Dr Mirela Delibegovic
Professional Address: Research Councils UK Fellow; College of Life Sciences and Medicine; Institute of Biological and Environmental Sciences; University of Aberdeen; Integrative Physiology Theme; Zoology Building Room 308; Tillydrone Ave Aberdeen, AB24 2TZ, Scotland, UK
e-mail: m.delibegovic@abdn.ac.uk
Qualifications: PhD
Research interests (including relevant publications)along with any other pertinent information.
My main interests of study are the role of tyrosine phosphorylation and dephosphorylation in cell signaling and disease. Through the combined use of biochemical, cellular and gene knockout mouse models, my research focuses on the function of protein-tyrosine phosphatases (PTPs) in regulating insulin and leptin signaling pathways in whole body metabolism, and how deregulation of these pathways leads to the development of diseases such as Type 2 diabetes and obesity. Understanding the pathways regulating metabolic processes is of critical importance because these diseases are reaching epidemic proportions.
Most recent relevant Publications:
Mirela Delibegovic, Derek Zimmer, Caitlin Kauffman, Kimberly Rak, Eun-Gyoung Hong, You-Ree Cho, Jason K. Kim, Barbara B. Kahn, Benjamin G. Neel, and Kendra K. Bence.Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced ER Stress. Diabetes, 58(3): 590-9.
M. Delibegovic, K.K. Bence, N. Mody, J. Kim, B.B. Kahn, and B.G. Neel. Improved Insulin Sensitivity and Glucose Homeostasis in Mice with Muscle-specific Deletion of PTP1B (2007). Molecular and Cellular Biology, Nov;27(21):7727-34.
Bence K.K., Delibegovic M., Xue B., Gorgun C., Hotamisligil G., Neel B.G., and Kahn B.B. (2006). Neuronal PTP1B Regulates Body Mass/Adiposity and Is Required for the Development of Leptin Resistance. Nature Medicine, Aug, 12(8):917-924