Dr Catherine Jones

Dr Catherine Jones The University of Aberdeen School of Biological Sciences Dr Catherine Jones Senior Lecturer work +44 (0)1224 272403

Senior Lecturer

Dr Catherine Jones

Personal Details

Telephone: +44 (0)1224 272403
Email: c.s.jones@abdn.ac.uk
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Research Interests

The main focus of my current research is the evolution of parasite resistance, in particular, understanding host-parasite interactions at the molecular level. Research on the evolution of host defence mechanisms involves two main model systems. The first model system is the freshwater snail intermediate host and the causative agent of human schistosomiasis, the trematode Schistosoma spp. Current work spans the fields of population genetics, phylogenetics, the identification, and evolution of snail intermediate hosts, through to developing molecular approaches for the isolation and characterization of genes involved in parasite resistance. This research theme has been extended to include investigations of immune gene expression and parasite resistance in 3 fish systems including sealice, (Lepeophtheirus salmonis) and Gyrodactylus salaris resistance in Atlantic salmon and resistance to Tetracapsula bryosalmonae, PKX, causative agent of Proliferative Kidney Disease, PKD in trout.

An additional line of research is the genetics of sharks involving population genetics of globally distributed sharks such as the great white shark, hammerheads and basking sharks, as well as the study of microsatellite evolution in sharks.  


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Research Grants

2003-2009 Wellcome Trust; 'Biomphalaria glabrata: gene discovery, expression profiling and interval mapping to elucidate mechanisms of resistance to Schistosoma mansoni'. Principal Investigator.  (with Dr L.R Noble).

2004-2006 DEFRA; 'Conservation genetics of basking sharks'. Principal Investigator.(With Dr L.R.Noble).

2001/2004 MAFF. Immune Gene Expression during PKD infection. (With Prof. C. Secombes & Dr L.Noble).

2001/2004 EU Aberdeen University as Coordinators. (SALMOGYRO) The genetic basis of Gryrodactylus salaris Resistance in Altantic salmon (Salmo salar). (With Dr L.Noble).

1997/2002 BBSRC Advanced Fellowship to CSJ. Molecular genetic analysis and evolution of parasite resistance.

1999/ 2003 NERC Link Aquaculture / Scottish Salmon Growers/ Marine Harvest Scotland Identification of disease resistance genes and markers in Atlantic salmon differing in their susceptibility to sealice infection. (With Dr L. Noble & Prof. C. Secombes).


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Selected Publications

  

Lockyer, AE, Spinks, J, Kane, RA,Hoffmann, KF, Fitzpatrick, JF, Rollinson, D, Noble, LR & Jones, CS. (2008) Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni BMC Genomics 9, 634.

Thieltges, DW, Ferguson, MAD, Jones, CS, Noble, LR & Poulin, P. (2009) Distance decay of similarity among parasite communities of three marine invertebrate hosts Oecologia, 160, 163-173.

Thieltges, DW, Ferguson, MAD, Jones, CS, Noble, LR & Poulin, P. (in press) Biogeographical patterns of marine larval trematode parasites in two intermediate snail hosts in Europe Journal of Biogeography.

Lockyer, AE, Spinks, J, Noble, LR, Rollinson, D, & Jones, CS. (2007) Identification of genes involved in interactions between Biomphalaria glabrata and Schistosoma mansoni by suppression subtractive hybridisation Molecular and Biochemical Parasitology, 151, 18-27.

Lockyer, AE, Spinks, JN, Walker, AJ, Kane, RA, Noble, LR, Rollinson, D, Dias Neto, E, & Jones, CS. (2007) Biomphalaria glabrata transcriptome: Identification of cell-signalling, transcriptional control and immune related genes from open reading frame expressed sequence tags (ORESTES) Developmental and Comparative Immunology, 31, 763-782.

Collins, CM, Olstad, K, Sterud, E, Jones, CS, Noble, LR, Mo, TA, & Cunningham C.  (2007) Isolation of a novel fish Thymidylate Kinase gene, up regulated in Atlantic salmon (Salmo salar L) following infection with the monogenean parasite Gyrodactylus salaris Fish and Shellfish Immunology, 23, 793-807.

Gow, JL, Noble, LR, Rollinson, D, & Jones, CS. (2007)Contrasting temporal dynamics and spatial patterns ofpopulation genetic structure correlate with differences in demography and habitat between two closely related African freshwater snails Biological Journal of Linnean Society 90, 747-760.

Collins, CM, Olstad, K, Sterud, E, Jones, CS, Noble, LR, Mo, TA, & Cunningham C.  (2007) Isolation of a FIP-2 like gene from Atlantic salmon (Salmo salar) found up-regulated following infection with the monogenean parasite Gyrodactylus salaris Malmberg, 1957 Fish & Shellfish Immunology, 22, 282-288.

