age (Dordr). 2010 Jun;32(2):255-70.
5: Page MM, Robb EL, Salway KD, Stuart JA. Mitochondrial redox metabolism: aging,longevity and dietary effects. Mech Ageing Dev. 2010 Apr;131(4):242-52.
6: Robb EL, Page MM, Stuart JA. Mitochondria, cellular stress resistance, somatic cell depletion and lifespan. Curr Aging Sci. 2009 Mar;2(1):12-27.
7: Page MM, Salway KD, Ip YK, Chew SF, Warren SA, Ballantyne JS, Stuart JA.Upregulation of intracellular antioxidant enzymes in brain and heart during estivation in the African lungfish Protopterus dolloi. J Comp Physiol B. 2010 Mar;180(3):361-9.
8: Page MM, Stuart JA. In vitro measurement of DNA base excision repair in isolated mitochondria. Methods Mol Biol. 2009;554:213-31.
9: Page MM, Salmon AB, Leiser SF, Robb EL, Brown MF, Miller RA, Stuart JA.Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism. Free Radic Biol Med. 2009 Apr 15;46(8):1109-18.
10: Page MM, Peters CW, Staples JF, Stuart JA. Intracellular antioxidant enzymes are not globally upregulated during hibernation in the major oxidative tissues of the 13-lined ground squirrel Spermophilus tridecemlineatus. Comp Biochem Physiol A Mol Integr Physiol. 2009 Jan;152(1):115-22.
11: Robb EL, Page MM, Wiens BE, Stuart JA. Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD. Biochem Biophys Res Commun. 2008 Mar 7;367(2):406-12.
2008-2011: Sarah Hempenstall- PhD student; CLSM 50:50 funded studentship.
Room 211. Telephone: +44(0)1224272858/4396. E-mail: r04sh8@abdn.ac.uk
PhD title: An investigation of the molecular processes underlying the effects of caloric restriction in C57BL/6 mice. During the course of my PhD I will be examining the effects of caloric restriction (CR) on whole animal physiology as well as investigating the potential molecular mechanisms underpinning CR based lifespan extension. In particular I will be examining the role played by: Mitochondrial physiology and function; mTOR signalling; Autophagy. My primary interest is in the role played by mitochondria in the aging process. Currently, ours is one of only two lab groups in Scotland to run an Oroboros O2k Oxygraph and we are the only MiPNet Reference Laboratory currently listed in Scotland. This piece of apparatus allows for the accurate measurement of rates of mitochondrial respiration in isolated mitochondria, permeabilised cells and permeabilised muscle. We have carried out a number of experiments using the O2k Oxygraph to observe rates of Complex I and Complex II driven respiration, oxidative phosphorylation, fatty acid oxidation, uncoupled respiration and mitochondrial leak in permeabilised skeletal muscle and cardiac muscle.
Publications:
Hempenstall S*, Picchio L*, Mitchell SE, Speakman JR and Selman C. (2010). The impact of acute caloric restriction on phenotype in C57BL/6 and DBA/2 mice. Mechanisms of Ageing and Development. 131:111-118 *Joint 1st authors Mech Age Dev 2010_1.pdf
2009-2013: Ruth Banks- PhD student; BBSRC DTG funded studentship.Room 211. Telephone +44(0)1224272858/4396. E-mail: r.e.banks@abdn.ac.uk
PhD title: Does the tumour suppressor P21 play a role in alpha-tocopherol-induced lifespan extension? Vitamin E, in particular alpha- tocopherol, has been shown to exert regulatory transcriptional effects on a number of gene groups including the mono-oxygenase system of the liver as well as certain cell cycle regulatorygenes, such as CDKI1 (p21). Interestingly, these functional effects appear to be largely influenced by specific structural characteristics shared within the Vitamin E family of compounds. The aim of my research project is to clarify the regulatory transcriptional effects exerted by alpha- tocopherol within the aforementioned gene groups of interest; I will be using HepG2, a hepatocellular liver carcinoma cell line as my molecular model, and ultimately will apply a whole- genome array approach to examine these alterations in detail.I am also interested in determining whether my findings will be maintained under conditions of specific gene knockdown in lower organisms.
