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Dr Mody Nimesh

Current Research Physiology and molecular link between diet-induced obesity and insulin resistance in mouse models. I aim to study the interplay between genetic background and environmental challenges that lead to the development of obesity and type 2 diabetes. Mice fed high-fat diet rapidly undergo many molecular and physiological changes such as gain adipose (fat) mass and become insulin resistant. Prolonged exposure to a high-fat diet leads to morbid obesity, severe insulin resistance and diabetes. I have funding from the British Heart Foundation (Intermediate Basic Science Research Fellowship) to investigate the mechanism of diet-induced obesity and insulin resistance and identify novel molecular target(s) for the development of new, more potent therapies to treat obesity and prevent diabetes.

Selected Publications In reverse chronological order:

1: Preitner F*, Mody N*, Graham TE, Peroni OD, Kahn B. (* co-first authors). Long-Term Fenretinide Treatment Prevents High Fat Diet-Induced Obesity, Insulin Resistance and Hepatic Steatosis. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1420-9.

2: Mody N, Graham T, Tsuji Y, Yang Q, Kahn BB. Decreased clearance of serum retinol binding protein and elevated levels of transthyretin in insulinresistant ob/ob mice. Am J Physiol Endocrinol Metab. 2008; 294(4):E785-93.

3: Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007; 27(21):7727-34.

4: Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes. 2007; 56(10):2533-40.

5: Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005; 21;436(7049):356-62

Personal Details Telephone: +44 (0)1224 273255 E-mail: n.mody@abdn.ac.uk

Address: University of Aberdeen College of Life Sciences & Medicine Institute of Biological and Environmental Sciences Zoology Building, Tillydrone Ave, Aberdeen, AB24 2TZ, Scotland, UK Web site: http://www.abdn.ac.uk/ibes/staff/n.mody