Gilbey, J, Verspoor, E, Mo, TA, Sterud, E, Olstad, K, Hytterød, S, Noble, LR, & Jones, CS. (2006) Identification of genetic markers associated with Gyrodactylus salaris resistance in Atlantic salmon (Salmo salar L) Diseases of Aquatic Organisms, 71,119-129.

Matejusová, I, Felix, B, Sorsa-Leslie, T, Gilbey, J, Noble, LR, Jones, CS, & Cunningham,CO. (2006) Gene expression profiles of some immune relevant genes from skin of susceptible and responding Atlantic salmon (Salmo salar L) infected with Gyrodactylus salaris (Monogenea) revealed by suppressive subtractive hybridisation International journal for Parasitology, 36, 1175-1183.

Lockyer, AE, Noble, LR Rollinson, D & Jones, CS. (2005) Isolation and characterization of the full length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni Memorias do Instituto Oswaldo Cruz, 100, 259-262.


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Publications

Contributions to Journals

Articles

  • Cauwelier, E., Gilbey, J., Jones, CS., Noble, LR. & Verspoor, E. (2010). 'Genotypic and phenotypic correlates with proliferative kidney disease-induced mortality in Atlantic salmon'. DISEASES OF AQUATIC ORGANISMS, vol 89, no. 2, pp. 125-135.
    [Online] DOI: 10.3354/dao02191
  • Campbell, G., Noble, LR., Rollinson, D., Southgate, VR., Webster, JP. & Jones, CS. (2010). 'Low genetic diversity in a snail intermediate host (Biomphalaria pfeifferi Krass, 1848) and schistosomiasis transmission in the Senegal River Basin'. Molecular Ecology, vol 19, no. 2, pp. 241-256.
    [Online] DOI: 10.1111/j.1365-294X.2009.04463.x
  • Gilbey, J., Cauwelier, E., Jones, CS., Mclay, A., Noble, LR. & Verspoor, E. (2009). 'Size-dependent growth of individual Atlantic salmon Salmo salar alevins from hatch to first feeding'. Journal of Fish Biology, vol 75, no. 10, pp. 2820-2831.
    [Online] DOI: 10.1111/j.1095-8649.2009.02497.x
  • Gubili, C., Johnson, R., Gennari, E., Oosthuizen, WH., Kotze, D., Meyer, M., Sims, DW., Jones, CS. & Noble, LR. (2009). 'Concordance of genetic and fin photo identification in the great white shark, Carcharodon carcharias, off Mossel Bay, South Africa'. Marine Biology, vol 156, no. 10, pp. 2199-2207.
    [Online] DOI: 10.1007/s00227-009-1233-y
  • Thieltges, DW., Ferguson, MA., Jones, CS., Noble, LR. & Poulin, R. (2009). 'Biogeographical patterns of marine larval trematode parasites in two intermediate snail hosts in Europe'. Journal of Biogeography, vol 36, no. 8, pp. 1493-1501.
    [Online] DOI: 10.1111/j.1365-2699.2008.02066.x
  • Thieltges, DW., Ferguson, MA., Jones, CS., Krakau, M., de Montaudouin, X., Noble, LR., Reise, K. & Poulin, R. (2009). 'Distance decay of similarity among parasite communities of three marine invertebrate hosts'. Oecologia, vol 160, no. 1, pp. 163-173.
    [Online] DOI: 10.1007/s00442-009-1276-2
  • Pade, NG., Queiroz, NM., Humphries, NE., Witt, MJ., Jones, CS., Noble, LR. & Sims, DW. (2009). 'First results from satellite-linked archival tagging of porbeagle shark, Lamna nasus: Area fidelity, wider-scale movements and plasticity in diel depth changes'. Journal of Experimental Marine Biology and Ecology, vol 370, no. 1-2, pp. 64-74.
    [Online] DOI: 10.1016/j.jembe.2008.12.002
  • Searle, JB., Jones, CS., Gunduz, I., Scascitelli, M., Jones, EP., Herman, JS., Rambau, RV., Noble, LR., Berry, RJ., Gimenez, MD. & Johannesdottir, F. (2009). 'Of mice and (Viking?) men: phylogeography of British and Irish house mice'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 276, no. 1655, pp. 201-207.
    [Online] DOI: 10.1098/rspb.2008.0958
  • Lockyer, AE., Spinks, J., Kane, RA., Hoffmann, KF., Fitzpatrick, JM., Rollinson, D., Noble, LR. & Jones, CS. (2008). 'Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni'. BMC Genomics, vol 9, pp. 634.
    [Online] DOI: 10.1186/1471-2164-9-634
  • Cauwelier, E., Jones, CS., Noble, LR. & Verspoor, E. (2006). 'The genetical architecture of outbreeding depression in Atlantic salmon'. Journal of Fish Biology, vol 69, pp. 240.