Publications:
Banks R, Speakman JR and Selman C. (2010). Vitamin E supplementation and mammalian lifespan. Molecular Nutrition and Food Research.54:1-7. Mol Nutr Food Res.pdf
Shona Fleming (SBS) Genotyping and general colony management (BSU).
Katrina Wallen (IMS) BSc undergraduate- 2011 Carnegie Trust vacation scholarship for undergraduates of exceptional merit.
VISITING STUDENTS/FORMER LAB. MEMBERS:
2010: Brendan Delehanty - PhD student (University of Toronto).
2009: Nathanael Boissen - MRes student (Clermond-Ferrand). Project title: Do dietary black tea theaflavins phenotypically alter C57BL/6 male mice? In collaboration with Dr Graham Rena, University of Dundee.
2009: Ruth Archer - Visiting PhD student (University of Exeter).
2008: Luccie Picchio - MRes student (Clermond-Ferrand). Project title: The effect of acute caloric restriction on metabolic rate, body composition and glucose homeostasis in DBA/2 mice.
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Collaborations
Prof. Dominic Withers, MRC Clinical Sciences Centre, Imperial College London
Dr Nick Royle and Dr John Hunt, University of Exeter
Prof. Rudi Boonstra and Brendan Delahanty, University of Toronto
Dr Dan Nussey, University of Edinburgh
Dr Steven Neale, University of Glasgow
Prof. Richard Faragher and Dr Angie Sheerin, University of Brighton
Dr Jeff Stuart, Brock University, Canada
Prof. Michael Frenneaux, University of Aberdeen
Dr Mirela Delibegovic, University of Aberdeen
Dr Nimesh Mody, University of Aberdeen
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Research Grants
2011 MRC Program grant. Effect of inorganic nitrite on cardiac and skeletal muscle: Physiology, pharmacology and theraputic potential. Co-I (PI Prof. M. Frenneaux, Univ. Aberdeen).
2011 Scottish Crucible Project Fund . Measuring the Young’s modulus of erythrocytes from mice on various diets to study ageing and obesity using optoelectronic tweezers. In collaboration with Dr Steve Neale (Univ. Glasgow) and Dr Nimesh Mody (University of Aberdeen).
2010 BBSRC New Investigator grant. Dissecting the mechanisms underlying lifespan extension in insulin signalling mutant mice.
2009 BBSRC DTG PhD studentship
2009 CLSM Pump Priming Initiative. Characterisation of the autophagic response in mice following caloric restriction.
2008 50:50 PhD studentship, CLSM
2008 CLSM equipment grant
2006 Journal of Experimental Biology Travelling Fellowship Award
2002 British Ecological Society Small Project Grant
2001 Society for Experimental Biology Travel Grant
2001 The Royal Society Travel Grant
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Teaching Responsibilities
BI2008 Diversity of Life- Lectures/Laboratories
Coordinator for BI2508 Principles of Animal Physiology- Lectures/Laboratories
BI1006 Biology for Undergraduates- Tutor
ZO3509 Environmental Physiology- Lectures
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External Responsibilities
Open Longevity Science - Editorial Advisory Board
British Society for Research on Ageing - Executive Board
RECENT INVITED PRESENTATIONS:
2011, July: Keynote Speaker, Society for Experimental Biology, Glasgow, UK.
2011, April: Cost Action FA0602: ‘Bioactive Food Components, Mitochondrial Function and Health (Mitofood)’, Wageningen, The Netherlands.
2011, April: Society of Endocrinology, Birmingham, UK.
2011, March: CBG/CGC Meeting, The molecular basis and modification of the aging process, Amsterdam, The Netherlands.
2010, Oct.: Prof. Dame Linda Partridge Laboratory Retreat, Max Planck Institute, Cologne, Germany.