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. (2005). 'A High incidence of clustered microsatellite mutations revealed by parent-offpring analysis in an African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)'. Genetica, vol 124, pp. 77-83.
    [Online] DOI: 10.1007/s10709-005-0204-6
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. (2005). 'High levels of selfing are revealed by a parent-offspring analysis of the medically-important freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)'. Journal of Molluscan Studies, vol 71, pp. 175-180.
    [Online] DOI: 10.1093/mollus/eyi020
  • Gow, J., Noble, LR., Rollinson, D., Mimpfoundi, R. & Jones, CS. (2004). 'Breeding system and demography shape population genetic structure across ecological and climatic zones in the African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata), intermediate host for schistosomes'. Molecular Ecology, vol 13, no. 11, pp. 3561-3573.
    [Online] DOI: 10.1111/J.1365-294X.2004.02339.X
  • Lockyer, AE., Noble, LR., Rollinson, D. & Jones, CS. (2004). 'Schistosoma mansoni: Resistant specific infection-induced gene expression in Biomphalaria glabrata identified by fluorescent-based differential display'. Experimental Parasitology, vol 107, no. 1-2, pp. 97-104.
    [Online] DOI: 10.1016/j.exppara.2004.04.004
  • Maclean, L., Pardini, AT., Noble, LR., Bishop, JDD. & Jones, CS. (2004). 'Polymorphic dinucleotide microsatellite loci in the clonal ascidian Diplosoma listerianum : predominance of compound and highly interrupted imperfect repeats'. Molecular Ecology Notes, vol 4, no. 2, pp. 283-285.
    [Online] DOI: 10.1111/j.1471-8286.2004.00643.x
  • Lockyer, AE., Jones, CS., Noble, LR. & Rollinson, D. (2004). 'Trematodes and snails: an intimate association'. Canadian Journal Of Zoology/Revue Canadien De Zoologie, vol 82, no. 2, pp. 251-269.
    [Online] DOI: 10.1139/z03-215
  • Holland, JW., Gould, CRW., Jones, CS., Noble, LR. & Secombes, CJ. (2003). 'The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD)'. Parasitology, vol 126, pp. S95-102.
    [Online] DOI: 10.1017/S0031182003003767
  • Emery, AM., Loxton, NJ., Stothard, R., Jones, CS., Spinks, J., Llewellyn-Hughes, J., Noble, LR. & Rollinson, D. (2003). 'Microsatellites in the freshwater snail Bulinus globosus (Gastropoda : Planorbidae) from Zanzibar'. Molecular Ecology Notes, vol 3, no. 1, pp. 108-110.
    [Online] DOI: 10.1046/j.1471-8286.2003.00368.x
  • Martin, AP., Pardini, AT., Noble, LR. & Jones, CS. (2002). 'Conservation of a dinucleotide simple sequence repeat locus in sharks'. Molecular Phylogenetics and Evolution, vol 23, no. 2, pp. 205-213.
    [Online] DOI: 10.1016/S1055-7903(02)00001-5
  • Jones, CS., Lockyer, AE., Verspoor, E., Secombes, CJ. & Noble, LR. (2002). 'Towards selective breeding of Atlantic salmon for sea louse resistance: approaches to identify trait markers'. Pest Management Science, vol 58, pp. 559-568.
    [Online] DOI: 10.1002/ps.511
  • Jones, CS., Lockyer, AE., Rollinson, D. & Noble, LR. (2001). 'Molecular approaches in the study of Biomphalaria glabrata - Schistosoma mansoni interactions: linkage analysis and gene expression profiling'. Parasitology, vol 123, pp. S181-S196.
    [Online] DOI: 10.1017/S0031182001008174
  • Webster, JP., Davies, CM., Ndamba, J., Jones, CS., Noble, LR. & Woolhouse, M. (2001). 'Spatio-temporal population genetics of Biomphalaria pfeifferi in the Zimbabwean Highveld using RAPD markers'. American Journal of Tropical Medicine and Hygiene, vol 95, pp. 515-527.
  • Jones, CS., Rollinson, D., Mimpfoundi, R., Ouma, J. & Noble, LR. (2001). 'Molecular evolution of freshwater snail intermediate hosts within the Bulinus forskalii group'. Parasitology, vol 123, pp. S277-S292.
    [Online] DOI: 10.1017/S0031182001008381