2011, Aug: Keynote Speaker, 3rd Young Investigator’s Workshop of ‘LifeSpan’ and ‘LINK-AGE’, London, UK.
2010, July: BSRA Annual Scientific Meeting 2010, Newcastle, UK.
2010, June: Rowett Research Institute, University of Aberdeen, UK.
2010, June: Bone and Musculoskeletal Research seminar, University of Aberdeen, UK.
2010, April: Joint Israel/UK Workshop on Pathways in Ageing and Premature Ageing, Israel.
2010, Feb.: Institute of Ageing, University of Newcastle, UK.
2010, Jan.: Centre for Cardiovascular Science, University of Edinburgh, UK.
2009, Sept.: Plenary session: 6th European Nutrigenomics Organisation, Montecatini, Italy.
2009, June: Department of Biological Sciences, University of Durham, UK.
2009, June: Konrad Lorenz Institute for Ethology, University of Vienna, Austria.
2009, March: Department of Neuroscience, University of Dundee, UK.
2008, Nov.: Institute of Evolutionary Biology, University of Edinburgh, UK.
2008, April.: O2k-Course on High-Resolution Respirometry. Schroeken, Austria.
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Admin Responsibilities
Member of University of Aberdeen Ethical Review Committee
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Publications
45. Speakman JR and Selman C. (2011). The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan. Bioessays. 33(4):255-9. Bioessays 2010.pdf
44. Selman C, Partridge L and Withers DJ. (2011). Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.PLoS One. 6(1):e16144.PLoS One 2011.pdf
43. Selman C and Withers DJ. (2011). Mammalian models of extended healthy lifespan. Phil. Trans. Royal Soc. B. 366: 99-107.
42.Wyse CA, Coogan AN, Selman C, Hazlerigg DG, Speakman JR. (2010). Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited. Biol Lett. 6: 696-698. Biol Lett 2010.pdf
41.Banks R, Speakman JR and Selman C. (2010). Vitamin E supplementation and mammalian lifespan. Molecular Nutrition and Food Research.54: 719-725. Mol Nutr Food Res 2010.pdf
40.Hempenstall S, Picchio L, Mitchell SE, Speakman JR and Selman C. (2010). The impact of acute caloric restriction on phenotype in C57BL/6 and DBA/2 mice. Mechanisms of Ageing and Development. 131: 111-118.
39.Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kosma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D and Withers DJ (2009). Ribosomal S6 kinase 1 signaling regulates mammalian life span. Science. 326: 140-4.
This paper was the subject of a ‘Perspective’ in the same Science issue (Aging is RSKy business. Kaeberlein M and Kapahi P; 2009) and was a research highlight in Nature (461, 700-701; 2009). It also was highlighted in an editorial in The New England Journal of Medicine (Aging- Lost in Translation. Kapahi P and Vijg J; 2010) Kapahi_2009NEJMCommentary.pdf and was selected for Faculty of 1000 Biology which ‘highlights and evaluates the most interesting papers published in the biological sciences’. It featured in The Telegraph, Daily Mail, Daily Express, Radio 4 Today Program, Fox News, NBC News and >100 other news-based websites.
38.Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJH,Batterham RL, Ashford MLJ,Vanhaesebroeck B and Withers DJ. (2009). Dominant role of the p110b isoform of PI3K over p110a in energy homeostasis regulation by POMC and AgRP neurons.Cell Metabolism. 10: 343-54.
37.Cantley J, *Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten, SK, Asare-Anane H, Batterham RL, Herrera P, Persaud, SJ, Duchen MR, Maxwell PH and Withers DJ. (2009). Deletion of the von Hippel-Lindau gene in pancreatic b cells impairs glucose homeostasis in mice. J. Clin. Invest.119: 125-135. *JOINT FIRST AUTHOR.
36.Archer CR, Royle N, South S, Selman C and Hunt J. (2009). Nutritional Geometry Provides Food for Thought. J Gerontol A Biol Sci Med Sci. 64(9):956-9. Journal of Gerontology 2009.pdf
35.Selman C, Lingard S, Gems D, Partridge L and Withers DJ. (2008) Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". Science. 320:1012. Science 2008.pdf
34.Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-QassabH, Speakman JR, Carmignac D, Robinson ICA, Thornton JM, Gems D, Partridge L and Withers DJ. (2008). Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 22: 807-818.
33.Selman C, McLaren JS, Collins AR, Duthie GG and Speakman JR. (2008). The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis. Proc Biol Sci. B. 275:1907-16. Proc Royal Soc B 2008.pdf
This paper was the subject of an ‘Outside JEB’ article in Journal of Experimental Biology (Cold voles live fast but don’t die young, Darveau, C. 2008).
32.Piper MD, Selman C, McElwee JJ and Partridge L. (2008). Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? J Intern Med. 263:179-91.
31.Selman C,McLaren JS, Mayer C, Duncan JS, Collins AR, Duthie GG, Redman R and Speakman JR. (2008). Lifelong ?-tocopherol supplementation increases median lifespan of C57BL/6 mice in the cold but has only minor effects on oxidative damage. Rejuv. Res. 11: 83-96.
30.McElwee JJ, Schuster EF, Piper MD, Thomas JH, Blanc E, Patel DS, Selman C, Kerrison N, Thornton JM, Withers DJ, Partridge L, Gems D. (2007). A public regulator of longevity acts via lineage-specific effectors. Genome Biology. 8: R132.
29.Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LGD, Clements M, Al-Qassad H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford MLJ, Carling D, Withers DJ. (2007). AMPK is essential for energy homeostasis regulation and glucose-sensing by POMC and AgRP neurons. J. Clin. Invest.117: 2325-2336.
This work was highlighted in an editorial in JCI ("AMPing up" our understanding of the hypothalamic control of energy balance Williams et al. 2007).
28.Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ. (2007). Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia. 50:1248-56.
27.Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI, Lingard S, Diakonov I, Patterson M, Ghatei M, Bloom SR, Franks S, Huhtaniemi I, Hardy K, and Withers DJ. (2007). Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biol. Reprod. 76: 1045-53.
26.Selman C, McLaren JS, Meyer C, Duncan JS, Redman P, Collins AR, Duthie GG and Speakman JR. (2006). Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes. Mech. Age. Dev.127:897-904.
25.Selman C, Kerrison ND, Cooray A, Piper MDW, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thorton, JM, Partridge L and Withers DJ. (2006). Coordinated multi-tissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol. Genomics. 27: 187-200.
24.Piper MDW, Selman C, McElwee JJ and Partridge L. (2005). Models of insulin signalling and longevity. Drug. Disc. Today: Disease Models.2: 249-256.
23.Humphries M, Boutin S, Thomas D, Ryan J, Selman C, McAdam A, Berteaux D and Speakman JR. (2005). Expenditure freeze: the metabolic response of small mammals to cold environments. Ecol. Letts. 8: 1326-1333.Ecol Lett 2005.pdf
22.Judge S, Mok Jang Y, Smith A, Selman C, Phillips T, Speakman JR, Hagen T and Leeuwenburgh C. (2005). Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289: 1564-1572.
21.Selman C, Phillips T, Staib SL, Duncan, JS, Leeuwenburgh, C and Speakman, JR. (2005). Energy expenditure of calorically restricted rats is less that predicted from their altered body composition. Mech. Age. Dev.126: 783-793. Mech Age Dev 2005.pdf
This paper was the subject of an ‘Outside JEB’ article in Journal of Experimental Biology (Eat little, die late, Valencak, T. 2005).
20.Selman C and Evans PR. (2005). Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds. Biol. Letts.1:101-104.Biol Lett 2005.pdf
19.Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, MacColl G, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford MLJ and Withers DJ. (2005). The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J. Clin. Invest.115: 940-950.