  • Lockyer, AE., Jones, CS., Noble, LR., Verspoor, E., Holland, JW. & Secombes, CJ. (2001). 'Isolation and characterisation of a putative interleukin 13 receptor a2 sequence from rainbow trout ( Oncorhynchus mykiss)'. Fish & Shellfish Immunology, vol 11, pp. 541-546.
    [Online] DOI: 10.1006/fsim.2001.0355
  • Pardini, AT., Jones, CS., Noble, LR., Kreiser, B., Malcolm, H., Bruce, BD., Stevens, JD., Cliff, G., Scholl, MC., Francis, M., Duffy, CAJ. & Martin, AP. (2001). 'Sex-biased dispersal of great white sharks'. Nature, vol 412, pp. 139-140.
    [Online] DOI: 10.1038/35084125
  • Gow, J., Noble, LR., Rollinson, D. & Jones, CS. (2001). 'Polymorphic microsatellites in the African freshwater snail, Bulinus forskalii (Gastropoda, Pulmonata)'. Molecular Ecology Notes, vol 1, pp. 237-241.
  • Campbell, G., Jones, CS., Lockyer, AE., Hughes, S., Brown, D., Noble, LR. & Rollinson, D. (2000). 'Molecular evidence supports an African affinity of the Neotropical freshwater gastropod, Biomphalaria glabrata, Say 1818, an intermediate host for Schistosoma mansoni'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 267, pp. 2351-2358.
  • Rollinson, D., Stothard, JR., Jones, CS., Lockyer, AE., de Souza, CP. & Noble, LR. (1998). 'Molecular characterisation of intermediate snail hosts and the search for resistance genes'. Memorias do Instituto Oswaldo Cruz, vol 93, pp. 111-116.
  • Jones, CS., Noble, LR., Lockyer, AE., Brown, DS. & Rollinson, D. (1997). 'Species-specific primers discriminate schistosome intermediate hosts: unambiguous PCR diagnosis of Bulinus forskalii group taxa (Gastropoda: Planorbidae)'. Molecular Ecology, vol 6, no. 9, pp. 843-849.
  • Rollinson, D., Jones, CS. & Noble, LR. (1996). 'New approaches to the identification of medically important freshwater snails associated with irrigated agriculture in Africa'. SLUGS, no. 66, pp. 312.
  • Bishop, JDD., Jones, CS. & Noble, LR. (1996). 'Female control of paternity in the internally fertilizing compound ascidian Diplosoma listerianum .2. Investigation of male mating success using RAPD markers'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 263, no. 1369, pp. 401-407.
  • Vernon, JG., Okamura, B., Jones, CS. & Noble, LR. (1996). 'Temporal patterns of clonality and parasitism in a population of freshwater bryozoans'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 263, no. 1375, pp. 1313-1318.
  • VERNON, JG., Jones, CS. & Noble, LR. (1995). 'RANDOM AMPLIFIED POLYMORPHIC DNA (RAPD) MARKERS REVEAL CROSS-FERTILIZATION IN BIOMPHALARIA-GLABRATA (PULMONATA, BASOMMATOPHORA)'. Journal of Molluscan Studies, vol 61, pp. 455-465.
  • Jones, CS., Noble, LR., JONES., JS., TEGELSTROM., H., TRIGGS, GS. & BERRY, RJ. (1995). 'DIFFERENTIAL MALE GENETIC SUCCESS DETERMINES GENE FLOW IN AN EXPERIMENTALLY MANIPULATED MOUSE-POPULATION'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 260, no. 1359, pp. 251-256.
  • Jones, CS., OKAMURA., B. & Noble, LR. (1994). 'PARENT AND LARVAL RAPD FINGERPRINTS REVEAL OUTCROSSING IN FRESH-WATER BRYOZOANS'. Molecular Ecology, vol 3, no. 3, pp. 193-199.
  • OKAMURA, B., Jones, CS. & Noble, LR. (1993). 'RANDOMLY AMPLIFIED POLYMORPHIC DNA ANALYSIS OF CLONAL POPULATION-STRUCTURE AND GEOGRAPHIC-VARIATION IN A FRESH-WATER BRYOZOAN'. Proceedings of the Royal Society of London. B, Biological Sciences, vol 253, no. 1337, pp. 147-154.

Chapters in Books, Reports and Conference Proceedings

Chapters

  • Noble, LR. & Jones, CS. (1996). 'A molecular and ecological investigation of the large arionid slugs of North-West Europe: The potential for new pests'. in WOC Symondson & JE Liddell (eds), Ecology of Agricultural Pests: Biochemical Approaches The Systematics Association Special Volume Series, Springer, pp. 93-131.

Other Contributions

  • Noble, LR., Jones, CS., Lockyer, AE., Spinks, J. & Rollinson, D. (2003). 'Molluscs, molecules and man: Towards new perspectives in Host-parasite interactions and future control strategies'.

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