18. Mok Jang M, Kendaiah S, Drew B, Phillips T, Selman C, Julian D and Leeuwenburgh C. (2004). Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. FEBS Letters.577: 483-490.
17.Speakman JR, Talbot DA, Selman C. Snart S, McLaren JS, Redman P, Krol E, Jackson DM, Johnson MS and Brand MD (2004). Uncoupled and surviving: individual mice with higher metabolism have greater mitochondrial uncoupling and live longer. Aging Cell. 3: 87-96.Age Cell 2004.pdf
16.Wiersma P, Selman C, Speakman JR and Verhulst (2004). Birds sacrifice oxidative protection for reproduction. Proc. R. Soc. Lond. B. Biol. Sci.S5:360-363.Biol Lett 2004.pdf
15.Gredilla R, Phaneuf S, Selman C, Kendaiah S, Leeuwenburgh C and Barja G (2004). Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria. Ann. NY. Acad. Sci. 1019:333-342.
14.Itoh M, Oh-ishi S, Hatao H, Leeuwenburgh C, Selman C, Ohno H, Kizaki T, Nakamura H and Matsuoka T (2004). The effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm. Am. J. Physiol. Regul. Integr. Comp. Physiol.287:33-38.AMJ 2004.pdf
13.Speakman JR and Selman C (2003) Physical activity and resting metabolic rate. Proc. Nutr. Soc. 62:621-634.
12.Selman C, Kendaiah S, Gredilla R and Leeuwenburgh C (2003) Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels. Exp. Gerontology38:897-903.Exp Geront 2003.pdf
11.Selman C, Gredilla G, Phaneuf S, Kendaiah S, Barja G and Leeuwenburgh C.(2003) Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats. Biogerontology 4:141-147. Biogeront 2003.pdf
10.Drew B, Phaneuf S, Dirks A, Selman C, Gredilla R, Lezza A, Barja G and Leeuwenburgh C. (2003) Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:R474-R480. AMJ 2003.pdf
9.Selman C, Grune T, Stolzing A, Jakstadt M, McLaren JS and Speakman JR. (2002). The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, Microtus agrestis. Free Radic Biol Med. 33:259-65. FRBM 2002.pdf
8.Selman C, McLaren JS, Collins AR, Duthie GG and Speakman JR. (2002) Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running. Arch. Biochem. Biophys. 401(2):255-61. Arch Biochem Biophys 2002.pdf
7. Speakman JR, Selman C, McLaren JS and Harper EJ. (2002). Living fast, dying when? The link between aging and energetics. J. Nutr. 132:1583S-1597S. J Nutr 2002.pdf
6.Selman C, McLaren JS, Collins AR and Speakman JR. (2002). The effects of voluntary exercise on antioxidant enzyme activities and oxidative DNA damage in a small mammal. J. Nutr. 132: 1784S-1786S.J Nutr 2002b.pdf
5.Selman C, Korhonen TK, Bünger L, Hill WG and Speakman JR. (2001).Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intake. J. Comp. Physiol. B.171:661-8.J Comp Physiol B 2001.pdf
4.Selman C, Lumsden S, Bünger L, Hill WG and Speakman JR. (2001) Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake. J. Exp. Biology. 204: 777-784.J Exp Biol 2001.pdf
3.Selman C, McLaren JS, Himanka M and Speakman JR. (2000).Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal. Free Rad. Biol. Med.28:1279-1285. FRBM 2000.pdf
2.Lindsay SW, Ansell J, Selman C, Cox V, Hamilton K and Walraven G. (2000). Effect of pregnancy on exposure to malaria mosquitoes. The Lancet. 355:1972. Lancet 2000.pdf
This paper was the subject of a ‘Comment’ for The BMJ (Mosquitoes prefer pregnant women, Dobson R. 2000) and was featured on the BBC News.
1.Redman P, Selman C and Speakman JR. (1999). Male short-tailed field voles (Microtus agrestis) build better insulated nests than females. J. Comp. Physiol. B.169:581-587.J Comp Physiol B 2001_1.pdf
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